Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Lapovok (2017)
Title HIV Type 1 Integrase Natural Polymorphisms in Viral Variants Circulating in FSU Countries.
Citation Curr HIV Res
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 93
NumPts 92
Subtype A, B, CRF63_02A1, CRF02_AG, CRF03_AB, C, CRF06_cpx

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
01UADN121 01UADN121 None None M41L  K11T, K20R, V35T, E36D, T39K, V60I, K122E, D123N, I135T, S162C, K173L, Q174K, D177E, Q207A, R211S, V245I, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
01UADN139 01UADN139 None None A62V  V35T, E36D, T39K, I50V, T69S, K122E, D123N, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I309L, I326V, G335D, R356K, M357K, R358G, G359S, A360T, E370A, A371V, I375V, K390R, T403M, L452I, Q464K, S468P, D471E, Q480H, L491S, K512Q, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554D, K558R  
01UAKV167 01UAKV167 None None   K49R, E53D, K166R, V245K, I293V, I329V, G333E, R356K, T377I, K390R, A400T, T403M, K431T N81I 
01UAKV252 01UAKV252 None None  E138A D123E, K166R, G196E, V245T, K277R, T286A, I293V, E297K, I329V, G333E, R356K, T377Q, T386I, K390R, A400T, T403M, K431T, Q464H, H483Y, Q487K, V493A, Q520K, K527Q, K530R, A534T F87V 
01UAKV254 01UAKV254 None None   K11T, V35T, E36D, T39K, K122E, D123S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R D17T 
01UAKV259 01UAKV259 None None   D123E, S162C, V179I, R211K, V245T, K277R, T286A, E297K, E312A, I329V, G333E, T377Q, T386I, K390R, A400T, T403M, K431T, H483Y, V493A, Q520K, K530R, G555E  
01UAOD10 01UAOD10 None None   K11T, V35T, E36D, T39N, K43R, K122E, D123S, A158S, E169D, K173S, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, A376V, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
01UAOD35 01UAOD35 None None  E138A V35T, E36D, T39D, K122E, D123S, A158S, K173L, Q174K, I202V, Q207A, R211S, V245M, E248D, A272P, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, I382L, K390R, T403M, L452M, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554S, K558R  
01UAOD89 01UAOD89 None None   K11T, V35T, E36D, T39K, K122E, D123S, I135T, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, D324E, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524G, K527G, K530R, A534S, A554Y, K558R  
01UAPol293 01UAPol293 None None   K11T, V35T, E36D, T39K, K122E, D123S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, T377I, K390R, E399D, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, S515A, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
01UAPol294 01UAPol294 None None   K11T, E28G, V35T, E36D, T39K, K122E, D123S, K173L, Q174K, D177E, Q207D, R211S, V245M, E248D, A272P, K277R, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, A376T, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
01UAPol303 01UAPol303 None None   K11T, V35T, E36D, T39K, K122E, D123S, S162C, K173L, Q174K, D177E, T200I, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, A376T, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
02UZ0659 02UZ0659 None None A62V  K11T, V35I, E36D, T39K, V60I, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, Q509L, K512R, E516G, L517I, S519N, Q520K, Q524K, K527E, A534S, A554N, K558R  
02UZ0663 02UZ0663 None None   V35T, K122E, D123S, A158S, K173S, Q174K, D177E, Q197*, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
02UZ0667 02UZ0667 None None A62V  K11T, V35I, E36D, T39K, K122E, D123S, I135V, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, V531I, A534S, A554N, K558R  
02UZ0672 02UZ0672 None None A62V  K11T, V35I, E36D, T39K, V60I, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, E516G, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, E546K, A554N, K558R  
02UZ0683 02UZ0683 None None   P14K, V35T, E36D, D121Y, K122E, I135V, S162A, K173I, Q174K, D177E, T200A, Q207A, R211K, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, R356K, M357K, G359S, K366R, A371V, I375V, K390R, K395R, E399D, E432D, L452R, D471E, Q480H, L491P, K512R, E514D, S519N, Q524K, K527G, E529D, A534S, A554S  
02UZ652 02UZ652 None None A62V  K11T, V35I, E36D, T39K, V60I, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, E516G, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, E546K, A554N, K558R  
02UZ693 02UZ693 None None   P14E, V35T, E36D, E53G, D121Y, I135V, S162A, K173I, Q174K, D177E, T200A, Q207T, R211K, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, A360T, K366R, A371V, I375V, K390R, K395R, E399D, E432D, L452R, V458I, D471E, Q480H, L491P, K512R, E514D, S519N, Q524K, K527G, E529D, K530R, A534S, A554S  
02UZ694 02UZ694 None None A62V  K11T, V35I, E36D, T39K, K43R, V60I, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, E516G, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
02UZ698 02UZ698 None None A62V  K11T, V35I, E36D, T39K, V60I, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, T477P, Q480H, L491S, K512R, L517I, S519N, Q520N, Q524K, K527E, K530R, A534S, E546K, A554N, K558R  
02UZ710 02UZ710 None None   P14K, V35T, E36D, D121Y, K122E, I135V, S162A, K173I, Q174K, D177E, T200A, Q207A, R211K, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, R356K, M357K, G359S, K366R, A371V, I375V, K390R, K395R, E399D, E432D, L452R, D471E, Q480H, L491P, K512R, E514D, S519N, Q524K, K527G, E529D, A534S, A554R  
02UZ740 02UZ740 None None A62V  K11T, V35I, E36D, T39K, V60I, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, L295M, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, E516G, L517I, S519N, Q520N, Q524K, K527E, K530R, A534S, E546K, A554N, K558R  
03GEMZ019 03GEMZ019 None None   E28K, K32E, V35I, K122Q, I135T, D177E, Q207E, V245M, K277R, T286A, E297A, L391I, A400T I37T 
03GEMZ037 03GEMZ037 None None   K11T, V35T, E36D, T39N, E40D, K104R, K122E, D123S, I135T, S162C, K173S, Q174K, D177E, Q207A, L210M, R211S, V245M, P247L, E248D, A272P, T286A, E291D, V292I, I293V, P294T, K311R, I326V, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, I506V, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
03RU20-06-13 03RU20-06-13 RTI RTI A62V  K11T, V35L, E36D, T39K, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, N447NS, L452I, S468P, D471E, K476KR, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
04RU001 04RU001 None None  V108I K20R, V35T, V60I, D123E, I142T, K166R, D177E, T200V, Q207E, R211K, V245E, E248D, D250E, A272P, K277R, T286A, K287R, E291D, V292I, I293V, E297A, Q334H, F346H, R356K, M357I, R358K, G359S, T377M, I382V, K390R, A400T, E413D, K431T, L452K, K465R, V467I, S468T, T470S, D471E, H483N, L491S, S519N, A534S, A554S  
04RU139095 04RU139095 None None   V60I, I142V, Q197E, R211K, V245E, A272P, T286A, V292I, E297K, K311R, G333E, R356K, K366R, T369V, Q373H, A376T, T377M, A400T, V435T, L469F, T470N, L491V, S519N, A554S  
09RU4457 09RU4457 RTI RTI   K32R, V35T, V60I, K122E, D123E, I135T, I142V, D177E, V189I, I202V, Q207K, R211K, A272P, K277R, T286A, I293V, I326V, I329V, M357T, R358K, T377Q, K390R, T450S, L452S, V467I, S468P, H483Y, K527Q, K530R  
09RU4829 09RU4829 Unknown Unknown   L34I, V35T, E36D, V60I, K104R, D121Y, K122E, S162A, K173R, Q174K, D177Q, I178V, T200A, Q207A, R211N, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357G, R358G, G359S, E370A, A371V, I375V, K390R, E399D, L452I, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, A534S, A554S  
10RU5983 10RU5983 Unknown Unknown  K103N, N348I V35T, E36D, D121Y, K122E, S162A, I167V, K173R, Q174K, D177E, T200A, Q207A, R211N, V245Q, E248D, A272P, K277T, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, A376S, I382T, K390R, E399D, L452I, D471E, Q480H, L491S, I495IV, K512R, L517I, Q520K, Q524K, K527E, A534S, A554S  
10RU6366 10RU6366 Unknown Unknown   V35T, E36D, V60I, D121Y, K122E, I135V, S162A, K173R, Q174K, D177E, T200A, Q207A, R211N, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, L301I, I326V, G335D, R356K, M357G, R358G, G359S, E370A, A371V, I375V, V381I, K390R, K395R, E399D, V435I, L452I, D471E, Q480H, H483Y, G490R, L491S, Q507H, K512R, L517I, Q524K, K527E, A534S, A554S, K558R  
10RU6509 10RU6509 Unknown Unknown   P14E, V35T, E40D, S162A, K173I, Q174K, D177E, T200A, Q207A, R211K, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P294T, S322T, D324E, A327V, R356K, M357K, G359S, T369A, A371V, I375A, K390R, K395R, E399D, A400T, E432D, L452K, V458I, D471E, Q480H, H483L, L491S, K512R, E514D, S519N, Q524K, K527G, E529D, A534S, A554S  
10RU6617 10RU6617 Unknown Unknown A62V  K11T, V21I, V35T, E36D, T39R, V90I, K122E, D123N, A158S, K173S, Q174K, D177E, T200I, Q207A, R211S, V245M, E248D, S251H, A272P, V276I, T286A, E291D, V292I, I293V, P294T, S322A, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, T403M, E432D, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
10RU6629 10RU6629 RTI RTI   K20R, V35I, A98S, K122Q, K166R, D177E, Q207S, R211K, V245T, E248D, A272P, K277R, T286A, E291D, I293V, E297T, K311R, I329V, Q334L, P345T, A360T, A371V, K390R, I434V, V435A, E514D, S519N, A554S  
10RU6637 10RU6637 Unknown Unknown   V35T, E36A, V60I, I135L, S162A, K173R, Q174K, D177E, T200A, Q207A, R211N, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, K390R, K395R, E399D, L452I, V467I, D471E, Q480H, G490R, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, A534S, A554S  
10RU6649 10RU6649 Unknown Unknown   V35T, E36D, D121Y, K122E, S162A, K173R, Q174K, D177E, T200A, Q207A, R211N, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, A376T, V381I, K390R, K395R, E399D, L452I, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, A534S, A554N  
10RU6792 10RU6792 Unknown Unknown A62V  K11T, V35I, E36D, T39K, V90I, K122E, D123S, A158S, S162C, K173L, Q174N, D177E, Q207A, R211S, V245M, E248D, A272P, V276I, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, T377Q, K390R, T403M, L452I, V466A, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554H, K558R  
10RU6829 10RU6829 Unknown Unknown   E36D, V60I, D121Y, K122E, I135T, S162A, K173R, Q174K, D177E, T200A, Q207A, R211N, V245Q, E248D, A272P, K277T, T286A, E291D, V292I, I293V, P294T, G335D, R356K, M357R, R358G, G359S, E370A, A371L, I375V, K390R, K395R, E399D, L452I, D471E, Q480H, L491S, E492K, K512R, L517I, S519N, Q520E, Q524K, K527E, A534S, A554S  
11RU18n 11RU18n Unknown Unknown   V35T, E36D, D121Y, K122E, I142V, S162A, K173R, Q174K, D177E, T200A, Q207A, R211N, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, A376T, V381I, K390R, K395R, E399D, T403M, L452I, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, A534S, A554S  
11RU21n 11RU21n RTI RTI  K103N K20R, V35I, K122P, I135T, E169D, D177E, Q207K, F214L, I274L, K277R, T286A, E297A, I326V, I329L, A400T, V458I, R461K, V548I  
11RU6900 11RU6900 Unknown Unknown   P14E, V35T, E36D, D121Y, K122E, I135V, S162A, K173A, Q174K, D177E, T200A, Q207A, R211K, V245Q, E248D, K275Q, K277R, T286A, E291D, V292I, I293V, P294T, V317I, S322T, I326V, G335D, R356K, M357K, G359S, A360T, K366R, A371V, I375V, K390R, K395R, E399D, E432D, T450N, L452R, V467I, S468T, D471E, Q480H, L491S, K512R, E514D, S519N, Q524K, K527E, E529D, A534S, A554S  
11RU6939 11RU6939 Unknown Unknown   K11E, P14K, V35T, E36D, V60I, D121Y, K122E, I135V, S162A, K173I, Q174K, D177E, T200E, Q207A, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294A, S322T, I326V, G335D, R356K, M357K, G359S, K366R, A371V, I375V, K390R, K395R, E399D, T403M, E432D, V442I, T450S, L452R, D471E, Q480H, L491P, K512R, E514D, S519N, Q524K, K527G, E529D, A554S  
11RU6950 11RU6950 Unknown Unknown   K11T, V35T, T39K, K122E, D123S, I135K, K173L, Q174K, I202V, Q207A, R211S, V245M, E248D, A272P, T286A, E291D, V292I, I293V, P294T, K311R, V317L, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, K451R, L452I, S468P, T470N, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
1280 1280 None None   P14S, A98S, A158S, V245K, E248D, A272P, K277R, T286A, E297Q, E298G, S322ST, R356K, A360T, K390R, V435E, D460N, Q509K, A554S  
129005 129005 None None   K64KR, K122E, I135K, S251I, I257IV, A272S, P294Q, R356K, A360T, K366R, A376V, V381VI, T386I, A400T, E432ED, V435A, D460N, V467I, L491S, A508AS, S519N, A554T, K558R  
12RU15r 12RU15r Unknown Unknown M184V  V35T, E36D, D121Y, K122E, S162A, K173R, Q174K, D177E, T200A, Q207V, R211S, V245Q, E248D, A272P, K277T, T286A, E291D, V292I, I293V, P294A, I326V, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, K390R, E399D, L452I, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, A534S, A554N  
139089 139089 None None   K102R, I142F, S162C, S163T, K166R, I178M, V245E, A272P, T286A, E291Q, E297K, K311R, G333E, R356K, K366R, T369V, Q373H, A376T, T377M, A400T, V435T, L469F, T470N, L491A, V531I, A554S  
97BL006 97BL006 None None M184MI M230I K11T, V35PT, E36D, T39K, M41MI, G51GR, K122E, D123S, Y127X, I135V, G141GR, A158S, K173L, Q174K, D177E, I195T, Q207A, R211S, L234X, V245M, E248D, A272P, K277R, R284RK, T286A, E291D, V292I, I293V, P294T, E312EK, G316GE, I326V, G335D, R356K, M357K, R358RG, G359S, D364DN, E370A, A371V, I375V, I380IL, V381I, I382L, K390R, T403M, W414*, G436R, L452I, R461*, G462R, S468P, D471E, Q480H, A485V, L491S, N494D, K512R, L517I, S519N, Q520K, Q524K, K530RS, A534S, W535*, G541R, G543GR, G544GE, A554N, G555GR, K558KR D76DH, R78RT, W88W*S, G231GR, G273E, W383W*, W398W*, W402W*, Y405YF, W410W*, G444R 
98GEMZ001 98GEMZ001 None None   S48ST, V60I, T69N, A98S, K122E, D123E, I135T, T200A, V245E, A272P, K277R, T286A, P294T, I326V, Q334N, R356K, T470A, K512R, L517I, A554S  
98GEMZ004 98GEMZ004 None None   V35T, E36A, T39E, S48T, K122E, K173T, Q174R, I178M, T200A, Q207E, R211K, V245Q, K249E, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359A, T377M, K390R, A400T, E404D, V435A, A437V, N447S, V466I, V467I, S468T, L469I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554S  
98GEMZ006 98GEMZ006 None None   E6D, D123E, I135T, Q207K, R211S, I244V, K277R, I293V, P294S, K311R, I329V, G333E, T386I, K390R, A400T, T403A, K431T, A508G, K527N, V559I  
DE00208RU002 DE00208RU002 RTI RTI  V108I P14E, V35A, K122N, S162A, K173S, Q174K, D177E, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, K366R, T369V, A371V, I375V, K390R, E399D, A400T, E432D, V435A, L452K, V458I, D471E, Q480H, L491P, K512R, E514D, S519N, Q524K, K527G, E529D, A534S, A554S F389M 
DEMA108RU003 DEMA108RU003 None None   E6D, V35T, T39M, K122E, D123S, S162C, K173L, Q174K, D177E, T200I, E203D, Q207A, R211S, V245T, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, K311R, V314M, D324E, G335D, R356K, M357K, R358G, G359S, E370A, I375V, T377A, K390R, E399D, T403M, V435A, L452I, D471E, Q480H, L491S, K512R, L517V, S519N, Q520K, Q524K, K527E, A534S, A554N, K558R  
DEMA108RU004 DEMA108RU004 None None   K11T, V35T, E36D, T39D, E53K, A158S, K173S, Q174K, D177N, Q207A, R211S, V245K, E248D, A272P, T286A, E291D, V292I, I293V, P294T, K311R, L325I, R356K, M357K, R358G, G359S, Q367E, E370A, A371V, I375V, A376S, K390R, E399K, T403M, G436E, L452I, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, E529K, K530R, A534S, A554H, K558R  
DEMA111UA002 DEMA111UA002 RTI RTI   K11T, K20R, V35T, T39R, K43E, K122E, D123K, A158S, K173A, Q174K, D177E, V179I, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, L295M, V317T, S322T, D324E, I326V, G335D, R356K, M357K, R358G, G359S, K366R, Q367E, E370A, A371V, I375V, K390R, T403M, V435I, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520R, Q524K, K527E, K530R, A534S, A554H, K558R  
DEMA111UA008 DEMA111UA008 RTI RTI   K11T, V35T, E36D, T39N, K122E, D123G, S162A, K173L, Q174K, D177E, Q207A, R211S, F214L, V245T, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, L295M, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, A376S, K390R, V435I, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
DEMA111UA009 DEMA111UA009 RTI RTI   V35T, E36D, T39N, A98S, K122E, D123N, K173L, Q174R, D177E, T200A, Q207A, R211S, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335E, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452N, S468P, D471E, Q480H, H483Y, K512R, L517I, S519N, Q524K, K527E, A534S, A554T, K558R  
DEMA112UA014 DEMA112UA014 RTI RTI   V35T, E36D, T39K, K43E, K122E, D123N, K173S, D177E, I178V, T200A, Q207A, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, V317A, I326V, G335D, R356K, M357N, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, S468P, D471E, L491T, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
DEMA112UA024 DEMA112UA024 RTI RTI   K11T, V35K, T39D, V60I, K64R, D121H, K122E, D123S, K173S, Q174K, D177E, T200A, Q207A, R211S, E248D, A272P, L283I, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, K390R, T403M, E404D, E432D, V435M, T450N, L452T, S468P, D471E, Q480H, L491S, K512S, E514D, L517I, S519N, Q520K, Q524K, K527E, A534S, A554Q  
DEMA112UA030 DEMA112UA030 RTI RTI   K11T, V35T, T39N, K122E, D123S, I142T, A158S, K166R, K173Q, Q174K, Q207A, R211K, V245K, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, D324E, I326V, G333E, R356K, M357K, R358G, G359S, E370A, A371V, I375V, A376S, K390R, T403M, L452M, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520N, Q524K, K527E, K530R, A534S, A554S  
DEMA112UA034 DEMA112UA034 RTI RTI K65R, Y115F, M184V K101E, Y181C, G190S K11A, V35T, T39M, K102R, K122E, D123S, R172K, K173V, Q174K, D177E, Q207A, V245K, A272P, T286A, E291D, V292I, T296S, E297A, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, A400T, T403M, E404D, E449D, L452I, T470N, D471E, Q480H, L491S, K512S, L517I, S519N, Q520K, Q524E, K527G, K530R, A534S, A554S  
DEMA112UA036 DEMA112UA036 RTI RTI   K20R, E28A, V35T, E36D, T39K, V60I, V118I, K122E, D123S, K173L, Q174K, Q207A, R211S, F214L, V245T, E248D, A272P, V276I, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, A376V, S379C, T386A, K390R, L452I, S468P, D471E, Q480H, L484M, L491S, K512R, S515A, L517I, S519N, Q520K, Q524K, K527A, K530R, A534S, A554H, K558R  
DEMA112UA042 DEMA112UA042 RTI RTI   E6D, V35T, T39E, K122E, D123S, A158S, K173S, Q174K, D177E, T200A, Q207A, R211S, V245K, E248D, A272P, T286A, E291D, V292I, I293V, P294T, I326V, R356K, M357Q, R358G, G359S, E370A, A371V, I375V, A376T, V381I, K390R, T403M, L452I, V467VI, S468P, D471E, Q480H, L491S, K512S, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
DEURF08RU001 DEURF08RU001 None None   P14E, V35A, K102R, S162A, K173S, Q174K, D177E, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, K366R, T369V, A371V, I375V, K390R, E399D, A400T, E432D, V435A, L452K, V458I, D471E, Q480H, L491P, K512R, E514D, S519N, Q524K, K527G, E529D, A534S, A554S F389M 
Irkutsk_5 Irkutsk_5 None None A62V  K11T, V35I, T39E, K122E, D123N, I135T, A158S, K166R, K173L, Q174R, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, I382X, W383X, G384X, K385X, T386X, P387X, K388X, F389X, K390R, V435A, L452M, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Q, K558R  
KAL153 KAL153 None None   K11T, V35T, E36D, T39K, K122Q, I135T, D177E, Q207E, K277R, T286A, E297A, I326V, M357L, A400T, L452S, K558E D76G, K201E 
KZKAR300435 02K300435 None None   K11T, V35T, E36D, T39M, K122E, D123S, A158S, K173L, Q174K, D177E, T200I, Q207A, R211S, V245M, E248D, A272P, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, K374R, I375V, K390R, T403M, L452I, R463K, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
KZPAV300480 02P300480 None None   K11T, V35T, E36D, T39K, K122E, D123S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272T, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, A376T, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
KZPAV300497 02P300497 None None A62V  K11T, V35I, E36D, T39K, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E308A, I326V, G335D, F346C, R356K, M357K, R358G, G359S, E370A, A371V, I375V, S379G, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, A534S, A554N, K558R  
KZPAV300502 02P300502 None None   K11T, V35T, E36D, T39K, K122E, D123S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, A376T, K390R, T403M, L452I, S468P, D471E, Q480H, L491A, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
KZYUZ300413 02Y300413 None None A62V  K11T, V35I, E36D, T39K, K122E, D123S, A158S, K173L, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, V417I, N447T, L452I, S468P, D471E, Q480H, L491A, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
KZYUZ300425 02Y300425 None None A62V  K11T, V35I, E36D, T39K, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E312K, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
MSK_SK_005 MSK_SK_005 None None   P14K, V35T, E36D, K102Q, D121Y, K122E, I135V, S162A, K173V, Q174K, D177E, T200A, Q207A, R211K, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, K366R, I375V, K395R, E399D, T403M, E432D, V435A, L452I, Q464H, V467I, D471E, Q480H, L491P, K512R, S519N, Q524K, K527G, E529D, A534S, A554S  
MSK_SK_006 MSK_SK_006 None None   K11T, V35I, E36D, T39K, K43Q, V60I, D121H, K122E, D123S, A158S, K173S, D177E, Q207A, R211S, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, V435L, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R A62C, E516KR 
MSK_SK_007 MSK_SK_006-1 None None   K11T, V35I, E36D, T39K, K43Q, V60I, D121H, K122E, D123S, A158S, K173S, D177E, Q207A, R211S, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, V435L, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R A62C, E516KR 
  MSK_SK_007 None None A62V  K11T, V35I, E36D, T39K, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335E, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554HQ, K558R  
PokA79Ru PokA79Ru RTI RTI A62V E138A K11T, V35I, T39N, V60I, W88C, K122E, D123S, A158S, S162A, K173S, Q174K, Q207A, R211K, E248D, A272P, T286A, I293V, P294T, I326V, G335D, T338S, R356K, M357K, R358G, G359S, E370A, I375V, T386I, K390R, T403M, V417I, T450N, L452I, S468P, D471E, Q480H, G490E, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N, K558R  
PV85 PV85 RTI RTI   K11T, V35T, T39N, V118I, D121H, K122E, D123S, I142M, A158S, T165I, K173A, Q174K, Q207A, R211K, F214L, E224D, E248D, A272P, T286A, E291D, I293V, P294T, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, I382L, K390R, A400T, T403M, V435A, L452T, S468P, T470S, D471E, K476Q, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554N  
RU00051 RU00051 Unknown Unknown T215A, K219KR  K11T, K32R, V35T, E36D, T39K, K122E, D123N, I142V, A158S, S162C, K166R, K173S, Q174K, D177E, I202V, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, K395R, T403M, R461K, D471E, Q480H, L491S, E492K, K512R, S515A, L517I, S519N, Q520K, Q524K, K527E, A534S, A554AS  
RU01029 RU01029 None None A62V  K11T, V35I, E36D, T39K, V90I, K122E, D123S, A158S, K173L, Q174K, D177E, R199RT, Q207A, R211S, E224EG, V245M, E248D, A272P, K277R, T286A, A288AT, E291D, V292I, P294T, R307RK, E312EK, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R I293MV, G384R 
RU98001 RU98001 None None A62V  K11T, V35I, E36D, T39K, I94L, K122Q, I135T, D177E, T200I, Q207D, K277R, T286A, V292I, E297A, E312V, I326V, M357L, G359S, A400T, T403A, L452S, T472I, Q480H, V531F  
RUA001 RUA001 None None A62V  K11T, V35I, E36D, T39K, T69S, D123N, A158S, K173V, Q174K, D177E, Q207A, R211S, V245T, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E300EK, I326V, E328EK, Q334L, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, V435I, L452I, D471E, Q480H, L491S, K512R, E516EK, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
RUA007 RUA007 None None A62V  K11T, V35I, E36D, T39K, K122E, D123S, R125K, A158S, K173L, Q174K, D177E, E194K, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335E, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, E516K, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554K, K558R  
RU_560_1125 RU_560_1125 None None A62V  K11T, V35I, E36D, T39K, K82KR, K122E, D123S, I135T, A158S, K173L, Q174K, D177E, Q207A, R211S, V245T, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, V381I, K390R, T397V, T403M, L452K, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  
RU_8141 RU_8141 Unknown Unknown   V35T, E36D, V60I, D121Y, K122E, S162A, F171Y, K173R, Q174K, D177E, T200A, Q207A, R211N, V245Q, A272P, K277T, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, A376S, T377M, K390R, K395R, E399D, L452I, R461K, V467I, S468T, D471E, Q480H, L491S, K512R, L517I, Q520K, Q524K, K527E, A534S, A554S  
RU_8169 RU_8169 Unknown Unknown   V35T, E36ED, V60I, D121H, K122E, I135IV, I142V, S162A, K173R, Q174K, D177E, I178L, Q197QK, T200A, E203ED, Q207D, R211K, I244IV, V245Q, E248D, A272P, K277T, T286A, E291D, V292I, I293V, P294T, I326V, Q334E, G335D, R356K, M357R, R358G, G359S, V365I, E370A, A371M, I375V, V381I, K390R, E399D, L452I, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527DE, E529ED, A534S, A554S W383W* 
RU_8501 RU_8501 Unknown Unknown  V179E E6ED, V35T, E36D, V60I, K102R, D121Y, K122E, I135V, S162A, K173R, Q174K, D177E, T200AV, E203ED, Q207ADE, R211KN, V245Q, E248D, A272P, T286A, E291D, V292IT, I293V, P294T, I326V, G335D, R356K, M357R, R358G, G359S, E370A, A371V, I375V, K390R, K395R, E399D, V435I, L452I, D471E, Q480H, H483Y, G490KR, L491S, K512R, L517I, S519N, Q520S, Q524K, K527E, A534S, A554S  
RU_915_1016 RU_915_1016 None None   K11T, V35T, E36D, T39N, D121DN, K122E, D123S, R125RK, I135V, R143RK, T165I, R172RK, K173L, Q174K, D177E, Q207A, R211S, V245T, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452M, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520N, Q524K, K527E, K530R, A534S, A554N, K558R  
RU_915_1035 RU_915_1035 None None   K11AT, V35T, T39R, K122E, D123S, S162A, K173S, Q174K, D177E, E194K, Q207A, R211S, V245M, E248D, A272P, T286A, E291D, V292I, I293V, P294T, V317A, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, D471E, Q480H, L491S, K512R, E516EK, L517I, S519N, Q520K, Q524K, K527E, A534S, A554N, K558R  
RU_915_1038 RU_915_1038 None None   K11T, V35T, E36D, T39KN, K122E, D123S, A158S, S162A, K173S, Q174K, D177E, Q207T, R211K, V245M, E248D, A272P, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554S, K558R  
RU_915_1041 RU_915_1041 None None   K11T, V35T, E36D, T39N, K122E, D123S, R125RK, I135T, R143K, S162C, E169K, K173L, Q174K, D177E, E194EK, R199RK, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, S322L, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, T386I, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q524K, K527E, K530R, A534S, A554H, K558R Q520EG 
RU_SP_B_049 RU_SP_B_049 None None   V10I, V35T, E36D, T39N, K122E, D123S, A158S, K173L, Q174K, D177E, Q207A, R211S, V245M, E248D, A272P, T286A, E291D, V292I, I293V, P294T, I326V, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, T403M, L452I, S468P, D471E, Q480H, L491S, K512R, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R  

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