Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Garrido (2012)
Title Plasma raltegravir exposure influences the antiviral activity and selection of resistance mutations.
Citation ARHR
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 34
NumPts 22
Subtype B, CRF12_BF, CRF17_BF

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
HCIII-01 HCIII-01-baseline-INT None    E11D, D41N, P90S, L101I, K156N, I208L, D256E  
  HCIII-01-failure-INT RAL 31 N155H  E11D, K14R, K34R, D41N, P90PS, L101I, K111KQ, S119R, K156N, I208L, D256E  
HCIII-02 HCIII-02-baseline-INT None    R20K, S24SN, L45LV, S81SR, V201I A129AP 
  HCIII-02-failure-INT RAL 157 G140GS, Q148R  R20K, V201I  
HCIII-03 HCIII-03-failure-INT RAL 22 N155NH  M50IT, L101I, L104I, T124A, E138ED, A205AS, T206S, I208IL, D256E  
HCIII-04 HCIII-04-failure-INT RAL 52 N155H  E11D, S17T, I72V, V151I, E198D, V201I, K211R D270DA 
HCIII-05 HCIII-05-baseline-INT None    E11D, V32I, V37I, L101I, I191IM, V201I, D232E, D256E G149GR, L213LV 
  HCIII-05-failure-INT RAL 31 G140S, Q148H  E11D, V31VI, V32I, V37I, L101I, V201I, D232E, D256E  
HCIII-06 HCIII-06-baseline-INT None    E11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, S255N, D256E  
  HCIII-06-failure-INT RAL 31 N155H D232N E11D, R20K, L101I, S119P, T122I, T124A, V151I, S195T, I203M, I220IM, Y227F, S255N, D256E  
HCIII-07 HCIII-07-baseline-INT None    V31I, L68V, K111T, S119T, T125A, V126L, I135V, I203M G245GA 
  HCIII-07-failure-INT RAL 31 Y143R T97A V31I, M50MI, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256E  
HCIII-08 HCIII-08-baseline-INT None    S17N, E96D, L101I, S119P, T122I, T124A, K156N, V201I, T206S, I208L, Y227F, D253Y, D256E  
  HCIII-08-failure-INT RAL 104 Y143YH, N155H  S17N, E96N, L101I, S119P, T122I, T124A, K156N, V201I, T206S, I208L, Q221QP, Y227F, D253Y, D256E R224RP 
HCIII-09 HCIII-09-failure-INT RAL 52 N155H  E11D, K14R, S17T, L101I, T112I, S119P, V151I, I162V  
HCIII-10 HCIII-10-failure-INT RAL 52 E138EK, S147G, Q148R  S39G, I72V, V88I, T124N, T125A, I135V, K173R, I203M, I220L, S230N, D253E, V259I P30PL, V31F 
HCIII-11 HCIII-11-baseline-INT None    D6DN, S17N, I60V, L68T, I72IT, T124N, T125A, V176L, E212A  
  HCIII-11-failure-INT RAL 83 N155H  S17N, I60V, I72V, K111E, T124N, T125A, K173R, V176L, I217V  
HCIII-12 HCIII-12-failure-INT RAL 52 G140S, Q148H  K14R, V31I, L101I, A128V, I135V, G163Q, G193E, V201I, D256E  
HCIII-13 HCIII-13-failure-INT RAL 52 N155H  E11D, R20K, S24G, D25E, L28I, L101I, S119P, T122I, T125A, V180I, S230N  
HCIII-14 HCIII-14-failure-INT RAL 52   E11D, L45Q, M50I, I72V, T125A, A265V  
HCIII-15 HCIII-15-failure-INT RAL 52   K156N, V201VI, L234H  
HCIII-16 HCIII-16-baseline-INT None    E10D, V32I, S39C, L101I, T218S, S230N, D253E  
  HCIII-16-failure-INT RAL 22   E10D, V32I, S39C, L101I, T218S, S230N, D253E  
HCIII-17 HCIII-17-failure-INT RAL 52   K156N, V201VI, L234H  
HCIII-18 HCIII-18-baseline-INT None    D6DN, S17N, V31I, I72V, K103KR, T112I, T124N, T125V, K156N, V201I, T206S  
  HCIII-18-failure-INT RAL 104   S17N, V31I, I72V, K103R, T112I, T124N, T125V, K156N, V201I, T206S  
HCIII-19 HCIII-19-baseline-INT None    K7R, L101I, T112I, S230N  
  HCIII-19-failure-INT RAL 135   K14R, L101I, T112I, S230N G272G* 
HCIII-20 HCIII-20-failure-INT RAL 52   R20K, I72V, L101I, I113L, T124N, T125V, I204V, T206S  
HCIII-21 HCIII-21-baseline-INT None    L2S, S17N, V32I, D41N, L68I, I72V, I84L, L101I, K111R, S119T, T124A, K136Q, V165I, V201I, A205S, K211R, T218I, L234V, D256E, D278DN  
  HCIII-21-failure-INT RAL 52   S17N, V32I, I72V, I84L, L101I, K111R, S119T, T124A, K136Q, V165I, V201I, A205S, K211R, T218I, L234V, D256E  
HCIII-22 HCIII-22-baseline-INT None    V31I, L101LI, K188KR, V201I, T206S, A265V, R269K  
  HCIII-22-failure-INT RAL 313 G140A, Q148R  V31I, D41N, L101I, V201I, T206S, I268L, R269K