Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Descamps (2015)
Title Dolutegravir in HIV-2-Infected Patients With Resistant Virus to First-line Integrase Inhibitors From the French Named Patient Program.
Citation Clin Infect Dis
SelectedGene IN
SelectedSpecies HIV2
SelectedType Clinical
NumIsolates 10
NumPts 10
Host Human

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
Pat1 Pat1_INT RAL  N155H  L2I, K4R, S39T, I72IV, I84V, E92A, G94A, H156X, R164K, I172V, A215S, L220F, L250I, R269K, G278S N30K, S93T, I133V, A153G, I180V, S197A, R199E, F212Y, D222N, I259V, I260V, G272G_GR, G283G_A, E288E_VA 
Pat10 Pat10_INT RAL  S138T, Y143R T97A K4S, S17G, S23V, G27Q, N30Q, I50V, A119T, Q124R, S163E, I175V, I180A A41D, Q42K, S93T, E125D, I133V, V141I, E167D, N170V, T171S 
Pat11 Pat11_INT RAL  S147SG  S23T, N30Q, V32VI, S39T, N55NS, T60V, I84IV, P90PS, L113V, H156R, I180A, A215R, K219N, L220F, R224Q, D232DE, E246D, L250I, G278S, R284G V19I, L58V, A119S, I133IV, V141A, H157HY, T171S, I175L, S197A, D222N, F227Y, R231K_GK, Q233AS, T255A, I259V, I260V, G272G_GR, M275L, S279T, G283G_A, E288E_VA 
Pat13 Pat13_INT RAL  S138T, G140S, Q148K  K4N, S17G, S23V, N30Q, I50V, I72V, S163D, I175V, I180A, L213F, S218L, K219N, L220F, R224Q, L250I, D256E, D270H, S277C, G278S, S279A, D286A G27R, R34K, A41HN, Q42K, T60TI, S93T, I133V, E167D, N170V, T171S, S197A, I201V, T205A, D222N, V251I, I259V, I260V, G272G_GG, Q273K, M275L, H280D, L281V, G283D_T, E285Q, G287R, E288E_MAQSG 
Pat3 Pat3_INT RAL  Y143HR T97TA S17N, S39T, A119T, I172M, Q214H, A215S, E246D, L250I I28L, N30K, A41P, I50M, N55D, L58V, Q91R, S93T, Q96QE, I133V, V141VI, I180V, S197A, D222N, I259V, I260IV, G272G_GR, H280N, G283G_A, E288E_VA 
Pat4 Pat4_INT RAL  N155H  L2I, K4R, S39T, I72IV, I84V, E92A, G94A, H156X, R164K, I172V, A215S, L220F, L250I, R269K, G278S N30K, S93T, I133V, A153G, I180V, S197A, R199E, F212Y, D222N, I259V, I260V, G272G_GR, G283G_A, E288E_VA 
Pat5 Pat5_INT RAL  Y143G T97A K4R, S39T, A119T, H156R, I172M, L220F, E246D, L250I K20Q, I28L, N30K, Q91R, S93T, I133AT, V141I, A153S, H157S, N170D, I180V, S197A, I201V, D222N, Q233P, I259V, I260IV, G272G_GR, E274G, H280N, G283G_A, E288E_VA 
Pat6 Pat6_INT RAL    Y15F, I72V, I172V, I175V, L213S, S218L, L220F, L250I, R269K V19I, I28L, N30K, A41AT, S93ST, E125D, I133V, E167D, I180V, S197A, D222N, I259V, G272G_GG, Q273K, M275L, G283G_A, E288E_VA 
Pat7 Pat7_INT RAL    N30Q, S39T, T60V, A215R, K219N, L220F, R224Q, E246D, L250I, G278GS, D286N S23I, L58LI, I133V, I180V, S197A, D222N, F227Y, I259V, I260V, G272G_GR, M275L, G283G_A, E288E_VA 
Pat8 Pat8_INT RAL   T97TA S17G, S23V, N30Q, S163D, I172M, I175V, L200V, S218L, K219Q, L220F, D222K, R224Q, L250I, D256E, D270H, S277C, G278S, S279A, E285*, D286A K4Q, V19I, A41D, Q42K, S93T, E125D, I133V, E167D, N170V, T171S, I180T, S197A, E198V, R199I, I201V, L213H, F227Y, V251I, I259V, I260V, G272G_GG, Q273K, M275L, H280D, L281V, G283D_T, G287R, E288E_MAQSN 

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