Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Hazuda (2018)
Title Understanding the Resistance Profile of the HIV-1 NNRTI Doravirine in Combination With the Novel NRTTI MK-8591.
Citation IAC
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 7
Lab Parent Strain NL43

 

Lab RT Isolates : Susceptibility Data


IsolateNRTIDRMsNNRTIDRMsMethodDrugFold Res.
A98G_M184V_F227C M184V A98G, F227C PhenoSense DOR >93 
      PhenoSense EFV 9.0 
A98G_V106I_M184V_H221Y_F227C M184V A98G, V106I, H221Y, F227C PhenoSense DOR >110 
      PhenoSense EFV 19 
K65R_M184V_V106M_F227C K65R, M184V V106M, F227C PhenoSense DOR >98 
      PhenoSense EFV 11 
K65R_V106A_P225H_Y318F K65R V106A, P225H, Y318F PhenoSense DOR >210 
      PhenoSense EFV 4.8 
M184V_Y188L M184V Y188L PhenoSense DOR >181 
      PhenoSense EFV >120 
V106I_F227C  V106I, F227C PhenoSense DOR >105 
     PhenoSense EFV 2.5 
V106I_M184V_H221Y_F227C M184V V106I, H221Y, F227C PhenoSense DOR >96 
      PhenoSense EFV 1.7