Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Marcelin (2019)
Title Resistance to integrase inhibitors: a national study in HIV-1-infected treatment-naive and -experienced patients.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 674
NumPts 674
Subtype B, CRF02_AG, A, F, D, CRF06_cpx, C, G, CRF11_cpx, CRF45_cpx, CRF25_cpx, CRF09_cpx, CRF01_AE, CRF37_cpx, H, CRF05_DF, CRF36_cpx, CRF13_cpx, CRF18_cpx, CRF12_BF, CRF28_BF, CRF69_01B, CRF29_BF, CRF17_BF, CRF43_02G

 
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Page 1   listing Isolate 1 to Isolate 100 from Total 674 Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
PT1 ISO1 RAL 187 N155H G163R E11D, D25E, V31I, V32I, I72V, L74V, L101I, T112A, I113V, T125A, V151I, H171Q, V201I, A205S, T206S, T218S, I220V  
PT10 ISO10 EVG, RAL 26  D232DN K7Q, K14R, V31I, L74I, A91S, L101I, T112I, I113IV, S119P, T124A, T125A, G134GD, D167E, I203M, T206S, L234I, D256E, S283G F121FV 
PT100 ISO100 EVG, RAL 26 T66I G163R S57G, I72V, Q95N, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269K, V281M Q146QK, G247GE 
PT11 ISO11 RAL 17   K14R, V31I, M50MI, L74M, T112V, T124A, T125A, V126M, G134N, I135V, K136T, V201I, T206S, E212Q, K215N, N222K, L234I, R269K, S283G  
PT12 ISO12 RAL 57   E11D, K14R, S24N, V31I, V32I, D41E, M50T, G106A, T112I, I113V, T125A, V201I, T206S, K211R  
PT13 ISO13 DTG 13   K14R, V32I, L101I, T112I, T124A, T125A, G134N, K136T, V201I, T206S, Y227F, L234V, S255N, D256E, S283G  
PT14 ISO14 RAL 13 E92EQ, Q148QR, N155NH  K14R, R20K, V31I, D41DN, L101I, T112V, T124A, T125A, I135V, K136T, I200M, V201I, T206S, L234I, S283G R262RS 
PT15 ISO15 RAL 39   K14R, V31I, S57G, L101I, T112V, S119P, T124A, T125A, G134S, K136T, V201I, T206S, D207E, T218S, I220L, Y227F, L234I, D253H, N254D, S283G, R284G, D288N  
PT16 ISO16 RAL 65   K14R, S24SG, D25E, L28I, L45Q, I72IV, V75VI, E96D, T112V, I113IV, T124N, T125A, V126M, I135V, K188KR, V201I, K211R, L234I, I268L, D270H, S283G  
PT17 ISO17 RAL 26   M154I, V176VI, F181Y, T218I, D256E, D278A  
PT18 ISO18 RAL 35 E92Q  K14R, D41N, S57G, L63I, I72V, L74I, E96D, L101I, T112I, T124A, T125A, G134N, I135V, K136T, F181L, V201I, T206S, L234I, S283G  
PT19 ISO19 RAL 30 N155H  E11D, K14R, S17T, S39C, I72V, L101I, T112V, S119P, T124A, T125A, G134N, I135V, K136T, D167E, V201I, T206S, T218I, L234I, R269K, S283G  
PT2 ISO2 RAL 104   D6E, E10D, L45Q, L101I, K111Q, T112A, T124A, I135V, K136R, E212Q, N222NH, D256E, I268L  
PT20 ISO20 EVG 39 E92EQ T97TA, A128AT, D232DN K14KR, I60IM, L63I, L74I, L101I, T112TI, S119P, T124TA, T125A, G134D, I135V, D167E, V201I, T218I, L234I, D256DE, S283G Q146R 
PT21 ISO21 RAL 30 E92Q  D3E, E11D, K14KR, R20K, V31I, L63V, I72V, L74I, T112V, I113V, T115S, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, L234I, S255N  
PT22 ISO22 RAL 170   E11D, K14R, I208M, L234F, D253E, A265V  
PT23 ISO23 DTG 48   V31I, I72V, L74LIM, T112I, I113V, T124N, T125M, V151I, D167E, V201I, T206S, I208L, S283SN  
PT24 ISO24 RAL 43   E11D, S17T, A23V, I72IV, I113V, S119X, T122I, T124N, T125TA, V201VI, T206S  
PT25 ISO25 RAL 17   I72V, K111R, T124A, F181FL, V201I, T206TS, K211KR, A265AV, R269RK, D270DN I268IF 
PT26 ISO26 DTG 17   K14R, V31I, M50I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, K173R, S195T, V201I, T206S, Y227F, L234I, N254K, S255G, I268L, R269K, S283G  
PT27 ISO27 RAL, DTG 43   V31I, M50L, T124A, A196AT, K219KQ  
PT28 ISO28 RAL 117   K14R, V31I, A33AT, S57G, I72X, T112V, I113V, S119P, T124AS, T125A, G134N, I135V, K136T, V201I, T206S, I220IV, L234I, S283G  
PT29 ISO29 DTG 17   S17N, L101I, K188R  
PT3 ISO3 RAL 396   K14R, S17N, V31I, V32I, I72V, L101I, T112V, T124A, T125A, K127KR, G134N, K136S, D167E, K173R, I182V, V201I, T206S, K219N, N222K, L234I, S255SR, D256E, S283G  
PT30 ISO30 RAL 235   K14R, V31I, S57G, I72IV, I84M, E96D, L101I, T112V, T124A, T125A, G134N, K136IT, V201I, T206S, L234I, R269K, S283G  
PT31 ISO31 RAL 78 Y143R  K14R, S17N, S24SN, V31I, A49P, I72V, K111Q, T112V, T124A, T125A, G134N, K136Q, D167E, K173R, V201I, T218S, N222R, D232DE, L234I, S283G  
PT32 ISO32Edited RAL 170   V31I, L101I, D232E, I251IV, A265V  
PT33 ISO33 RAL 78 N155H A128T S17N, P30S, V31I, M50T, I60T, K111T, I203M, K211R, S255R  
PT34 ISO34 RAL 26   R20K, M50I, L101M, T112V, S119R, T124E, T125V, D167E, H171Q, T206S  
PT35 ISO35 RAL 22   E11D, E13D, S24N, S119P, T122I, T124A, T218S, I220L  
PT36 ISO36 RAL 17   V31I, I60L, I72V, L74I, V88I, L101I, E152K, E157K, V176L, A239T  
PT37 ISO37 RAL, DTG 130   R20RK, D25E, V31I, M50I, G52GR, G59GE, F100Y, L101I, T112V, T125A, K136N, G163GE, K173R, G193GDE, V201I, I203M, Q221H, N222R, L234I, D256E, V260I, I268L, S283SG, D286DN  
PT38 ISO38 RAL 44   K14R, S24G, D25DE, L28I, S39C, M50MI, L101I, K156N, V201I  
PT39 ISO39 DTG 13  E157Q K14R, R20K, N27H, V31I, S39N, G106A, T112V, T125A, G134S, K136Q, K173R, G193E, V201I, T206S, T218S, L234I, S283G, R284G, D286N  
PT4 ISO4 RAL 17   M50I, E96D, L101I, G193E, V201I, D288N  
PT40 ISO40 RAL 17  G163GR S17N, I72V, K103R, T112I, I113V, T124N, T125A, K136Q, V165VI, V201I, I208L, L234I, S283G  
PT41 ISO41 RAL 30   K14R, V31I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, V201I, T206S, L234I, I268L, R269RK, D270DH, S283G  
PT42 ISO42 RAL 65  T97TA, E157Q K14R, A21AT, V31I, M50T, L101I, T112V, T124A, T125A, G134N, I135V, K136T, K160Q, V201I, T206S, Q221H, N222Q, L234I, D256E, S283G  
PT43 ISO43 RAL 30   E11D, S17C, V54VI, L101I, T124N, I135V, K211R, L234I, A265V  
PT44 ISO44 RAL 69   E11D, S24N, I72V, K111KR, T112V, T125A, V126L, I135V, V201I, L234I, A265AV  
PT45 ISO45 EVG 17  E157Q K14R, S24N, D25DE, V31I, M50T, L101I, T112V, T124A, T125A, G134N, I135V, K136T, K160Q, V201I, T206S, Q216H, L234I  
PT46 ISO46 RAL 204   V31I, L101I, K111N, T112X, I113IL, S119ST, T124N, A205AS, I208IL, N222NH  
PT47 ISO47 RAL 52   K14R, L28I, L45Q, S57G, L63LV, G70GE, L101I, T112V, T124A, T125S, I135V, K136T, E157EK, V201I, T206S, T218I, L234I, R269K, D278G, S283G, R284RG, D288N D167EV 
PT48 ISO48 EVG 26 Q148QR, N155NH  S17N, I72V, E92X, T124A, E152EK, K188R, G193R, S195T, T206S, I220L, I251L, A265AV, K273Q  
PT49 ISO49 RAL 35   E11D, E13ED, K14R, S24N, V31I, L45LI, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218L, K219N, N222K, L234I, R269K  
PT5 ISO5 EVG 35   K14R, S39C, M50I, L101I, T112V, T124A, I135V, G163E, V201I, T206S, L234I, V259VI  
PT50 ISO50 EVG 48 E138EK, Q148QR, N155NH S230SR R20K, V31I, L101I, S119SR, K156N  
PT51 ISO51 RAL 365   K14R, V31I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, F181L, G189GR, V201I, T206S, L234I N117NS, D202DN 
PT52 ISO52 DTG 26   E11D, K14R, A21T, M50I, I72V, T124A, T125A, V126L, M154L, V165I, D167E, T206S, T218S, I220M, Y227F, D256E  
PT53 ISO53 RAL 104 Y143R  K71KQ, I72X, L74M, E96N, L101I, S119G, T122I, T124N, T125A, E138ED, V201I  
PT54 ISO54 RAL 135   L101I, T112V, T124N, T125IV, G134D, I135V, I161L, V201I, T206S, L234I, S255N  
PT55 ISO55 RAL 9  E157Q I72V, L74I, L101I, T112V, I113V, T124A, T125A, G134D, I135V, K136T, K160Q, V201I, L234I, R269K  
PT56 ISO56 RAL 322 N155H D232N L101I, T124A, T125A, G134N, I135V, K136T, E138D, V151I, V201I, T206S, L234I, R269K  
PT57 ISO57 RAL 109 Y143YC  L74I, S119P, T125A, K136Q, M154I, H171Q, D256E E152EQ 
PT58 ISO58 RAL 104   L101I, T112IV, T124G, T125A, K127KR, G134N, I135V, K136T, G163M, V201I, T206S, L234I  
PT59 ISO59 RAL    H51D, I73V, L101I, T206S  
PT6 ISO6 RAL 26   M50I, I72V, S119P, T122I, T124A, T125A, I162V, S195T, T206S  
PT60 ISO60 EVG, RAL 4 N155H T97A L101I, S119R, T125V, G163E, A205S  
PT61 ISO61 RAL 35   I72IV, A91AT, T112V, I113V, S119ST, T124A, T125A, V126M, I135V, V201I, K211KR, L234I, K244R  
PT62 ISO62 RAL 317 N155H  I84V, T112I, T122I, T124N, M154I, V201I, Q216R, K219Q, D256E, Q274K  
PT63 ISO63 RAL 126   I72V, L101I, T112V, S119P, T122I, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I  
PT64 ISO64 RAL 4   I60IV, L101I, T112V, T124A, T125A, G134N, I135V, K136T, G193GR, V201I, T206S, T218L, K219Q, L234I  
PT65 ISO65 RAL 300   I72V, T112I, I113V, T124AV, K156N, V201I, E212A, T218S, I220L  
PT66 ISO66 RAL, DTG 26 N155NH D232DN I72V, L101I, K111KT, S119X, T122TI, V151VI, K211KQ, I220IV, D288G  
PT67 ISO67 RAL 17 N155H  H51D, I84IM, L101I, S119P, T122I, K173R, G193E, V201I  
PT68 ISO68 RAL 78 N155H  L101I, I113V, S119R, T125A, I220L  
PT69 ISO69 RAL 30   L101I, S119P, S195T, V201I, T218S  
PT7 ISO7 RAL 26   K14R, R20K, V31I, L101I, T112V, T124A, G134N, K136T, K173R, V201I, T206S, I220L, L234I  
PT70 ISO70 RAL 326   H51D, I72V, M154I, V201I  
PT71 ISO71 RAL 222   I72V, V88L, K111T, S119P, T122I  
PT72 ISO72 RAL 22   L101I, K173R, F181L, Y227F, S230N, D256E  
PT73 ISO73 RAL 82 Q148R D232N I72V, K111Q, T112V, I113V, T124A, V201I, L234I  
PT74 ISO74 RAL 187   L74I, V75I, L101I, G106GR, K111T, T124A, T125A, D167E, A179S, V201I, I220L, Y227F  
PT75 ISO75 RAL 187  T97TA I72V, L101I, T112V, S119T, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I A76AV 
PT76 ISO76 RAL 243 N155H  I72V, L101I, S119P, T122I, E170A, T218I, A265V  
PT77 ISO77 RAL 39   L101I, S119P, T122I, T124A, V201VI, I203IM, D256E  
PT78 ISO78 RAL 82 N155H  I72V, K111R, K136R, V151VI, M154I, K173R  
PT79 ISO79 RAL 143 N155H  L101I, K111T, T122I, V151I, D167E  
PT8 ISO8 EVG 65 P145S  V31I, L101I, I113L, A205S, K211R, L234I  
PT80 ISO80 RAL 217   L101I, T112V, T124A, T125A, G134N, I135V, K136T, G163T, V201I, T206S, T218I, L234I, S255N  
PT81 ISO81 RAL 30   I60M, K71Q, A91T, A98G, L101I, G106A, T112V, S119R, T124A, K136Q, V201I, A205S, T206S, L234V, D256E  
PT82 ISO82 RAL, DTG 9 G140S, Q148H, N155NH  V201I, T206S  
PT83 ISO83 RAL 204   M154I, K173R  
PT84 ISO84 EVG, RAL, DTG 209   I72V, L101I, S230N  
PT85 ISO85 RAL, DTG 30 N155H  K156N, V201I, K211R, E212T, P233PS  
PT86 ISO86 RAL, DTG 13 G140S, Q148H T97A I60M, L101I, T112S, K160N, R187K, V201I, S230N, K240R, D256E  
PT87 ISO87 RAL, DTG 17 E138EK, G140GA, Q148R T97A, D232DN L101I, G106A, K111Q, T112V, T125V, G134N, K136T, V165I, V201I, T206S, L234V, D256E, R284RI R269RI 
PT88 ISO88 DTG 48   I72V, S119P, T122I, T124A, V165VI, V201I, K211KR, K219NT, I220L  
PT89 ISO89 EVG, DTG 17 E92Q  L74I, Y99YH, S119P, I220L  
PT9 ISO9 DTG 22   S17N, I72V, I113V, T124A, T125A, I141IT, K156N  
PT90 ISO90 RAL, DTG 22   S57G, I72V, K111KR, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218S  
PT91 ISO91 RAL, DTG 30   L101I, T112V, T124A, T125A, G134N, K136T, D167E, V201I, T206S, Y227F, L234V, D256E  
PT92 ISO92 RAL, DTG 13   S57G, I72V, E96D, L101I, K111N, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, S255G, R269K  
PT93 ISO93 RAL, DTG 35   L101I, T112A, T124A, T125A, V201I, D232E, L234I, V249I R187S 
PT94 ISO94 RAL, DTG 13 E92Q, S147G, N155H  I60M, I73V, L74M, T112V, I113V, T124A, T125A, K136Q, I162V, V201VI, I208IM, L234V  
PT95 ISO95 RAL, DTG 52 G140S, Q148H T97A M50K, T124A, T125A, F139Y, V201I, I208L  
PT96 ISO96 RAL, DTG 9  T97A T112I, I113V, T124A, T125A, V201I, L234I  
PT97 ISO97 EVG, RAL 17   S57G, I72V, L101I, G106GA, T112V, T124A, T125A, G134S, I135V, K136T, V201I, T206S, L234I, D256E  
PT98 ISO98 EVG 48   H51D, L101I, T112V, T124TN, T125V, G134D, K136T, V201I, T206S, L234I, D256E, R269K, C280CR  
PT99 ISO99 EVG 43 E138K, S147SG, Q148R  I72V, I84M, K111R, T112V, I113V, T124N, T125A, V201I, T206S, K211Q, L234I H114HY 

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