Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Scherrer (2012)
Title Polymorphic mutations associated with the emergence of the multinucleoside/tide resistance mutations 69 insertion and Q151M.
Citation JAIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 46
NumPts 46
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
SHCS401 SHCS401 RTI RTI M41L, T69S_SG, M184V, L210W, T215Y Y188L, K238KN K20R, K32E, V35R, T39A, V118I, D123E, I135T, T139I, S162Y, D177E, G196E, R211K, L228H, D237E, V245E, D250E, A272P, I274IV, K277R, E297R, D324E, Q334G  
SHCS402 SHCS402 RTI RTI D67N, T69T_T, K70R, K219Q  K64N, K82KR, V90VI, K104R, K173E, P176K, I178L, T200IR, Q207R, D218E, V245E, V317A, Q334L, G359S, A371V  
SHCS403 SHCS403 RTI RTI M41L, T69S_SA, L210W, T215Y  W88C, V118I, D123E, Q207E, R211K  
SHCS404 SHCS404 RTI RTI M41L, D67S, T69S_CT, L74I, M184V, L210CW, T215Y K103N K43KN, A98S, V111I, V118I, K122E, I142V, V189VI, G196E, T200AV, H208HY, R211K  
SHCS405 SHCS405 RTI RTI M41L, D67S, T69S_CT, M184V, L210W, T215Y  K20R, K43N, V60I, W71X, V118I, K122E, S162Y, E203D, Q207E, R211K, E224D, A272P, K277R, I293V, E297Q  
SHCS406 SHCS406 RTI RTI M41L, T69S_ES, M184V, L210W, T215Y  V35I, K122E, I142T, R172K, R211K, L228H, I293V, V317VA  
SHCS407 SHCS407 RTI RTI M41L, D67E, T69S_TT, L210W, T215Y  K20KR, V60I, K122Q, D123DE, K166KR, D177E, G196GE, T200E, R211K, A272P, K277R, R284K, T286A, I293V, E297A, I326V  
SHCS408 SHCS408 RTI RTI M41L, D67E, T69S_VT, L210W, T215Y  W88C, H208Y, R211K  
SHCS409 SHCS409 RTI RTI M41L, A62V, T69S_TA, L74V, L210W, T215Y  V35I, K43N, R83K, V111X, G112X, K122E, I135T, Q174R, D177DE, I178M, R211K  
SHCS410 SHCS410 RTI RTI M41L, T69S_SA, M184I, T215Y N348I T39R, K43E, D67A, A98S, I142T, S162Y, T200E, Q207E, A272P, A288S, V292I, E312A, S322T, Q334N, A360T, K390R, A400T  
SHCS411 SHCS411 RTI RTI M41L, D67G, T69S_EA, L74V, L210W, T215Y L100I, K103N T39A, V60I, A98S, K102Q, K122E, I135T, Q174R, G196E, K223R  
SHCS412 SHCS412 RTI RTI M41L, T69S_SX, T215Y  K122E, I135T, I142T, S162C, R211K  
SHCS413 SHCS413 RTI RTI M41L, T69S_SG, T215Y  R83K, D121Y, K122E, I135T, T165I, D177E, I178L, I202V, R211K, F214L, A272P, K277R, I293V, Q334D, G335S, M357T, G359N, I393IM, A400L  
SHCS414 SHCS414 RTI RTI M41L, D67E, T69S_VT, T215Y  V35K, T39A, I135T  
SHCS415 SHCS415 RTI RTI M41L, T69S_VT, L74LV, T215Y K103KN, V108VI, Y181C A98S, K101KQR, S117SA, I135V, V179I, Q207E, R211K  
SHCS416 SHCS416 RTI RTI M41L, T69S_SS, K70R, M184MV, L210LW, T215Y Y188YC K30E, V35A, I37V, E40G, G45R, R83K, D123E, Q207E, R211K K49I 
SHCS417 SHCS417 RTI RTI M41L, T69T_VS, M184I, T215Y  K64R, P133PL, I135T, I178L, Q207D Q85P, H96L 
SHCS501 SHCS501 RTI RTI A62V, V75I, F77L, F116Y, Q151M  K20R, I135IT, S162C, R211K, A272P, K277R, T286A, A288P, I293V, I326V, E328D, Q334N  
SHCS502 SHCS502 RTI RTI F77FL, F116Y, Q151M  V35I, V118VI, D123E, S162A, E169D, Q207E, R211K, A272P, I293V, V317VA, Q334L  
SHCS503 SHCS503 RTI RTI K70R, F116Y, Q151M, M184V, K219Q K103N, V106VI D67X, S68SG, T69TN, K122R, D123E, I135T, D177E, I202V, R211K, I244V, K277R, A288S, I293V, E297R, I326V, Q334L  
SHCS504 SHCS504 RTI RTI F116Y, Q151M K103N, Y188L W88C, T200A, I202V, R211K, V276I, Q278H, T286A, A288S, D324E, I329L  
SHCS505 SHCS505 RTI RTI M41L, D67N, V75I, F77L, Y115F, F116Y, Q151M, M184V, L210W, T215D K101E, Y181C, G190A E44D, Q85X, V111I, K122E, G196K, R211K, D218E, K219G  
SHCS506 SHCS506 RTI RTI M41ML, D67N, L210LW Y181C, G190S V35I, E44D, R83K, V90I, K122E, Q151X, T165TI, V179I, G196E, R211RK, T215X, E224ED  
SHCS507 SHCS507 RTI RTI A62V, K65R, V75I, F77L, Y115F, F116Y, Q151M, M184MV, K219Q K101EQ, K103NS, G190GA V21I, V35I, T58TN, K64R, K122E, I135T, S163A, T165I, I178L, G196E, I202V, V245E, A272P, K277R, E297K, V317A, D324E, T369A, A376T, K390R, A400T S68P 
SHCS508 SHCS508 RTI RTI K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E K101E, Y181C, G190A V35I, K49R, S68G, R83K, V90I, D123E, T165I, E169D, D177E, I178L, G196E, I202V, L228R  
SHCS509 SHCS509 RTI RTI A62V, D67N, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184I, T215Y K103N, Y188H T58N, S68N, K122E, S134SR, I135T, I167V, V179I, I202V, R211K  
SHCS510 SHCS510 RTI RTI A62V, D67N, K70R, V75I, F77L, F116Y, Q151M, M184V, T215V, K219E K103N, V108I V35T, E40A, K49R, T69N, V118I, K122E, D123N, I135LM, N137S, S162D, E169KR, K173E, V189VI, I202V, E203EK, F214L, F227Y, L228LF, K259KR, A272P, K277R, Q278H, E297K, G333DE, Q334CY  
SHCS511 SHCS511 RTI RTI D67DN, Y115F, F116Y, Q151M, M184V, K219E L100I, K103N, V108I V35I, T39AS, V60VI, T69X, A98S, K122E, I135T, T165TI, D192DN, G196E, F214L  
SHCS512 SHCS512 RTI RTI A62V, V75I, F77L, F116Y, Q151M  V35T, K122E, I135T, D177E, T200E, R211RK, A272P, K277R, L283I, R284K, I293V, E297T  
SHCS513 SHCS513 RTI RTI F116Y, Q151M  V60I, S68G, K122E, D123DN, I135T, M164I, K173N, D177E, R211G, F214L, A272P, V317A, I329V, Q334L, G359S, T369V, A371V, A376T, K390R, A400T T69M, N265NS 
SHCS514 SHCS514 RTI RTI M41ML, A62AV, V75VI, F77FL, F116FY, M184MV  R83RK, K122KE, I135IT, Q151X, T165TI, E169ED, G196E, T200TI, I202IV, R211X  
SHCS515 SHCS515 RTI RTI D67DN, F116Y, Q151M  V60I, W88C, I135V, I178IL, I202IV, Q207QE, H208HY, R211K  
SHCS516 SHCS516 RTI RTI Q151M, M184V  A33AV, I178M, T200A, V245IKR, K249Q, A272P, K277R, Q278H, K281R, A288T, I293V, E297A  
SHCS517 SHCS517 RTI RTI D67N, K70R, F77L, Q151M, T215F, K219E V108I K20KR, E29EK, V35I, T69N, D121Y, K122E, K173KE, D177E, I202V, E203ED, A272P, K277R, E297A  
SHCS518 SHCS518 RTI RTI A62V, K65R, K70T, V75I, F77L, Y115F, F116Y, Q151M, M184V  K49R, S68G, I135T, S162Y, L210F, V292I, I293V, K311R  
SHCS519 SHCS519 RTI RTI A62V, V75I, F77L, F116Y, Q151M, M184V K103N T58N, S68G, T69TI, A98S, K122E, I135T, I142M, I195T, T200A, L210F  
SHCS520 SHCS520 RTI RTI D67N, K70G, Q151M, K219Q  P4H, D121H, K122E, I135T, G196E, T200I, I244V, V245E, A272P, K281R, I293V, P294S, E297K, K311R, P345S, T369I, A376T, T386I  
SHCS521 SHCS521 RTI RTI D67N, K70G, Q151M  K49R, R83K, K122E, I159V, D177E, I178L, I202V, R211K  
SHCS522 SHCS522 RTI RTI M41L, D67N, K70R, Q151M, M184V, T215F, K219E K103N, V108VI E6D, K20R, K64KR, T69TN, I94L, K102KR, K122E, S162CY, Q197E, T200A, F214FL, D218DE, L228H, V245T, R284K, I293V  
SHCS523 SHCS523 RTI RTI A62V, K65R, V75VI, F77L, Q151M V106I S68G, K102Q, D123E, K166KR, I178L, I202V, R211K, A288S, P294PT, E297R  
SHCS524 SHCS524 RTI RTI F116Y, Q151M  V60I, R83K, D123E, I135T, S162C, G196E, F214L  
SHCS525 SHCS525 RTI RTI A62V, F116Y, Q151M, M184V  V60I, R83K, V118I, T200A, F214L  
SHCS526 SHCS526 RTI RTI D67N, K70R, F116Y, Q151M, T215FV, K219Q K101P, K103N K20R, V60VI, K64KN, V118VI, K122E, D123Q, I135V, S162Y, Q207E, H208HY, V245A, E297K, E312Q, R356RK, K366R, S379C, A400T  
SHCS527 SHCS527 RTI RTI A62V, K65KR, D67N, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E  P1PL, V35VA, T58TN, S68G, T69I, V118I, K122E, H208HY, R211K, F214L, V245M, R284K, T286A, P294T, I329L, Q334E, A376T, T386A, A400T L209M 
SHCS528 SHCS528 RTI RTI A62V, V75I, F77L, Y115F, F116Y, Q151M Y181C P4PT, V35I, T58N, S68G, T69I, D123E, I135KR, T139TA, I202IV, W239WG, A272P, T286P, E297K, V317A K122G 
SHCS529 SHCS529 RTI RTI D67N, Y115F, F116Y, Q151M, T215V, K219Q Y188L E6P, V35I, V60VI, T69N, A98S, K102Q, V118I, K122E, D123N, I135IT, R172K, D177N, T200A, L205F, F214L, L228H, D237N, A272S, I293IV, S322SA, Q334E, M357MI, R358K, K366KR, K390R  

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