Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Le Hingrat (2018)
Title A new mechanism of resistance of HIV-2 to integrase inhibitors: a 5 amino-acids insertion in the integrase C-terminal domain.
Citation Clin Infect Dis
SelectedGene IN
SelectedSpecies HIV2
SelectedType Clinical
NumIsolates 20
NumPts 11
Host Human

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
PHENO-ISO4 PHENO-ISO4 RAL, DTG  S138T, Y143R  S17N, S23V, N30Q, A56S, I72V, S163D, I175V, A215T, S218L, L220F, L250I, D256E, D270N, S277C, G278S, S279A, G283D, D286A A41D, Q42K, S93T, E125D, V129A, Q146E, E167D, N170V, T171S, I180T, S197A, L200I, I201V, K221Q, D222N, F227Y, E240D, V251I, I259V, Q273K, M275L, H280D, L281V, R284M, E285Q, G287R 
PHENO-ISO5 PHENO-ISO5 RAL  Y143G T97A   
PHENO-ISO6 PHENO-ISO6 RAL  E92Q, S138T T97A S17N, S23V, N30Q, A56S, I72V, S163D, I175V, A215T, S218L, L220F, L250I, D256E, D270N, S277C, G278S, S279A, G283D, D286A A41D, Q42K, S93T, E125D, V129A, Q146E, E167D, N170V, T171S, I180T, S197A, L200I, I201V, K221Q, D222N, F227Y, E240D, V251I, I259V, Q273K, M275L, H280D, L281V, R284M, E285Q, G287R 
PHENO-ISO7 PHENO-ISO7 RAL  E92Q, S138T, N155H T97A S17N, S23V, N30Q, A56S, I72V, S163D, I175V, A215T, S218L, L220F, L250I, D256E, D270N, S277C, G278S, S279A, G283D, D286A A41D, Q42K, S93T, E125D, V129A, Q146E, E167D, N170V, T171S, I180T, S197A, L200I, I201V, K221Q, D222N, F227Y, E240D, V251I, I259V, Q273K, M275L, H280D, L281V, R284M, E285Q, G287R 
PHENO-ISO8 PHENO-ISO8 RAL, DTG  G140S, Q148H    
PT1 PT1BL RAL  S138T  N30Q, S39T, A41S, I84IV, I172MV, T206A, L220F, D222K, E246D, L250I S23C, I28L, R34K, L58IMV, S93ST, Q96QHR, I133V, S163SG, E167D, I180V, H181HQ, S197A, F227Y, I259V, I260V, M275L, S279SP, H280N 
  PT1M10 RAL  S138T  N30Q, S39T, A41S, I84IV, I172M, T206A, L220F, D222K, L250I, S279SA S23C, I28L, R34K, L58V, S93T, I133V, E167D, I180V, S197A, F227Y, R231R_SREGK, V251I, I259V, I260V, M275L, H280N, G283GS 
  PT1M28 RAL  S138T  N30Q, S39T, A41S, I84IV, Q96X, I172M, T206A, L220F, D222K, L250I S23C, I28L, R34K, L58V, S93ST, I133V, E167D, I180V, S197A, F227Y, R231R_SREGR, V251I, I259V, I260V, G272G_GR, M275L, H280N, G283G_A, E288E_MA 
PT2 PT2BL RAL  S138T  K4S, S17G, S23V, N30Q, A56S, I72V, S163D, I175V, T206A, A215T, S218L, L220F, L250I, D270H, G278S, S279A, L281M, G283D, D286A A41D, Q42K, L58I, S93T, E125D, V129A, I133V, I162M, E167D, N170V, T171S, I180T, S197A, L200I, I201V, K221Q, D222N, F227Y, V251I, I259V, Q273K, M275L, H280D, E285Q, G287R 
  PT2M14 RAL    S17G, S23V, N30Q, A56S, I72V, S163D, I175V, I191L, A215R, S218L, L220F, L250I, D270H, G278S, S279A, L281M, G283D, D286A A41D, Q42K, L58I, Q91R, S93T, E125D, V129A, I133V, V141A, I162M, E167D, N170V, T171S, I180T, S197A, L200I, I201V, D222N, F227Y, R231R_YREGR, V251I, I259V, Q273K, M275L, H280D, E285Q 
PT3 PT3BL RAL  S138T  S17G, S23V, N30Q, S39T, I50IV, S163D, I175V, L213S, S218L, L220F, R224Q, L250I, D256E, D270H, S277R, G278S, S279A, L281M, G283D, D286X R34K, A41D, Q42K, S93T, E125D, V129VA, I133IV, I165L, E167D, N170V, T171S, I180T, S197A, I201V, F212Y, D222N, F227Y, V251I, I259V, Q273K, M275L, H280D, E285Q 
  PT3M6 RAL  S138T  S17G, S23V, S39T, S163D, I175V, L213S, S218L, L220F, R224Q, L250I, D256E, D270H, S277R, G278S, S279A, L281M, G283D, D286V N30L, R34K, A41D, Q42K, Q91QR, S93T, L104LV, E125D, V129A, I133IV, I165L, E167D, N170V, T171S, I180T, S197A, I201V, F212Y, D222N, F227Y, R231R_SREGR, V251I, I259V, Q273K, M275L, H280D, E285Q 
  PT3M30 RAL, DTG 104  D232N S17G, S23V, S39T, Q137H, S163D, I175V, L213S, S218L, L220F, R224Q, L250I, D256E, R269RK, D270H, S277CR, G278S, S279A, L281M, D286V N30L, R34K, A41D, Q42K, S93T, L104V, E125D, I133V, I165L, E167D, N170V, T171S, I172IL, I180T, R188W, S197A, I201V, F212Y, D222N, F227Y, R231R_SREGK, V251I, I259V, G272G_GG, Q273K, M275L, H280D, G283D_T, E285Q, E288E_VAQSD 
PT4 PT4BL RAL    L213F, S218L, L220F, R224Q, L250I, D256E, D270H, G278S, S279A, G283D, D286V S197A, I201V, K221Q, D222N, F227Y, V251I, I259V, I260V, Q273K, M275L, S277N, H280D, L281V, E285Q, G287R 
  PT4M13 RAL  S138T  S17G, S23V, N30Q, I50V, S163D, I175V, L213F, S218L, L220F, R224Q, L250I, D256E, D270H, G278S, S279A, G283D, D286A R34K, A41D, Q42K, S93T, E125D, V129A, E167D, N170V, T171S, I180V, S197A, I201V, K221Q, D222N, F227Y, R231R_GK, V251I, I259V, I260V, Q273K, M275L, H280D, L281V, E285Q, G287R 
  PT4M27 RAL  S138T  S17G, S23V, N30Q, I50V, I84V, S163D, I175V, L213LF, S218L, L220F, R224Q, L250I, D256E, D270H, G278S, S279A, G283D, D286A R34K, A41D, Q42K, S93T, E125D, E167D, N170V, T171S, M178MR, I180V, S197A, I201V, K221Q, D222N, F227Y, R231K_GYKGK, V251I, I259V, I260V, Q273K, M275L, H280D, L281V, E285Q, G287R 
PT5 PT5BL RAL  S138T  S17G, S23V, N30Q, Q137H, S163D, I175V, L213F, S218L, L220F, R224Q, L250I, D256E, D270H, S277C, G278S, S279A, G283D, D286A R34K, A41D, Q42K, S93T, E125D, I133V, I165L, E167D, N170V, T171S, I172L, I180T, S197A, I201V, D222N, F227Y, V251I, I259V, I260V, Q273K, M275L, H280D, L281V, E285Q, G287R 
  PT5M10 RAL  S138T  S17G, S23V, N30Q, V88VI, Q137H, S163D, I175V, L213F, S218L, L220F, R224Q, L250I, D256E, D270H, S277C, G278S, S279A, G283D, D286A R34K, A41D, Q42K, S93T, E125D, I133V, I165L, E167D, N170V, T171S, I172L, I180T, S197A, I201V, D222N, F227Y, R231R_YREGR, V251I, I259V, I260V, Q273K, M275L, H280D, L281V, E285Q, G287R 
  PT5M21 RAL  S138T  S17G, S23V, N30Q, Q137H, S163D, I175V, L213F, L220F, R224Q, L250I, D256E, D270H, S277C, G278S, S279A, D286A R34K, A41D, Q42K, S93T, E125D, I133V, I165L, E167D, N170V, T171S, I172L, I180T, S197A, I201V, D222N, F227Y, R231R_GYRGR, V251I, I259V, I260V, G272G_GG, Q273K, M275L, H280D, L281V, G283D_T, E285Q, G287R, E288E_VAQSD 
PT6 PT6M26 RAL  S138T  K4N, S17G, S23V, N30Q, A56S, I72V, I135IV, S163D, I172IV, I175V, A215T, S218L, L220F, L250I, D256E, R269K, S277C, G278S, S279A, L281M, G283D, D286A G27R, I28L, R34K, A41D, Q42K, E57ED, S93T, E125D, V129A, E167D, N170V, T171S, I180T, S197A, L200I, I201V, D222N, F227Y, R231R_GYRGR, V251I, I259V, Q273K, M275L, H280D, E285Q