Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Ojwach (2018)
Title Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection.
Citation J Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 487
NumPts 487
Subtype C

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 487 Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
None None   P4S, V35T, E36A, T39E, S48T, K122E, K173A, D177E, Q207E, R211K, V245Q, K277R, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377L, K390R, A400I, E404D, V435A, L452I, V466I, D471E, H483Q, L491S, I526V, K530R, A534S, V548A, A554S  
as030740 as030740 None None   V35T, E36A, T39E, S48T, K122E, D123X, A158AS, S162X, K173ST, D177DE, I178IM, T200X, Q207EG, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317VA, D324E, Q334HP, G335D, R356K, G359T, T377TM, S379X, K390R, A400IT, E404D, I434V, V435A, A437V, L452I, V466I, D471E, T477A, H483L, L491S, V493A, Q507H, S519N, I526V, K530R, A534S, A554K  
as030942 as030942 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123N, K173A, D177E, T200A, Q207E, V245K, E248D, D250E, A272P, K277R, K281R, T286A, E291D, V292I, I293V, K311R, Q334C, G335D, R356K, M357Q, G359T, V365I, A376S, T377L, K390R, A400R, E404D, V435A, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554R, G555R L12W 
as050876 as050876 None None   V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123G, K173T, D177E, T200A, R211K, V245N, A272S, K277R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377Q, K390R, A400T, E404D, I434M, V435A, A437V, L452M, S468T, L469I, T470N, D471E, L491P, S519N, Q524E, K530R, A534S, A554S  
as050933 as050933 None None   T27S, V35T, E36A, T39E, E40D, K122E, D123G, S162C, K173A, D177G, Q197P, T200A, Q207E, R211K, D218E, V241I, V245K, A272S, K281R, T286A, E291D, V292I, I293V, V317A, S322SL, D324E, Q334Y, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, L452I, V466I, V467I, S468H, T470N, D471E, H483R, L491T, S519N, Q524E, K530R, A534S, A554K  
as050968 as050968 None None D67G  V35T, T39N, S48T, V60I, D121A, K122E, D123G, T139A, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, A272S, E291D, V292I, I293V, V317A, D324E, Q334N, G335D, F346Y, R356K, G359A, T377L, K390R, A400I, E404D, V435A, L452E, V466I, T470S, D471E, Q480R, H483Q, L491S, S519N, E529D, K530R, A534S, A554S  
as051001 as051001 None None   V35A, E36A, T39D, S48T, V60I, K122E, K173A, D177E, T200A, Q207K, R211Q, V245Q, A272P, V276T, K277R, L283I, T286V, E291D, V292I, I293V, K311R, Q334N, G335D, R356K, M357R, R358K, G359A, T377M, K388R, K390R, A400T, E404D, V435VA, A446S, L452I, V466I, S468H, T470S, D471E, H483Q, A508S, K512N, S519N, A534S, A554S  
AS1323 AS1323 None None   P4S, I5V, K22R, V35T, E36A, T39E, S48T, K122E, D123S, I135V, S163T, T165I, K173A, D177E, I178M, T200A, Q207E, R211K, V245K, A272P, I274IV, Q278N, L283I, T286V, E291D, V292I, I293V, I329V, Q334QH, G335D, R356K, M357R, R358G, G359T, E370A, A371V, I375V, T377M, K390R, A400T, E404D, K431T, I434M, V435A, A437V, L452V, S468T, T470N, D471E, H483Q, L491S, I506L, Q509H, K512N, L517I, S519N, Q524E, K530R, A534S, A554S  
AS1876 AS1876 None None   V35T, E36A, T39E, S48T, V60I, A98AS, D123E, K166T, F171Y, K173T, Q174K, D177E, I178M, T200A, Q207E, K238R, V245K, A272P, K277R, E291D, V292I, I293V, D324E, G335D, R356K, M357R, G359T, K366R, T377M, K390R, A400T, E404D, I434M, V435I, A437V, L452I, R461K, S468T, D471E, H483Q, L491S, S519N, Q524E, E529D, K530R, A534S, A554S E438EG 
AS1919 AS1919 None None   V35T, E36A, T39D, S48T, V60I, W88S, K122E, K166R, K173A, Q174A, D177E, I178L, T200A, Q207A, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, H315Q, V317A, R356K, G359T, T377V, K390R, A400T, E404D, V435E, A437V, K454R, V467I, S468N, D471E, H483Q, L491S, K527N, K530R, A534S, A554K  
as210187 as210187 None None   E28R, K32E, V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123G, S162F, K173A, D177E, T200A, Q207E, R211K, W239R, V245K, D250E, A272P, V292I, I293V, K311R, D324E, Q334D, G335D, R356K, M357R, G359A, A376S, T377M, K390R, A400L, E404D, V435S, A437V, F440Y, L452I, K454R, R463K, S468T, T470N, D471E, H483Q, L491S, L517V, S519N, Q524E, K530R, A534S, A554N  
AS21034(1036) AS21034(1036) None None   T7TI, V35T, T39E, S48T, V60I, K122E, D123G, I135R, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, G359T, T377L, T386I, K390R, A400I, E404D, V435P, A437V, T450N, K454R, V467VI, T470S, D471E, H483Q, L491S, S519N, K530R, A534S, A554K  
AS21037 AS21037 None None   E28K, K32E, V35T, E36A, T39E, S48T, V60I, I135V, S162C, K166KR, K173A, D177E, Q197E, T200A, Q207E, R211K, V245Q, A272P, K275R, K277R, Q278N, T286A, E291D, V292I, I293V, P294PS, E297K, Q334HY, G335D, R356K, G359T, T377L, K390R, A400T, V435A, L452M, D460DN, R461K, V466I, S468A, T470TN, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554S Q269Q* 
AS2110 AS2110 None None   K11Q, V35K, T39E, S48T, K122E, D123S, S162C, K173A, Q174K, D177E, I195L, T200A, Q207N, R211K, V245Q, A272P, E291D, V292I, I326V, Q334E, R356K, M357R, R358G, G359T, A360T, K366R, T377M, K390R, Q394H, A400T, E404D, L429M, V435T, L452I, K454R, V466I, S468T, L469I, T470S, D471E, Q487R, L491P, S519N, K527S, E529N, K530R, A534S, A554N  
AS21325 AS21325 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135R, S162A, K173A, D177G, T200A, I202V, Q207E, V245K, A272P, Q278N, T286A, E291D, V292I, I293V, D324E, G335D, R356K, M357R, G359T, K366R, T369A, A371V, T377M, K390R, A400I, W402WG, E404D, E432D, V435A, A437V, L452M, S468T, D471E, H483Q, L491S, Q509H, S519N, Q524E, K530R, A534S, A554N  
AS21569 AS21569 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, I142IV, K173A, D177DE, T200A, Q207E, R211RK, V245Q, K281R, T286A, E291D, V292I, I293V, D324DE, I329IV, Q334N, G335D, R356K, G359T, A376AS, T377M, K390R, A400I, E404D, V435A, V466I, S468P, T470S, D471E, H483Q, L491PS, V496VI, S519N, K530R, A534S, A554N  
AS216 AS216 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, I142L, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D320N, D324E, I329L, Q334E, G335D, R356K, M357R, R358K, G359S, T377L, K390R, A400I, E404D, V435A, G436E, L452MT, V466I, S468P, D471E, H483Q, L491P, S519N, Q524L, K527N, K530R, A534S, V548I, A554S  
AS21630 AS21630 None None   E6D, V35T, E36A, T39E, S48T, K122E, D123G, A158S, S162Y, K173S, T200A, Q207G, V245Q, A272P, K277R, K281R, E291D, V292I, I293V, V317A, Q334P, G335D, R356K, G359T, S379A, K390R, A400I, E404D, V435A, A437V, L452I, R461K, V466I, S468T, T470N, D471E, L491S, S519N, K530R, A534S, A554S  
AS2174 AS2174 None None  E138A E6T, K11H, V35T, E36A, T39E, S48T, K49R, V60I, K122E, D123S, K173A, Q174K, T200A, Q207G, R211K, F214L, V245Q, A272S, K281R, R284K, T286A, E291D, V292I, I293V, H315Y, G335E, R356K, G359T, A371V, T377L, K390R, A400I, E404D, V435A, G436E, L452T, A455T, S468H, D471E, T477A, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
AS2184 AS2184 None None  E138A E6D, V35T, E36A, T39E, S48T, K104R, K122E, D123G, I142T, K173A, Q174K, D177G, T200A, Q207K, R211K, V245Q, A272S, E291D, V292I, I293V, R307K, R356K, R358K, G359S, T377Q, K390R, A400I, E404D, G436E, L452M, R461K, V466I, D471E, T477A, Q480T, H483Q, L484I, L491S, S519N, K527N, K530R, A534S, A554N  
AS2207 AS2207 None None   V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123G, K173A, Q174K, I195L, T200A, I202V, E204D, Q207E, R211K, F214L, V245K, A272P, T286A, E291D, V292I, I293V, P294T, K311KR, V317VA, S322ST, Q334C, G335D, R356K, G359T, K366R, T377L, K390R, A400T, E404D, V435X, N447ND, L452A, R461K, V466I, S468T, T470N, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554S  
AS2341 AS2341 None None   E6N, K20R, V35T, E36A, T39D, S48T, V60I, K122E, K173A, Q174K, D177E, T200A, E204K, Q207E, R211K, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, Q334D, R356K, M357Q, G359T, T369A, T377Q, K390R, E399D, A400I, E404D, V435T, A437V, L452M, V466I, S468T, T470D, D471E, T477A, L491S, S519N, V531I, A534S, A554S  
AS2358 AS2358 None None   K20R, T39E, S48T, V60I, V118I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207A, R211K, F214L, V245Q, A272P, K275Q, V276I, L283I, E291D, V292I, I293V, Q334E, R356K, G359T, T369A, T377M, K390R, A400T, E404D, V435P, A446S, V458I, V466I, S468T, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554S  
AS2483 AS2483 None None   V35T, E36A, T39E, S48T, K122E, I135V, S162C, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334Y, G335D, F346H, R356K, G359T, K390R, A400T, E404D, E432D, A437V, L452M, V466I, S468P, D471E, H483Q, L491P, Q507H, S519N, K527S, K530R, A534S, A554S  
AS250 AS250 None None   V35T, T39N, S48T, V60I, K64R, K122E, I135V, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291N, V292L, I293L, T296N, A299T, E300Q, A304T, N306T, E308Q, L310I, E312V, I326V, Q334D, G335D, R356K, M357R, G359T, T377M, K390R, A400T, T403TA, E404D, V435A, G436GE, A437AV, A446AS, L452IV, V458VI, V466I, S468T, D471E, H483Q, L491S, S519N, Q524QE, K527KN, K530R, A534S, A554R F61Y, T286AD, K287S, L289R, T290R, E298Q, L301S, E302N, E305N 
AS2802 AS2802 None None   V35T, E36D, T39K, S48T, K82R, K122E, K166R, K173T, T200A, Q207D, R211K, V245Q, E248T, A272P, K277R, E291D, V292I, I293V, I329L, Q334H, G335D, R356K, M357MI, G359T, V365VA, T377M, S379C, K390R, A400T, E404D, I434M, V435A, A437V, L452A, V467I, S468C, D471E, H483L, L491S, E514EG, S519N, K527R, K530R, A534S, A554S  
AS2945 AS2945 None None  E138A K20R, V35T, T39E, K122E, D123N, K173I, Q174K, T200A, Q207E, F214L, V245Q, A272P, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, R358K, G359T, T377L, K390R, E396D, A400T, E404D, L452S, V466I, V467I, S468P, T470N, D471E, T477A, H483Q, L491T, K527N, K530R, V531I, A534S, A554K  
AS2973 AS2973 None None   V35T, E36A, T39E, S48T, K64R, K122E, D123S, S162N, K166R, K173T, D177E, T200A, Q207E, R211K, V245Q, A272T, K275Q, T286A, E291D, V292I, I293V, Q334E, R356K, G359T, T369A, I375V, T377L, S379G, K390R, E399D, A400I, E404D, V435A, G436E, N447S, L452Q, T470S, D471E, H483Q, L491P, S519N, E529K, K530R, A534S, A554R P421N 
AS317 AS317 None None   P4S, V35K, T39E, S48T, V60I, K101R, K122E, D123S, K173T, Q174K, D177E, T200A, I202V, R211K, V245H, A272P, K277R, T286A, E291D, V292I, I293V, I326V, Q334D, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, V435A, A437V, K454R, S468T, L469I, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554N  
AS3268 AS3268 None None   K32R, V35T, E36A, T39E, S48T, V60I, K122E, I135R, K173T, D177E, T200A, Q207E, V245K, K277R, T286A, E291D, V292I, I293V, S322L, Q334H, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, V435A, L452I, V458I, R461K, V466I, D471E, T477A, H483Q, K512N, S519N, K527N, K530R, V531I, A534S, A554S  
as330182 as330182 None None   V35T, T39E, S48T, V60I, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, Q334N, G335D, Y342F, R356K, M357R, G359T, T377Q, K390R, A400T, E404D, V435A, G436E, L452M, V466I, T470N, D471E, Q480H, H483Q, L491S, K512N, S519N, K527N, K530R, A534S, A554S  
as330763 as330763 None None   K20R, V35T, T39K, K122E, D123N, S162A, K173A, D177E, T200A, Q207T, R211K, F214L, V245Q, E291D, V292I, I293V, Q334E, Y339F, E344D, R356K, G359T, K366R, T369A, T377M, K390R, A400I, E404D, V435E, A446S, E449D, L452I, V466I, S468T, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
as330987 as330987 None None  E138A P4H, K11Q, K20R, V35T, E36A, T39E, S48T, K122E, D123N, S162A, D177N, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, L310I, V317A, Q334D, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V435A, L452A, V466I, T470S, D471E, L491S, S519T, K530R, A554S  
as331351 as331351 None None   V35T, E36A, T39E, S48T, K122E, K173A, D177E, T200A, Q207E, R211K, V245Q, E248D, A272P, K275R, K277R, L283LF, T286A, E291D, V292I, I293V, P294S, E297T, I329L, Q334E, G335D, R356K, G359T, Q367L, T369A, I375V, T377Q, K390R, A400T, E404D, V435A, A446T, S468N, D471E, T477A, H483Q, L517I, S519N, K527N, K530R, V531I, A534S, A554S  
as331702 as331702 None None   K32N, V35R, E36A, T39E, S48T, K122E, D123N, S162C, K173A, Q174R, D177E, T200A, E203D, Q207E, R211K, V245Q, A272P, T286V, E291D, V292I, I293V, K311Q, V317A, G335S, R356K, G359T, T369A, T377S, K390R, A400T, E404D, V435A, L452I, R461K, R463K, V466I, V467I, S468T, D471E, H483Q, L491A, S519N, K530R, A554N  
AS3369 AS3369 None None   V35T, T39K, S48T, V60I, K104R, K122E, E169D, K173T, Q174K, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293V, P294Q, Q334D, G335D, R356K, M357R, G359T, T377L, K390R, A400I, E404D, V435A, L452M, V466I, S468T, T470S, D471E, Q480K, H483Q, L491S, S519N, K530R, A534S, A554S  
AS3458 AS3458 None None   V35T, T39K, K43E, S48T, V60I, S68SN, K122E, D123G, K166R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297A, D324E, Q334N, G335D, R356K, G359T, K366R, T377L, K390R, A400T, E404D, V435A, G436E, L452I, V466I, S468T, T470N, D471E, H483Q, L491S, S519N, K527R, K530R, A534S, A554S  
AS3513 AS3513 None None   V35T, T39E, E40D, S48T, V60I, K122E, D123S, T165I, K173A, Q174K, G196E, T200A, Q207E, R211K, F214L, V245Q, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359A, A376S, T377L, K390R, A400I, T403K, E404D, V435A, A437V, K454R, T470S, D471E, H483Q, L491S, S519N, K530R, A534S, A554N  
AS3759 AS3759 None None   P4S, V35T, E36A, T39D, S48T, V60I, V90I, K122E, D123G, I142R, T165I, K173A, Q174K, D177E, V179I, G196E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, R356K, G359T, T377L, K390R, A400I, E404D, L452K, R461K, V466I, D471E, T477A, H483Q, K527Q, K530R, A534S, A554S  
AS5508 AS5508 None None  Y181C, H221Y V21I, V35I, T39D, S48T, K49R, V60I, K101N, K122E, E169K, K173T, D177E, T200A, Q207E, V245K, A272P, T286A, E291D, V292I, I293V, Q334P, G335D, R356K, M357K, G359T, K366R, T377M, K390R, A400I, E404D, V435A, G436E, E449D, L452I, S468T, L469I, D471E, H483Q, L491S, S519N, Q524E, E529D, K530R, A534S, A554S  
AS5548 AS5548 None None   V35T, T39E, S48T, V60I, K173E, Q174R, D177E, T200A, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, D324E, G335D, R356K, M357R, G359T, K390R, A400T, E404D, F416Y, V435A, L452M, V466I, S468P, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
AS5643 AS5643 None None   P4S, V35T, E36A, T39E, S48T, K49R, V60I, K122E, D123S, K173A, D177E, I195M, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, L301F, Q334H, G335D, R356K, M357R, G359A, T377Q, K390R, A400T, E404D, I434M, A437V, E449D, L452M, R461K, V467I, S468T, D471E, H483Q, L491P, L503I, K512R, S519N, Q524E, K530R, A534S, A554N  
None None   K20R, V35T, T39E, E40D, S48T, K122E, D123G, K173A, Q174R, D177E, I178L, Q197K, T200A, Q207D, R211K, V245Q, E248T, A272P, K277R, E291D, V292I, I293V, Q334Y, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, I434L, V435I, A437V, L452A, V467I, T470A, D471E, T477A, H483Q, L491S, S519N, Q524E, K530R, V531I, A534S, A554S  
None None  E138A P4S, V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, K173S, Q174K, D177E, Q197R, T200A, Q207D, R211K, V245Q, D250E, A272P, K277T, T286A, E291D, I293V, Q334H, G335D, R356K, M357R, G359T, T377Q, T386I, K390R, A400T, E404D, V435S, A437V, N447S, L452M, D471E, T477A, H483Q, L491S, S519N, A534S, A554S  
None None  E138A P4S, V35T, E36A, T39E, S48T, V60I, V118I, K122E, D123N, E169Q, K173T, Q174K, T200A, Q207E, F214L, K238R, V245Q, E248D, D250E, A272S, K277R, E291D, V292I, I293V, H315Y, I329L, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V435A, A437V, L452Q, R461K, V466I, D471E, T477A, H483Q, S519N, K527Q, K530R, A534S, A554S R211L 
None None   V35T, E36A, T39E, S48T, K122E, D123S, I142L, A158S, K173A, Q174R, D177E, G196M, T200A, Q207E, R211K, V245Q, E248D, D250E, A272P, K277R, Q278N, L279M, T286A, E291D, I293V, Q334D, G335D, R356K, G359T, T377L, T386M, K390R, A400I, E404D, V435I, L452I, V466I, T470N, D471E, T477S, H483Q, L491S, S519N, A534S, A554N, K558R  
None None   V35T, E36A, T39E, S48T, K122E, D123S, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435A, L452M, V466I, D471E, H483Q, S519N, K527T, K530R, A554S  
None None   P4H, V35T, E36A, T39E, S48T, K122E, K166R, K173A, D177E, I178M, T200A, Q207N, V245Q, A272P, T286A, E291D, V292I, I293V, Q334G, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435I, E449D, D471E, H483Q, S519N, Q524E, K530R, A534S, A554S C280W 
NA NA None None   V35T, E36A, T39E, S48T, K122E, D123N, I142IV, K173A, Q174K, D177E, I178M, T200A, E204K, Q207D, R211K, V245Q, A272S, K277R, E291D, V292I, I293V, I329L, Q334N, G335D, R356K, G359T, K366R, T377M, S379C, K390R, A400T, E404D, I434V, A446S, L452I, R461K, V466I, S468T, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
OC OC None None   V35T, E36A, T39E, S48T, K122E, D123S, I135R, S162F, K173A, D177E, T200A, Q207E, R211K, V245H, D250E, K277R, Q278A, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359A, A376V, K390R, A400T, T403A, E404D, I434L, A437V, L452M, V466I, D471E, H483Q, L491P, I495IL, A508G, S519N, K527S, K530R, A534S, A554S P243G, L246Q, P247R, E248G, S251K, W252F, T253R, V254D, N255Y, D256G, I257K, K259M, L260A, V276D, L349LP, V435EK 
OE OE None None   V35K, T39E, S48T, K122E, S162C, K173A, Q174K, D177E, G196K, T200A, E204D, Q207A, R211E, V245Q, A272Q, E291D, V292I, I293V, E312Q, S322A, I329L, Q334DN, R356K, G359AT, T377M, K390R, E399D, A400I, E404D, I434M, V435A, A437V, E449D, L452I, R461K, S468T, L469I, D471E, H483Q, L491P, S519N, K527Q, K530R, A534S, V548I, A554S L205G 
OG OG None None  E138A V35T, E36A, T39E, S48T, K122E, D123N, K173T, T200A, Q207K, R211I, V245A, D250E, A272P, I274V, K277R, E291D, V292I, I293IV, Q334QH, G335D, R356K, G359N, A360T, K366R, I375V, T377M, K390R, A400T, E404D, V435E, L452T, R461K, V466I, V467VI, S468T, H483Q, L491S, S519N, K527S, K530R, A534S, A554NS  
OJ OJ None None   E6D, V35T, E36A, T39E, S48T, K122E, K173A, Q174K, D177E, T200A, Q207T, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, I326V, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435I, L452A, V466I, S468T, L469I, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
OQ OQ None None  E138A V21I, V35T, E36A, T39E, S48T, K102Q, K122E, D123G, K173A, T200A, Q207K, R211K, V245Q, A272S, K277R, Q278E, T286A, E291D, V292I, I293V, P294T, I329L, Q334H, G335D, R356K, G359T, T377L, T386I, K388R, K390R, A400T, E404D, V435A, A437V, L452A, K454R, V467I, S468T, D471E, H483N, L491S, S519N, K530R, A534S, A554K  
OS OS None None   V35T, E36A, T39E, S48T, E53D, K122E, D123N, K173T, D177E, I178L, T200A, Q207K, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, E297A, G333E, Q334H, G335S, R356K, G359T, T377M, S379C, K390R, T403I, E404D, V435A, E449D, T450S, R461K, V466I, D471E, T477A, H483Q, L491P, V493A, K527T, K530R, A534S, A554S  
OU OU None None  E138A V35T, E36A, T39E, S48T, K104KR, K122E, D123N, A158S, T165TI, K173A, D177EG, T200A, I202V, Q207D, R211K, V245Q, E248T, A272P, Q278QK, E291D, V292I, I293V, Q334H, G335D, I341V, R356K, G359T, T369A, A371V, T377M, K390R, A400T, E404D, I434M, A437V, L452E, V467I, S468T, D471E, Q480H, L491S, S519N, K527KN, K530R, A534S, A554S  
OW OW None None   V35T, E36A, T39D, S48T, K122E, D123G, S162C, K166R, K173A, Q174R, D177E, I178L, T200A, Q207A, R211K, W212G, V245Q, A272P, K277R, T286A, V292I, I293V, E297K, L310I, I329L, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435M, A437V, N447X, E449D, L452M, V466I, S468T, D471E, T477A, H483Q, L484V, L491P, S519N, K530R, A534S, A554S  
OX OX None None   V35T, E36A, T39E, S48T, K173A, D177Q, G196M, T200A, Q207E, R211K, V245Q, A272P, V276I, Q278Y, T286A, E291D, I293V, Q334N, G335D, R356K, M357R, G359T, K366R, A371V, S379G, V381I, T386V, F389L, K390R, A400T, E404D, V435A, A437I, L452I, V467I, S468T, L469V, D471E, H483Q, L491S, A508S, L517I, S519N, K530R, A534S, A554S D256DG 
OZ OZ None None   V35T, T39E, S48T, K122E, I135R, K173A, D177E, I178L, T200A, Q207E, R211K, P243S, V245K, D250E, A272P, K277R, T286A, E291D, V292I, Q334H, G335D, R356K, G359T, A376S, T377M, T386I, K390R, E399D, A400T, E404D, V435L, E449N, L452K, V466I, V467I, L469I, T470D, D471E, H483Q, L491S, S519N, K530R, A534S, A554N  
PC PC None None   V35T, T39E, S48T, K122E, D123N, A158S, K173A, Q174K, D177E, T200A, Q207R, R211K, D250E, A272S, K277R, T286A, E291D, V292I, I293V, Q334D, G335D, I341V, R356K, G359T, T377M, K390R, A400T, E404N, V435I, L452M, R461K, V466I, L469F, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, A554S  
PD PD None None   E6A, V35T, E36A, T39E, S48T, K122E, D123N, A158S, K173T, D177E, T200A, Q207E, V245Q, K277R, T286A, E291D, V292I, I293V, L310I, Q334H, G335D, R356K, G359T, T377M, S379C, K390R, E404D, V435A, A437V, L452I, V467I, S468C, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554N  
PO PO None None   V35T, E36A, T39E, E40D, S48T, K122E, D123N, K173A, I195T, T200A, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, Q334N, G335D, R356K, G359T, T377L, A400T, V417I, E432D, I434L, V435A, A437V, L452K, T470A, D471E, T477A, Q480E, H483Q, L491S, V531I, A534S, A554S  
PP PP None None   V35T, E36A, T39E, S48T, K122E, D123G, K173A, D177E, I178M, T200A, Q207G, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, I329L, Q334H, G335D, R356K, G359T, V365I, A376C, T377M, K390R, A400T, E404D, A446S, R448K, L452I, K454R, V466I, V467I, S468N, L469LI, D471E, H483Q, L491V, S519N, K530R, A554S  
PT1273310893 ISO1273310893 None None   K11R, K20R, V35T, V60I, K122E, D123G, K166R, K173T, D177E, T200A, E204K, Q207E, R211K, F214L, V245K, A272P, K275R, K277R, T286A, E291D, V292I, I293V, E297K, R307K, S322A, Q334D, G335D, R356K, G359T, A360T, A371V, I375V, T377L, K390R, A400T, T403S, E404D, P421H, V435A, G436E, F440Y, N447H, L452T, V466I, T470A, D471E, T477A, H483L, Q487K, S519N, K527N, K530R, V531I, A534S, A554H  
PT12733122102 ISO12733122102 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, A158S, K173A, Q174K, D177E, E194EK, T200A, Q207T, V245E, T286A, E291D, V292I, I293V, V317A, D324E, G335D, I341V, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, A437V, S468T, D471E, H483Q, L491S, K512R, S519N, Q524E, K530R, A534S, A554S  
PT12733251186 ISO12733251186 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, T165I, E169D, Q174K, D177E, G196E, T200A, Q207A, F214L, V245Q, A272P, K281R, T286A, E291D, V292I, I293V, S322A, Q334D, G335D, E344D, R356K, M357R, G359T, T377L, K390R, A400T, E404D, V435A, G436E, A437V, R448K, L452I, K454R, S468T, T470S, D471E, H483Q, L491S, S519N, Q524E, E529K, K530R, A534S, A554K, K558R  
PT12733303208 ISO12733303208 None None   V35T, E36A, T39E, S48T, K122E, A158S, K173A, D177E, T200A, Q207G, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A, I329L, G335D, R356K, G359T, T377L, K390R, A400T, E404D, I434M, V435VA, A437V, L452I, K454R, R463K, S468T, T470N, D471E, H483Q, L491P, S519N, K530R, A534S, A554K  
PT12733387272 ISO12733387272 None None   K22R, T27S, V35T, T39K, S48T, K122E, P133PL, S162C, K173A, Q174K, D177E, E194D, G196E, T200A, I202V, Q207E, R211K, V245Q, S251I, A272P, K275R, V276I, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377M, T386I, K390R, A400I, E404D, V435A, L452M, V458I, V466I, V467I, S468Y, T470N, D471E, H483Q, L484I, L491P, S519N, Q520K, K530R, A534S, A554K  
PT12733396267 ISO12733396267 None None   K32R, V35T, T39D, S48T, K122E, I142T, K173A, T200A, Q207E, R211K, V245Q, S251D, A272P, T286A, E291D, V292I, I293V, L310I, G335D, R356K, M357R, G359T, A371V, K390R, A400T, E404D, F416Y, P421H, V435A, K451R, L452M, S468T, D471E, H483Q, L484I, L491S, L517I, S519N, K530R, A534S, A554S, K558R  
PT12733397268 ISO12733397268 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q, S251N, K277R, E291D, V292I, I293V, Q334N, G335D, M357R, G359T, T377M, K390R, A400I, E404D, V435A, A437V, S468H, T470S, D471E, T477A, H483Q, L491S, E516D, S519N, K527N, K530R, V531I, A534S, A554S  
PT12733398271 ISO12733398271 None None   V35T, T39E, S48T, V60I, K64R, D121H, K122E, A158S, K173A, D177E, T200A, Q207K, R211K, V245Q, E248D, A272P, E291D, V292I, I293V, S322T, Q334E, R356K, M357R, R358K, G359T, A360T, T369A, E370D, I375V, T377M, K390R, E399D, A400T, E404D, E432D, V435A, A437V, F440Y, L452M, K454R, R463K, S468T, D471E, H483Q, L484I, L491P, K512N, S519N, Q524E, K530R, A534S, A554R  
PT12733442309 ISO12733442309 None None   V35T, T39E, S48T, K122E, I135T, K173T, Q174R, D177E, T200A, I202V, Q207E, R211Q, V245E, A272P, K277R, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, M357L, G359S, K366R, T369A, I375V, T377I, K385R, K390R, A400T, E404D, E413D, V435A, A437V, D471E, H483Q, L491T, S519N, E529D, A534S, A554S  
PT12733450318 ISO12733450318 None None   K102Q, S162C, G196E, T200A, Q207A, R211K, D237N, V245Q, S251I, A272P, K277R, T286A, E291D, V292I, I293V, Q334E, R356K, G359T, T377L, K390R, A400T, E404D, V435P, N447K, E449D, L452I, V466I, V467I, D471E, L491S, L503I, Q509K, S519N, K527N, K530R, A534S, A554S  
PT127339779 ISO127339779 None None  K103N V35T, E36A, T39D, S48T, V60I, K102Q, K122E, D123N, P170S, K173A, Q174K, N175H, D177E, I178V, Q182QH, T200A, Q207A, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, V317A, Q334N, G335D, R356K, G359S, T377L, K390R, A400T, E404D, V435M, A437V, E449D, S468P, T470N, D471E, Q480H, L491S, S519N, K530R, A534S, A554S  
PT79 ISO79 None None  K103N V35T, E36A, T39D, S48T, V60I, K102Q, K122E, D123N, P170S, K173A, Q174K, N175H, D177E, I178V, T200A, Q207A, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, V317A, Q334N, G335D, G359S, T377L, K390R, A400T, E404D, V435M, A437V, E449D, S468P, T470N, D471E, Q480H, L491S, S519N, K530R, A534S, A554S  
QA QA None None   E28R, K32E, V35T, E36A, T39E, S48T, K122E, D123N, K173A, Q174K, D177E, G196K, Q197E, Q207E, R211K, P243A, V245Q, D250E, A272P, I274V, E291D, V292I, I293V, E297A, L301I, Q334N, G335D, R356K, G359T, K366R, T377M, K390R, A400T, E404D, E432D, E449D, L452M, V458I, V466I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
QC QC None None   K32R, V35T, T39K, S48T, V60I, K122E, D123G, A158S, S162A, K173A, D177E, T200A, Q207E, V245Q, K277R, E291D, V292I, I293V, V317A, Q334N, G335D, R356K, G359A, T377M, K390R, A400T, E404D, K431KE, V435A, G436E, A446S, L452I, S468T, T470S, D471E, Q480H, H483Q, L491S, S519N, K530R, A534S, A554N  
QD QD None None  E138A V21I, V35T, E36A, T39E, S48T, K102Q, K122E, D123G, K173A, T200A, Q207K, R211K, V245Q, A272S, K277R, Q278E, T286A, E291D, V292I, I293V, P294T, I329L, Q334H, G335D, R356K, G359T, T377L, T386I, K388R, K390R, A400T, E404D, V435A, A437V, L452A, K454R, V467I, S468T, D471E, H483N, L491S, S519N, K530R, A534S, A554K  
QI QI None None   V35T, E36A, T39E, E40D, S48T, E53D, K122E, D123S, I135R, S162Y, K173T, D177E, T200A, E203D, Q207D, R211K, V245Q, D250E, S251D, A272P, K277R, T286A, E291D, V292I, I293V, V317A, Q334C, G335D, R356K, G359T, K366R, A376S, T377M, T386I, K390R, E404D, I434M, V435M, A437V, V458I, S468T, D471E, H483Q, L491P, S519N, A534S, A554X  
QP QP None None   V35T, E36A, T39E, S48T, K122E, D123S, K173T, D177E, T200A, E204Q, Q207D, R211K, V245Q, E248I, A272P, E291D, V292I, I293V, R356K, G359T, T377Q, K390R, E404D, E413D, I434M, V435A, A437V, L452M, V467I, S468T, D471E, H483Q, L491S, S519N, K527S, K530R, A534S, A554N  
QT QT None None   V35T, E36A, T39E, S48T, K122E, D123S, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, D250E, T286A, E291D, V292I, I293V, D324E, I329L, Q334N, G335D, F346Y, R356K, R358K, G359T, T377M, K390R, A400L, E404D, V435A, A437V, L452E, V466I, D471E, T477A, I482V, H483Q, L491S, S515A, S519N, A534S, A554K  
RA RA None None   K20R, V35T, E36A, T39E, S48T, K122E, D123G, K173T, Q174K, D177E, V179I, T200A, Q207D, R211K, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, Q334H, G335E, R356K, G359T, A360T, T369A, A376V, T377M, K390R, A400T, V435AT, L452I, V466I, D471E, H483Q, L491S, A534S, A554K  
RB RB None None   V35T, E36A, T39D, S48T, V60I, K122E, K173A, Q174K, D177E, T200A, Q207E, R211K, V245E, D250E, S251E, K277R, T286A, E291D, V292I, I293V, S322T, I329L, Q334N, G335D, R356K, G359T, V365I, A376S, T377M, K390R, A400T, E404D, E432D, I434M, A437V, E449D, L452M, S468T, D471E, H483Q, L491P, S519N, K527Q, K530R, A534S, A554S L149LF 
SK1 SK1 None None  P225PH V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, I178IM, T200A, E204D, Q207E, R211K, V245Q, D250DE, A272P, K277R, T286A, E291D, V292I, Q334D, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, E432D, V435IT, S468T, L469I, D471E, H483Q, L491PS, S519N, Q524E, K530R, A534S, A554S  
SK10 SK10 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, I142IV, K166R, K173A, Q174K, D177E, T200A, Q207A, R211K, F214L, V245Q, A272P, K277R, K281R, T286A, A288AS, E291D, V292I, I293V, E297K, Q334D, G335D, R356K, G359T, T377L, K390R, A400IT, E404N, V435A, L452M, V466I, S468P, T470S, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
SK11 SK11 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, V245Q, A272R, K277R, T286TA, E291D, V292I, I293V, Q334G, G335D, R356K, G359T, T377X, K390R, A400T, E404D, V435A, N447NS, L452I, R461K, V466I, S468T, T470N, D471E, H483Q, L491S, S519N, K530R, A534S, A554NS  
SK13 SK13 None None   K20R, V35T, E36EA, T39E, S48T, K122E, D123N, I135V, S162C, K173A, N175H, D177E, T200A, Q207EK, R211RK, V245Q, A272P, K277R, E291D, V292I, I293V, G335D, E344D, R356K, G359T, A376G, T377L, K390R, A400I, E404D, V435A, E449D, L452I, S468H, D471E, H483Q, L484I, L491S, L517LI, S519N, K527R, K530R, A534S, A554N  
SK14 SK14 None None   V35T, E36A, T39E, S48T, K49R, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K275Q, L279I, T286A, A288S, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377L, K390R, A400I, E404D, E432D, V435A, L452I, K454R, V466I, T470N, D471E, T477A, H483Q, L491S, V493I, I495L, S519N, L533M, A534S, A554K  
SK15 SK15 None None   P1S, V35T, E36A, T39E, S48T, V60I, K122E, D123S, T165I, K173A, D177E, T200A, I202V, Q207E, V245Q, A272P, G273R, K275R, Q278Y, K281R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, G359T, A376C, T377M, K390R, A400I, E404D, V435A, V466I, T470S, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
SK16 SK16 None None   V35T, E36EA, T39E, S48T, T69TI, K122E, D123X, K173I, Q174K, D177E, T200A, Q207E, R211K, F214FL, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334X, G335D, R356K, G359T, H361HP, T362TP, I375V, T377L, K390R, A400T, E404D, T409TP, L452A, V467I, S468T, L469LI, T470N, D471E, H483Q, L491S, S519N, Q520QK, Q524E, A534S, A554N  
SK17 SK17 None None   V35T, T39D, S48T, V60I, D121DY, K122E, D123X, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, D250E, A272P, K277KR, T286A, E291D, V292I, I293V, S322SA, Q334E, R356K, G359T, A376T, T377L, K390R, A400T, E404D, E432ED, V435VA, L452I, R461RK, D471E, H483Q, L491LS, S519N, K527N, K530R, A534S, A554S  
SK18 SK18 None None   V21I, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, K173A, Q174K, D177E, G196E, T200A, Q207E, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, V317A, D324DE, Q334N, G335D, R356K, G359T, T377L, K390R, A400I, E404D, V435A, A437V, S468SP, T470S, D471E, H483Q, L491S, S519N, K527KN, K530R, A534S, A554S M16MR, C38W 
SK2 SK2 None None  E138A D17DE, K32KQ, V35T, E36I, T39E, S48T, K122E, D123S, T165I, Q174K, I178L, Q197QP, T200A, I202V, Q207E, R211K, F214L, V245Q, E248N, A272P, V276VA, K277R, Q278N, T286A, E291D, V292I, I293V, E297EA, P313T, V317A, Q334H, G359T, A376T, T377L, K388KR, A400T, E404D, V435A, L452A, S468H, T470A, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554S  
SK3 SK3 None None   V8I, V35T, E36A, T39E, S48T, V60I, K122E, D123NS, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277KR, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, M357R, G359T, A360AT, T377M, K390R, A400I, E404D, V435A, A437V, L452IM, R461RK, V466IM, S468H, T470NS, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
SK4 SK4 None None   V35T, T39E, S48T, E53D, V60VI, K122E, D123N, K173X, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286TA, E291D, V292I, I293V, D324DE, Q334D, G335D, R356K, G359T, A376AT, T377LM, K390R, E396D, A400T, E404D, E413D, V435A, V466IT, L469I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554K  
SK5 SK5 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, K166R, K173A, D177E, I178M, T200A, Q207A, V245K, A272P, K277R, E291D, V292I, I293V, E297A, I326V, Q334E, G335D, R356K, M357R, R358RK, G359T, A360AT, T377MV, K390R, A400T, E404D, V435A, A437AV, L452M, S468T, T470N, D471E, H483HQ, S519N, Q524E, K530R, A534S, A554NS, V559I  
SK6 SK6 None None   K11Q, V35T, T39E, K43KR, S48T, S68G, T69N, D121Y, K122E, D123G, T139A, S162C, K173A, D177E, T200A, Q207E, R211K, V245Q, A272S, K277R, T286V, E291D, V292I, I293V, Q334D, G335D, R356K, G359N, T377L, K390R, A400V, E404D, V435A, A437AV, L452I, R461K, V466I, T470S, D471E, H483Q, L491PS, S519N, K530KR, A534S, A554S  
SK7 SK7 None None T215Y K103N, G190GA V35T, T39E, V60VI, K64KR, K122E, D123X, I135M, T165TI, K173A, Q174E, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, Q278QH, T286A, E291D, V292I, I293V, E297EA, Q334D, R356K, R358K, G359S, T377L, K390R, A400I, E404D, V435A, A437V, N447NS, L452LIM, V466VI, S468T, D471E, H483Q, L491S, S519N, K527N, V531VG, A534S, A554K  
SK8 SK8 None None   K20R, V35T, T39E, S48T, V60I, K122E, D123DG, K173A, T200A, Q207K, V245EK, K249KQ, D250DE, K277R, T286A, E291D, V292I, I293V, G335D, R356K, M357R, R358K, G359A, T377M, K390R, A400T, E404D, I434M, V435VA, A437V, L452I, V467I, S468T, D471E, Q487QKR, L491S, Q524E, A534S, A554S  
SK9 SK9 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123DG, K166R, E169A, K173A, Q174K, D177E, T200E, Q207E, R211K, F214L, V245Q, D250DE, A272P, K277R, V292I, I293V, Q334N, G335D, R356K, G359T, T377L, K390R, E399D, A400I, E404D, E413D, V435A, G436E, L452M, V466I, S468N, D471E, H483Q, L491P, S519N, K530R, A534S, A554NS