Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Yebra (2018)
Title A high HIV-1 strain variability in London, UK, revealed by full-genome analysis: Results from the ICONIC project.
Citation PLoS ONE
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 268
NumPts 268
Subtype B, C, CRF02_AG, A, CRF01_AE, D, G, CRF06_cpx, F, B + F, G + CRF02_AG, CRF13_cpx, CRF18_cpx, CRF03_AB, CRF09_cpx, CRF07_BC, CRF25_cpx, CRF49_cpx

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 268 Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
PT13592_1_32.3 ISO13592_1_32.3 Unknown Unknown   K122E, I135T, T200A, R211K, V245K, L283F, T286A, A288G, I293V, A327V, I329V, A360T, K390R, E399D, A400T  
PT13592_1_6.4 ISO13592_1_6.4 Unknown Unknown  K103N E44D, K122E, D123N, I142V, S162C, E204Q, Q207A, R211K, V245M, I293V, K311R, I329L, M357V, A360T, A376S, K390R, T403M, V435A, A446S, K451R  
PT13612_1_16.3 ISO13612_1_16.3 Unknown Unknown A62V, D67G, K70R V106M K20R, V35T, T39D, K102R, K122E, D123N  
PT13612_1_18.3 ISO13612_1_18.3 Unknown Unknown   E6D, V35M, T39A, R83K, K102R, T200V, V245E, P294Q, E344D, P345T, A376T, K385R, K390R, E399D, A400T, L452S, L469I, T470A, H483Y, L491S, L503X, E516G, V518G, K527N, E529D  
PT13612_1_3.3 ISO13612_1_3.3 Unknown Unknown   V35T, V60I, R72K, D121H, K122E, I135T, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, D250E, K281R, T286A, E291D, I293V, P294T  
PT13612_1_30.3 ISO13612_1_30.3 Unknown Unknown   K11Q, V35T, T39E, S48T, V60I, S68G, T69N, D121Y, K122E, D123E, K173A, Q174K, T200A, Q207A, R211E, V245Q, A272P, K277R, K281R, T286A, V292I, I293V, E297A, S322A, I329L, Q334D, G335D, R356K, G359T, I375V, T377L, K390R, A400T, E404D, V435A, N447H, L452Q, V466I, V467I, T470S, H483Q, L491P, S519N, Q520K, K527R, K530R, A534S, A554S, K558R  
PT13659_1_74.3 ISO13659_1_74.3 Unknown Unknown  V179D S48T, T165I, E169D, Q207E, R211K, F214L, V245Q, K277R, I293V, D324G, I329L, M357T, K390R, K395R, A400T  
PT13659_1_79.3 ISO13659_1_79.3 Unknown Unknown   E6D, V35T, T39R, E40D, V60I, E169D, K173T, Q174K, D177E, I178L, G196E, T200A, Q207E, R211K, F214L, V245Q, L246M, E248D, D250E, S251N, A272P, K275R, T286A, E291D, V292I, I293V, E297A, S322A, D324E, I329V, Q334L, G335D, R356K, M357R, A371V, I375V, T377L, S379C, K390R, K395R, A400T, E432D, V435L  
PT13659_1_82.3 ISO13659_1_82.3 Unknown Unknown  K103N V35T, E40D, K49R, V60I, K122Q, E169D, T200I, Q207E, R211K, K238R, V245Q, D250E, A272P, K277R, L282C, L283I, I293V, H315Q, V317A, G335D, P345Q, F346Y, R356K, M357T, A360T, T377Q, S379C, K390R, A400T, K451N, L452R, G453V, K454R K347T 
PT13774_1_52.3 ISO13774_1_52.3 Unknown Unknown   E6D, V35T, E36A, T39E, E40D, K122E, I135T, K173M, Q174K, Q207T, R211K, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, I326V, Q334H, G335D, R356K, M357R, G359T, A376T, T377M, K390R, A400T, E404D, V435A, K451R  
PT13774_1_57.3 ISO13774_1_57.3 Unknown Unknown  E138A V35T, K122E, D123N, I135V, S162A, T165I, K173T, Q174K, D177E, G196E, T200A, I202V, Q207E, R211K, V245Q, K281R, T286A, A288T, E291D, V292I, I293V, P294T  
PT13774_1_68.3 ISO13774_1_68.3 Unknown Unknown   V35T, T39E, S48T  
PT14535_1_23.3 ISO14535_1_23.3 Unknown Unknown  V106I K11Q, P14T, V35T, E36A, T39K, K43E, D123E, I142V, S162Y, K173L, Q174H, D177E, V179I, Q197E, Q207A, F214L, V245T, E248A, S251N, A272P, V276I, K281R, R284K, K287R, E291D, I293V, E312D, I326V, G335D, M357R, G359S, K366R, T369V, A371V, I375V, A376V, E399D, A400T, T403M, W410C, E432D, V467I, T470N, D471E, Q480Y, L491S, L517I, Q524K, K527E, E529K, A534S, A554S  
PT14592_1_60.3 ISO14592_1_60.3 Unknown Unknown   K11E, I142V, I202V, R211Q, F214L, V245M, K275Q, V276T, K277R, I293V, P294Q, V317A, I329V, Q334L, K366R, A376S, T403A, V435I, H483Y, A534T, K558R  
PT14667_1_35.3 ISO14667_1_35.3 Unknown Unknown   V35T, E36A, T39D, S48T, V60I, K122E, D123N, Q207E, R211K, I293V, L295M, E297A, S322T, I329V, F346H, V365I, T377Q, K390R, E399D, T403M, L452S, S468P, T470A, H483Y, E529D  
PT14667_1_36.3 ISO14667_1_36.3 Unknown Unknown   K122E, I135T, S162C, T200A, I202V, A272P, T286A, I293V, S322T, P345Q, F346Y, R356K, K390R, T403V, L452I, S468P, A554S  
PT14667_1_37.3 ISO14667_1_37.3 Unknown Unknown   V60I, I135T, I178M, R211T, V245I, S251I, A272G, I293V, S322T, G436E, L452S, V467I, S468T, A554T, K558R  
PT14667_1_38.4 ISO14667_1_38.4 Unknown Unknown   V35T, T39N, V60I, K173T, Q174E, T200A, Q207E, V245Q, E248D, D250E, S251N, A272P, E291D, V292I, I293V, D324E, I329V, Q334L, G335D, F346Y, M357R, R358G, G359S, T377V, T386V, Q394R, A400V, E413D, K431T, V435P, F440Y, D460N, R461K, R463K, V466I, V467I, S468T, L469I, T470Q, D471E, T477A, Q480H, H483Q, L491S, K512R, S519N, A534T, A554N  
PT14667_1_39.4 ISO14667_1_39.4 Unknown Unknown   V35T, T39E, S48T, D121H, K122E, S162A, K173T, D177E, I178L, T200A, E204D, Q207N, R211K, V245Q, A272P, E291D, V292I, I293V, E297D, Q334D, G335D, R356K, M357R, G359T, T377M, K390R, E404D, V435L, N447S, L452Q, V458I, V466I, T470S, D471E, L491P, L517I, S519N, K530R, A534S, A554S, K558R  
PT14727_1_40.3 ISO14727_1_40.3 Unknown Unknown   V35I, D86E, I202V, R211K, A272P, A288S, I329L, G333E, M357S, A376T, A400T, V466A, S468T, L469I  
PT14727_1_41.4 ISO14727_1_41.4 Unknown Unknown   T27S, V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173T, T200A, Q207E, V245Q, E248Q, D250E, A272P, T286A, E291D, V292I, Q334N, G335D, R356K, G359T, K366R, T369V, Q373H, T377Q, K390R, A400T, E404D, L452I, V467I, D471E, H483Q, S519N, K527G, K530R, A534S, A554S F416H 
PT14727_1_42.3 ISO14727_1_42.3 Unknown Unknown   V35T, E36A, T39E, S48T, V60I, K64R, K122E, D123G, K166R, K173A, D177E, T200A, Q207G, R211K, V245E, K277R, Q278C, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359T, A360T, T377M, K390R, A400T, E404D, V435A, A437V, E449D, L452I, V467I, S468T, L469V, D471E, H483Q, L491S, L517I, S519N, Q524E, A534S, A554S  
PT14727_1_44.3 ISO14727_1_44.3 Unknown Unknown   V118I, D123E, I135T, Q174R, D177E, R211K, F214L, V245E, A272P, K277R, K281R, V292I, I293V, E297A, F346L, A355T, V365I, K366R, I375V, T377L, K390R, A400T, N418S, L517I, S519N, K527Q, A554T Q367H 
PT14727_1_45.3 ISO14727_1_45.3 Unknown Unknown  E138A V35T, T39D, S48T, V60I, D121H, K122E, I142V, T165I, K173T, D177E, T200A, I202V, Q207A, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359N, T369A, T377M, K390R, A400T, E404D, V435I, L452I, R461K, V466I, L469M, D471E, H483Y, L491S, S519N, A534S, V548I, A554S  
PT14727_1_46.4 ISO14727_1_46.4 Unknown Unknown   K20R, V35T, V60I, I142T, D177E, I178M, T200V, Q207E, R211K, V245E, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, Q334H, F346H, R356K, M357I, R358K, G359S, E370D, A376S, T377M, K390R, A400T, E413D, K431T, V435A, L452I, D460N, R461K, V467I, S468T, T470S, D471E, H483N, L491S, S519N, A534S, A554S  
PT14727_1_49.3 ISO14727_1_49.3 Unknown Unknown   V35T, E36A, T39E, E40D, K43R, K122E, D123S, T139A, I142V, K173A, D177E, T200V, Q207A, R211K, V245Q, E248D, A272P, L283I, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T369A, T377Q, K390R, E404D, V435A, A437V, L452M, V466I, T470D, D471E, Q480H, L491S, L517I, K530R, A534S, A554S  
PT14727_1_50.3 ISO14727_1_50.3 Unknown Unknown  E138A V35T, V60I, K122E, I135T, I142V, K173A, Q174K, D177G, V179I, T200A, I202V, Q207A, R211S, F214L, V245M, E248D, D250E, S251H, A272P, T286A, V292I, I293V, P294T, I326V, G335D, M357K, G359S, A371V, I375V, A376V, E399D, A400T, T403M, E404D, E432D, N447S, R461K, D471E, Q480H, H483Y, L491S, Q524K, K527E, E529D, A534S, A554S  
PT14727_1_51.3 ISO14727_1_51.3 Unknown Unknown   V35T, T39I, K122E, D123S, G196E, T200A, Q207N, R211K, V245Q, K277R, L283I, I293V, E297K, S322A, I329V, G333D, Q334N, R356K, M357I, S379G, K390R, A400T, E432D, V435A, D471E, Q480H, H483Y, L517V, S519N, Q524E, A534S, A554S  
PT14727_1_53.3 ISO14727_1_53.3 Unknown Unknown   S68G, D123E, I135T, S162C, K166R, D177E, T200I, R211K, A272G, K277R, A288S, I293V, D324E, I329L, K347R, A360P, K366R, T369V, K395R, A400T, V435A, S468P, H483N  
PT14727_1_54.7 ISO14727_1_54.7 Unknown Unknown   V35T, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, I178M, T200A, Q207A, R211K, V245E, E291D, V292I, I293V, D324E, Q334E, G335D, R356K, M357R, G359T, A360T, Q367M, T377M, K390R, A400I, E404D, I434M, V435A, L452K, S468N, T470A, D471E, T477A, Q480I, H483Q, L484I, L491S, L517V, S519N, Q524E, K530R, A534S, A554N  
PT14727_1_55.3 ISO14727_1_55.3 Unknown Unknown K65R K101E, G190S E6D, V8I, M16V, V35T, T39K, K43A, K82R, R83K, V111I, K122E, D123S, K173T, Q174K, T200A, Q207A, R211S, K238R, V245E, T286A, I293V, E297K, A304E, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K390R, A400T, T403M, E432D, D460N, V467I, D471E, K476Q, Q480H, L491S, L517I, S519N, Q524E, A534S, A554S  
PT14727_1_59.4 ISO14727_1_59.4 Unknown Unknown   V60I, K122E, D123N, I135T, K166R, Q207N, I244V, A272P, T286A, D324E, I329L, M357T, R358K, V365I, D460N, S468P, H483Y, A554S  
PT14727_1_60.3 ISO14727_1_60.3 Unknown Unknown   E6D, K11T, V35T, T39E, E40D, S68G, K122E, D123N, I135T, K173T, Q174K, I178M, T200A, Q207A, R211S, K238R, V245E, K281R, E291D, V292I, I293V, E312T, S322A, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K385R, K390R, K395R, A400T, V435L, N447S, V467I, S468H, D471E, L491S, K512R, L517I, S519N, Q524E, A534S, A554S  
PT14727_1_62.3 ISO14727_1_62.3 Unknown Unknown   E28A, V35T, V60I, D121H, I135T, K173A, Q174K, D177E, V179I, T200A, Q207A, R211K, V245K, D250E, T286A, I293V, P294T, V314I, I326V, G335E, R356K, M357Q, R358G, G359S, K366R, A371V, I375V, T377R, T386I, A400T, T403M, E404D, E432D, V435A, D471E, Q480H, Q487K, G490E, L491S, K512R, L517I, Q524E, K527R, E529D, K530R, A534S, V548A, A554S  
PT14727_1_63.3 ISO14727_1_63.3 Unknown Unknown   D177E, I178L, V179I, I244V, V245E, S251I, K277R, I293V, E297K, D324E, L325I, Q334L, T377S, S379C, V381I, K390R, A400T, R461K, R463K, V467I, Q524E, A554S  
PT14727_1_65.3 ISO14727_1_65.3 Unknown Unknown  E138A V35T, T39E, S48T, V60I, K122E, D123N, I135V, I142V, K173I, Q174K, T200A, Q207A, R211K, F214L, V245Q, E248D, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, I329L, Q334E, R356K, G359T, T377M, K390R, E396D, T397I, A400T, E404D, V435A, K454R, V466I, V467I, S468P, D471E, T477A, H483Q, L491S, E492D, S519T, Q520N, K530R, V531I, A534S, A554S  
PT14727_1_66.3 ISO14727_1_66.3 Unknown Unknown  V106I K20R, V21I, V60I, K122E, I135T, S162H, Q174R, D177E, T200A, E203D, Q207E, R211K, V254I, A272P, Q334L, K350R, G359S, T377N, K390R, A400S, V435I, S468P, K512Q, S519N, A554S  
PT14727_1_67.3 ISO14727_1_67.3 Unknown Unknown   P4T, K20R, V35T, T39K, E40D, K49R, V60I, D123E, K173T, Q174N, D177E, I195L, Q207E, R211K, F214L, V245T, D250E, A272P, Q278H, K281R, T286A, E291D, V292I, I293V, E297A, L301M, D324E, I329V, Q334P, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, S379G, T386V, Q394R, A400V, E404D, K431T, V435L, F440Y, R461K, R463K, V466I, V467I, S468T, D471E, T477A, Q480H, H483Q, G490K, L491S, K512R, S519N, A534S, A554S  
PT14727_1_68.6 ISO14727_1_68.6 Unknown Unknown   V35T, E40D, K49R, V60I, D121Y, K122E, E169D, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359P, V365I, T386V, Q394R, A400L, Q428R, K431T, V435L, F440Y, R463K, V466I, V467I, S468T, L469I, T470Q, Q480H, H483Q, L491S, K512R, L517I, S519N, A534T, A554S  
PT14727_1_69.3 ISO14727_1_69.3 Unknown Unknown   R83K, K122E, I178M, V179I, E194K, I195L, G196E, T200A, I202V, R211K, A272P, K275Q, K277R, I293V, P294S, E297K, Q334D, G335N, F346Y, R356K, G359S, A376V, T386I, K390R, E399D, A400T, D460N, V467I, L491S, L517I, K527Q, L533M  
PT14727_1_70.3 ISO14727_1_70.3 Unknown Unknown  E138A W88S, D123E, I135T, E169D, I202V, V245T, A272P, K277R, T286P, E297K, I326V, Q334D, R356K, G359S, A376T, T386I, K390R, T403M, V435I, S468P, L469I, H483Y  
PT14727_1_71.3 ISO14727_1_71.3 Unknown Unknown D67N, T215L, K219Q N348I E6D, T27S, V35T, T39A, V60I, T69N, K102Q, K122E, I142V, K173S, V179I, Q197L, I202V, Q207A, K223Q, V245K, D250E, S251N, A272P, I293V, P294T, E312D, D324G, G335D, P345Q, M357R, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403R, E404D, F416Y, E432D, V435I, E449D, T470P, D471E, Q480H, H483Y, L491S, E492Q, K512S, S519N, Q524K, K527E, E529D, A534S, A554S, K558R  
PT14727_1_75.3 ISO14727_1_75.3 Unknown Unknown  V106I K20R, V21I, V60I, K122E, I135T, S162H, Q174R, D177E, T200V, Q207E, R211K, V254I, A272P, K277R, Q334L, K350R, G359S, T377N, K390R, A400S, V435I, S468P, K512Q, S519N, A554S  
PT14727_1_76.3 ISO14727_1_76.3 Unknown Unknown   V35T, E36D, T39M, D123E, I135R, S162A, K173T, Q174K, D177E, R211S, F214L, V245T, A272P, R284K, I293V, P294S, I326V, Q334L, M357T, T377M, K390R, A400T, D460N, V466A, V467I, S468P, H483L, A554S  
PT14727_1_77.3 ISO14727_1_77.3 Unknown Unknown  V179D K20R, V60I, D123N, I135T, V189I, Q207E, F214L, V245Q, K277R, T286A, I293V, E297R, V317A, I329V, M357I, R358K, T377M, K388R, K390R, V435L, V467I, S468P, L491S, K530R, V531I, A554T  
PT15171_1_1.3 ISO15171_1_1.3 Unknown Unknown D67G, K70E, Y115F, M184V K101E, Y181I K20R, S48T, T165I, R211K, A272P, L283I, S322A, Q334L, R358K, K390R, E399G, A400S, E404D  
PT15171_1_10.3 ISO15171_1_10.3 Unknown Unknown  V106I V35I, E40D, K49R, K104R, D123E, I135L, S162C, E169D, K173A, Q174K, D177G, I178L, T200A, Q207D, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, E297A, Y339F, R356K, G359S, T377L, T386I, K390R, Q394L, E399D, A400T, K431T, V435A, A446S, K451R, L452K, V466A, V467I, D471E, T477A, Q480H, H483Q, L484I, L491S, S519N, A534S, A554S, V559I  
PT15171_1_11.3 ISO15171_1_11.3 Unknown Unknown   V35T, E36D, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, P243T, V245Q, Q278N, T286A, E291D, V292I, I293V, P294A, S322T, I326V, R356K, M357K, G359S, K366R, A371V, I375V, T377L, V381I, K390R, T403M, E432D, A446S, V467I, S468T, L469I, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527E, E529D, A534S, A554S  
PT15171_1_12.3 ISO15171_1_12.3 Unknown Unknown   K20R, V35I, D123E, T165I, N175H, V179I, G196E, T200V, V245Q, A272P, T286A, P294A, G333E, Q334L, M357T, T377Q, S379C, K390R, E396D, A400T, E404D, V435R, A437V, A446S, K454R, S468T, L491S, A554K  
PT15171_1_13.3 ISO15171_1_13.3 Unknown Unknown   V60I, V118I, K122E, D123E, F214L, V245T, A272P, S322A, G333E, Q334H, M357T, K390R, K431R, K451R, S468P, H483Y, K512R, E516Q, A554S  
PT15171_1_15.3 ISO15171_1_15.3 Unknown Unknown M184I  K11T, V35T, T39K, K43E, E53D, K122E, D123A, I135T, S162Y, K173S, D177E, V179I, G196R, T200A, I202V, Q207A, R211K, F214L, V245Q, S251I, A272P, T286A, E291D, I293V, E312D, I326V, G335D, M357K, G359S, T369V, A371V, A376I, K390R, A400T, T403M, E404D, W410H, E432D, V435A, Y441F, S468T, T470P, D471E, Q480H, L491S, E492T, K512R, E514D, L517I, S519N, Q520K, Q524K, K527E, A534S, A554S  
PT15171_1_17.3 ISO15171_1_17.3 Unknown Unknown  E138A, V179E V35T, E40D, K49R, V60I, K122E, D123N, I135T, K173T, Q174K, T200A, Q207D, R211K, F214L, V245M, E248S, D250E, A272P, T286A, E291D, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A360T, K366R, T369V, A371V, S379G, V381I, T386V, Q394R, E399D, A400L, E413D, K431T, V435P, F440Y, R463K, V467I, S468T, L469I, T470Q, D471E, Q480H, H483Q, L484I, L491P, K512R, S519N, K530R, A534T, A554S  
PT15171_1_18.3 ISO15171_1_18.3 Unknown Unknown   E6D, V35T, E40D, V60I, D121H, K122E, D123S, I135T, K173T, Q174K, D177E, I195L, G196E, Q207E, V245Q, E248D, D250E, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357R, G359S, T386I, K390R, E432D, V435M, G436E, L452I, V466I, T470P, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527E, E529D, A534S, V548I, A554S  
PT15171_1_19.3 ISO15171_1_19.3 Unknown Unknown   V35I, D123E, K173A, Q174K, D177E, I202V, Q207N, R211K, V245Q, A272P, L283I, T286V, E291D, I293V, E297D, I326V, G335D, R356K, M357R, G359A, T369A, A371V, T377M, K390R, A400T, E404D, V435A, E449D, V466I, V467E, D471E, Q480H, H483Y, L491P, S515T, Q524E, K530R, A534S, A554S  
PT15171_1_2.3 ISO15171_1_2.3 Unknown Unknown   V35T, V60I, D123E, I135L, I142V, S162H, K166R, K173M, Q174E, T200A, Q207A, R211K, V245Q, A272P, K277R, Q278R, L283I, E291D, V292I, I293V, E297T, V317A, S322A, P345T, F346Y, R356K, G359S, A371V, T377L, K395R, K431T, V435T, A446S, L452Q, V466A, S468F, D471E, T477A, H483Y, L491S, S519N, K527Q, K530R, V531I, A534S, A554S  
PT15171_1_20.3 ISO15171_1_20.3 Unknown Unknown   K20R, V35T, V60I, D123E, A158S, K173T, Q174K, D177E, T200A, R211K, P243T, V245Q, E248D, T286A, E291D, V292I, I293V, E297A, I329L, Q334G, F346H, M357R, R358K, G359A, V381I, K390R, A400T, K431T, V435I, R448K, L452K, S468T, D471E, H483K, S519N, K527N, A534S, A554S  
PT15171_1_22.3 ISO15171_1_22.3 Unknown Unknown   E6D, V35T, E36A, T39D, S48T, V60I, K122P, K173T, Q174K, D177E, I178L, V179I, T200A, Q207E, R211K, V245Q, D250E, S251N, A272P, Q278N, V292I, I293V, K311R, Q334H, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, F416Y, V435I, L452I, S468T, T470N, D471E, L491S, L517I, S519N, I526V, K530R, A534S, A554S  
PT15171_1_24.3 ISO15171_1_24.3 Unknown Unknown   K20R, G196E, E204Q, Q207E, R211A, V292I, I293V, I326V, Q334L, A360T, K451R  
PT15171_1_25.4 ISO15171_1_25.4 Unknown Unknown   V60I, K103R, D123E, I135T, I142V, R211K, V245E, A272P, K277R, I326V, A327V, F346L, M357V, K366R, T377L, T386I, E404D, V435A, K451R, V466A, S468P, K512Q, S519N  
PT15171_1_26.3 ISO15171_1_26.3 Unknown Unknown   V35T, E36D, V60I, I135V, S162A, K173A, Q174K, D177E, I178M, T200A, Q207E, L228Q, T286A, V292I, I293V, P294I, S322T, G335D, R356K, M357K, G359S, I375V, A376S, T377Q, K390R, E432D, V435I, L452Q, T470N, D471E, Q480H, L491S, K512R, S519N, Q520L, Q524K, K527E, E529D, A534S, A554S  
PT15171_1_3.5 ISO15171_1_3.5 Unknown Unknown   V35T, E36D, K122E, D123E, I135V, S162A, K166R, K173A, Q174N, D177E, T200A, Q207E, F214L, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, I329V, Q334H, G335D, R356K, M357R, G359S, K366R, T369V, A371V, K374R, I375V, K390R, V435I, A437V, D460N, H483C, L491S, S519N, Q524E, V548I, A554S  
PT15171_1_31.3 ISO15171_1_31.3 Unknown Unknown   K20R, V60I, S68G, T69N, D123E, K166R, D177E, T200I, R211G, V245E, A272P, T286A, S322A, Q334L, M357S, T377M, S379C, A400L, T403M, F416Y, T470A, A554T, K558R  
PT15171_1_32.3 ISO15171_1_32.3 Unknown Unknown   A98S, D121H, K122E, D177E, A272P, T286A, E297A, K311R, Y342F, M357T, A376T, K390R, E399D, A400T, V435L, D460N, R461T, S468T, L491P, A534S, A554S, K558R  
PT15171_1_33.5 ISO15171_1_33.5 Unknown Unknown   I135T, I178M, R211K, F214L, A272P, K281R, T286P, E297K, K311R, S322T, A376T, K390R, E399D, A400T, K431T, V435T, A446S, L452T, D460N, R461K, D471E, T477A, Q480H, H483Q, L491S, E492K, S519N, K527N, A534S, A554S, V559I  
PT15171_1_35.4 ISO15171_1_35.4 Unknown Unknown   D121Y, K122E, S162C, Q207A, R211K, V245E, E248D, K277R, R284K, T286A, A288S, I293V, T296S, E297K, M357I, K390R, A400T, T403M, S468P, A554T  
PT15171_1_38.3 ISO15171_1_38.3 Unknown Unknown   V21I, V35T, T39K, E40D, V60I, K122E, D123S, S162A, K173A, D177E, D192N, T200A, Q207E, R211K, V245Q, E248N, A272P, K277R, T286A, E291D, V292I, I293V, Q334N, G335D, P345Q, R356K, G359A, T377L, S379C, K390R, A400I, E404D, E432D, V435A, E449D, L452I, L469I, H483Q, L491S, S519N, K527N, K530R, A534S, A554N  
PT15171_1_4.3 ISO15171_1_4.3 Unknown Unknown   E6D, V35T, T39K, K43E, V60I, K122E, D123S, I135T, K173I, Q174K, D177E, V179I, T200A, Q207A, R211S, I244V, V245E, A272S, E291D, V292I, I293V, E305K, E312T, I329V, G335D, M357K, G359S, K366R, A371V, S379G, K390R, K395R, A400T, E432D, N447S, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524E, A534S, A554S K275M 
PT15171_1_41.3 ISO15171_1_41.3 Unknown Unknown   I135T, S162C, I178M, R211K, A272P, K281R, E297K, K311R, S322T, A376T, K390R, E399D, A400T, K431T, V435T, A446S, L452E, D460N, D471E, T477A, Q480H, H483Q, L491S, E492K, S519N, K530Q, A534S, V559I  
PT15171_1_42.3 ISO15171_1_42.3 Unknown Unknown   S48T, D123E, T165I, T200A, R211K, A272P, V292I, P294S, I326V, Q334L, R356K, M357T, R358K, T377M, K390R, A400L, E404D, V435E, L452I, D460N, S519N, A554S  
PT15171_1_43.3 ISO15171_1_43.3 Unknown Unknown   V35T, T39D, S48T, V60I, K122E, D123S, K173T, D177E, I178M, T200A, Q207K, R211Q, V245K, A272P, K277R, T286A, E291D, V292I, I293V, S322T, I329L, G335D, R356K, M357R, G359A, T377V, K390R, A400T, E404D, E432D, V435A, E449D, L452M, V466I, V467I, D471E, H483Q, L491P, S519N, Q524E, A534S, A554S  
PT15171_1_44.3 ISO15171_1_44.3 Unknown Unknown   P4N, I5V, V35T, V60I, K122E, D123S, I135T, E169Q, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, F214L, V245Q, D250E, A272T, T286A, E291D, V292I, I293V, E312N, S322A, G335D, M357Q, R358K, G359S, A360T, K366R, T369A, A371V, I375V, A376V, A400T, T403R, E404D, E432D, V435A, L452I, R461K, T470N, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524K, K527E, E529D, A534S, A554S, K558R  
PT15171_1_6.3 ISO15171_1_6.3 Unknown Unknown   P4N, I5V, V35T, V60I, K122E, D123S, I135T, E169Q, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, F214L, V245Q, D250E, A272T, T286A, E291D, V292I, I293V, E312N, S322A, G335D, M357Q, R358K, G359S, A360T, K366R, T369A, A371V, I375V, A376V, A400T, T403R, E404D, E432D, V435A, L452I, R461K, T470N, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524K, K527E, E529D, A534S, A554S, K558R  
PT15171_1_7.5 ISO15171_1_7.5 Unknown Unknown   D121Y, K122E, S162C, Q207A, R211K, V245E, E248D, K277R, R284K, T286A, A288S, I293V, T296S, E297K, K311R, M357I, K390R, A400T, T403M, S468P, A554T  
PT15171_1_8.3 ISO15171_1_8.3 Unknown Unknown   P4T, K20R, V35T, E36A, T39E, S48T, V60I, A158S, T165I, K173A, Q174K, D177E, T200E, Q207E, R211K, D250E, S251H, A272P, K277R, T286A, E291D, V292I, I293V, G335D, G359T, A376S, T377M, K390R, A400T, E404D, L452I, D471E, H483Q, L491S, L503I, L517I, S519N, K527N, K530R, A534T, A554S  
PT15228_1_45.4 ISO15228_1_45.4 Unknown Unknown   V60I, A98S, K122P, I142V, S162A, D177E, Q207E, A272P, T286A, I293V, K311R, R356K, M357T, K395R, A400T, E432D, V435I, S468P, T470A, H483Y, L491I, L503I, K512Q, S519N, L533M, K558R  
PT15228_1_46.3 ISO15228_1_46.3 Unknown Unknown   V35T, T39E, V60I, K122E, I142K, K173S, Q174K, I178L, T200A, Q207D, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, I293V, I329L, Q334D, G335D, R356K, G359T, T377M, K390R, E399D, A400T, T403S, E404D, F440Y, L452M, R463G, V466I, D471E, T477A, H483Q, L484I, L491P, S519N, Q524E, A534S, Q547K, A554K  
PT15228_1_48.3 ISO15228_1_48.3 Unknown Unknown   I5V, E28K, V35T, T39N, V60I, V90I, K122E, D123S, S162A, K173T, Q174K, T200A, Q207K, R211N, V245Q, A272P, K275R, T286A, E291D, V292I, I293V, P294T, L295M, E297M, I326V, G335D, R356K, M357K, G359S, K366R, T369V, A371V, I375V, A376T, T386I, K390R, A400T, T403M, E432D, V435M, A437V  
PT15228_1_50.3 ISO15228_1_50.3 Unknown Unknown   E28K, K32E, V35T, T39K, V60I, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, G196E, T200A, Q207N, R211K, F214L, V245Q, E248D, D250E, S251V, A272S, K281R, T286A, I293V, P294T, E312D, I326V, G333E, R356K, M357R, R358S, G359S, Q367E, E370K, A371V, I375V, K390R, T403M, E404D, E432D, L452Q, K454R, D471E, Q480H, H483Y, L491S, E492A, K512Q, L517V  
PT15228_1_51.3 ISO15228_1_51.3 Unknown Unknown   V35T, V60I, T107S, K122E, D123N, I142V, K173R, I178M, T200M, Q207E, R211K, V245E, D250E, K277R, T286A, P294A, E312N, G335D, P345Q, F346H, R356K, M357R, A360T, T377Q, K390R, Q394T, E399D, V435E, A437V, K451X, L452X, L469I, H483N, L491S, L517V, S519N, A534S, A554K  
PT15228_1_52.3 ISO15228_1_52.3 Unknown Unknown   V35T, T39K, K43E, K49R, I135L, S162G, K173N, Q174K, D177E, E194K, I195T, T200A, Q207E, R211K, F214L, V245Q, A272P, P294E, S322T, I326V, G335D, R356K, M357R, G359S, T369A, A371V, I375V, A376V, T386A, K388R, K390R, A400T, Y405H, T409N, E432D, V435I, S468T, D471E, K476R, Q480Y, H483Y, L491S, A502T, K512R, L517I, S519N, K527R, E529D, A534S, A554S, K558R L193W 
PT15228_1_57.3 ISO15228_1_57.3 Unknown Unknown   V35T, E36A, T39E, G45E, S48T, V60I, K122E, D123S, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, D250E, A272S, T286A, E291D, V292I, I293V, V317A, D324E, Q334H, G335D, R356K, R358K, G359S, T377M, K390R, E396D, A400T, E404D, E432D, V435I, A437V, L452I, V466I, D471E, H483Q, L491S, S519T, K527N, K530R, A534S, A554S  
PT15228_1_59.3 ISO15228_1_59.3 Unknown Unknown   E6D, V35T, E36D, T39E, K103R, K122E, D123S, K173L, Q174K, D177E, G196E, Q207A, R211S, V245M, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, K311R, R356K, M357R, R358G, G359S, E370A, A371V, I375V, A376S, V381I, K390R, K395R, V435L, D471E, Q480H, H483Y, D488E, L491S, K512S, L517I, S519N, Q520K, Q524K, K527E, A534S, V548I, A554S, K558R  
PT15228_1_61.3 ISO15228_1_61.3 Unknown Unknown   E6D, K11T, V35T, K122E, D123S, I135T, K173M, Q174K, D177E, I202V, Q207N, R211K, K238R, V245E, E248D, K281R, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, A376S, T377I, I382L, T386I, K390R, E399D, A400I, T403M, E432D, N447S, Q464K, D471E, H483Y, L491S, E492K, K512R, L517I, S519N, Q524E, A534S, A554S Y342W 
PT15228_1_62.3 ISO15228_1_62.3 Unknown Unknown   I5V, V35T, T39I, K43R, V60I, D121Y, K122E, I135V, S162C, K173A, Q174K, D177E, I178L, T200A, Q207G, R211K, V245Q, A272P, K277R, L282C, T286A, I293V, V317A, D324E, G335E, P345Q, F346Y, R356K, M357S, A360T, T369A, T377Q, S379C, I393M, A400T, V435I, S468T, H483N, G490E, E492A, S519N, L533X, A534S, A554S, V559I  
PT15228_1_66.3 ISO15228_1_66.3 Unknown Unknown   V21I, V35T, E40D, V60I, K104R, K122E, D123N, I135T, K173A, Q174K, D177E, I178M, T200A, Q207N, V245Q, E248D, K249Q, D250E, S251D, A272P  
PT15228_1_67.4 ISO15228_1_67.4 Unknown Unknown   A98S, K122E, V189I, V245K, I257L, E297K, K311E, I326V, M357T, V365I, A376S, T377R, T386I, K390R, T403V, V435T, S468P, H483Y, A554T, V559I K104S 
PT15228_1_68.4 ISO15228_1_68.4 Unknown Unknown   V35M, E36A, T39E, S48T, K122P, I135V, S162C, K173T, D177E, T200E, E204Q, Q207D, R211K, V245Q, A272P, E291D, V292I, I293V, I326V, Q334D, G335D, R356K, M357R, G359T, T377V, K390R, E399D, A400T, T403A, E432D, V435T, A437V, N447S, E449D, L452I, S468T, D471E, H483Q, L491P, S519N, K527R, K530R, A534S, A554S  
PT15228_1_69.3 ISO15228_1_69.3 Unknown Unknown   V35T, E36A, T39D, S48T, V60I, K173R, Q174K, T200A, Q207N, R211K, E291D, V292I, I293V, P294T, G333E, R356K, M357I, G359T, K366R, T377M, K385R, K390R, A400T, E404N, V435M, K454R, V466I, S468T, T470N, D471E, H483Q, S519N, K527L, E529D, K530R, A534S, A554S  
PT15228_1_70.3 ISO15228_1_70.3 Unknown Unknown   V35T, K64R, K122E, D123E, K173A, Q174K, D177E, I178L, G196E, T200A, Q207E, R211K, V245Q, E248D, D250E, S251I, T286A, E291D, I293V, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376T, K390R, A400T, E432D, V435I, A437V, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527E, E529N, A534S, A554N  
PT15228_1_71.3 ISO15228_1_71.3 Unknown Unknown   K11T, V35T, E36D, K64R, K122E, D123N, I135V, S162A, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, E248D, I257V, A272P, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357R, G359S, T369A, E370D, I375V, V381I, K390R, K395R, T403R, E432D, T450S, L452I, D471E, Q480H, H483Y, L491S, L517V, S519N, Q524K, K527E, E529D, A534S, A554N  
PT15228_1_72.3 ISO15228_1_72.3 Unknown Unknown   E6T, V35R, K49R, V60I, D121Y, K122E, S162Y, D177E, T200I, Q207G, R211K, V245K, D250E, A272P, K277R, L282C, T286A, S322L, G335D, I341V, P345Q, F346Y, R356K, M357R, A360T, T377Q, S379C, K390R, A400T, T470A, H483N, P510S, S519N, K530R, A534S, V548I, A554N  
PT15228_1_73.3 ISO15228_1_73.3 Unknown Unknown   V60I  
PT15228_1_75.4 ISO15228_1_75.4 Unknown Unknown M184V  E29K, V35T, T39N, V60I, D121C, K122E, D177E, I178M, Q197R, T200I, Q207E, L228R, V245E, D250E, A272P, I274V, K281R, L282C, T286A, A288T, I293V, E297A, G335D, P345Q, F346Y, R356K, A360T, T377Q, S379C, A400T, T403S, N447S, L452I, R461Y, H483N, L491S, S519N, K530R, A534S, A554N, V559I  
PT15228_1_76.3 ISO15228_1_76.3 Unknown Unknown T215S V106I K11R, V35A, V60I, S68G, K70X, V90I, K122E, I135T, S162C, E169D, I195T, Q207E, V245E, L283I, T286A, I293V, E297K, R356K, M357T, A360V, K390R, V435E, D460N, R461K, S468T, K512Q, K527N, A554N E399A 
PT15228_1_77.3 ISO15228_1_77.3 Unknown Unknown   V21I, V35T, T39I, W88S, I135T, T165I, K173A, T200A, Q207A, R211K, V245Q, A272Q, T286A, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, G359S, T377S, S379A, K390R, A400T, T403S, E404D, V435A, F440Y, V466I, D471E, Q480H, L491S, S519N, K527N, K530R, A534S, A554S  
PT15228_1_79.3 ISO15228_1_79.3 Unknown Unknown   V35T, E40D, V60I, D121H, K122E, T139K, I142V, S162X, S163X, M164X, T165X, K166X, I167X, L168X, E169X, P170X, F171X, R172X, K173X, Q174X, N175X, P176X, D177X, I178X, V179X, I180X, Y181X, Q182X, Y183X, M184X, D185X, D186X, L187X, Y188X, V189X, G190X, S191X, D192X, L193X, E194X, I195X, G196X, Q197X, H198X, R199X, T200X, K201X, I202X, E203X, E204X, L205X, R206X, Q207X, H208X, L209X, L210X, R211X, W212X, G213X, F214X, T215X, T216X, P217X, D218X, K219X, K220X, H221X, Q222X, K223X, E224X, P225X, P226X, F227X, L228X, W229X, M230X, G231X, Y232X, E233X, L234X, H235X, P236X, D237X, K238X, W239X, V245E, D250E, S251D, V261I, A272G, E291D, V292I, I293V, P294T, E312D, D324E, G335D, M357K, G359S, K366R, A371V, I375V, A376V, T377I, E399D, A400T, E404D, E432D, V435T, D471E, Q480H, H483Y, L491S, K512R, E514D, S519N, Q524K, K527E, E529D, A534S, A554S, K558R I159M 
PT15228_1_80.3 ISO15228_1_80.3 Unknown Unknown   V35T, E36A, T39D, D121Y, K122E, K173E, T200A, Q207K, R211Q, V245Q, P247T, D250E, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359T, A376T, T377Q, K390R, E399D, A400T, E404D, E432D, L452I, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, A554K, K558R  
PT15228_1_81.4 ISO15228_1_81.4 Unknown Unknown   V35T, E36A, T39E, S48T, K122E, A158S, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, I293V, D324E, I326V, Q334N, G335D, A355T, R356K, M357R, G359T, A360T, T377M, K390R, E404D, V423I, V435M, A446S, K454R  
PT15228_1_82.3 ISO15228_1_82.3 Unknown Unknown   V35I, D123N, I135T, F214L, V245L, A272P, V276I, K277R, Q334D, T338S, A376S, Q394H, Y405H  
PT15228_1_83.3 ISO15228_1_83.3 Unknown Unknown   V35T, K49R, V60I, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, K366R, A371V, I375V, T377V, K390R, K395R, T403M, E413D, E432D, V435A, A437V, A446S, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527E, E529D, A534S, A554N