Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Jespersen (2018)
Title Protease Inhibitors or NNRTIs as First-Line HIV-1 Treatment in West Africa (PIONA): A Randomized Controlled Trial.
Citation JAIDS
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 83
NumPts 56
Subtype CRF02_AG, A

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
PT1 1BL None    I13V, K14R, G16E, K20I, M36I, R41K, L63S, I64M, H69K, I72V  
  1FU None    I13V, K14R, G16E, K20I, M36I, R41K, L63S, I64M, H69K, I72IV  
PT10 10BL None    I13V, L19P, K20I, M36I, N37S, R41K, H69K, L89M  
  10FU None    T12TP, I13V, L19P, K20I, M36I, N37S, R41K, H69K, L89M  
PT13 13BL None    L10V, I13V, I15V, E35D, M36I, N37D, R41K, K43KR, H69K, L89M  
  13FU None    L10X, T12TP, I13V, I15V, E35D, M36I, N37DE, R41K, K43R, H69K, K70KR, L89M  
PT14 14FU None    I13V, K20I, M36I, N37S, P39S, L63T, H69K, V82I, L89M  
PT15 15FU LPV    I13V, K14R, G16E, Q18K, K20I, M36I, R41K, F53FY, R57K, H69K, K70R, L89M  
PT16 16BL None    I13V, K14R, G17E, K20I, M36I, R41K, H69K, K70R, L89M  
  16FU None    L10X, I13V, K14R, G17E, K20I, M36I, R41K, L63LP, H69K, K70R, L89M  
PT17 17BL None    I13V, K14R, G17E, K20I, M36I, R41K, K43R, L63P, L89I  
  17FU None    I13V, K14R, I15X, G17E, K20I, M36I, R41K, K43R, L63P, L89I  
PT18 18FU LPV    I13V, K14R, G17E, K20V, M36I, N37D, R41K, H69K, L89M  
PT19 19FU None    L10X, T12N, I13AV, I15IV, K20I, A22AV, M36I, R41K, K43R, L63LP, I64IV, H69Q, L89I  
PT2 2FU LPV    I13V, K14R, G17E, K20I, E35Q, M36I, N37S, R41K, R57K, H69K, L89M  
PT20 20FU LPV    V11VA, I13V, K14R, G16E, K20I, M36I, R41K, H69K, K70R, L89M  
PT21 21FU LPV    I13A, K20I, M36I, N37S, R41K, H69K, L89IM  
PT22 22FU LPV    I13V, G16E, K20I, M36I, R41K, K43KR, H69K, K70R, L89M  
PT25 25BL None    L10V, I13V, K14R, G16E, E35D, M36I, R41K, L63S, H69K, L89M  
  25FU LPV    L10V, I13V, K14R, G16E, E35D, M36I, R41K, L63S, H69K, L89M T26TP 
PT26 26BL None    I13V, K14R, G17E, K20I, M36I, R41K, L63P, H69K, K70R, L89I  
  26FU None    V11VI, T12TP, I13V, K14R, I15IV, G17E, K20I, M36I, R41K, L63P, H69K, K70R, L89I  
PT27 27FU None    I13V, K20I, M36I, N37S, R41K, L63LP, H69K, K70KR, I72M, L89M  
PT28 28BL None    I13V, I15L, L19I, K20I, M36I, N37S, R41K, I64IM, H69K, L89M  
  28FU LPV    I13V, I15L, L19I, K20I, M36I, N37S, R41K, H69K, L89M  
PT29 29FU None    I13V, K14R, G16E, G17E, K20I, E34Q, M36I, P39S, R41K, H69K, K70R, L89M, T91TN  
PT3 3BL None    L10V, T12I, I13V, E35D, M36I, N37DE, R41K, R57K, I62IV, L63LP, H69K, L89M  
  3FU None    L10V, T12I, I13V, E35D, M36I, N37E, R41K, R57K, I62IV, L63P, H69K, L89IM  
PT30 30BL None    I13V, K14KR, L19P, K20I, M36I, N37D, R41K, H69K, K70R, L89M  
  30FU LPV    I13V, K14KR, L19P, K20I, M36I, N37D, R41K, K43KR, L63LP, H69K, K70R, L89M  
PT31 31FU None    I13V, K20I, M36I, N37NS, R41K, H69K, L89M  
PT32 32FU LPV    Q7QH, L10I, I13V, K14R, L19P, K20I, M36I, R41K, H69K, K70R, L89M  
PT33 33FU LPV    L10I, I13V, L19LPS, K20IV, M36I, N37S, R41K, H69K, L89M  
PT34 34BL None    I13V, K14R, G16E, K20I, M36I, R41K, H69K, K70R, L89M  
  34FU None    I13V, K14R, G16E, K20I, M36I, R41K, H69K, K70R, L89M  
PT37 37BL None    I13V, K14R, G17E, K20I, M36I, N37S, R41K, L63P, H69K, L89M  
  37FU None    I13V, K14R, G17E, K20I, E35EG, M36I, N37S, R41K, H69K, K70R, L89M  
PT38 38BL None    L10V, I13V, G16E, L19P, K20I, M36I, R41K, H69K, I72V, L89M  
  38FU None    L10V, I13V, G16E, L19P, K20I, M36I, R41K, H69K, I72V, L89M  
PT39 39BL None    I13V, I15V, K20I, M36I, N37S, R41K, L63P, H69K, I72M, L89M  
  39FU None    Q7QH, I13V, I15IV, K20I, M36I, N37S, R41K, L63LP, H69K, I72M, L89M  
PT4 4FU LPV    I13V, K14R, G16E, K20I, M36I, R41K, H69K, K70R, L89M  
PT40 40BL None    I13V, L19P, K20I, M36I, N37S, R41K, H69K, K70KR, L89M  
  40FU None    I13V, L19P, K20I, T31TP, M36I, N37S, R41K, H69K, K70R, L89M  
PT41 41FU LPV    L10I, I13V, E35D, M36I, R41K, L63LI, H69K, L89M T26TP 
PT42 42FU None    I13V, K14R, G16D, K20I, E35D, M36I, R41K, L63P, H69K, L89IM  
PT43 43BL None    I13V, G16E, K20I, E35N, M36I, R41K, H69K, L89M  
  43FU None    I13V, G16E, K20I, D25X, E35D, M36I, R41K, H69K, L89M  
PT44 44FU LPV    I13V, I15L, G16E, K20I, M36I, R41K, H69K, I72IV, V75VI, L89M  
PT45 45FU LPV    I13V, K14R, G17E, K20I, M36I, R41K, L63LP, K70R, L89M  
PT46 46BL None    I13V, K14R, G16E, K20I, M36I, R41K, H69K, L89M  
  46FU None    I13V, K14R, G16E, K20I, M36I, R41K, H69K, L89M  
PT49 49BL None    I13V, K14R, G16E, K20I, M36I, R41K, H69K, L89M  
  49FU LPV    I13V, K14R, G16E, K20I, M36I, R41K, H69K, L89M  
PT5 5FU LPV    I13V, K14R, L19P, K20I, M36I, R41K, H69K, L89M  
PT50 50FU LPV    L10V, I13V, I15V, G16A, K20I, M36I, R41K, K43KR, L63LP, H69K, I72IM, T74TS, L89M, I93V  
PT51 51BL None    L10I, I13V, L19P, K20I, M36I, R41K, K43R, L63P, I64V, H69K, K70R, L89I  
  51FU LPV    L10I, I13V, L19P, K20I, M36I, R41K, K43R, Q61QH, L63P, I64V, H69K, K70KR, L89I  
PT52 52BL None    I13V, K14R, L19P, K20I, M36I, N37D, R41K, H69K, L89M  
  52FU LPV    I13V, K14KR, L19P, K20I, M36I, N37ND, R41K, H69K, K70KR, L89M  
PT53 53BL None    T12A, I13V, K14R, I15V, G17E, K20I, M36I, R41K, L63P, H69K, L89I  
  53FU None    T12A, I13V, K14R, I15V, G17E, K20I, M36I, R41K, L63P, H69K, L89I  
PT54 54FU LPV    I13V, K14R, G17E, K20I, M36I, N37D, R41K, H69K, L89M  
PT55 55FU LPV    I13V, K14R, G16E, G17E, K20I, M36I, R41K, K43R, H69K, I72M, L89I  
PT56 56BL None    I13V, K14R, L19P, K20I, M36I, R41K, L63P, H69K, K70R, L89I  
  56FU None    I13V, K14R, L19P, K20I, M36I, R41K, L63H, H69K, K70R, L89I  
PT59 59FU LPV    Q7QH, L10I, I13V, E35D, M36I, R57K, H69Q, L89M  
PT6 6BL None    I13V, K14R, G16E, K20I, M36I, N37ND, R41K, H69K, L89M  
  6FU LPV    I13V, K14R, G16E, K20I, M36I, N37ND, R41K, H69K, L89M  
PT60 60BL None    I13V, K14R, G17E, K20I, E35ED, M36I, N37K, R41K, K43R, L63LP, H69K, L89M  
  60FU None    I13V, K14R, G17E, K20I, E35ED, M36I, N37K, R41K, K43R, L63LP, I64IM, H69K, L89M  
PT61 61BL None    I13V, G16E, K20I, E35D, M36I, R41K, H69K, L89M  
  61FU LPV    T12TP, I13V, G16E, K20I, E35D, M36I, R41K, I64IM, H69KT, K70KR, L89M  
PT62 62BL None    I13V, K20I, M36I, R41K, H69K, L89M  
  62FU None    I13V, K20I, M36I, N37NS, R41K, H69K, L89M  
PT63 63FU None    L10V, T12K, I13V, G16E, K20I, M36I, R41K, H69K, K70R, L89M, I93M K14Y 
PT64 64FU LPV    I13V, I15L, G16E, K20I, M36I, R41K, H69K, L89M  
PT65 65FU LPV    I13V, I15V, L19P, K20I, M36I, N37D, R41K, I64L, H69K, K70KR, L89M  
PT66 66FU None    L10V, I13V, I15V, G16E, G17E, K20I, M36I, N37S, R41K, H69K, I72R, L89M  
PT7 7FU LPV    V11VI, T12X, I13V, K14R, I15V, L19LP, K20I, M36I, R41K, K43KR, L63P, H69K, K70R, L89I  
PT8 8BL None    I13V, G17E, K20I, E35Q, M36I, N37S, R41K, L63P, H69K, L89M  
  8FU None    I13V, G17E, K20I, E35Q, M36I, N37S, R41K, L63P, H69K, L89M  
PT9 9FU None    I13V, L19P, K20I, M36I, N37S, R41K, H69K, L89M