Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Tsiang (2016)
Title Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.
Citation Antimicrob Agents Chemother
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 13
NumPts 13
Subtype B, D, CRF01_AE, C, F, A, CRF02_AG


Clinical RT Isolates

SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
1475MV 01CM.1475 None None   I5V, V35T, E40A, K46Q, K104R, K122E, D123G, I135V, S162A, K173T, Q174A, D177E, Q207E, V245Q, K277R, T286A, E291D, V292I, I293V, P294I, S322A, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376T, K390R, T403L, E432D, D471E, Q480H, L491S, K512R, L517I, S519N, Q524K, K527E, E529D, A534S, V548I, A554N, K558R, V559I  
92UG037 92UG037A35 None None   E6S, K20R, V21I, V35T, T39A, E40D, V60I, K122E, D123S, I135T, S162A, K173S, Q174K, Q207E, R211K, V245E, D250E, E291D, V292I, I293V, P294T, E312D, V317A, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V435A, D471E, Q480H, L491S, K512R, S519N, Q524K, K527E, E529D, A534S, A554S  
93BR020 93BR020 None None   V35T, T39M, I135T, I142V, S162Y, E169D, K173A, Q174K, Q207E, R211K, F214L, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297T, V317A, R356K, G359S, A376S, T377L, K390R, Q394L, E399D, A400T, K431T, A446S, L452K, V466A, D471E, T477A, H483Q, L491S, S519N, A534S F130S 
93IN905 ISO301905 None None   V35T, E36A, T39D, S48T, V60I, D121Y, K122E, I135V, S162C, K166R, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, A288T, E291D, V292I, I293V, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, E449D, L452I, V466I, D471E, H483C, L491S, S519N, K530R, A534S, A554N  
98UG57128 98UG57128 None None   V8I, V35T, S48T, V60I, D121Y, K122E, D123E, I142V, K166R, D177E, I178L, T200I, Q207E, R211K, V245E, D250E, A272P, K277R, L282C, T286A, I293V, G335D, P345Q, F346Y, R356K, A360T, T377Q, S379C, K390R, A400T, E404D, L469I, H483N, L491S, V518I, S519N, K527N, V531I, A534S, A554N, V559I  
98US_MSC5016 98US_5016 None None   V35T, T39E, S48T, K122E, D123S, K166R, K173A, D177E, T200A, Q207K, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, G359T, T377M, K390R, E396D, A400T, E404D, L452Q, V466I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
99UGA07412 99UGA07412 None None   I31V, V35I, K49R, V60I, D121Y, K122E, D177E, I178M, T200I, Q207G, R211K, P243S, V245K, K249Q, D250E, A272P, V276VI, K277R, L282C, L283I, T286TA, I293V, K311R, G335D, P345Q, F346Y, R356K, M357V, A360T, A376T, T377Q, S379C, T386P, K390R, A400I, H483N, A534S, A554N, V559I  
BB_85US_Ba-L 85US_Ba-L None None   V35M, R83K, D123E, K166R, D177E, A272P, E297K, A376T, A400T, V435I, D460N, A554N  
BB_96TH_M02138 96TH_02138 None None   E6D, V35T, T39K, K43E, K122E, D123N, S162C, K173V, Q174K, D177E, T200A, Q207A, R211S, V245E, I293V, K311R, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K390R, K395R, A400T, T403M, E432D, N447S, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
BB_96TH_NP1046 96TH_1046 None None  V108I E6D, K11T, V35T, T39K, K43E, K102R, K104R, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, A272P, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, I341L, M357K, G359S, K366R, A371V, V381I, T386I, K390R, K395R, A400T, E432D, D471E, Q480H, H483Y, L491S, K512R, L517V, Q524E, A534S, A554S  
BZ167 BZ167 None None   K122E, I178M, I293V, M357T, A376T, S379C, T386I, A400T, T470P, Q524E, K530R, A554S  
US1 US1 None None   R83K, K122E, S162C, I178L, T200I, A272P, K277R, E297A, M357V, A400T, D460N, R461K, L469I, H483Y, L491S, V559I  
US4 US4 None None   D123E, G196E, Q207G, V245K, K277R, T286A, I293V, D324E, G333E, T377R, S379C, T386I, A400T, T403I, Y405H, L517I, A554S