Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Tsiang (2016)
Title Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.
Citation Antimicrob Agents Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 60
NumPts 60
Subtype NA, B, C, CRF01_AE, D, F, A, CRF02_AG


Clinical IN Isolates

1475MV 01CM.1475 None    K14R, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, H171Q, V201I, T206S, I208M, T218I, L234I, A265V, R269K, D286N  
92UG037 92UG037A35 None    K14R, V31I, I72V, T112V, I113V, T124A, T125A, G134N, I135V, D167E, V201I, T206S, I208L, N222K, L234I, A265V, R269K, S283G  
93BR020 93BR020 None    S17N, L28I, P30A, I84L, S119T, T124A, K136Q, V165I, I200T, V201I, K211R, T218I, L234V, D256E, S283G  
93IN905 ISO301905 None   G163R K42Q, L101I, T112V, T124A, T125A, K136Q, V201I, L234I, R269K, D278A, S283G  
98UG57128 98UG57128 None    I5V, S17N, M50L, E69G, I72V, T112I, I113V, T124A, T125A, T174A, V201I, T218I, L234I, D256E  
98US_MSC5016 98US_5016 None    E11D, D25E, V31I, F100Y, L101I, T112V, S119P, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
99UGA07412 99UGA07412 None    S17N, M50L, I72V, Q95QH, T112V, I113V, T124A, T125A, G134D, V201I, Q221QKR, L234I, D256E  
BB_85US_Ba-L 85US_Ba-L None    V88I, M154I  
BB_96TH_M02138 96TH_02138 None    K14R, A21T, A23V, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283G  
BB_96TH_NP1046 96TH_1046 None    K14R, A21T, V31I, V32I, M50I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, T206S, L234I, S283G  
BZ167 BZ167 None    L101I, T125A, I135V, D167DE, G193R, V201I, I208L, K211T, A265V, S283G  
PT01 PT01:L74M_T97A Unknown   T97A L74M  
PT02 PT02:L68V_Y143C Unknown  Y143C  L68V  
PT03 PT03:L68LV_L74M_Y143R Unknown  Y143R  L68LV, L74M  
PT04 PT04:T97A Unknown   T97A   
PT05 PT05:T97A_F121Y Unknown  F121Y T97A   
PT06 PT06:T97A_Y143R Unknown  Y143R T97A   
PT07 PT07:F121Y Unknown  F121Y    
PT08 PT08:L74M_N155H Unknown  N155H  L74M  
PT09 PT09:T97A_N155H Unknown  N155H T97A   
PT10 PT10:T97A_Y143C Unknown  Y143C T97A   
PT11 PT11:E92Q_E157EQ Unknown  E92Q E157EQ   
PT12 PT12:E92Q Unknown  E92Q    
PT13 PT13:N155H_E157EQ Unknown  N155H E157EQ   
PT14 PT14:E92Q Unknown  E92Q    
PT15 PT15:Y143R Unknown  Y143R    
PT16 PT16:Y143R Unknown  Y143R    
PT17 PT17:N155H Unknown  N155H    
PT18 PT18:Y143C Unknown  Y143C    
PT19 PT19:T97A_Y143C Unknown  Y143C T97A   
PT20 PT20:Q148R_E138A Unknown  E138A, Q148R    
PT21 PT21:N155H_G163R Unknown  N155H G163R   
PT22 PT22:E92Q_N155H Unknown  E92Q, N155H    
PT23 PT23:E138K_Q148R Unknown  E138K, Q148R    
PT24 PT24:G140S_Q148H Unknown  G140S, Q148H    
PT25 PT25:E92Q_N155H_G163R Unknown  E92Q, N155H G163R   
PT26 PT26:G140A_Q148R Unknown  G140A, Q148R    
PT27 PT27:G140S_Q148H Unknown  G140S, Q148H    
PT28 PT28:G140S_Q148H Unknown  G140S, Q148H    
PT29 PT29:G140S_Q148H Unknown  G140S, Q148H    
PT30 PT30:E138K_G140S_Q148H Unknown  E138K, G140S, Q148H    
PT31 PT31:G140S_Q148H Unknown  G140S, Q148H    
PT32 PT32:G140S_Q148H_G163K Unknown  G140S, Q148H G163K   
PT33 PT33:G140S_Q148H Unknown  G140S, Q148H    
PT34 PT34:E138K_G140S_Q148H Unknown  E138K, G140S, Q148H    
PT35 PT35:E138K_G140S_Q148H Unknown  E138K, G140S, Q148H    
PT36 PT36:G140S_Q148H Unknown  G140S, Q148H    
PT37 PT37:G140S_Q148R Unknown  G140S, Q148R    
PT38 PT38:G140S_Q148H Unknown  G140S, Q148H    
PT39 PT39:G140S_Q148H Unknown  G140S, Q148H    
PT40 PT40:T97A_G140S_Q148H Unknown  G140S, Q148H T97A   
PT41 PT41:E138K_G140C_Q148R Unknown  E138K, G140C, Q148R    
PT42 PT42:L74LM_G140A_Q148R Unknown  G140A, Q148R  L74LM  
PT43 PT43:G140S_Q148R Unknown  G140S, Q148R    
PT44 PT44:G140S_Q148H_E138A Unknown  E138A, G140S, Q148H    
PT45 PT45:T97A_G140S_Q148H Unknown  G140S, Q148H T97A   
PT46 PT46:L74M_G140C_Q148R Unknown  G140C, Q148R  L74M  
PT47 PT47:E138K_G140A_Q148K Unknown  E138K, G140A, Q148K    
US1 US1 None    S17N, I72V, I84V, T124A, M154I, K173R  
US4 US4 None    L101I, T122I, T124N, A265V