Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Svard (2017)
Title Drug resistance testing through remote genotyping and predicted treatment options in human immunodeficiency virus type 1 infected Tanzanian subjects failing first or second line antiretroviral therapy.
Citation PLoS ONE
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 82
NumPts 82
Subtype A, C, D, B, CRF10_CD

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
1st_1 1st_1 AZT, 3TC EFV M41L, M184V, L210W, T215Y K103N, V106A V35T, V60I, D121H, K122E, I135T, T165L, K173A, Q174K, V179I, T200A, I202V, Q207A, R211K, V245E, D250E  
1st_108 1st_108 3TC, D4T NVP M41L, D67N, K70R, L74I, M184V, T215F, K219Q A98G, K103N, V108I, K238T E28A, V35T, K43KR, V60I, K122E, D123S, I135T, S162A, K173S, Q174K, D177E, V179VI, T200A, Q207A, R211S, V245T, E248D, K249KQ  
1st_109 1st_109 AZT, 3TC EFV M41L, T69D, M184V, T215F K101E, V108I, Y181C, G190A V8I, K20R, E28R, K32E, V35T, K49R, V60I, V118I, D121C, K122E, T139TA, S162N, D177E, T200R, Q207E, L228H, K238R, Q242H, V245E, D250E  
1st_14 1st_14 3TC, D4T NVP M41L, D67N, T69D, K70R, M184V, T215F A98G, K101H, Y181C, G190A, H221Y, F227L P4S, V8I, V35T, T39E, S48T, V60I, K122E, D123E, T139R, S162C, K173A, D177E, T200A, I202V, Q207E, R211K, V245Q, E248V  
1st_18 1st_18 3TC, D4T NVP K70GR, M184V L100I, K103N K20R, V35T, K49R, V60I, V90I, K122E, D123N, T139K, T200A, Q207K, H208L, R211K, L228H, I244V, V245K, D250E, S251D  
1st_19 1st_19 AZT, 3TC EFV M41L, M184V, L210W, T215FY V106M, Y188L V35T, V60I, K122E, D123S, I135T, S162Y, K173L, Q174K, V179I, Q207A, R211S, F214L, K223KE, F227FY, L228R, K238Q, V245M, D250E  
1st_20 1st_20 NRTI NNRTI M41L, T215Y K103N V35M, V60VI, D121Y, K122E, S162C, D177E, I178L, Q207E, R211K, L228R, V245N, E248D, D250DE, I257L  
1st_27 1st_27 3TC, D4T NVP M41L, D67N, M184V, L210W, T215F, K219W A98G, V108I, Y181C K20KR, K32E, V35K, T39D, E44D, S48T, I94L, V118I, K122E, D123NS, I135T, K173A, D177E, I178L, V179I, I195L, G196GE, T200A, Q207E, H208Y, R211K, D218E, L228LH, V245T  
1st_28 1st_28 AZT, 3TC NVP D67N, K70R, M184V, T215F, K219Q A98G, K101P, K103N K11T, K20R, V21I, T27S, V35T, T39R, K43E, K122E, D123S, S162A, K173S, Q174K, D177G, I202V, Q207A, V245Q, E248D, D250E  
1st_3015 1st_3015 3TC, D4T NVP M184AV K103N, V108I, P225PH E6D, V35T, K49R, V60I, K122E, D123S, I135T, T139TK, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, L228LF, W229WG, V245K, D250E Y181YH 
1st_3016 1st_3016 3TC, D4T NVP M41L, D67N, V75M, M184V, L210W, T215Y K101P, K103N, E138Q V35T, E44D, V60I, K122E, I135T, K173A, Q174K, D177E, V179I, T200A, E203K, Q207D, H208Y, R211K, V245M, D250E  
1st_3022 1st_3022 TDF, 3TC EFV   T7P, V35T, K49R, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, V245E, D250E S162E 
1st_3023 1st_3023 AZT, 3TC EFV T69S_ES, L74I, M184V, L210W, T215Y K103N, V108I K20R, I31L, V35M, T39A, E40D, W88S, K122E, K173T, Q174R, D177E, T200A, Q207A, R211N, L228H, V245Q, E248N  
1st_3027 1st_3027 3TC, D4T NVP D67N, T69D, K70R, M184V, K219Q E138Q, G190A V35T, T39TA, V60I, K101A, K122E, D123N, I135T, T165I, K173S, Q174K, D177E, V179I, Q207A, R211K, D250E  
1st_3032 1st_3032 3TC, D4T NVP M41L, D67N, V75M, M184V, L210W, T215Y, K219N K101E, G190A E28A, V35T, T39A, K43Q, E44D, V60I, V118I, D121Y, K122E, D123E, K126X, I135T, I142V, Q207E, H208F, R211K, V245Q, E248D, D250E, S251D L149F 
1st_33 1st_33 3TC, D4T NVP M41L, D67N, K70R, L74I, M184V, T215F, K219E A98G, K103N, Y181C, G190A, K238N V35M, E36A, T39E, S48T, V60I, T69N, K122E, D123N, I135T, K173A, Q197K, T200E, E203K, Q207E, L228H, P243A, V245Q  
1st_36 1st_36 3TC, D4T NVP M41L, D67N, L74V, M184V, L210W, T215Y K101P, G190A, H221Y, K238T K11T, V35T, T39A, K43E, V60I, V118I, D121H, K122E, I135V, D177E, V179I, T200A, E203K, L205F, Q207D, H208Y, R211K, E224K, V245E, D250E L120LI 
1st_37 1st_37 AZT, 3TC NVP M41L, D67N, M184V, T215Y K103N E28R, V35T, E44D, K49R, I94L, K101Q, D121Y, K122E, E169D, D177E, I178L, T200Q, Q207E, L210S, R211K, P243S, V245Q  
1st_38 1st_38 3TC, D4T NVP D67N, K70G, M184V, K219Q A98AG, K103N, Y181C, G190A, H221Y E28K, K32E, V35T, T39A, V60I, K101N, K122E, D123N, I135T, K173T, D177E, T200A, R211K, F214L, D218E, V245E, D250E  
1st_39 1st_39 AZT, 3TC NVP M41L, D67N, K70R, M184V, T215Y, K219E A98G, K101E, Y181C E28G, V35T, T39A, K122E, I135L, E169Q, K173T, D177E, I178L, T200A, Q207E, R211K, P243A, V245E  
1st_41 1st_41 AZT, 3TC NVP M41L, D67IN, T69D, M184V, T215Y Y181C, G190A, H221Y V35T, K49R, V60I, A98AS, K122E, D123S, I135R, S163T, T165I, D177E, I178M, V179I, Q207E, R211K, P243T, V245Q, E248ED  
1st_45 1st_45 TDF, FTC EFV K65R, M184V, K219E L100I, K103N K22R, K32R, V35K, T39E, S48T, S68G, T69K, V118I, K122E, I135T, T165I, K173T, Q174R, T200A, I202V, Q207E, R211K, F214L, P243T, V245H, K249Q  
1st_47 1st_47 AZT, 3TC NVP K65R, M184V K101P, G190A K20R, V35T, E36D, T39K, K43E, V60I, S68G, K122E, D123N, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245M, D250E  
1st_50 1st_50 3TC, D4T NVP M184V Y181C K20R, V35T, K49R, V60I, T69S, D123E, T139R, D177E, I178L, T200I, Q207E, R211K, V245Q  
1st_55 1st_55 AZT, 3TC EFV M41L, D67N, V75I, M184V, L210W, T215Y, K219N V108I, Y181C, G190A, H221Y V35T, K43E, E44A, V60I, K102Q, K122E, D123N, I132L, K173A, Q174K, D177E, V179I, V189I, Q207A, R211N, K238R, V245M, D250E  
1st_56 1st_56 AZT, 3TC NVP D67T, K70R, M184V, T215I, K219E K101E, V108I, Y181C, G190A K20R, V35T, T39A, V60I, T69N, D121H, K122E, D123S, I135T, T139I, S163T, K173S, Q174K, V179I, Q207K, R211S, D218E, D250E  
1st_57 1st_57 3TC, D4T NVP D67N, K70E, M184V, T215F K101E, V108I, Y181C, G190A, H221Y, F227L V35T, E36A, T39D, S48T, K122E, T139K, A158S, S162A, K173A, T200A, Q207E, R211K, V245Q  
1st_58 1st_58 AZT, 3TC NVP M41L, D67N, V75I, M184V, L210W, T215Y Y181I V35T, T39M, E44D, V60I, V118I, I132L, I135T, K173Q, Q174K, D177E, I178M, V179I, G196E, T200A, E203K, Q207D, R211N, L228H, V245I, D250E  
1st_65 1st_65 3TC, D4T NVP A62V, T69S_QS, M184V, L210W, T215F L100I, K101E, E138G, G190A T7A, K20R, V35T, K49R, S68N, K122E, D123N, I135T, K173S, Q174R, D177E, I178M, V179I, T200A, Q207E, R211K, L228H, V245Q, E248D  
1st_68 1st_68 NRTI NNRTI M184V, T215Y K103N, K238T K11T, K20R, V21I, V35T, T39K, E40AD, K43E, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, T200A, I202V, Q207A, R211N, V245Q, E248D  
1st_71 1st_71 AZT, 3TC EFV M41L, V75M, M184V, T215Y A98G, K101E, G190A, F227L P4H, K11A, E28K, K32E, V35T, V60I, K103R, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211H, D250E  
1st_72 1st_72 3TC, D4T NVP M41L, D67N, K70R, V75M, M184V, T215F, K219Q V108I, Y181C, H221Y, K238N V35T, K49R, V60I, K122E, D123S, I135T, K173A, Q174K, D177E, I178M, T200A, Q207E, V245Q P243K 
1st_73 1st_73 AZT, 3TC NVP A62V, V75I, F77L, F116Y, Q151M, M184V V108I, Y181C, H221Y V35T, S68G, T69X, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200E, Q207A, R211N, F214L, V245T, D250E  
1st_74 1st_74 3TC, D4T NVP  G190GA V35T, K43N, K49R, V60I, K122E, D123DN, I135V, E169D, K173L, Q174K, D177E, V179I, G196KR, Q197E, T200AE, Q207A, R211S, V245E, D250E, S251D  
1st_76 1st_76 TDF, FTC EFV K70N, Y115F, M184V V106M, E138G, V179D V35T, T39A, S48T, E53D, K102R, K103R, K122E, D123N, K173A, Q174K, I178L, T200A, Q207A, R211K, V245Q, E248T, D250E  
1st_79 1st_79 AZT, 3TC EFV D67N, T69D, K70R, M184V, T215V, K219Q K103N, P225H K11E, V35T, T39A, E40D, S48T, K49R, V60IL, D121H, K122E, D123S, I135T, K173A, Q174K, D177E, T200A, Q207A, R211K, P243S, I244V  
1st_8 1st_8 AZT, 3TC NVP D67G, T69D, K70R, T215F, K219Q A98G, K103N, Y181C K20R, V35T, T39S, S48T, V60I, K122E, D123N, I135T, S162A, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, F214L, L228R, V245N, D250E  
1st_80 1st_80 AZT, 3TC NVP M41L, D67N, K70KR, V75M, M184V, L210W, T215Y K103N, Y181C V35T, V60I, V111I, K122E, D123N, F124FL, I135T, T139K, S162A, K173S, Q174K, D177E, V179I, G196E, T200A, E203D, Q207S, R211N, H221C, V245I, D250E  
1st_84 1st_84 3TC, D4T NVP M41L, M184V, L210W, T215Y  V35T, E44D, K49R, V60I, V90I, V118I, K122E, I135T, I142V, S162D, D177E, I178M, Q207E, R211K, L228H, Q242H, V245Q, D250E  
1st_88 1st_88 3TC, D4T NVP M41L, M184V, T215F, K219W V179D, Y188L E6K, V35T, T39R, K43E, E44D, V60I, S68G, K103R, V118I, K122E, D123S, I135T, K173S, Q174K, N175Y, I180L, T200A, I202V, Q207E, R211K, F214L, V245Q  
1st_90 1st_90 AZT, 3TC NVP  K103N V35T, V60I, K122E, D123S, K173S, Q174K, D177E, G196E, T200A, Q207A, R211S, V245E, D250E  
1st_92 1st_92 3TC, D4T NVP D67G, T69D, K70R, M184V, T215F, K219Q K101P, K103N, P225H, M230L K32R, V35T, E40D, V60I, K122E, D123N, D177E, T200IM, Q207D, R211K, L228LH, K249R  
1st_96 1st_96 NRTI NNRTI   V35T, E36A, T39E, A98S, K122E, D123N, I135T, S162C, K173A, Q174R, D177E, T200A, Q207E, R211K, V245Q, E248D, D250E  
2nd_2004 2nd_2004 AZT, 3TC, TDF, FTC NVP M184V, T215Y K103N V8I, K20R, V35T, K49R, V60I, V90I, K122E, D123G, I135T, S162D, S163ST, K166KR, E169AD, D177E, I178M, T200R, Q207E, R211K, V245Q  
2nd_2005 2nd_2005 TDF, 3TC, D4T, FTC NVP D67N, M184V, L210W, T215Y A98G, K103N V35T, T39E, V118I, K122E, D123S, I135L, I142T, A158S, K173A, Q174K, N175Y, D177E, G196E, T200A, Q207E, R211K, V241I, V245Q  
2nd_2015 2nd_2015 3TC, D4T, TDF, FTC NVP D67N, K70R, M184V, T215F, K219E A98G, Y181C, G190A K20R, V35T, T39N, E40D, V60I, K122E, D123N, K173S, Q174K, V179I, T200A, I202V, Q207D, R211K, K238R, P243T, V245E, D250E, S251H  
2nd_2017 2nd_2017 3TC, D4T, TDF, FTC NVP K65R, M184V, T215NY K103N V35T, E36A, T39E, S48T, S68T, K122E, D123N, K173A, D177E, T200A, Q207E, R211K, D250N  
2nd_2021 2nd_2021 3TC, D4T, TDF, FTC NVP M41L, V75I Y188L V35T, T39E, K43R, S48T, E53D, V118I, K122E, D123S, T139A, K173A, D177E, I178M, T200A, Q207E, R211K, F214L, V245Q  
2nd_2023 2nd_2023 3TC, D4T, TDF, FTC NVP M184V, T215F A98G, K101E V35T, T39A, V60I, S68G, D121Y, K122E, D123E, I135K, S162C, Q174K, D177E, I178M, T200M, Q207E, R211K, K238R, V245E  
2nd_2025 2nd_2025 AZT, 3TC, TDF, FTC NVP   V35T, T39E, E40D, S48T, K122E, D123S, K173A, D177E, T200A, Q207E  
2nd_2027 2nd_2027 3TC, D4T, TDF, FTC EFV D67N, L74I, M184V  T7A, V35T, K43E, V60I, D121H, K122E, I135T, S162A, K173R, G196R, T200L, E203K, Q207E, R211K, V245M  
2nd_2028 2nd_2028 AZT, 3TC, TDF, FTC EFV M184V K103N V35T, E40D, K49R, V60I, T69TN, V90I, K101Q, D177E, T200A, Q207R, R211K, V245K  
2nd_2030 2nd_2030 3TC, D4T, TDF, FTC NVP   E28D, V35T, V60I, K122E, D123S, I135T, S162H, K173A, Q174K, D177E, V179I, Q207A, R211S, V245I, D250DE, S251I  
2nd_2033 2nd_2033 3TC, D4T, TDF, FTC NVP M184V, L210W, T215Y, K219KQ K101E, G190A E28R, K32E, V35T, K49R, V60I, A98S, D121Y, K122E, D123E, S162D, E169D, D177E, I178IM, V179I, T200K, Q207E, R211K, P243S, V245K, D250E  
2nd_2034 2nd_2034 AZT, 3TC, ABC EFV   V35T, V60I, K122E, D123S, K173A, Q174K, I178M, T200A, Q207E, R211K, V245Q, D250E, S251C  
2nd_2035 2nd_2035 AZT, 3TC, ABC, DDI NVP M184V  K20R, E28A, V35T, T39M, V60I, D121H, K122E, I135T, K173S, Q174K, V179I, T200A, Q207A, R211S, F214L, V245Q  
2nd_2039 2nd_2039 AZT, 3TC, TDF, FTC NVP M184V, T215F A98G, G190A E6Q, K11Q, M16T, K20R, V35T, T39E, K43R, S68G, K122E, D123N, S162C, D177E, I178M, T200AV, Q207E, R211K, Y232YD, V241I, V245T  
2nd_2042 2nd_2042 AZT, 3TC, TDF, FTC NVP  K103N V35T, T39E, V90I, K122E, D123S, I135T, K166R, D177DE, T200A, Q207E, R211K, I244V, V245K, D250E  
2nd_2044 2nd_2044 3TC, D4T, TDF, FTC NVP  K103N, Y181C K11T, K20R, V35T, E40D, T69N, D121H, K122E, I135T, S162A, K173S, Q174K, D177E, I178L, V179I, V189I, I195L, T200A, I202V, Q207A, R211K, F214FL, D250E E138M 
2nd_5008 2nd_5008 3TC, D4T, ABC, DDI NVP  K103S, E138Q V35T, V60I, K122E, D123S, K173A, Q174K, V179I, T200A, Q207A, R211S, D237E, V245Q, D250E  
2nd_5009 2nd_5009 3TC, D4T, TDF, FTC NVP   T27S, V35T, T39A, E40D, V60I, K122E, D123S, I135T, K173S, Q174R, D177E, V179I, T200A, Q207A, R211S, E248ED, D250E  
2nd_5016 2nd_5016 3TC, D4T, TDF, FTC EFV D67N, T69D, K70R, M184V, L210W, T215Y, K219E K103S, G190A K20R, V35T, E44D, V60I, V118I, K122E, K173S, Q174K, N175Y, D177E, V179IT, T200S, K201R, I202V, Q207A, R211N, K223Q, V245Q, E248D, D250E, I257L  
2nd_5017 2nd_5017 3TC, D4T, TDF, FTC NVP D67N, K70R, T215F, K219E K103N, E138G V35T, E40D, K49R, V60I, I94L, K122E, D123S, I135T, T165L, K173S, Q174K, D177E, T200K, I202V, Q207A, R211S, V245Q, D250E  
2nd_5019 2nd_5019 TDF, 3TC, D4T, ABC, DDI EFV M41L, M184V, L210W, T215F K103N, V108I, Y181C V35T, T39TA, K49R, V60I, K102Q, D121H, K122E, I135V, E169D, Q174R, D177E, I178L, V179I, T200TA, Q207E, R211K, L228H, Q242H, V245K  
2nd_5020 2nd_5020 NRTI, TDF, FTC NNRTI   V35T, T39E, V60I, W88C, K122E, D123S, I135T, K173S, Q174K, D177E, I178V, T200A, Q207A, R211S, F214L, V245E, D250E  
2nd_5022 2nd_5022 AZT, 3TC, NRTI NVP M41L, M184V, L210W, T215Y Y188L E28K, V35T, T39E, V60I, K104R, K122E, D123N, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, E248N, D250E  
2nd_5023 2nd_5023 AZT, 3TC, TDF, FTC EFV M184V K103N, Y188F V35T, K49R, V60I, K122E, D123S, I135T, T165L, K173S, Q174K, D177E, V179T, T200A, Q207A, R211K, V245K, E248D, D250E  
2nd_5045 2nd_5045 AZT, 3TC, TDF, FTC EFV M184V A98G, K101E, Y181C, G190A T27S, V35T, V60I, K122E, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, F214L, L228H, V245E, D250E  
2nd_5047 2nd_5047 AZT, 3TC, NRTI NVP A62V, K65R, M184V V179D, G190A K11R, V35T, E36A, T39D, S48T, K103R, K122E, I135T, A158S, S162T, K173T, Q174E, T200A, Q207E, V245Q  
BL_4001 BL_4001 None None   V35T, V60I, K122E, D123S, I135T, K173T, Q174K, D177E, V179I, T200A, Q207A, R211S, D250Q  
BL_4002 BL_4002 None None   V35T, E36A, T39E, E40D, S48T, D123N, K173A, D177E, T200A, Q207A, R211K, F214FL, P243T, V245Q, E248D  
BL_4003 BL_4003 None None   K20R, V35T, E36A, T39E, S48T, D121H, K122E, D123E, S162C, K173A, D177E, T200A, E203D, Q207N, R211K, V245Q, E248D  
BL_4005 BL_4005 None None   V8I, V35T, E36A, T39E, S48T, V60I, D121Y, K122E, D123G, I135T, S162C, K166R, K173A, D177E, T200A, Q207E, R211K, V245L  
BL_4006 BL_4006 None None   V35T, T39E, S48T, K122E, D123N, I142V, K173A, Q174K, D177E, Q207E, R211K, V245Q, S251SN  
BL_4007 BL_4007 None None   V35M, E36T, T39E, S48T, K102R, K122E, D123S, I135T, S162C, K173A, D177E, T200A, Q207E, R211K, V245Q  
BL_4009 BL_4009 None None   V35T, V60I, K122E, D123S, I135T, K173T, Q174K, D177E, V179I, T200A, Q207A, R211S, D250Q N255Y 
BL_4011 BL_4011 None None  E138A K20R, V35T, E36A, T39D, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179VI, G196E, T200S, Q207A, R211N, F214FL, V245L, E248ED  
BL_4012 BL_4012 None None   K20R, V35T, V60I, K122E, D123N, I135L, T165I, K166R, K173A, Q174K, V179I, T200A, Q207A, R211K, V245M, D250E  
BL_4013 BL_4013 None None   V35T, E36A, T39E, S48T, K122E, D123S, I135T, K173A, D177E, T200A, Q207E, R211RK, V245Q  
BL_4014 BL_4014 None None  K103N V35T, E36A, T39E, S48T, V60I, A98S, K122E, D123N, I135RT, K173T, Q174K, T200A, Q207E, R211K, V245Q, D250E  
BL_4015 BL_4015 None None   K20R, V35T, K49R, V60I, D121Y, K122E, Q174H, D177E, T200A, Q207E, R211K, P243H, V245Q  
BL_4019 BL_4019 None None   K32R, V35T, K49R, V60I, D121Y, K122E, K173S, Q174KR, P176PS, G196E, T200A, Q207A, R211K, V245K, D250E  

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