Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Herring (2001)
Title Natural variation in HIV-1 integrase.
Citation Direct Genbank Submission
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 16
NumPts 16
Subtype B

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
1052 PT1052
Consensus 
None    H16HP, L101I, T125A, I135V, M154L, K211R, S230N  
  clone: 1 None    L101I, T125A, I135V, M154L, K211R, S230N  
  clone: 2 None    H16P, L101I, T125A, I135V, M154L, K211R, S230N  
  clone: 3 None    L101I, T125A, I135V, M154L, K211R, S230N  
  clone: 4 None    L101I, T125A, I135V, M154L, K211R, S230N  
1101 PT1101
Consensus 
None  E138EK  S17N, S39SN, T124A, T125A, D167DN, D232E, D256E  
  clone: 1 None    S17N, S39N, T124A, T125A, D167N, D232E, D256E  
  clone: 2 None    S17N, T124A, T125A, D232E, D256E  
  clone: 3 None  E138K  S17N, T124A, T125A, D232E, D256E  
  clone: 4 None    S17N, T124A, T125A, D232E, D256E  
1117 PT1117
Consensus 
None    S17N, M50MT, T124A, T125A, A175AV, V180VI, D232E, D256E  
  clone: 1 None    S17N, T124A, T125A, A175V, D232E, D256E  
  clone: 2 None    S17N, M50T, T124A, T125A, D232E, D256E  
  clone: 3 None    S17N, T124A, T125A, V180I, D232E, D256E  
  clone: 4 None    S17N, T124A, T125A, D232E, D256E  
1609 PT1609
Consensus 
None    E10D, M50I, I72V, E92EK, T124N, K156KN, D256E  
  clone: 1 None    E10D, M50I, I72V, T124N, K156N, D256E  
  clone: 2 None    E10D, M50I, I72V, E92K, T124N, K156N, D256E  
  clone: 3 None    E10D, M50I, I72V, T124N, D256E  
  clone: 4 None    E10D, M50I, I72V, T124N, K156N, D256E  
1620 PT1620
Consensus 
None  V151VA  S17SN, A23AV, I72V, P90S, L101I, T124TA, V201I, K219KE, S283G H183HY, R263RG 
  clone: 1 None  V151A  S17N, A23V, I72V, P90S, L101I, T124A, V201I, S283G  
  clone: 2 None    S17N, I72V, P90S, L101I, T124A, V201I, S283G  
  clone: 3 None    S17N, I72V, P90S, L101I, T124A, V201I, S283G  
  clone: 4 None    I72V, P90S, L101I, V201I, K219E, S283G H183Y, R263G 
  clone: 5 None    S17N, I72V, P90S, L101I, T124A, V201I, S283G  
1658 PT1658
Consensus 
None    E10EG, E11ED, S24SN, N27NG, V31VI, V32VI, D55DG, S57SG, I72IV, L101LI, S119SP, T122TI, I135IV, V201VI, D207DG, S230SG, A265AV, D286DE  
  clone: 1 None    E11D, S24N, V31I, S119P, T122I, V201I, D207G, A265V, D286E  
  clone: 2 None    E11D, S24N, V31I, S119P, T122I, V201I, A265V  
  clone: 3 None    N27G, V32I, I72V, L101I, I135V, S230G  
  clone: 4 None    E10G, N27G, V32I, I72V, L101I, I135V, S230G  
  clone: 5 None    N27G, V32I, D55G, S57G, I72V, L101I, I135V, S230G  
1660 PT1660
Consensus 
None    D6DE, K7KQ, Q9QP, E11ED, S24SN, N27NG, V31VI, V32VI, G70GR, I72IV, I89IL, L101LI, S119SP, T122TIA, I135IV, G197GR, V201VI, T218TS, S230SG, S255SG, D256DE, A265AV, S283SN I5IM, Q44QP, E48EV, Q216Q*, K273KE 
  clone: 1 None    N27G, V32I, I72V, L101I, T122A, S230G, A265V  
  clone: 2 None    E11D, S24N, V31I, I72V, S119P, T122I, V201I, Q216*, T218S, A265V, S283N  
  clone: 3 None    D6E, K7Q, Q9P, E11D, N27G, V32I, I72V, L101I, I135V, G197R, S230G I5M, E48V 
  clone: 4 None    D6E, K7Q, Q9P, E11D, N27G, V32I, I72V, L101I, I135V, S230G, S255G I5M 
  clone: 5 None    E11D, S24N, V31I, G70R, I72V, I89L, S119P, T122I, V201I, T218S, D256E, A265V Q44P 
  clone: 6 None    E11D, S24N, V31I, I72V, S119P, T122I, V201I, T218S, A265V  
  clone: 7 None    E11D, S24N, V31I, S119P, T122I, V201I, T218S, A265V K273E 
1661 PT1661
Consensus 
None  E92EV  E10D, N27G, V31I, H51HQ, I72V, G82GR, L101I, I135V, V201VI, S230G M22MT, T93TI 
  clone: 1 None    E10D, N27G, V31I, I72V, L101I, I135V, V201I, S230G M22T 
  clone: 2 None    E10D, N27G, V31I, H51Q, I72V, L101I, I135V, S230G  
  clone: 3 None  E92V  E10D, N27G, V31I, I72V, L101I, I135V, S230G  
  clone: 4 None    E10D, N27G, V31I, I72V, L101I, I135V, S230G  
  clone: 5 None    E10D, N27G, V31I, I72V, G82R, L101I, I135V, S230G T93I 
1663 PT1663
Consensus 
None    K14KR, R20RK, A21AT, V37VI, M50ML, I72IV, G82GE, E87X, S119G, T122I, T124TA, T125TA, I182IV, V201I, L234X, D256DE M22MT, D202DG, K211KRI 
  clone: 1 None    I72V, S119G, T122I, T124A, V201I, K211R, D256E  
  clone: 2 None    R20K, I72V, S119G, T122I, I182V, V201I, K211R, L234X, D256E M22T 
  clone: 3 None    K14R, I72V, S119G, T122I, V201I, D256E  
  clone: 4 None    V37I, G82E, S119G, T122I, T125A, V201I, D256E  
  clone: 5 None    I72V, S119G, T122I, T124A, V201I  
  clone: 6 None    A21T, M50L, I72V, E87X, S119G, T122I, T125A, V201I D202G, K211I 
1664 PT1664
Consensus 
None    E10D, N27G, L28LM, V31VI, V32VI, I72V, L101I, I135IV, K160KE, Q164QK, K211KR, R224RW, S230G, S283SG L2LW, A8AV, F26FL, Y226YH 
  clone: 1 None    E10D, N27G, V31I, I72V, L101I, R224W, S230G Y226H 
  clone: 2 None    E10D, N27G, V31I, I72V, L101I, I135V, S230G  
  clone: 3 None    E10D, N27G, V31I, I72V, L101I, I135V, S230G A8V 
  clone: 4 None    E10D, N27G, L28M, V31I, I72V, L101I, K160E, K211R, S230G, S283G F26L 
  clone: 5 None    E10D, N27G, V31I, I72V, L101I, S230G L2W 
  clone: 6 None    E10D, N27G, V32I, I72V, L101I, Q164K, S230G  
  clone: 7 None    E10D, N27G, I72V, L101I, S230G  
1665 PT1665
Consensus 
None    S17SN, N27G, V31VI, V32VI, V54VA, I72V, L101I, I113X, M154MI, V201VI, S230G, I251IV K14KE, I204IT 
  clone: 1 None    S17N, N27G, V31I, I72V, L101I, S230G  
  clone: 2 None    N27G, V31I, I72V, L101I, S230G  
  clone: 3 None    N27G, V32I, I72V, L101I, M154I, V201I, S230G  
  clone: 4 None    N27G, V31I, I72V, L101I, I113L, S230G I204T 
  clone: 5 None    N27G, V31I, V54A, I72V, L101I, M154I, S230G, I251V K14E, I113T 
1672 PT1672
Consensus 
None    D6E, E10D, S17SN, D25X, V31VM, M50I, E69EK, L101I, S119SG, T122TI, T124N, T125TA, E152EK, K156N, I208IL S81SN 
  clone: 1 None    D6E, E10D, D25E, M50I, L101I, S119G, T124N, T125A, K156N  
  clone: 2 None    D6E, E10D, M50I, L101I, S119G, T124N, T125A, K156N  
  clone: 3 None    D6E, E10D, V31M, M50I, L101I, S119G, T124N, T125A, K156N  
  clone: 4 None    D6E, E10D, D25N, M50I, E69K, L101I, S119G, T124N, T125A, E152K, K156N, I208L  
  clone: 5 None    D6E, E10D, S17N, M50I, L101I, T122I, T124N, K156N S81N 
1687 PT1687
Consensus 
None    E10D, S17SN, M50I, L101I, T112I, T125A, K156N, E157EK, V201I, I203M, I208L, N222K, S230N L74LP, L234LP 
  clone: 1 None    E10D, M50I, L101I, T112I, T125A, K156N, V201I, I203M, I208L, N222K, S230N L234P 
  clone: 2 None    E10D, S17N, M50I, L101I, T112I, T125A, K156N, V201I, I203M, I208L, N222K, S230N  
  clone: 3 None    E10D, M50I, L101I, T112I, T125A, K156N, V201I, I203M, I208L, N222K, S230N  
  clone: 4 None    E10D, M50I, L101I, T112I, T125A, K156N, E157K, V201I, I203M, I208L, N222K, S230N L74P 
1688 PT1688
Consensus 
None    V31VI, L45LT, M50I, G189GR, V201VI, I217IV, D232E, A265V D6DG, D202DG 
  clone: 1 None    M50I, V201I, I217V, D232E, A265V  
  clone: 2 None    V31I, M50I, V201I, D232E, A265V  
  clone: 3 None    L45T, M50I, D232E, A265V D6G, D202G 
  clone: 4 None    M50I, G189R, V201I, D232E, A265V  
1702 PT1702
Consensus 
None    R20RG, E48EK, M50MT, D64DG, I72V, K111T, T124TN, T125A, V126L, M154MVI, G193R, T206S, I208IM, K211KR, S230N, Q274QR, R284RG F26FL, E69E*, N120ND, I135IT, F223FS, G237GR, R262RS 
  clone: 1 None    I72V, K111T, T124N, T125A, V126L, G193R, T206S, S230N, Q274R, R284G E69E* 
  clone: 2 None    I72V, K111T, T124N, T125A, V126L, G193R, T206S, S230N  
  clone: 3 None    I72V, K111T, T124N, T125A, V126L, G193R, T206S, K211R, S230N, R284G F223S, R262S 
  clone: 4 None    I72V, K111T, T124N, T125A, V126L, M154V, G193R, T206S, S230N  
  clone: 5 None    M50T, I72V, K111T, T124N, T125A, V126L, G193R, T206S, S230N  
  clone: 6 None    R20G, E48K, D64G, I72V, K111T, T125A, V126L, M154I, G193R, T206S, I208M, S230N F26L, N120D, I135T, G237R 
1708 PT1708
Consensus 
None    D3DN, G4GE, D6DN, E13EK, W19WR, R20RK, D25DN, D41DN, G47GE, E48EK, G94GR, L101I, T112TA, S119SG, E152EK, K160KR, F181L, S195T, I220L, I268IV, S283G A8AT, E11DN, T122TIP 
  clone: 1 None    E11D, L101I, T122I, K160R, F181L, S195T, I220L, S283G  
  clone: 2 None    E11D, W19R, L101I, T122I, E152K, F181L, S195T, I220L, I268V, S283G  
  clone: 3 None    E11D, L101I, F181L, S195T, I220L, S283G  
  clone: 4 None    E11D, G94R, L101I, S119G, F181L, S195T, I220L, S283G  
  clone: 5 None    D3N, G4E, D6N, E13K, R20K, D25N, D41N, G47E, E48K, L101I, F181L, S195T, I220L, S283G A8T, E11N 
  clone: 6 None    E11D, L101I, T112A, F181L, S195T, I220L, S283G T122P