Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Brenner (2016)
Title Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 4
Lab Parent Strain NL43


Lab IN Isolates : Susceptibility Data

IsolateINIMajorDRMsINIMinorDRMsMethodDrugFold Res.
118R G118R  TZM-McGill DTG 1.0 
     TZM-McGill EVG 0.9 
     TZM-McGill MK-2048 0.4 
     TZM-McGill RAL 0.8 
118R138K G118R, E138K  TZM-McGill DTG 1.7 
     TZM-McGill EVG 4.1 
     TZM-McGill MK-2048 139 
     TZM-McGill RAL 4.4 
66A118R138K T66A, G118R, E138K  TZM-McGill DTG 6.5 
     TZM-McGill EVG 6.6 
     TZM-McGill MK-2048 175 
     TZM-McGill RAL 4.6 
66AL74M118R138K151I T66A, G118R, E138K  TZM-McGill DTG 8.0 
     TZM-McGill EVG 10 
     TZM-McGill MK-2048 300 
     TZM-McGill RAL 11