Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Deuzing (2015)
Title Mutation V111I in HIV-2 reverse transcriptase increases the fitness of the nucleoside analogue-resistant K65R and Q151M viruses.
Citation J Virol
SelectedGene RT
SelectedSpecies HIV2
SelectedType Lab
NumIsolates 7
Lab Parent Strain ROD


Lab RT Isolates : Susceptibility Data

IsolateNRTIDRMsNNRTIDRMsMethodDrugFold Res.
RT_K65R K65R  HeLa-CD4 reporter gene 3TC >200 
     HeLa-CD4 reporter gene ABC 2.0 
     HeLa-CD4 reporter gene AZT 5.4 
     HeLa-CD4 reporter gene TDF 7.5 
RT_K65R_V111I K65R  HeLa-CD4 reporter gene 3TC >200 
     HeLa-CD4 reporter gene ABC 1.2 
     HeLa-CD4 reporter gene AZT 4.8 
     HeLa-CD4 reporter gene TDF 6.4 
RT_M184V M184V  HeLa-CD4 reporter gene 3TC >200 
     HeLa-CD4 reporter gene ABC 1.2 
     HeLa-CD4 reporter gene AZT 1.4 
     HeLa-CD4 reporter gene TDF 1.0 
RT_M184V_V111I M184V  HeLa-CD4 reporter gene 3TC >200 
     HeLa-CD4 reporter gene ABC 1.4 
     HeLa-CD4 reporter gene AZT 2.0 
     HeLa-CD4 reporter gene TDF 1.4 
RT_Q151M Q151M  HeLa-CD4 reporter gene 3TC 2.1 
     HeLa-CD4 reporter gene ABC 2.9 
     HeLa-CD4 reporter gene AZT 51 
     HeLa-CD4 reporter gene TDF 1.1 
RT_Q151M_V111I Q151M  HeLa-CD4 reporter gene 3TC 1.1 
     HeLa-CD4 reporter gene ABC 0.5 
     HeLa-CD4 reporter gene AZT 28 
     HeLa-CD4 reporter gene TDF 1.9 
RT_V111I   HeLa-CD4 reporter gene 3TC 0.5 
    HeLa-CD4 reporter gene ABC 0.4 
    HeLa-CD4 reporter gene AZT 1.2 
    HeLa-CD4 reporter gene TDF 1.4