Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Li (2016)
Title The prevalence of drug resistance among treatment-naive HIV-1-infected individuals in China during pre- and post- 2004.
Citation BMC Infect Dis
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 478
NumPts 478
Subtype CRF01_AE, B, CRF07_BC, CRF08_BC, C, CRF55_01B, CRF65_cpx, CRF68_01B, B + CRF01_AE, B + C, CRF06_cpx

 
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Page 1   listing Isolate 1 to Isolate 100 from Total 478 Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
CN-001 CN-001 None None   E6D, K11KT, V21I, V35T, T39K, K43E, K122E, D123S, S162C, E169D, Q174K, D177E, Q207D, K238R, V245E, K249Q, T286A, E291D, V292I, I293V, E312T, V317T, I326V, I329V, M357K, G359S, K366R, A371V, A400T, T403M, E404D, N447S, L452LI, D471E, Q480QH, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, V548VI, A554S  
CN-011 CN-011 None None   E6D, K11T, V35T, T39K, K43E, K122E, D123S, K173T, Q174K, D177E, V179I, Q207A, R211S, V245E, A272S, T286A, E291D, V292I, I293V, E312T, I326V, E328EK, I329V, G335D, Y342F, P345PS, M357K, G359S, K366R, T369A, A371V, A376V, T386A, K390KR, K395R, A400T, E432D, V435I, N447S, T470S, D471E, T477N, Q480H, H483Q, K512R, L517V, S519N, Q524E, L525V, A534S, A554S  
CN-014 CN-014 None None M184V, L210W, T215Y A98G, K103N E6D, K11T, V35T, T39K, K43E, E44D, S68G, K122E, D123S, I135L, K173I, Q174K, D177E, I178M, T200K, Q207A, R211K, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, K350R, M357R, G359S, K366R, T369V, A371V, K390R, I393M, K395R, A400T, T403M, E432D, N447S, Q464K, D471E, Q480H, H483Q, L491S, Q509H, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-015 CN-015 None None   E6D, K11T, V35T, T39N, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, G196E, T200I, Q207A, R211S, K238R, V245E, K275R, V276I, T286A, E291D, V292I, I293V, E312T, I326V, G335D, M357K, G359S, K366R, A371V, I375V, K395KR, A400T, E432D, N447S, D471E, Q480H, H483Q, L491S, K512R, L517I, S519N, Q524E, A534S, A554S  
CN-026 CN-026 None None  V179D E6D, E28K, K32E, V35T, T39A, K122E, D123N, I135T, I142V, K173I, Q174K, D177E, T200I, Q207A, R211S, F214L, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, R356K, M357K, G359S, K366R, T369A, A371V, K395R, A400T, E432D, N447S, D460N, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524E, I526V, A534S, A554S  
CN-030 CN-030 None None   E6D, V35T, T39K, K43E, V75VL, K122E, D123S, K173L, Q174K, D177E, T200I, Q207A, R211S, K238R, V245E, I274V, K281KR, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, I375IV, K385R, K390R, K395R, A400T, T403M, E432D, N447S, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, A554S K22KIR 
CN-033 CN-033 None None   P4X, E6D, K11T, V35T, T39K, K43E, K122E, D123S, S162C, E169ED, K173R, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, K277R, T286TA, E291D, V292I, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, T377Q, K390R, A400T, T403M, E404D, A437V, D471E, Q480H, H483HQ, L491S, K512R, L517V, S519N, Q524E, A534S, A554S V241VD 
CN-034 CN-034 None None   E6D, V35T, T39K, V60I, K122E, D123S, I142V, K173M, Q174K, D177E, T200K, Q207A, R211S, K238R, V245K, E248EK, T286A, E291ED, I293V, K311Q, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K390R, K395KR, A400T, T403M, E432D, N447S, D471E, Q480H, H483Q, L491PS, K512R, L517V, S519N, Q524E, A534S, A554S L303LF 
CN-046 CN-046 None None D67N, K70R, M184V, T215F, K219E V108I, Y181C, N348I E6D, K11T, V35T, T39EK, V118I, K122E, D123S, S162N, K173I, Q174K, D177E, T200IR, Q207A, R211S, F214L, D218E, K238R, V245E, K277KR, R284K, E291D, V292I, I293V, E312T, I326V, I329V, G335D, P345PL, A355S, R356K, M357R, G359S, A371V, I375IV, I382T, K390R, A400T, T403M, E432D, N447S, Q464R, D471E, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, A554S I37IT, S191SP 
CN-047 CN-047 None None   E6D, K11KT, V35T, T39R, K43E, K102R, K122E, D123S, S162C, D177E, I178M, E203D, Q207A, R211S, K238R, V245E, V276I, T286A, E291D, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K388R, K390R, A400T, N447S, D471E, Q480H, L491S, K512R, L517A, S519N, Q524E, A534S  
CN-053 CN-053 None None   E6D, K11T, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, T200L, Q207A, R211S, I244V, V245E, L283I, E291D, V292I, I293V, K311R, E312N, I329V, G335D, M357K, G359S, A371V, S379G, V381I, K390R, A400T, E432D, N447S, D471E, Q480H, H483Q, L491S, K512R, L517I, S519N, Q524K, K527Q, K530R, A534S, A554S  
CN-063 CN-063 None None   E6D, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, T200I, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312N, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K390KR, K395R, A400T, T403M, E432ED, V435VI, N447S, G462GR, T470TIN, D471E, Q480H, H483Q, L491S, L517V, S519N, Q524E, L525LI, A534S, A554S  
CN-064 CN-064 None None   E6D, K11T, V35IT, T39K, K43E, T69TA, V111I, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, T200I, Q207A, R211S, K238R, V245E, T286TA, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K390R, K395R, A400T, T403M, E432D, N447S, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-070 CN-070 None None   K122KE, I135V, S162C, T200A, K277R, Q278E, I293V, Q334L, F346Y, M357MR, K366KR, T369TA, E404D, V417T, V435E, A446AG, D460N, R461K, Q464QE, S468T, L491A  
CN-075 CN-075 None None   E6D, K11T, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, Q207A, R211S, K238R, V245E, A272P, T286A, V292I, I293V, N306D, E312T, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, I375L, K390R, K395R, A400T, T403M, E404D, E432D, N447S, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-085 CN-085 None None   E6D, K11T, V21VI, V35T, T39K, K43E, K122E, D123S, K173T, Q174K, D177E, V179I, Q207A, R211S, V245E, E248EK, A272S, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, Y342F, M357K, G359S, K366R, T369A, A371V, A376V, T386A, K395R, A400T, E432ED, V435I, N447NS, D471E, Q480H, H483Q, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-091 CN-091 None None   E6D, K11T, V35T, T39R, K43E, V75L, K122E, D123S, I135T, S162C, D177E, I178M, E203D, Q207A, R211S, K238R, V245E, V276I, T286A, E291D, I293V, E312T, V317T, I329V, G335D, I341V, M357K, G359S, K366R, A371V, V381I, T386A, K388R, K390R, A400T, T403V, V466A, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, A534S  
CN-094 CN-094 None None   E28K, K32E, V35T, E36A, T39D, S48T, V60I, D121Y, K122E, R211RG, V245Q, E248V, K249Q, A272P, K277R, T286TAP, E291D, V292I, I293V, G335D, T338S, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, D471E, Q480H, H483C, L491S, S519N, K530R, A534S, A554S  
CN-098 CN-098 None None   E6D, V35T, T39K, K43E, T69TS, K122E, D123T, S162SN, K173I, Q174K, D177E, I178IL, T200I, Q207A, R211KT, K238R, I244V, V245E, A272P, V276I, E291D, V292I, I293V, E312T, V317A, I326V, I329V, Q334E, M357KN, R358G, G359S, K366R, A371V, K390R, A400T, T403M, V466A, T470TN, D471E, Q480H, L491S  
CN-099 CN-099 None None   E6D, K11T, V35T, T39KR, K43E, K122E, D123S, S162C, F171Y, Q174K, D177E, I178M, T200A, E203ED, Q207NT, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, V317T, I326V, I329V, G335D, Y342F, M357K, G359S, K366R, A371V, T377M, K390R, A400T, T403M, A437V, N447S, L452Q, D471E, Q480H, L491S, K512R, L517I, Q524E, A534S, A554S  
CN-103 CN-103 None None M184V V179D I135L, T200A, E203K, Q207E, Q278E, E297A  
CN-105 CN-105 None None  V179E E6EAD, V35T, T39K, K43E, K122E, D123S, I135R, R211K, F214L, V245A, K275Q, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K388R, K390R, A400T, D460N, R461K, H483Y, L491S, S519N, Q524QR, K527N, K530R, A554S  
CN-115 CN-115 None None   E6D, V35T, T39N, S48T, V60I, D121Y, K122E, T200I, R211K, V245Q, A272P, K277R, V292I, I293V, H315Q, V317A, S322A, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V417I, E432D, L452I, D471E, H483C, L484I, L491P, S519N, K530R, A534S, A554N  
CN-119 CN-119 None None   I5IM, E6D, V8I, K11T, V35T, T39K, K122E, D123N, I135T, K173I, Q174K, D177E, T200I, Q207A, R211S, F214L, K238R, V245E, V276I, T286A, E291D, V292I, I293V, P294PT, E312T, I326V, I329IV, G335D, M357K, G359S, K366R, T369A, A371V, K390R, K395R, A400T, E432D, V435I, N447S, D460N, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524E, I526V, A534S, A554S  
CN-122 CN-122 None None   V35T, E36A, T39D, S48T, V60I, D121Y, K122E, K166KR, I178L, V245Q, A272P, K277R, L283I, T286V, E291D, V292I, I293V, P313Q, G335D, R356K, G359T, T377M, K390R, A400T, E404D, A437V, Q464K, D471E, H483C, L491A, S519N, K530R, A534S, A554S  
CN-125 CN-125 None None   E28K, K32E, V35T, E36A, T39D, S48T, V60I, F87L, D121Y, K122E, Q197L, V245Q, E248V, K249Q, A272P, K277R, T286A, E291D, V292I, I293V, P313T, G335D, T338S, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, D471E, Q480H, H483C, L491S, S519N, K530R, A534S, A554S S268SG 
CN-126 CN-126 None None  V106I K122E, I135T, G196GR, R211K, F214L, I244IV, I257L, V261I, V276I, I293V, V317VA, I329L, R356K, M357I, A376V, T386I, K388R, A400T, T403M, E449D, T450S, S468T, H483Q, L517I, S519N  
CN-132 CN-132 None None   V35T, E36A, T39D, S48T, V60I, K102R, D121Y, K122E, T165X, D177E, V245Q, A272P, K277R, T286V, E291D, I293V, P313T, G335D, R356K, G359T, V365I, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, D471E, H483C, L484I, L491S, S519N, K530R, A534S, V548I, A554S  
CN-133 CN-133 None None V75VIM V179AD E6D, K11T, K20R, V35T, T39K, K43E, T69P, K122E, D123S, S162SC, S163ST, D177E, I178M, Q207A, R211S, K238R, V245E, V276I, T286A, E291D, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, T369TA, A371V, I375IV, K388R, A400T, T403M, N447S, D471E, Q480QH, L491S, K512R, L517A, S519N, Q524E, E529D, A534S, A554S  
CN-134 CN-134 None None   E28K, K32E, V35T, E36A, T39D, S48T, E53D, V60I, K102Q, K173R, T200TI, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, G359T, I375IV, A376AS, T377LM, T386I, K390R, A400T, E404D, E432D, I434IT, V435A, A437V, L452I, D471G, H483Y, L484I, L491S, S519N, K530R, A534S, A554S  
CN-138 CN-138 None None   V35T, E36A, T39D, S48T, V60I, D121DY, K122E, Q174L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311R, V317A, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, D471E, H483C, L484I, L491S, S519N, K527R, K530R, A534S, A554S  
CN-144 CN-144 None None  E138A K11KR, V35T, E36A, T39D, S48T, E53D, V60I, I135V, S162C, T200TI, Q207EK, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311KR, V317AT, D324E, Q334HY, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, D471E, Q475QH, H483Y, L484I, L491S, S519N, K530R, A534S, A554S  
CN-151 CN-151 None None   E6D, V35T, E36A, T39D, S48T, E53D, V60I, V90I, D121Y, K122E, D177G, V245Q, A272P, K277R, V292I, I293V, V317T, D324E, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437AV, L452I, Q464K, D471E, H483C, L484I, L491S, S519N  
CN-154 CN-154 None None   V35T, E36A, T39D, S48T, E53D, V60I, D123E, I135V, S162C, I178L, Q207E, R211K, V245H, A272P, T286TA, V292I, I293V, V317A, D324E, Q334H, G335D, R356K, M357R, G359T, T369A, A371V, I375V, T377M, T386I, K390KR, A400T, E404D, V435I, L452I, Q464R, V466I, D471E, H483Y, L484I, L491S, L517IV, S519N, K530R, A534S, A554S  
CN-164 CN-164 None None   I135T, D177E, F214L, V245I, V261I, A272P, K275Q, K277R, Q278H, I293V, E297A, V317VA, I329L, Q334H, T369A, I375V, T386I, A400T, T403I, V435A, E449D, Q507H, V531I, A554S  
CN-171 CN-171 None None   V118I, I135T, Q174R, F214L, V245M, I257L, V261I, I293V, E312V, D324E, I329L, Q334H, T386I, A400T, T403I, E449D, H483Y, Q507H S117L 
CN-176 CN-176 None None   K22KR, E28K, K32E, V35T, E36A, T39D, S48T, V60I, D121Y, K122E, Q207QE, V245Q, E248IV, K249Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, T338S, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, D471E, Q480H, H483C, L491S, S519N, K530R, A534S  
CN-180 CN-180 None None   E6D, K11T, V35T, E36D, T39K, K43E, K122E, D123S, S162C, D177E, I178M, T200I, E203D, Q207A, R211S, K238R, V245E, T286A, E291D, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, E370D, A371V, K388R, K390R, A400T, T403M, N447S, D471E, Q480H, L491S, K512R, L517A, S519N, Q524E, A534S  
CN-181 CN-181 None None  V179D E6D, K11T, V35T, T39K, K43E, K122E, D123S, S162C, D177E, Q207A, R211S, V245E, T286A, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K388R, K390R, A400T, T403M, N447S, D471E, L491S, K512R, L517T, S519N, Q524E, A534S  
CN-188 CN-188 None None   E6D, V35T, T39KR, E40EG, K43KE, K101KQ, K102KM, K122E, D123S, S162C, Q174EK, D177E, V179I, E203D, Q207A, R211S, K238R, V245E, T286A, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366KR, K388R, K390R, A400T, T403M, N447S, D471E, Q480QH, L491S, K512R, L517T, S519N, Q524E, A534S, A554N  
CN-189 CN-189 None None   K122E, I135L, S162Y, K277R, Q278E, P321PS, F346Y, M357T, V417I, V435E, D460N, R461K, S468T, L491A, K512R, V548I  
CN-192 CN-192 None None   E6D, K22R, V35T, T39K, K43E, S68G, K122E, D123S, I135T, K173T, Q174K, D177E, T200I, Q207A, R211S, K238R, V245E, V276I, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K390R, K395R, A400T, W402WG, T403M, E432D, N447S, D471E, H483Q, L491A, E514D, L517V, S519N, Q524E, A534S, A554S  
CN-199 CN-199 None None  V106I, V108VI, Y181C, H221Y K82R, V118I, D121H, K122E, I135T, T139A, K166KR, I178M, F214L, V245K, A272P, I293V, P294Q, D324E, I329L, G359S, V381VI, T386I, A400T, N447NS, E449D, S468SP, H483HY, L491LV, Q507H, A554S H96HL 
CN-202 CN-202 None None  V179D E6D, K11T, V35T, T39R, K43E, D121H, K122E, D123S, Q174K, D177E, I202V, Q207AD, R211S, V245E, T286A, E291D, I293V, E312T, V317T, D324E, I326V, I329V, G335D, M357K, G359S, K366R, A371V, T377M, K390R, A400T, T403M, V435I, N447S, D471E, Q480H, L491S, Q507H, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-206 CN-206 None None   E28K, K32E, V35T, E36A, T39E, S48T, V60I, D121Y, K122E, V245Q, E248V, K249Q, A272P, K277R, T286A, E291D, V292I, I293V, I309L, G335D, T338S, R356K, G359T, A376S, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452M, Q464K, T470N, D471E, Q480H, H483CY, L491S, S519N, K530R, A534S, A554S  
CN-210 CN-210 None None  V179D E6D, K11T, K20R, V35T, T39R, K43E, K122E, D123S, S162C, D177E, Q207A, R211S, V245E, T286A, E291D, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K388R, K390R, E399ED, A400T, T403M, E404ED, N447S, D471E, Q480H, L491S, K512R, E514D, L517A, S519N, Q524E, K530KR, A534S  
CN-219 CN-219 None None   E6D, K11T, V35T, T39K, K43E, K122E, D123S, S162C, K173R, Q174K, D177E, I178IM, V179I, Q207A, R211S, V245E, K275R, V276I, T286A, E291D, V292I, I293V, E312N, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, T377M, A400T, T403M, N447S, T470S, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-220 CN-220 None None   A272P, K277R, T286A, V292I, E297R, V317A, Q334E, T338S, M357R, R358K, K366R, T369V, A371AV, I375V, A376T, K390R, E399D, A400T, E404D, D460N, R461K, L491S, A502AT, A554T  
CN-223 CN-223 None None   E28K, K32E, V35T, E36A, T39E, S48T, V60I, D121Y, K122E, V245Q, E248V, K249Q, A272P, K277R, T286A, E291D, V292I, I293V, I309IL, G335D, T338S, R356K, G359T, E370EK, T377M, A400T, E404D, E432D, V435A, L452M, Q464K, T470N, D471E, Q480H, H483CY, L491S, S519N, K530R, A534S A437AEV 
CN-236 CN-236 None None   E6D, K11T, V35T, T39R, K43E, K102R, K122E, D123S, S162C, D177E, I178M, Q207A, R211S, V245E, V276VI, K277KR, T286A, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K388R, A400T, N447S, D471E, Q480H, L491S, K512R, L517T, S519N, Q524E, A534S, A554T  
CN-237 CN-237 None None   V60VI, K122E, D123NS, I135T, K173T, Q174K, D177E, T200I, Q207A, R211S, F214L, K238R, V245E, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K390R, K395R, A400T, T403A, E432D, N447S, D460S, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524E, I526V, A534S, A554T  
CN-239 CN-239 None None   V276I, E291D, V292I, I293V, E312T, I326V, I329V, G335D, P345Q, F346Y, M357K, G359S, K366R, A371V, K390R, A400T, E432D, N447S, D460N, D471E, Q480Y, H483HY, L491S, K512R, L517V, S519N, Q524E, I526V, A534S  
CN-249 CN-249 None None  V179E K122E, I135T, D177A, T200A, Q207E, F214L, V245M, V261I, V276I, I293V, K311KR, V317VA, D324E, I329L, G359S, V372I, A376T, T386I, A400T, V435I, E449D, S468T, H483Y, L517V, Q524E, E546D  
CN-251 CN-251 None None  V106VI E6D, K11T, V35T, T39R, K43E, K102KR, K122E, D123S, I142V, S162C, D177E, I178IM, V179VI, E203D, E204EK, Q207A, R211S, K238KR, V245E, K277KR, T286A, E291D, E312T, S322SP, I326V, I329V, G335D  
CN-262 CN-262 None None   T286A, E291D, I293V, E297T, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, T377M, S379C, K390R, A400T, T403M, V417VI, N447S, V466VI, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, A534S  
CN-270 CN-270 None None   V35T, E36A, T39D, S48T, V60I, D121H, K122E, D123E, I135T, T200EG, V245Q, A272P, K277R, V292I, I293V, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, A437V, L452I, Q464K, S468P, L469I, T470S, H483C, L491S, S519N, K530R, A534S, A554S  
CN-280 CN-280 None None  V106I V118I, K122E, K173N, Q207QH, R211EKQ, F214L, V245I, V261I, V276I, I293V, K311KR, A327E, E328K  
CN-294 CN-294 None None   E6D, I135T, S162C, T200TA, I202V, A272P, K277KR, Q278E, L283I, P294PS, E298A, E312V  
CN-295 CN-295 None None  V179E V118I, K122E, I135T, K166R, R211K, F214L, V245M, V261I, V276I, I293V, E312V  
CN-298 CN-298 None None   E6D, K20R, V60I, V118I, I135T, D177N, G196E, T200I, I202V, V245M, A272P, V276I, Q278H, I293V, E297EG, P313T  
CN-310 CN-310 None None   E6D, K11T, E28K, K32E, V35T, T39K, K122E, D123N, S162C, K173T, Q174K, D177E, I178M, T200K, Q207N, R211S, K238R, V245E, T286TA, I293V, E312T, I329V, G335D, M357K, G359S, K366R, A371V, S379G, V381I, K390R, A400T, T403M, E432D, N447S, D471E, Q480H, H483Y, G490GE, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-313 CN-313 None None A62AV, V75I, F77L, F116Y, Q151M, M184MIV, K219R K101E, V106I, G190A K11KT, K20KR, E28K, V35I, S68SG, I135L, S162CF, T200E, L210F, D237E, A272P, K275KR, K277R, Q278E, L283I, E291D, I293V, T296S, E297K, Q334L, P345Q, F346Y, M357T, V365I, K390R, V435E, D460N, R461K, S468T, T470N, L491A  
CN-318 CN-318 None None   E6D, K11T, V35T, T39K, K43E, K122E, D123S, K173IT, Q174K, D177E, I178M, V179I, T200I, Q207A, R211S, V245E, K275R, E291D, V292I, I293V, K311R, E312T, I326V, I329V, G335D, M357K, G359S, A371V, T377L, S379X, K390R, A400T, E432D, N447S, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-322 CN-322 None None  V179E E6D, V35T, T39K, K43E, K122E, D123S, I135R, P176PS, R211K, F214L, V245A, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K388R, K390R, A400T, D460N, R461K, H483Y, L491S, S519N, I522IV, I526IV, K527N, K530R, A554S  
CN-325 CN-325 None None   S162C, K173T, Q174K, V179I, T200E, I202V, Q207A, R211S, K238R, V245E, S251H, T286A, E291D, V292I, I293V, L310I, E312T, I329V, G335D, M357K, G359S, K366R, A371V, I375V, K390R, K395R, A400T, T403M, E404D, V417I, E432D, N447S, D471E, Q480H, H483Y, L491S, K512R, L517V, S519N, Q524E, A534S, P537X, V552VG, A554Q L551L*S 
CN-328 CN-328 None None L74V, M184V V179D, Y181C, G190A, H221Y K103R, V111I, S162X, F214L, V245VG, K275KR, K277KR, Q278E, L283I, A288T, I293V, E312A, P345Q, F346Y, R356RK, K366R, S379C, K390R, V417T, V435E, D460N, R461K, S468T, L491A  
CN-329 CN-329 None None   V35T, E36A, T39D, S48ST, V60I, T69S, T107TS, D121Y, K122E, S162X, R211K, V245Q, A272P, K277R, T286A, V292I, I293V, V317A, G335D, P345PQ, R356K, G359T, T377M, K390R, A400T, E404D, E432D, L452I, Q464K, D471E, H483C, L484I, L491S, S519N, K530KR, A534S, A554S R199RG 
CN-333 CN-333 None None   V35T, T39D, E53D, V60I, T69S, I135V, I142V, S162C, V189I, Q207E, R211K, K238R, V245E, V261VG, K275Q, T286A, E291D, V292I, I293V, E297G, E312T, I326V, I329V, G335D, M357K, G359S, K366R, K390R, K395R, A400T, T403M, E432D, N447S, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, A534T W266WG, A371GV 
CN-337 CN-337 None None   E6D, V35T, T39K, K43E, K122E, D123N, K173T, Q174K, D177E, Q207A, R211S, K238R, I244V, V245E, A272P, V276VI, T286A, E291D, V292I, I293V, E312T, I326V, I329V, Q334E, G335D, R356RK, M357K, R358G, G359S, K366R, A371V, K390R, K395R, A400T, T403M, V435E, D460N, V466A, D471E, Q480H, L491S, K512R, L517I, S519N, Q524E, A534S, A554S  
CN-338 CN-338 None None   E6D, K11T, V35T, T39K, S68SG, K122E, D123S, I135T, S162C, K173I, Q174K, D177E, Q207S, L210M, R211S, K238R, V245E, A272AP, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K390R, K395R, A400T, T403M, E432D, N447S, D471E, Q480H, H483HY, L491S, K512R, L517V, Q524E, A534S  
CN-341 CN-341 None None   E28K, K32E, V35T, E36A, T39D, S48T, V60I, D121Y, K122E, V245Q, E248V, K249Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, T338S, R356K, G359AT, T377M, K390R, A400AT, E404D, E432D, V435A, A437V, L452I, R461K, Q464K, D471E, Q480H, H483C, L491S, S519N, K530R, A534S, A554S  
CN-345 CN-345 None None   V8VI, E53ED, V90I, I178M, T200IR, R211K, V245L, A272P, I293V, T296S, E297K, I329L, R356K, I375V, V381VI, V435I, L452LI, D460N, K530R, V548I W337W* 
CN-352 CN-352 None None  V179E E6D, V35T, T39K, K43E, V118VI, K122E, D123S, I135R, R211K, F214L, V245A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K388R, K390R, A400T, D460N, R461K, H483Y, L491S, S519N, K527N, K530R, A554S  
CN-358 CN-358 None None   E6D, V35T, T39K, K43E, V60VI, K122E, D123S, I135T, S162W, K173R, Q174K, D177E, V179I, Q207A, R211S, K238R, V245E, A272P, K275R, K281KR, T286TA, E291D, V292I, I293V, E312T, V317T, I326IV, I329V, G335D, R356K, M357KN, G359S, A371V, T377M, K390R, A400T, T403M, N447S, T470S, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-359 CN-359 None None T69G, K70N, V75I  S68R, K73X, K122E, D123S, S162C, T165X, K173I, Q174K, D177E, I178M, Q207K, R211S, V245E, K249R, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, K350R, M357K, G359S, K366R, A371V, K390R, A400T, T403M, E432D, D460N, D471E, Q480H, H483Y, L491S, K512R, L517V, S519N, Q524E, A534S, A554S K66N, L74F, D76K, F77V, E79Q, L80Y, N81D, K82Q 
CN-368 CN-368 None None   E6D, K32R, V35IT, T39KQ, K43DN, K122E, D123NS, K166R, K173I, Q174K, D177E, Q207A, R211S, K238R, I244V, V245E, A272P, V292I, I293V, E312T, I326V, I329V, Q334E, M357K, R358G, G359S, K366R, A371V, I375V, K395R, A400I, V435E, N447NH, V466A, D471E, Q480H, L491S, K512R, L517I, S519N, Q524E, A534S, A554S  
CN-375 CN-375 None None   V35T, T39K, K43E, V60VI, K122E, D123S, I135IV, S162A, K173I, Q174K, D177E, V179I, Q207A, R211S, K238R, V245E, T286A, E291D, I293V, E300Q, K311R, E312T  
CN-378 CN-378 None None   K11R, V35T, T39DN, S48ST, V60I, K173T, D177E, I178L, T200A, Q207K, R211K, F214L, V245E, A272P, K277R, E291D, I293V, D324E, G335D, R356K, G359T, K390R, A400I, E404D, E432D, V435A, E449D, L452I, Q464S, V466I, D471E, H483C, L491S, S519N, K527G, A534S, A554Q  
CN-379 CN-379 None None  H221HY T27TS, V35T, E36A, T39D, S48T, V60I, I135T, K173A, D177E, I178L, T200A, Q207K, R211RK, F214L, V245E, A272P, K277R, E291D, V317A, D324DE, G335D, R356K, G359T, T369TA, T377I, K390R, A400T, E404D, E432D, V435A, L452I, Q464S, V466I, D471E, H483C, L491S, S519N, K527N, A534S, A554Q  
CN-391 CN-391 None None   E6D, V8I, K11T, V35T, T39K, K43E, K49R, K122E, D123S, I135T, K173I, Q174K, D177E, I178V, V179I, T200I, I202V, Q207A, L210F, R211S, K238R, V245E, K281R, T286A, E291D, V292I, I293V, E312N, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K390R, A400T, T403M, E404D, E432D, V435E, N447S, D460N, D471E, Q480H, L491S, K512R, S519N, Q524E, A534S, A554S, K558R  
CN-398 CN-398 None None   E6D, V8I, K11T, K20R, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, K281KR, T286A, E291D, V292I, E312T, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, K390R, K395R, A400T, T403M, E432D, N447S, L452Q, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
CN-405 CN-405 None None   V118I, K122E, I135M, R211RK, F214L, V245I, V261I, I293IV, K311R, D324E, L325LI, I329L, A376AT, V381I, T386I, A400T, E449D, Q507H, Q509K, K512R, L517LI, S519N  
CN-407 CN-407 None None   I5V, V118I, K122E, I135M, F214L, V245I, V261I, K281R, I293V, D324E, I329L, R356K, V372I, K374R, A376T, T386I, A400T, K431N, E449D, T470A, Q507H, Q509K, K512R, L517V, A554T  
CN-412 CN-412 None None   V60I, K102R, K103KR, V111I, V118VI, D123E, I135T, T165I, K173KR, R211K, F214L, V245E, A272P, T286A, E291EK, V292I, I293IV, E297K, V317A, Q334E, T338S, R358K, K366R, T369A, K374KR, I375IV, A376T, K390R, E399D, A400T, E404D, D460N, R461K, L491S, A554N  
CN-417 CN-417 None None   E6D, K11T, V35T, T39R, K43E, K122E, D123S, S162C, D177E, I178M, V179I, E203D, Q207A, R211S, K238R, V245E, T286A, E291D, I293V, E312T, V317T, I326V, I329V, G335D, M357R, R358G, G359S, K366R, A371V, K388R, K390R, A400T, T403M, N447S, D471E, Q480H, L491S, K512R, L517A, Q524E, A534S  
CN-432 CN-432 None None   E6D, V35T, E36EA, T39DN, V60I, D121Y, K122E, I135T, I142IV, D177DE, R211K, V245Q, A272P, K277R, V292I, I293V, P294PT, E297EA, V317VA, G335D, R356K, G359T, T377M, I382IV, T386V, K390R, K395KR, A400IT, E404D, E432D, V435A, L452I, Q464K, V466A, D471E, Q480H, H483Y, L484I, L491S, E516Q, S519SN, K530R, A534S, A554S  
CN-433 CN-433 None None   V35T, E36A, T39E, S48T, E53D, V60I, K122KE, D123DE, S162SC, T200A, I202V, Q207G, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, T377M, T386I, K390R, A400T, T403K, E404D, E432D, V435A, A437V, L452I, Q464K, V466VI, D471E, H483Y, L484LI, L491S  
CN-436 CN-436 None None   T7P, V35T, E36A, T39E, S48X, E53D, V60I, I135V, S162C, G196E, T200TA, Q207E, R211K, V245Q, A272P, K277KR, T286A, E291D, V292VI, I293V, V317A, D324E, Q334H, G335D, K350R, R356K, G359T, A371V, I375T, T377M, T386IV, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, T470TP, D471E, L484I, L491S, S519N, E523ED, K530R, A534S, A554S  
CN-438 CN-438 None None   E6D, K11T, V35T, T39K, K43E, R78RK, D121H, K122E, D123X, S162C, K173R, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E297EA, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, I375IV, V381VI, A400T, T403M, N447S, R461K, D471E, Q480H, L491S, K512R, E514D, L517V, S519N, Q524E, A534S  
CN-440 CN-440 None None   K20R, V35T, E36A, T39E, S48T, E53D, V60I, K102KR, I135V, S162C, D177DG, Q207E, R211K, V245H, A272P, V276T, K277KR, K281KR, T286V, E291D, V292I, I293V, H315Q, V317A, K323KE, D324E, G335D, E344EK, R356K, G359T, T377M, T386TI, K390R, E396D, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483Y, L484I, L491S, K530R, A534S, A554S  
CN-450 CN-450 None None   E6D, K11T, V35T, T39K, K43E, K64R, K122E, D123S, I135R, S162C, K173S, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E, V276I, T286TA, E291D, V292I, I293V, E312T, V317T, I329V, G335D, P345S, M357K, G359S, K366R, A371V, A400T, T403M, N447S, D471E, Q480H, L491S, K512R, L517V, S519N, K527D, A534S, A554S  
CN-451 CN-451 None None   E6D, K11T, V35T, T39K, K43E, K64R, D121H, K122E, D123S, S162C, K173KR, Q174E, D177E, I178IM, E204K, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, T386I, A400T, T403M, N447S, D471E, Q480H, L491S, E492EK, K512R, L517V, S519N, Q520L, Q524E, K527N, A534S, A554S  
CN-458 CN-458 None None   I5V, E6D, K11T, K20R, V35T, E36D, T39K, K43E, V118I, K122E, D123S, I135T, S162C, K173R, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E, E248EK, V261VG, T286A, E291D, V292I, I293V, E312T, V317T, I329V, G335D, M357K, G359S, K366R, T369A, A400T, V435VAE, N447S, D460N, D471E, Q480H, H483HY, G490GE, L491S, K512R, L517IV, S519N, Q524E, V531VI, A534S, A554S  
CN-459 CN-459 None None   V35T, E36EA, T39D, S48X, E53D, V60I, I135V, S162C, Q207A, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, V317A, D324E, K331KN, G335D, K347KR, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452IM, Q464K, V466IT, D471E, H483Y, L484I, L491S, S519N, K527R, K530R, A534S, A554S  
CN-460 CN-460 None None   E6D, K11T, V35T, T39K, K43E, K122E, D123N, S162C, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E, E291ED, V292I, I293V, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, I375V, A400T, T403TM, V435VI, N447S, D471E, Q480H, L491S, K512R, L517IV, S519N, Q520E, K527N, A534S, A554S  
CN-462 CN-462 None None D67N, T69DN, M184V, T215TI, K219E K101H, V106M, Y181YC, G190A P4PS, E6EK, T7TP, V35T, E36A, T39E, E40D, V60I, S68SG, A98S, K122E, D123S, K173T, Q174K, T200TA, I202IV, Q207G, R211K, F214FL, L228Q, V245Q, A272P, E291D, V292I, I293V, K311KR, H315HN, Q334N, G335D, R356K, M357R, G359T, T377R, S379C, K390R, E404D, L452LI, K454KR, V466I, V467I, K476Q, H483Q, L491S, S519N, K527N, K530R, V531I, A534S  
CN-465 CN-465 None None M184V K103N K102R, T139TK, S162C, V189I, T200A, E203EK, Q278E, L283I  
CN-470 CN-470 None None M184V K103N, Y181C I135V, T200A, F214L, L228H, A272P, K275R, K277R, Q278E, E297A, A327E, E328K  
CN-474 CN-474 None None M184V V106I, V108I, Y181C, H221HY T7A, S68G, K104R, D121H, K122E, I135T, E169D, R211S, F214L, V245M, V261I, K277R, T286A, A288S, I293V, E297H, E300EK  
CN-476 CN-476 None None   E6D, V35T, T39K, K43E, K122E, D123S, S162C, K173R, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E297A, E312T, V317T, I326V, I329V, G335D, M357K, G359S, K366R, A371V, A376AS, T377M, S379C, K390R, A400T, T403M, V435I, N447S, D471E, Q480H, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  

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