Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Cavaco-Silva (2014)
Title HIV-2 integrase polymorphisms and longitudinal genotypic analysis of HIV-2 infected patients failing a raltegravir-containing regimen.
Citation PLoS ONE
SelectedGene IN
SelectedSpecies HIV2
SelectedType Clinical
NumIsolates 79
NumPts 72
Host Human

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
BM16604 BM16604 None  S138ST  S39T, A49P, I172M, L220F, E246D, L250I V19M, N30K, E69ED, I133V, I180V, D222N, H280N, L281LV 
BM17043 BM17043 None    L2I, S39T, I172V, T206A, L220F, L250I, D256E, R269K N30K, A41P, E167D, I180V, S197A, D222N, I259V, S279P 
BM17109 BM17109 None    S39T, D222K, E246D, L250I K20R, L58V, I133V, I180V, K221Q, I259V, L281V 
BM18379 BM18379 None  S138ST  K4KR, S39T, I50IV, I72V, I84IV, L101LI, T111TR, I172V, A215T, S218L, L220F, E246D, L250I, R269K V19I, I28L, N30T, N55D, S93ST, I133V, I180V, S197A, D222N, L234LQ, E240D, I259V, I260V, M275L, S279SP 
BM18747 BM18747 None    S39T, I72V, I172V, L220F R34K, E57D, S93T, I133V, E167D, I180V, S197A, D222N 
BM19240 BM19240 None    N30Q, S39T, I72IV, I172V, I175V, A215AS, S218L, L220F, K221R, L250I, D256E V19I, S23C, I133V, I180V, S197A, D222N, I259V, I260V 
BM19552 BM19552 None    S39T, S163N, I172V, K219R, E246D, L250I, M275V V19I, K20Q, I28L, N30K, E57D, S93T, I180V, D222N, I259V, S279P 
BM19562 BM19562 None    S39T, I72V, I172V, L220F R34K, E57D, S93T, I133V, E167D, I180V, S197A, D222N 
BM19661 BM19661 None    S39T, I172V, T206A, E246D, V249I, L250I, D256E I28L, N30K, I133IV, I180V, S197A, D222N, V251A, M275L 
BM20575 BM20575 None    K4R, S39T, S163D, I172V, L220F, E246D, L250I, G278S I28L, S93T, I133V, E167D, I180V, S197A, D222N, I259V, I260V, Q273K, S279P 
BM20853 BM20853 None    S39T, I72V, S163D, I172V, L220F, E246D, L250I V19VI, I28L, N30K, A41P, S93T, I133V, I180V, S197A, D222N, I259V, I260V, M275L 
BM21558 BM21558 None    S39T, T60V, I84V, I172V, I210IV, Q214QH, A215AT, S218SL, E246D, L250I, R269K N30K, A41T, I133IV, E167D, I180V, S197A, K221KQ, D222N, T255TA, I259V, I260V, M275L 
BM21583 BM21583 None    K4KR, S39T, T60X, S163D, R224Q, E240Q, L250I, G278S Q96QH, I110IV, A119AD, I133IV, I180V, S197A, D222N, I259V, M275ML, S279P, H280N 
BM21735 BM21735 None    K4KR, S39T, S163D, I172V, A215S, E246D, L250I, R269K S23C, I28L, N30T, R34K, I180V, S197A, D222N, I259V, I260V, E274G, G283S 
BM21782 BM21782 None  S138T  L2I, K4KR, Y15F, S39T, I72V, I172V, I175V, T206A, A215T, K219E, E246D, L250I, R269K, D286N N30K, A41AT, E57D, S93T, I133V, I180V, S197A, D222N, I259V, I260IV, M275L 
BM21800 BM21800 None  S138T  S39T, I72V, I172V, E246D, L250I, R269K R34K, A41P, S93T, I180V, K221Q, D222N, E240K, I259V, I260V, H280N 
BM22178 BM22178 None    K4R, S39T, I72IV, I172V, I180A, T206A, L220F, E246D, L250I, G278GS K20Q, S23A, I28L, N30K, I133V, S197A, D222N, I259V 
BM22709 BM22709 None    S39T, I72V, Q124H, I172V, E246D, L250I, M275V I28L, A41T, I133V, A153S, E167D, I180V, D222N, I259V, I260V, S279P 
BM22796 BM22796 None    K4R, S39T, S163D, I172V, T206A, L250I, E282G A41AT, E57A, L58V, Q96Y, I133V, I180V, N217K, K221Q, D222N, I259V, H280Q, G283GR 
BM23158 BM23158 None  S138T  S39T, I72IV, A119P, T122IV, R164K, I172M, I175V, T206A, A215T, E246D, L250I N30K, L58V, S93ST, E125D, I133V, I180T, S197A, D222N, T255A, I260V, M275L, S279SP 
BM23495 BM23495 None    K4R, I50T, I72V, S163D, T206A, E246D, L250I, G278S V19I, I28L, N30K, S93T, I133V, I175L, I180V, S197A, D222N, T255A, I260V, S279P 
BM24243 BM24243 None    Y15F, I72V, I172V, T206A, I268IV, R269K I28L, N30K, A41T, T60I, S93T, H157P, E167D, E173K, S197A, D222N 
BM25708 BM25708 None    Y15F, L31I, S39T, H51Q, S163D, I172M, L213F, S218L, L220F, R224Q, L250I, D286DN K20Q, S23A, I28L, N30K, I133A, I180V, S197A, K221Q, D222N, F227Y, E240K, T255A, I259V, I260V, M275L, S277SN, S279P 
BM26527 BM26527 None    S39T, T60M, L250I, R269K V19I, N30K, A41P, S93ST, I133V, M178R, C182Y, D222N, T255A, S279SP, H280HN 
BM26716 BM26716 None    N30Q, S39T, I72V, E87EK, I172V, T206A, E246D, L250I, G278S I28L, S93T, V129A, E167D, S197A, D222N, I260V, S279P 
BM28874 BM28874 None    K4KR, V32VI, S39T, T206A, Q214H, L250I K20Q, I28L, N30K, I50M, S93T, N170I, I180V, S197A, N217ND, D222N, I259V 
BM28876 BM28876 None    S39T, I172V, T206A, E246D, L250I I28L, N30K, A41T, T60IV, Q96QH, I133V, E167D, I180V, S197A, D222N, L234Y, W235S, L241H, I259V, M275L, S279P 
BM28877 BM28877 None    Y15F, S17SG, I50V, I72V, A119P, I172V, I175V, I180A, S218L, L220F, D222K, R224Q, E246D, L250I, R269RK, H280R, D286N V19I, K20R, N30K, L58I, S93T, I133V, H156HP, N170E, R188W, G189E, G190E, S197A, K221Q, T255A, I260V, M275L 
BM28955 BM28955 None    L2I, K4R, I72V, S163D, I172M, A215T, L220F, L250I V19M, I28L, N30K, A41AT, L58I, S93T, I133AV, I180V, S197A, D222N, I259V, S279P 
BM29126 BM29126 None    S39ST, I50T, A119P, I172V, T206A, E246D, L250I, R269K, M275MV, G278GS I28L, N30K, T60I, S93T, I133V, E167D, I180V, S197A, D222N, S279P 
BM30143 BM30143 None    S39T, I72IV, S163D, I172V, E246D, L250I V19I, N30K, I133V, E167D, I180V, S197A, D222N, T255A, I260IMV, L281LV 
BM30909 BM30909 None  S138ST  L2I, Y15F, S39T, I72V, A119X, I172V, I175V, I180A, T206S, D222K, R224Q, L250I V19VI, N30K, A41P, I50M, S93T, I133V, E167D, S197A, K221Q, T255A, M275L 
BM31355 BM31355 None    N30Q, S39T, I72V, I172V, T206TA A41P, S93T, I133IV, E167D, I180V, D222N, V251A, T255A 
BM31445 BM31445 None    L2I, K4R, S39T, A41AG, I72IV, S163D, I172V, T206A, E246D, L250I, M275V I28L, N30K, I133V, E167D, I180V, S197A, D222N, I260V, S279P 
BM31845 BM31845 None    L2I, S39T, I50T, I72V, I172V, I175V, I180A, L220F, D222K, S277C S23C, S93T, I133V, E167D, K221Q, L250IV, V251A, M275L 
BM31959 BM31959 None    N30Q, S39T, I72V, I133T, T206A, Q214H, A215S, S218L, L220F, L250I, G278S V19M, A41P, L58V, S93T, E167D, I180V, S197A, D222N, I259V, I260V, M275L, S279P, H280N 
BM32450 BM32450 None   R95K L2I, K4R, S39T, I72V, S163D, I172V, T206A, E246D, L250I, D256E I28L, N30K, I180V, D222N, E229EK, Q233H, I259V, I260V, M275L, H280N 
BM32511 BM32511 None    L2I, S39T, I172V, A215T, D222K, E246D, L250I, R269K, G283D, E288EG V19I, N30K, A41P, I180V, K221Q, I259V, I260V, L281V, D286T 
BM32677 BM32677 None    K4R, S39ST, I72IV, I133T, R164K, I172M, T206A, E246D, L250I V19M, S23A, I28L, R34K, S93T, I180V, S197A, D222N, T255A, I260V, M275L 
BM33738 BM33738 None    L2I, S23T, S39T, I172V, I175V, T206A, L213F, E246D, L250I, R269K V19I, N30K, I50M, I133V, V141I, E167D, I180V, S197A, D222N, T255A, M275L, S279P, G283S 
BM33853 BM33853 None    L2I, S23T, N30Q, S39T, I72IV, H181Y, T206TA, I210IV, Q214QH, E246D, L250I, D256E L58I, S93T, I133V, M178I, S197A, E207D, D222N, T255TA, I259V, I260V, M275L 
BM34602 BM34602 None    S39T, L213F, L250I, R269K, G278GS V19I, N30K, N55D, S93T, I133V, I180V, S197A, D222N, I259V, S279P 
BM35346 BM35346 None  S138T  S17T, S39T, I72V, I172V, I175V, L220F S23C, I28L, N30M, R34K, T60TI, I133V, E167D, S197A, D222N, I259V, M275L, S279P 
BM35855 BM35855 None    S39T, I72V, T206A, E246D, L250I, G278S V19I, I28L, N30K, N55D, Q96H, I133V, S197A, D222N, I259V, I260V, M275L, S277N, H280HN 
BM35864 BM35864 None    N18ND, S39T, A41N, I72V, R164K, I172V, T206A, F212FL, E246D, L250I, R269K I28L, N30K, T60I, S93T, I133V, H156L, E167D, I180V, S197A, D222N, I259V, M275L, S279P 
BM35953 BM35953 None    L2I, S39T, I72V, A119G, I172V, D222K, E246D, L250I, R269K N30K, I180V, K221Q, T255A, I259V, L281V 
BM36649 BM36649 None    S39T, I72IV, S163SN, I172M, T206A, E246D, L250I V19VI, N30K, A41AT, N55D, L58F, S93T, S106G, I133V, I180V, S197A, D222N, T255A, I260V, S279P 
BM38011 BM38011 None    S39T, I172V, Q214QH, A215N, E246D, L250I S93T, E167D, I180V, D222N, I259V, I260V 
BM38018 BM38018 None    S17T, N30Q, S39T, I72V, S163X, R164K, L200V, I210V, K216KR, S218L, L220F, L250I I28L, A41P, L58I, S93T, I133IV, L177V, S197A, D222N, I259V, I260V, M275L 
BM38019 BM38019 None  S138T  Y15F, S39T, I72V, R164K, A215AT, E246D, L250I V19VI, N30K, R34K, N55D, S93T, I133V, I180T, S197SA, D222N, T255A, I259V, I260V, M275L, S279P 
BM38341 BM38341 None    N30Q, S39T, I72V, S163N, I172V, E246D, L250I, G278GS S23C, I28IL, A41T, S93T, E167D, I180V, L200F, D222N, I260V, S279P 
BM38589 BM38589 None    L2I, S39T, I50IT, I72V, I172V, I175V, K219N, L220F, E246D, L250I N30K, S93T, I133V, I180V, E207D, D222N, R228RK, I260V, M275L, S279P, G283GS 
BM39196 BM39196 None  S138T  S39T, I172V, E246D, L250I I28L, N30K, A41T, I133V, I180V, D222N, S279P 
BM39754 BM39754 None    K4R, S39T, I72V, I172V, L220F, E246D, L250I, R269K V19I, S23A, I28L, N30K, S93T, I133V, E167D, I180V, I201IV, K221Q, D222N, I259V, I260V, S279P 
BM41864 BM41864 None  S138T  N30Q, L31I, S39T, I172V, T206A, K219KR, E246D, L250I, R269K V19M, Q42Q*, E57D, S93ST, H114HQ, I133V, I180V, D222N, I259V, I260V, M275L 
BM44207 BM44207 None    L31I, S39T, I72V, I172V, T206A, Q214H, A215AS, S218L, E246D, L250I, I268IV, R269K, D286N K20Q, I28ILM, N30K, N55D, I180V, S197SA, D222N, I259V, I260V 
BM44558 BM44558 None  S138T  K4X, S39T, I72V, I172V, I175V, D222K, E246D, L250I, R269K, G278S V19I, N30NK, R34RK, A41T, I133IV, I180V, S197A, K221Q, T255A, I259V, M275L, D276DG, S279P 
BM44683 BM44683 None  S138T  S17T, S39T S23C, I28L, N30T, L58V, I133V, I180V, D222N, S277N 
BM45160 BM45160 None    S39T, I50V, I72V, I84V, A215S, L220F, E246D, L250I, D286N S23A, I28L, N30L, R34K, S93T, I133V, A153S, I180V, D222N, I260V, M275L, S279P 
BM46095 BM46095 None    S39ST, I50T, A119P, I172V, T206A, E246D, L250I, R269K, G278GS I28L, N30K, T60I, S93T, I133V, E167D, I180V, S197A, D222N, S279P 
BM46206 BM46206 None    S39T, I84IV, H156R, S163D, I175V, I210IV, L220F, D256E V19VI, K20Q, I28L, N30K, S93T, I133V, E167D, I180V, D222N, V251A, I259V 
BM46587 BM46587 None    I72V, L113V, S163N, T206A, V249VI N30T, L58I, Q96H, I133V, E167D, I180T, S197A, I201T, D222N, V251A, T255A 
BM47037 BM47037 None    K4R, S39T, A119AP, S163D, K219R, L220F, E246D, V249VI, L250I, D256E, I267IV, R269K I28L, N30K, T122TIM, I133IV, E167D, I180V, D222N, I259V, I260V, M275L 
HIV2_001 BM32050 RAL  Q148R  I72V, I172V, T206A, E246D, L250I, R269K, G278GS V19I, S23A, I28L, N30K, A41T, T60I, S93T, I133V, E167D, I180V, S197A, D222N, I260V, M275L, S279P 
HIV2_002 BM19690 RAL  S138T, N155H  S39T, Q44QH, I72V, I84V, E92A, I172V, E246D, L250I, D286N S23C, I28L, N30K, A41T, S93T, I133V, A153G, I180V, G190E, D222N, I260V, M275L, S279P 
HIV2_003 BM22175 RAL  N155H  S39T, I84V, I172V, I175V, T206A, A215N, E246D, L250I I28L, N30K, I50M, S93T, I133V, A153G, I180V, S197A, D222N, T255A, M275L, S279SP 
HIV2_004 BM31028 RAL  E92Q, N155H T97A K4R, Y15F, S39T, Q44H, K71R, I72IV, K127R, S163D, T206A, L250I V19I, N30T, A41P, Q45QH, S93T, I133V, I180V, S197A, D222N, I259V, M275L, S279P 
HIV2_005 BM36920 RAL  S138ST, N155H D232N K4R, N30Q, S39T, I72V, I84V, E92A, I172V, S218Q, D222K, E246D, L250I, R269K V19M, S23A, I28L, R34K, S93T, I133V, A153G, I180V, S197A, K221Q, K236T, E240DN, T255A, I259V, I260V, E274D, M275L, D276G 
HIV2_006 BM19302 RAL  E92EQ, N155H  I72V, I84V, I172V, E246D, L250I I28L, N30QR, S93T, I133V, E167ED, I180V, D222N, I260V 
  BM29665 RAL  E92Q, N155H  N30Q, I72V, I84V, H156R, I172V, L220LF, E246D I28L, V32VM, A33S, R34RK, C43W, S93T, I133V, I180V, D222N, L250IV, I260V 
  BM46590 RAL  E92G, N155H  S39T, K46KR, I72V, V151VI, I172V, T206A, Q214QH, S218SL, E246D, L250I, I268IV, R269K V19I, N30K, A41P, T60I, I133V, N160NK, E167D, I180V, S197A, D222N, I259V, I260V 
  BM36989 RAL, Unknown  E92Q, N155H  N30Q, K46R, I72V, I84IV, H156R, H157X, I172V, Q214QH, L220LF, E246D, L250I I28L, S93T, I133V, A153AS, N160ND, E167ED, I180V, D222N, I260V 
HIV2_007 BM20055 RAL  N155H  Y15F, V32I, T60V, I72V, A119AP, I172IV, T206A, L213F, L250I, R269K V19I, N30K, A41T, S93T, I133V, E167D, I180V, S197A, D222N, L242LP, T255A 
  BM23864 RAL  N155H D232DN Y15F, V32I, K46KR, T60V, I72V, A119P, T122TI, I172IV, T206A, L213F, L250I, R269K V19I, N30K, A41T, Q91QR, S93T, I133V, E167D, I180V, S197A, D222N, T255A 
  BM32818 RAL  E92EQ, N155NH  Y15F, V32I, K46KR, T60V, I72IV, A119AP, H156X, I172V, T206A, L213F, L250I, R269K V19I, N30K, A41T, S93T, I133V, E167D, I180V, S197A, D222N, T255A 
  BM47172 RAL  E92Q T97A Y15F, V32VI, K46R, T60V, I72V, I172V, T206A, L213F, L250I, R269K, G278GS V19I, N30K, A41T, S93T, I133V, H156G, N160K, E167D, N170D, I180V, S197A, D222N, T255TA, I260IV, S279SP, L281LV 
HIV2_009 BM25541 RAL  E92Q, S138T T97A K4R, S39T, R164K, I172IM, L220F, E246D, L250I, K264KR, R269K N30K, L58V, E85EK, S93ST, I133V, H156GR, I180T, S197A, D222N, I260V, M275L, S279P 
HIV2_010 BM32451 RAL  S138T  S39T, I50T, T122TI, I172M, I175V, E246D, L250I V19I, K20KR, S23C, S93T, I133IV, I180V, S197A, D222N 
  BM45481 RAL  E92EQ, S138T T97A S39T, I50T, H156HR, I172M, I175V, E246D, L250I, G278GS V19I, S23C, S93T, I133V, I180V, S197A, D222N, M275L, S279P 

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