Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Inzaule (2016)
Title Prevalence and dynamics of the K65R drug resistance mutation in HIV-1-infected infants exposed to maternal therapy with lamivudine, zidovudine and either nevirapine or nelfinavir in breast milk.
Citation J Antimicrob Chemother
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 21
NumPts 21
Subtype A, D

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
1.0079.3.7 1.0079.3.7 NRTI NNRTI M184V K101E, G190A E6T, E28A, V35T, V60I, D121F, K122E, D177E, I178M, E203Q, Q207E, R211K, V245K, D250E, I257L, A272S, L282C, A288T, I293V, D324E, I329L  
1.0195 1.0195 AZT, 3TC NVP  K103KN E6D, V35T, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, V245K, D250E, A272S, K277T, L282C, T286A, I293V, P294S, E297K  
1.0212 1.0212 AZT, 3TC NVP  Y181C V35T, E40D, V60I, K122E, D123S, I135T, S162H, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, K238R, V245E, D250E, K281KR, T286A, E291D, V292I, I293V, E312N  
1.023 1.023 AZT, 3TC NVP M184V  V35T, K49R, V60I, K122E, I135T, D177E, T200A, Q207E, R211K, I244V, V245K, A272P, K277R, L282C, L283I, I293V  
1.0278 1.0278 AZT, 3TC None M184V  V35T, T39M, K49R, V60I, D121Y, K122E, D123E, I135IT, K173S, Q174K, D177E, V179I, I195L, T200I, Q207E, R211K, V245I, D250E, L282C, L283I, R284K, I293V, D324E A98Q 
1.0289 1.0289 AZT, 3TC None M184V  K11Q, V21I, V35T, V60I, K64R, D121H, K122E, D123S, I135T, E169N, K173S, Q174K, D177E, V179I, T200A, Q207E, R211S, D250E, A272P, T286A, E291D, I293V, P294T, E312D, Q334P, G335E  
1.0317 1.0317 AZT, 3TC NVP M184I Y181C E6D, V35T, T39L, E40D, K49R, V60I, K64R, D121Y, K122E, I135R, D177E, T200I, Q207E, R211K, V245I, D250E, L282C, L283I, T286A, I293V  
1.0357 1.0357 AZT, 3TC None M184V  V21I, T27S, V35T, T39A, E40D, V60I, K122E, D123G, I135T, K173S, Q174K, D177E, I178M, T200A, Q207D, R211K, I244IV, V245E, D250E, T286A, E291D, V292I, I293V, P294T  
1.036 1.036 AZT, 3TC None M184V  V35T, T39I, K49R, I50V, D121Y, K122E, I135T, S162C, K173L, Q174K, E204ED, Q207AS, R211S, V245E, D250E, V276I, T286A, E291D, V292I, I293V, E312D  
1.041 1.041 AZT, 3TC None M184MIV  V35T, K43R, V60I, D121Y, K122E, I142V, D177E, T200I, Q207G, R211K, V245K, D250E, V276I, L282C, L283I, T286A, I293V  
1.0410.4.5 1.0410.4.5 NRTI NNRTI K65KR, M184MV  V35T, K43R, V60I, D121Y, K122E, I142V, D177E, T200I, Q207G, R211K, V245K, D250E, V276I, L282C, L283I, T286A, I293V  
1.0437 1.0437 AZT, 3TC None M184I  I5V, K11Q, V35T, V60I, D121Y, K122E, D123G, I135T, K173A, Q174K, D177E, V179I, V189I, Q207A, R211S, V245M, D250E, T286A, A288S, V292I, I293V, P294T, E312D  
1.0457 1.0457 AZT, 3TC None K65KR, M184MV  V21I, T27S, V35T, T39A, E40D, V60I, K122E, D123G, I135T, K173A, Q174K, D177E, T200A, Q207A, R211S, F214L, A272P, T286A, I293V, P294A, E312D, I329V  
1.0457.9.7 1.0457.9.7 NRTI NNRTI K65R  K20R, V35T, E40D, V60I, D121H, K122E, K173A, Q174K, D177E, T200A, Q207A, R211S, F214L  
1.0472 1.0472 AZT, 3TC NVP K65KR, M184MV K103N, Y181YC K11S, K20R, V21I, V35T, T39N, E40D, I50V, D123N, K173S, D177G, V179I, T200A, I202V, Q207A, R211K, L228LR, V245Q, E248N, T286A, E291D, I293V, E312D  
1.0472.8.8 1.0472.8.8 NRTI NNRTI M184MV K103KN, Y181YC K11S, K20R, V21I, V35T, T39N, E40D, I50V, D123N, K173S, D177G, V179I, T200A, I202V, Q207A, R211K, L228LR, V245Q, E248N  
1.0496 1.0496 AZT, 3TC None K65KR, M184MV H221Y V35T, V60I, K104R, K122E, D123S, I135T, I142V, K173S, Q174R, D177E, V179I, T200A, Q207A, R211S, V245Q, D250E, A272PR, I274IV, K281R, T286A, E291D, I293V  
1.0496.6.8 1.0496.6.8 NRTI NNRTI   V35T, V60I, K104R, K122E, D123S, I135T, I142V, K173S, Q174R, D177E, V179I, T200A, Q207A, R211S, V245Q, D250E  
1.0517 1.0517 AZT, 3TC None M184V  V35T, E40D, K49R, V60I, E79ED, D121H, K122E, D123G, I135T, K173S, Q174K, D177E, V179I, Q207E, V245M, D250E, A272P, T286A, E291D, V292I, I293V, E312D, S322A  
1.066 1.066 AZT, 3TC NVP K65KR, D67DG G190A K11T, K20R, V21I, V35T, T39M, V60I, D121Y, K122E, K173S, Q174K, I178L, V179I, T200A, Q207A, R211S, V245M, D250E, A272P, T286A, E291D, V292I, I293V, K311R, E312D, I326V  
1.079 1.079 AZT, 3TC NVP  Y181YC, G190GA E6T, E28A, V35T, V60I, D121F, K122E, D177E, I178M, E203EQ, Q207E, R211K, V245K, D250E, I257L, A272S, L282C, A288T, I293V, D324E, I329L  

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