Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Liang (2015)
Title The combination of the R263K and T66I resistance substitutions in HIV-1 integrase is incompatible with high-level viral replication and the development of high-level drug resistance.
Citation J Virol
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 5
Lab Parent Strain NL43

 

Lab IN Isolates : Susceptibility Data


IsolateINIMajorDRMsINIMinorDRMsMethodDrugFold Res.
263K R263K  TZM-McGill DTG 4.8 
     TZM-McGill EVG 4.0 
     TZM-McGill RAL 1.3 
66I T66I  TZM-McGill DTG 0.1 
     TZM-McGill EVG 10 
     TZM-McGill RAL 2.4 
66I138K263K T66I, E138K, R263K  TZM-McGill DTG 0.1 
     TZM-McGill EVG 164 
     TZM-McGill RAL 2.5 
66I263K T66I, R263K  TZM-McGill DTG 0.1 
     TZM-McGill EVG 22 
     TZM-McGill RAL 1.6 
WT   TZM-McGill DTG 1.0 
    TZM-McGill EVG 1.0 
    TZM-McGill RAL 1.0 

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