Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Rossouw (2015)
Title Factors associated with the development of drug resistance mutations in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy in South Africa.
Citation PLoS ONE
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 65
NumPts 65
Subtype C

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
MIV001 MIV001 3TC, D4T, AZT, DDI, ABC NVP D67N, T69D, V75T, Y115F, M184V, T215Y Y188L T39E, S48E, K73M, D123E, K166R, K173A, Q174K, D177E, T200A, Q207A, H208Y, R211K, V245Q  
RP003 RP003 3TC, D4T EFV L74LV, M184V K101P, K103N T39K, K122E, D123A, K173A, D177G, T200A, Q207E, V245Q  
RP005 RP005 3TC, D4T EFV M184V K103N, P225PH T39E, S48T, K122E, D123N, I135L, K173A, Q174K, D177E, I195T, G196V, T200A, Q207G, R211K, V245Q  
RP020 RP020 3TC, D4T, ABC, DDI NVP K65KR, L74LV, Y115YF, M184V K103N, Y181C, H221HY T39E, S48T, V90VI, K122E, D123S, I135T, S162SC, T165ILV, K173A, Q174K, D177E, I178IL, T200A, Q207D, R211K, V245Q F116FL 
RP025 RP025 RTI RTI D67N, K70R, M184V, K219Q K103N, E138Q V35M, T39E, S48T, V60I, K122E, D123S, K166R, K173A, Q174N, D177E, T200A, Q207A, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E298EK, E300X, E302EK  
RP030 RP030 3TC, D4T None M184V E138A T39E, S48T, K122E, D123G, K173T, T200A, Q207A, R211K, V245L, L246I  
RP031 RP031 3TC, D4T None M184V  T39E, S48T, V60I, K122E, F171FL, K173A, Q174K, D177E, T200A, Q207V, R211K, F214L, V245Q  
RP032 RP032 AZT, 3TC EFV M184V K103KN T39K, K122E, D123N, I135T, T200A, I202V, Q207E, R211K, F214L, V245Q  
RP033 RP033 3TC, D4T None M184V  T39E, S48T, K122E, D123N, A158AS, K166KR, K173A, D177G, T200A, Q207E, R211K, V245Q  
RP034 RP034 3TC, D4T None M184V  T39E, S48T, K122E, D123N, A158S, K173A, T200A, Q207E, R211K, E224ED, V245Q  
RP036 RP036 3TC, D4T None M184V  T39E, S48ST, K49KR, V60VI, V118VI, K122E, D123GS, I135IR, S162D, K166R, E169R, K173A, D177E, T200A, Q207E, R211K, F214FL, V245Q  
RP038 RP038 3TC, D4T None M184V  S48T, K122E, D123S, K173T, D177N, T200A, E203EK, Q207A, R211K, V245Q  
RP039 RP039 3TC, D4T None M184V  T39E, S48T, V60I, K64R, K122E, D123S, I135IV, K173A, Q174K, D177E, T200A, Q207K, R211Q, V245Q  
RP043 RP043 3TC, D4T None M184V  T39E, S48T, K49KR, K122E, D123G, S162C, K173A, D177E, I178L, T200A, E204K, Q207D, R211K, V245Q  
RP045 RP045 3TC, D4T None M184V  V21I, E28EK, K32KE, V35T, E36A, T39E, S48T, W88S, K122E, D123S, I135V, T139A, S162Y, K166R, K173A, Q174K, D177E, T200A, Q207G, F214L, V245Q, A272P, K275R, K277R, T286A, E291D, V292I, E297K A267AG 
RP051 RP051 RTI RTI M184V L100I, K103N T39E, S48T, K49R, K122E, D123S, I135R, E169K, K173A, E194K, G196E, T200A, E203K, Q207E, H208Y, R211K, V245Q  
RP053 RP053 3TC, D4T None M184V  P4T, T27S, V35T, T39E, S48T, K122E, D123G, I135IT, S162F, K173A, D177E, T200A, E204Q, Q207D, R211K, V245Q, A272K, K277R, E291D, V292I, I293V  
RP054 RP054 RTI RTI M41L, M184V K103KN, E138EA, V179VD, Y181YC S48T, W88WS, D121DH, K122E, D123DG, F130FL, I135LV, K166KR, K173X, Q174K, D177EG, I178IL, Q197QP, T200A, Q207E, R211K, F214FL  
RP059 RP059 RTI RTI M184V K103KN, P225PH T39E, S48T, E53ED, S68SG, K122E, D123DE, I135X, S162SCT, K173KT, Q174QK, D177DE, V179VI, T200A, Q207X, R211K, F214FL, V245Q  
RP061 RP061 RTI RTI M184V K103N T39E, S48T, V60I, K102KR, K122E, D123S, K173T, Q174K, D177E, T200A, R211RK, V245K  
RP068 RP068 3TC, D4T None M184MV  T39E, S48T, V60VI, K122E, D123GS, S162X, K173AT, Q174QK, D177DE, T200A, E204EQ, Q207DE, R211RK, V245Q  
RP069 RP069 RTI RTI M184V K103N, V108I, P225H V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135L, K173A, Q174K, D177E, Q197P, T200A, Q207E, V245Q, A272P, L279I, E291D, V292I, I293V, L303I  
RP073 RP073 3TC, D4T None   T39E, S48T, V60I, K64R, K122E, D123S, K173A, D177E, T200A, Q207E, H208HY, R211K, V245K  
RP074 RP074 3TC, D4T None M184V  T39E, S48T, K122E, S162A, K173A, D177E, T200A, E203K, Q207E, R211K, V245Q  
RP077 RP077 3TC, D4T None   V35T, E36A, T39E, S48T, V60I, V118I, D121H, K122E, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377L, T386A, K390R, E396D, A400AT, I434V, V435A  
RP080 RP080 3TC, D4T None K65KE, M184V  T39E, S48T, K122E, D123G, K173I, Q174K, D177E, T200A, I202V, Q207T, R211K, P243T, V245Q  
RP081 RP081 3TC, D4T EFV D67N, K70R, M184V, K219Q K101P, K103N K20R, V35T, E36A, T39E, S48ST, V60I, K122E, D123N, I135T, K173A, D177EG, T200A, Q207D, D218E, L228LH, V245Q, A272P, E291D, V292I, I293V, L301F, V317A, D324DE, I326IV, I329IV, Q334H, G335D, R356K, M357R, G359T, A371V, I375IV, T377Q, K390R, A400T, E404D, V435I  
RP083 RP083 3TC, D4T EFV D67N, K70R, M184V, K219Q K103N, V106M K20R, E28EA, V35T, T39E, V60VI, K102R, K122E, D123S, I135T, K173T, Q174K, D177E, I178IM, T200A, Q207E, R211K, F214L, V245Q, A272AS, T286A, E291D, V292I, I293V, V317A, Q334HN, G335D, R356K, G359AT, T369V, E370EG, T377TI, K388KR, K390R, A400T, E404D, A408AV  
RP084 RP084 3TC, D4T EFV M184V A98G, K103N, V108VI, P225PH T39E, S48T, K122E, K173I, Q174K, D177E, T200L, I202V, Q207D, R211K, V245Q  
RP085 RP085 3TC, D4T None M184V  V35T, T39E, S48T, K122E, D123S, I135IV, T165TI, K173T, G196E, T200A, Q207A, A272P, V292I, I293V, E298EK, E300EK, E302K  
RP087 RP087 3TC, D4T None M184V  E6D, V35T, E36A, T39E, K102KR, K122P, I135IM, S162C, K173T, Q174K, D177E, I178IM, T200A, Q207E, P243T, V245Q, D250E, A272P, K277R, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T369A, A376S, T377M, K390R, A400T, E404N, K431P, V435P  
RP088 RP088 3TC, D4T, AZT, DDI EFV D67N, K70R, T215FY, K219Q L100I, K103N, P225H V35T, T39E, S48T, V90VI, K102KR, K122E, D123G, I135V, K173A, D177G, T200A, Q207A, R211K, L228R, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, Q334Y, G335D, R356K, G359S, V365VI, T369V, T377L, K390R, A400R, E404D  
RP089 RP089 3TC, D4T, AZT, DDI NVP, EFV M41L, D67N, T69D, L210W, T215Y, K219KN Y188L, G190A E6D, V8VI, K32KR, V35T, E36Q, T39E, E44ED, V60I, K122E, D123N, K173T, D177N, G196E, T200A, E203ED, Q207E, R211RK, D237N, V261VI, A272S, E291D, V292I, I293V, L310V, E312Q, H315F, D324E, Q334N, G335D, K350R, R356K, G359T, T377M, K390R, A400T, T403S, E404D  
RP090 RP090 3TC, D4T EFV D67DN, K70KR, M184V Y181C, H221HY, N348I L34I, V35T, T39E, S48T, K49KR, K122E, I135IRT, T139TK, A158AS, K173T, Q174QK, D177E, I178IL, T200A, I202IV, Q207N, R211K, V245Q, E248D, D250E, A272P, K277R, E291D, V292I, I293V, E297A, A304E, I326IV, Q334E, R356K, G359T, K366KR, T377Q, K390R, A400S, E404D, V435A, A437V  
RP096 RP096 3TC, D4T None M184V  V35T, E36A, T39E, S48T, A98S, K103R, K122E, D123E, I135T, K173A, D177G, T200A, Q207A, F214L, V245Q, A272P, K277R, I293V, S322A, Q334H, G335D, R356K, G359T, T377Q, K390R, A400T, E404D, V435A  
RP099 RP099 3TC, D4T, ABC, DDI None D67DN, M184V, T215Y  P4S, K20KR, V35T, T39E, S48T, A98S, V118VI, K122E, D123NS, I135KR, K173T, Q174K, D177E, I178L, T200A, E203K, Q207E, H208HY, R211RK, K223KEQ, V245Q, A272P, K277KR, R284RK, T286A, V292I, I293V, G335D, R356RK, M357IT, G359T, T377Q, K385KR, K390R, A400T, E404D  
RP102-1 RP102-1 RTI RTI D67N, K70R, T215F, K219EQ E138A, G190E P4S, V35T, T39E, S48T, V60I, K103R, V118I, K122E, D123S, I135IT, M164L, Q174H, I178IL, V179VA, T200A, Q207E, R211K, F214L, A272P, K277R, T286A, E291D, V292I, I293V  
RP103-1 RP103-1 3TC, D4T, ABC, AZT None M184V  V21VI, T27S, V35T, E36A, T39E, S48T, K102KR, K122E, D123S, K166R, K173A, Q174QR, G196K, T200E, I202V, Q207EK, R211K, V245K, D250E, A272P, K277R, Q278H, T286A, A288AT, I293V, D324DE, I329IV, Q334D, G335D, R356K, G359T, K366R, E370EK, T377Q, I380IV, K390R, A400T, T403A, E404D, E413D, E430K, E432N P150PL, Q161Q* 
RP104 RP104 3TC, D4T None M184V E138K V35T, E36A, T39E, S48T, A98S, K103KE, K122E, K173A, Q174K, D177DE, V179I, Q197QR, T200A, I202IV, E203ED, Q207N, R211KT, F214FL, V245Q, A272P, K277R, L283I, I293V, E297EK, L303LW, Q334H, G335D, R356K, G359T, A371AV, T377Q, T386TI, K390R, A400L, E404D, V435A K30KT 
RP106-1 RP106-1 3TC, D4T, AZT, DDI NVP D67T, K70R, T215F, K219E K103N, Y181C T27S, V35T, T39E, T69N, A98AS, K102KR, K122E, D123G, S162X, K173A, Q174K, D177E, I178L, T200E, E204D, Q207K, L228H, V245Q, A272P, Q278Y, T286A, E291D, V292I, I293V, E300EK, L303I  
RP107-1 RP107-1 3TC, D4T EFV M184V K101P, K103S E6EK, E28A, V35T, T39E, E40D, K102R, K122E, D123N, K173T, Q174K, T200A, I202IV, R211K, V245Q, K277R, L283I, T286A, V292VI, I293V, E297K  
RP108 RP108 3TC, D4T, AZT, DDI, ABC EFV M41L, D67G, K70R, L74LI, T215F, K219Q V106M, V179DE, G190A K22KR, V35T, T39E, S48T, V60I, S68G, K122E, D123N, I135IT, S162SN, K173T, Q174R, T200A, E203EV, Q207E, R211K, K223E, L228LR, V245S, D250E, A272P, K277R, T286A, E291D, V292I, I293V, R356K, G359T, K390R, E396D, A400T, E404ED, E413EG Q161Q* 
RP112-3 RP112-3 3TC, D4T None M184V  V21VI, T27TS, V35T, E36A, T39E, S48T, V90VI, A98S, K122E, D123G, S162A, K173A, Q174QK, D177E, I178IL, V179VI, G196K, T200A, I202V, Q207E, R211A, V245Q, T286A, V292I, I293V, E300EK, E302K  
RP116 RP116 3TC, D4T EFV M184V Y188L, N348I V35T, T39E, S48T, K122E, D123N, K173T, D177E, V179VI, T200A, E203ED, Q207KR, R211K, F214FL, E248D, A272P, V276VI, K277R, E291D, I293IV, I329IL, Q334HN, G335D, P345PQ, R356K, M357MR, G359T, A376S, T377M, K390R, T397M, A400IMV, E404D, F440Y  
RP117 RP117 3TC, D4T None M184V  V35M, T39G, S48T, K122KE, K173T, D177E, T200A, I202V, Q207E, V245N, A272P, K277R, E291D, V292I, I293V  
RP123-1 RP123-1 RTI RTI D67N, T69D, K70KR, T215F K103N, V106M P14PA, K20KR, V35T, E36A, T39E, S48T, A98S, K122E, D123S, T165I, K173A, Q174K, D177E, I178L, T200A, R206RK, Q207E, R211T, F214L, D218DN, V245Q, E248DN, A272P, T286A, E291EK, V292VI, I293V, E297K, E300EK  
RP125 RP125 AZT, 3TC EFV M184V A98G, V106M, F227L T27S, V35T, E36A, T39E, S48T, K122E, D123S, K173A, Q174K, D177E, T200A, R211K, V245Q, A272S, E291D, V292I, I293V, E297K N136S 
RP126 RP126 3TC, D4T, AZT, DDI EFV D67N, T69D, K70R, T215F, K219Q K103N, E138A, Y188L K20R, V35T, E36A, T39D, S48T, V60I, K122E, D123S, T139A, I142V, K173R, Q174K, T200A, Q207E, R211K, F214L, A272P, K277R, T286A, E291D, I293V  
RP129 RP129 3TC, D4T None M184V  V35T, E36A, T39E, S48T, A98S, K122E, K173A, Q174K, D177G, T200A, I202V, Q207V, R211K, V245Q, A272P, T286A, V292I, I293V, E300EK  
RP130 RP130 3TC, D4T EFV A62V, M184V K103N, V106M, Y188F V35T, E36A, T39E, K122E, D123S, I135K, K173AV, D177E, I178L, T200A, E203Q, Q207E, R211K, V245Q, K281R, T286A, E291D, V292I, I293V  
RP135 RP135 3TC, D4T NVP M184V Y181C, G190GA V35T, T39K, S48T, K122E, D123N, K173A, D177E, T200A, Q207G, R211K, V245Q, E248D, A272P, K277R, T286TA, A288AV, E291D, V292I, I293V, E302EK  
RP136 RP136 3TC, D4T EFV K70KR, M184V K103N, V106VIM K20R, V35T, E36EA, T39D, S48T, T69TN, K101X, K122E, D123N, K173A, D177E, I178IM, T200A, Q207E, R211K, F214FL, V245Q, K249KR, D250E, S251D, A272K, R284RK, T286A, E291D, V292I, I293V  
RP138 RP138 3TC, D4T None M184V  E6K, V21I, I31V, V35T, E36A, T39E, S48T, K122E, K173I, Q174K, T200A, Q207E, V245Q, A272P, K275R, Q278N, T286A, E291D, V292I, I293V, E300EK  
RP142 RP142 3TC, D4T EFV M184V K103S, V106M V35T, E36A, T39E, S48T, K102R, K122E, D123N, I135L, G141GE, K173A, Q174QK, D177G, G196K, T200E, Q207E, R211K, F214FL, V245E, E248D, D250E, A272P, K277KR, Q278H, K281KR, T286A, E291D, I293V, E298EK  
RP144 RP144 3TC, D4T EFV M184V K103N, E138G, P225H, K238T V35T, E36A, T39E, V90VI, A98S, K122E, D123S, I135L, S163AT, T165I, K173A, Q174K, D177E, I178L, V179I, T200A, Q207D, I244IV, V245Q, E248D, A272P, K277R, I293V  
RP145 RP145 RTI RTI K65R, M184V Y181C V35T, E36A, T39E, S48T, R83RK, K122E, D123N, K173T, V179VI, T200A, Q207K, R211K, F214L, V245K, E248D, A272P, K277R, E291D, V292I, I293V, L303I  
RP152 RP152 ABC, 3TC None L74V, Y115F, M184V  V35T, E36A, T39E, S48T, K122E, D123DG, K173A, Q174K, D177G, I178V, T200A, I202V, R211K, V245Q, D250E, A272P, I274V, Q278H, K281R, T286V, A288T, V292I, I293V  
RP154 RP154 3TC, D4T None M184V  V21I, V35T, E36A, T39E, E40D, S48T, W88S, I135IV, S162Y, K166R, K173A, Q174K, D177E, I178L, T200A, Q207R, R211Q, V245Q, A272P, T286A, E291D, V292I, I293V  
RP156 RP156 3TC, D4T None D67DN, K70R, M184V  V35T, T39E, S48T, K49R, E53D, K122E, D123N, I135V, K173T, I178L, E194EK, G196K, T200A, E203D, Q207A, V245C, A272P, K277R, Q278N, T286A, E291D, V292I, P294T, E297T  
RP159 RP159 3TC, D4T None D67N, M184V  V35I, T39E, E40D, S48T, E53D, D121Y, K122E, T139R, S162C, K173T, Q174K, T200A, Q207D, R211RK, F214L, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293IV, L303I  
RP167 RP167 3TC, D4T, ABC None L74V, M184V  V35T, T39K, S48T, K122E, D123G, T165I, K173A, Q174R, D177E, T200A, R211K, F214L, V245Q, I257IV, A272P, K277R, T286A, E291D, V292I, I293V, L303I  
RP169 RP169 3TC, D4T None M184V  V21I, V35T, T39K, K43R, S48T, D121Y, K122E, K173A, N175H, D177E, T200A, K201T, E204K, Q207QE, L210F, R211RK, V245Q, A272P, E291D, V292I, I293V  
RP174 RP174 3TC, D4T None M184V  K13KR, K20R, E29EG, V35T, T39E, E42EG, S48E, D123G, A158APS, S162SR, S163SN, K166KT, E169X, P170PL, K173T, Q174QK, N175X, D177EKQ, I178L, T200A, Q207EG, R211RK, F214FL, V245Q, P247A, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, E300EK I5IF, R143RI, R172RM 
RP176 RP176 3TC, D4T None D67DN, M184V  K20KR, V35M, T39E, K122P, D123S, K173A, Q174R, N175NI, D177E, I178L, V179I, T200A, Q207D, R211K, V245Q, A272P, E291D, V292I, I293V, E300EK  
RP177 RP177 ABC, 3TC None M184V  V35T, E36A, T39E, S48T, V60I, K122E, K173I, Q174K, D177EK, G196E, T200A, Q207E, R211K, F214L, V245Q, E248EK, A272P, T286TA, E291D, V292I, I293V