Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Molina (2012)
Title Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treatment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: randomised, double-blind, phase 3, non-inferiority study.
Citation Lancet Infect Dis
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 413
NumPts 172
Subtype B

 
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Page 1   listing Isolate 1 to Isolate 100 from Total 413 Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
3015 3015_1 EVG 1   E11D, L101I, T124A, K136KT, F181L, G193R, V201I, T206S, D253E, D256E, R284RG  
  3015_2 EVG 14   E11D, L101I, T124A, K136KT, F181L, G193R, V201I, T206S, D253E, D256E, R284RG  
3021 3021_1 None    L101I, G106GA, T124A, K156N, V201I, I217V, P261S, R262L  
  3021_2 EVG 12   P90PS, L101I, T124A, K156N, V201I, I217V, L234LF  
  3021_3 EVG 26   L101I, T124A, K156N, V201I, I217V  
  3021_4 EVG 58   L101I, T124A, K156N, Q164E, V201I, I217V  
  3021_5 EVG 75  T97TA V31VMI, I72IN, L101I, T124A, K156N, V201I, I217V  
3069 3069_1 None    V31I, L101I, S119G, T122I, T124N, F181L, V201I, I220IL, S283G, R284G G118GD 
  3069_2 RAL 73   V31I, L101I, S119G, T122I, T124N, F181L, V201I, I220IL, S283G, R284G  
3092 3092_1 None    E11D, R20K, L101I, I162IV, S195T, D278DN, S283SG  
  3092_2 RAL 21   E11D, R20RK, L101I, S195T, L234LF, S283SG  
3094 3094_1 None    E11D, D25E, V31I, L101LI, K111T, I113IV, S119X, T122TI, T124TA, V126VMI, V201I, S230N, A265V  
  3094_2 EVG 36   E11D, D25E, V31I, I60IT, P90PS, K111T, I113IV, S119T, T125TA, V126M, V201I, S230N, A248AT, I251IL, A265V S39SI 
3185 3185_1 None    E11D, E13D, A21T, L101I, S119G, T122I, T124S, K136N, D256E  
  3185_2 RAL 40 N155NH T97TA E11D, E13D, A21T, M50MI, L101I, S119G, T122I, T124S, K136N, D256E  
3211 3211_1 None   E157Q S17SN, S24SN, M50MI, T124TA, T125A, K156N, K211Q, D256E, S283SG, R284G, D288N  
  3211_2 RAL 89 E92G, N155H E157Q S17N, L101LF, T125A, K156N, V201I, T210TI, K211Q, L234LF, D256E, S283G, R284G, D288N L241LF 
3225 3225_1 None    S17N, L28LI, S39C, L101LI, T124N, T125A, I135IV, F181FL, I191IM, G193GE, V201I, T206S, K219N, N222K, A265AV, I268IL, D270DH  
3227 3227_1 None    S17N, V31VI, M50MI, L101I, T112V, T124N, I135V, G193D, S195C, D207DG, D256E, A265V, D278A  
  3227_2 RAL 72   S17N, V31I, L45LMI, M50MI, G59GE, L101I, T112V, T124N, I135V, G193D, S195SC, D256E, A265V, D278A  
3240 3240_1 None    D6DE, S17N, L45V, K111KR, T112I, T124N, T125A, I203IM, T206S, D256E  
  3240_2 EVG 41   S17SN, L45V, I89L, L101I, K111R, T112I, T124N, T125A, I203M, T206S, D256E  
3247 3247_1 None    S17N, D25E, M50I, L101I, T124TA, K156N, I204IL, Q221S, N222K, D253E  
  3247_2 RAL 32   S17N, D25E, M50I, L101I, T124A, K156KN, Q221S, N222K, D253E  
  3247_3 RAL 49 N155H  S17N, D25E, M50I, L101I, S119SR, T124A, K156N, Q221S, N222K F26FL 
3252 3252_1 None    V31I, L101I, T112I, T124A, T125V, I135V, G163QH, A179G, F181L, V201I, T206S, L234I, D256E, I268L, D270H  
  3252_2 RAL 16   V31I, P90PS, L101I, T112I, T124A, T125V, I135V, G163QH, A179G, F181L, V201I, T206TS, L234I, D256DE, A265V, D270DH  
  3252_3 RAL 33   V31I, K46KR, L101I, T112I, T124A, T125V, I135V, G163QH, A179G, F181L, V201I, T206S, L234I, D256E, I268L, D270H  
3275 3275_1 None   A128T S17N, L28I, D41E, L45V, M50L, T112I, I220L, Q221H, N222T, D270H, R284G  
  3275_2 EVG 17   S17N, L28I, S39SN, D41E, L45X, K188R, I220L, Q221QH, N222NT, R269RK, D270H  
  3275_3 EVG 46  A128T S17N, L28I, D41E, L45V, M50L, T112I, I220L, Q221H, N222T, D270H, R284G  
  3275_4 EVG 85  A128AT S17N, D25DE, L28I, S39SN, D41E, L45X, M50ML, T112TI, K188KR, K211KR, Q216QH, T218TI, I220IL, Q221H, N222NT, D270H, R284G  
3277 3277_1 None   A128T E10ED, E11ED, E13ED, M50L, L101I, K111T, T125A, Y227F, S230N, D256E, A265V  
  3277_2 RAL 19  A128T E11D, E13D, M50L, L101I, K111T, T125A, Y227F, S230N, D256E, A265V L241LF 
3297 3297_1 None    V31I, L101I, I203IM, T206S, K211R, Q216H, I268L, D270H, R284G  
  3297_2 EVG 58   V31VI, L101I, T206S, K211R, Q216H, I268L, D270H, R284G  
  3297_3 EVG 96   V31VI, L101I, T206S, K211R, Q216H, I268L, D270H, R284G  
3303 3303_1 None    E11D, S24N, V31I, L101I, K136N  
  3303_2 RAL 16   E11D, S24N, V31I, L101I, K136N  
  3303_3 RAL 26   E11D, S24N, V31I, L101I, K136N, D256DE  
3325 3325_2 RAL 81   R20RK, V31I, E48EK, L101I, I113IV, S119ST, T125A, M154L, K173R, F181L, G193E, T206S, T210I, T218I, I220V, L234H, D279G  
3326 3326_1 None    E11D, S24N, K34KR, I72IV, I84M, A91T, L101I, T125V, V201I, K211KR, S230N, R262L, S283G  
  3326_2 RAL 42 G140S, Q148H  E11D, S24N, K34R, I72IV, I84M, A91T, L101I, T125V, I161T, V201I, K211KR, S230N, V260L, S283G P261F 
  3326_3 RAL 48 G140S, Q148H  E11D, S24N, K34R, I72IV, I84M, A91T, L101I, T125V, I161IT, V201I, K211R, S230N, S283G  
3346 3346_2 EVG 88 E92EQ, N155NH  S17N, M50I, E96EA, T124A, G163E, V201I, D256DE  
3365 3365_1 None    E11D, V31VI, L101IV, K111T, S119SG, T122I, V201I F181FI, T206PS 
  3365_2 RAL 50   E11D, V31VI, L101IV, K111T, T122I, V201I, T206S P90PLS 
  3365_3 RAL 88   E11D, V31I, L101IV, K111T, T122I, V201I, T206S  
3370 3370_1 None    M50TI, G70D, L101I, I113IV, S119R, T124N, T125A, I135V, F181L, T206S, I251IV, D256E  
  3370_2 RAL 24   M50TI, G70D, L101I, I113IV, S119R, T124N, T125TA, I135V, F181L, T206S, D256E  
3382 3382_1 None    S17N, A23AS, V31I, G47GR, E48EG, I72IN, I84IM, L101I, K103KR, T124S, T125A, K156N, G189GR, E198D, V201I, T206S, D232E, A265V  
  3382_2 RAL 34   S17N, V31I, L101I, K103R, T124S, T125A, E198D, I200IL, V201I, T206S, D232E, A265V  
  3382_3 RAL 40 N155NH  S17N, V31I, L101I, T122TI, T124S, T125A, I135IV, Y143X, E198D, V201I, T206S, D232E, A265V  
3404 3404_2 EVG 56   L101LI, K111TA, S119G, T122I, T125A, V201I P30PL, A105AT 
3405 3405_1 None    E10D, E11ED, V31VI, S39SC, M50I, I60IM, G106A, K156N, V201I, T206S, D232E, L234H  
  3405_2 RAL 21   E10D, E11D, S39C, M50I, I60M, G106A, K156N, V201I, D232E, L234H I162IM 
3420 3420_1 None    E11ED, K14KR, A21T, M50I, V176VL A133AG 
  3420_2 EVG 27   E11ED, K14R, A21T, M50I, K156KR, V176L  
  3420_3 EVG 50   E11ED, K14KR, A21T, M50I, V176L  
3442 3442_2 EVG 59   K7KR, L28I, P30S, S39C, L45LS, M50MT, L101LI, T112A, V201I, I220L, D253E, S255SN N117NS 
3456 3456_2 RAL 73 N155NH  K14R, V32I, L101I, T124N, M154MI, V201I, N222H, S230N, D256E  
3471 3471_1 None    K14KR, S17SN, V31I, D41DN, L101I, K111KR, T112V, T124A, T125A, G134N, I135V, K136T, M154MI, T206S, L234I, S283G  
  3471_2 EVG 8 T66TI, E92EQ  K14R, S17SN, R20RK, V31I, D41DN, L101I, T112V, T124A, T125A, G134N, I135V, K136T, R187RK, T206S, L234I, V249VI, S283G  
3480 3480_1 None    S17N, V31I, I60L, T124N, T125A, K173R, I182V, K215KN, Y227F, D253Y, D256E  
  3480_2 RAL 19   S17N, V31I, I60L, T124N, T125A, K173KR, V180VI, I182V, K215KN, Y227F, D253Y, D256E, D278E  
4018 4018_2 EVG 58   D6E, S17N, E35Q, S39N, D55S, I72IV, L101I, T124A, F181L, V201I, I220L, R284G  
4020 4020_1 None    V31I, P90PS, T112AV, T124A, M154L, K211R, T218S, S230N, S283G  
  4020_2 EVG 73   V31I, P90S, T112AV, T124A, G134GS, M154L, K211R, T218S, S230N, S283G  
4027 4027_1 None    E11D, V31VI, V32I, D41DN, L68V, I73V, Q95QR, L101LI, T125A, I135V, V201I, R284G  
  4027_2 EVG 24   E11D, V31VI, V32VI, D41DN, M50MT, L68V, I73V, T112TA, T125A, I135V, V201I, R284G  
4031 4031_1 None    K111T, Q216H, D232DE, D256DE  
  4031_2 RAL 19   K111T, Y194YC, Q216H, D232DE, D256DE  
4042 4042_1 None    R20RK, I84IV, L101I, T112TI, T125TA, M154I, V165I, H171L, K211R  
  4042_2 EVG 48   L101I, M154I, V165I, H171L, K211R M22MV 
  4042_3 EVG 106   A91AT, L101I, M154I, V165I, H171L, K211R, S283SG  
4054 4054_2 RAL 82   S17SN, L101LI, V151VI, M154I, I203IV  
4064 4064_1 None    R20K, K156KR, I200IM, V201I, D270DN  
4069 4069_1 None    E11D, V31VI, M50I, K111T, S119P, T124A, T206S  
  4069_2 EVG 23   E11D, V31VI, M50I, I72IV, K111T, S119P, T124A, T206S, D279DG  
  4069_3 EVG 54   E11D, M50I, K111T, S119P, T124A, T206S, K219KR  
4078 4078_1 None    A21T, L45V, T124Q, T125V, I182V, D256E, R262L  
  4078_2 RAL 46   E11ED, R20RK, A21T, L45V, T124QH, T125X, D167DE, I182V, D256E  
4092 4092_1 None    K14R, V31I, L45LV, T124X, T125TA, L172LP, K215N, S230N, R231K, D253E, N254Q, S255G, D256E  
  4092_2 RAL 17 N155H  K14R, V31I, T124X, T125TA, K215N, S230N, R231K, D253E, N254Q, S255G, D256E, V260L K258N, V259L 
4103 4103_2 RAL 94   E11D, S24N, S39C, T124TA, V201I, S230N, R284RG  
4105 4105_1 None    P90S, E212A, K215N, I220L, S230SN  
4106 4106_1 None    P30A, A49AS, P90PS, L101I, T112A, S123C, T124N, V201I, T218I, D256E, S283G  
  4106_2 EVG 23   S17SN, P30A, L101I, T112A, S123C, T124N, V201I, T218I, R224RQ, D256E, S283G  
  4106_3 EVG 48   P30A, L101I, T112TA, S123C, T124N, V201I, K215KN, T218I, D256E, S283G  
4112 4112_1 None    K14R, V31I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, I162IV, V201I, I203M, T206S, Y227F, L234I, S255N, D256E, S283G  
  4112_2 EVG 12   K14R, V31I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, V201I, I203M, T206S, Y227F, L234I, S255N, D256E, S283G  
4127 4127_1 None    S17C, I72IV, K111KN, K173KR  
  4127_2 RAL 33   S17C, S24SG, T125TA, S255SN  
4132 4132_2 EVG 83   S39SN, P90PS, L101I, M154I, V201I, T210TI, K215N, L234LF, D279G L242LF 
4162 4162_1 None    E11D, S24G, D25E, L28I, V37VI, S39C, K71KR, L101I, K215N, S230N A8AG 
  4162_2 RAL 24   E11D, S24G, D25E, L28I, S39C, K71R, K215N, S230N  
4204 4204_2 EVG 91   E11D, V32VI, V37I, S39SC, D41DN, I60V, S119G, T122TI, T124N, T125A, V201I, I203M  
4239 4239_2 RAL 100 E92EQ, N155H S230SR E10D, V31VMI, L45LR, L101I, T112TI, T124TA  
4248 4248_1 None    S57SG, G59E, L101I, T206S, D256E, S283SG  
  4248_2 RAL 41   M50MI, G59GE, I84IV, L101I, T206TS, K211KR, D256DE  

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