Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Li (2012)
Title Recombination form and epidemiology of HIV-1 unique recombinant strains identified in Yunnan, China.
Citation PLoS ONE
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 58
NumPts 58
Subtype C, B, CRF07_BC, CRF08_BC, A, B + C, B + C + CRF01_AE, B + CRF01_AE, CRF65_cpx, CRF01_AE

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
1431 1431 Unknown Unknown M184I Y181C, N348I V35M, K101R, I135V, S162C, D177E, I178M, V189I, T200A, E203EK, Q207E, R211K, V245Q, A272P, K275R, K277R, E291D, V292I, I293V, E312K, V317I, G335D, T338S, R356K, M357K, G359T, A360T, K366R, T377M, A400T, E404D, E432D, N447S, D471E, Q480H, G490E, L491S, K512R, E514D, L517I, S519N, Q524E, K530R, A534S, A554S, I556V  
1434 1434 Unknown Unknown  G190GS V35T, T39E, S48T, V60I, D121H, K122E, S162D, K166R, K173A, T200A, Q207A, R211K, V245M, A272P, K277R, T286A, I293V, G333E, G335D, R356K, G359T, T377R, K390R, A400T, E404D, E432D, V435A, R463K, Q464K, V466I, D471E, H483Y, L484I, L491P, S519N, K530R, A534S, A554S, K558R  
1437 1437 Unknown Unknown M184V, T215Y K103N V8I, V35T, T39D, S48T, V60I, V90I, D121H, K122E, I135MT, T139R, S162Y, V179I, T200A, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, G335A, R356K, G359T, T369V, T377M, I382T, K390R, A400T, E404D, E432D, D460N, R461K, V466I, S468T, H483Y, L491S, S519N, K527R, K530R, A534S, A554S  
1439 1439 Unknown Unknown   V35T, T39D, S48T, V60I, D121Y, K122E, I135R, S162Y, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, I293V, V317S, G335D, K350R, R356K, G359T, A376S, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, D471E, H483Y, L484I, L491S, S519N, K530R, A534S, A554S  
1440 1440 Unknown Unknown M41L, M184V G190S, N348I V35T, E36A, T39D, S48T, V60I, K122E, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, I293V, G335D, R356K, G359T, A376S, T377R, A400T, E404D, V435A, D460N, S468T, T470A, H483Y, L484I, L491S, S519N, A534S, A554S  
1444 1444 Unknown Unknown  K103N D123E, S162C, Q197H, Q207E, R211K, V245Q, A272P, G285E, E291D, V292I, I293V, V317A, Q334L, F346Y, M357V, A360T, T377R, V435E, D460N, R461K, S468N, H483HY, L491V, K512Q, S519N, V548I  
1449 1449 Unknown Unknown M184V K103N, Y181C, H221HY I135V, S162C, D177E, T200A, Q207E, R211RK, V245Q, K275R, V276VI, Q278E, L283I, A288T, I293V, E297A, F346H, K347Q, R356K, K366KR, A400AT, V435E, R461K, S468T, T470TN, L491S, K530R, A534S, A554HN, K558KR  
1452 1452 Unknown Unknown M184MI V179D, M230L V35T, E36A, T39D, S48T, V60I, K103R, D121Y, K122E, D177E, T200V, Q207E, R211K, V245Q, K277R, Q278E, T286A, E312T, D324E, Q334L, F346Y, G359T, V435E, N447S, D460N, R461K, S468T, L491S, E492Q, S519N, K530R, A534S, V548I, A554S  
151 151 Unknown Unknown D67N, M184I Y181C, H221Y K101Q, D123E, I135V, S162C, V245T, Q278E, L283I, A288G, E312A, P313T, Q334L, P345Q, F346Y, M357T, R358K, K366R, A400V, V435E, K454R, D460N, R461K, S468T, L491E, V548I  
154 154 Unknown Unknown M184V K103N, K238N K20R, V35T, K122E, I135T, S162C, Q174H, T200A, Q207A, R211RK, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, V317A, I329V, Q334N, G335D, Y342F, E344D, G359T, T369V, A376S, T377L, K390R, E399D, A400T, E404D, E432D, V435A, L452I, Q464R, V466I, D471E, H483Y, L484I, L491S, S519N, I526V, K530R, A534S, A554S, V559I  
156 156 Unknown Unknown M184V V179D, Y181C, H221Y V35T, E36A, T39D, S48T, D121Y, K122E, I135T, S162C, T200A, Q207E, R211H, D237N, V245Q, A272P, K277R, L283I, T286A, E291D, V292I, I293V, P313T, V317A, S322A, G335D, M357T, G359T, A376S, T377M, T386I, K390R, E399N, A400T, E404D, V435A, D460N, R461K, V467I, S468T, L491A, K512R, S519N, K527R, K530R, A534S, A554S  
162 162 Unknown Unknown M184V Y181C, H221Y V35T, E36A, T39D, S48T, E53D, V60I, V90I, I135V, T139K, S162Y, G196R, Q207E, F214L, V245Q, I257L, A272P, K277R, T286A, E291D, V292I, I293V, K311R, P313S, V317A, R356K, G359T, T377M, K390R, A400T, E404N, Q428H, E432D, V435A, A437V, L452I, Q464K, D471E, H483Y, L484I, L491S, S519N, A534S, A554S  
177 177 Unknown Unknown M41L, M184V, T215Y K103N V35T, T39D, S48T, V60I, W88C, K122E, D123N, I135L, Q207G, R211K, K223T, L228R, V245Q, A272P, K277R, E291D, V292I, I293V, H315Q, V317A, D324E, R356K, G359T, T377M, I382V, K390R, A400T, E404N, E432D, V435A, L452I, Q464K, D471E, H483C, L484I, L491S, S519N, E529D, K530R, A534S, A554S  
2314 2314 Unknown Unknown   V8I, V35T, T39D, S48T, V60I, I135V, S162C, K166KR, K173A, D177E, I178L, G196R, T200A, Q207DE, R211K, V245Q, E248D, A272P, K277R, T286AV, E291ED, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, D471E, H483Y, L484I, L491S, S519N, K527Q, A534S, V548I, A554S  
2315 2315 Unknown Unknown M184V Y181C, Y318F, N348I V35T, E36A, T39D, S48T, V60I, V90I, D121Y, K122E, I135T, S162H, K166R, K173A, D177DE, T200A, Q207E, R211K, V245Q, E248V, A272P, K277R, E291D, I293V, Q334N, G335D, R356K, G359A, A376S, T377R, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, Q480QH, H483Y, L484I, L491S, S519N, K530R, A534S, A554S  
2316 2316 Unknown Unknown  K101E, E138A V35T, E36A, T39D, S48T, V60I, D121Y, K122E, S162C, E169D, G196R, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, A288T, V292I, I293V, Q334P, G335D, P345Q, R356K, G359T, K366R, A376S, T377M, T386TI, K390R, A400T, E404D, V435E, L452I, D460N, R461K, S468T, L469I, L491V, Q524E, K527R, A554S  
2325 2325 Unknown Unknown   V35T, E36A, T39D, S48T, V60I, D121Y, K122E, S162C, I178L, G196R, T200A, Q207EK, R211K, V245Q, A272P, K277R, T286A, A288T, E291D, V292I, I293V, Q334P, G335D, G359T, K366KR, A376S, T377M, K390R, A400T, E404D, V435E, D460N, R461K, V467VI, S468T, L491V, K530R, A554S  
2327 2327 Unknown Unknown  K103N V35T, T39N, V60I, D121Y, K122E, S162A, K173A, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, T286V, E291D, I293V, G335D, R356K, G359T, A376S, T377M, K390R, A400T, E404D, E432D, V435A, Q464R, V466I, D471E, H483Y, L484I, L491S, S519N, K530R, A534S, A554S  
2331 2331 Unknown Unknown   E6D, V35I, T39K, K43E, K173I, Q174K, D177E, V179T, T200A, I202V, Q207E, R211K, V245Q, A272P, R284K, T286A, E291D, V292I, I293V, E297A, L310I, K311N, E312T, I326V, I329V, Q334P, G335D, M357K, G359S, T369A, A371V, K390R, K395R, A400T, T403A, E432D, N447S, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, E529D, A534S, A554S, K558R  
2342 2342 Unknown Unknown  V179D V35T, T39D, S48T, E53D, V60I, S162C, T200A, Q207E, R211K, V245E, A272P, V292I, I293V, E312NT, I326V, I329V, G335D, M357K, G359S, K366R, T369A, A371V, T377M, K395R, A400T, T403M, E432D, N447S, D471E, Q480H, H483Q, L491S, K512R, L517I, S519N, Q524E, A534S, A554S  
2344 2344 Unknown Unknown A62V, M184V  D121H, K122E, Y188N, T200A, I202V, Q207E, R211K, A272P, L283I, R284K, T286A, E291D, V292I, I293V, E297A, L310I, V317T, Q334L, E344D, P345Q, F346Y, N348Y, A360T, T377M, K390R, A400S, E404D, E432D, V435E, A437V, D460N, S468T, L491A, L517I, K527Q, A554S  
2345 2345 Unknown Unknown D67N, M184V, T215Y V106A, F227L V35I, I135L, S162C, V179I, G196E, T200A, H208HY, R211K, K223E, V245Q, A272P, K277R, T286A, E291D, V292I, I309L, Q334L, P345A, F346HY, M357I, A360T, A376S, T386TI, K390R, V435E, L452V, D460N, R461K, V466I, V467I, S468T, L491V, K530R, V548I E203R 
2346 2346 Unknown Unknown   V35T, E36A, T39D, S48T, V60I, D121Y, K122E, V179I, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A, I329V, G335D, R356K, G359T, T377N, A400T, E404D, V417I, V435E, D460N, R461K, S468T, L491T, S519N, A534S, A554N  
2347 2347 Unknown Unknown   I5V, V35T, I135L, S162C, G196E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, Q334L, P345Q, F346Y, V365I, K366R, K390R, T403A, V435E, A437V, L452I, D460S, R461K, V466I, V467I, S468T, H483Y, L491V, V559I  
2349 2349 Unknown Unknown M184V K101E, G190A E28G, V35T, T39K, K43E, S68G, A98S, K173V, Q174K, D177E, V179T, T200I, Q207A, R211S, V245Q, A272P, E291D, V292I, I293V, E312V, I326V, I329V, G335D, M357K, G359S, K366R, T369V, A371V, I382T, K390R, A400T, T403I, E432D, R461K, D471E, Q480H, L491S, L517V, S519N, Q524E, A534S, A554S  
2403 2403 Unknown Unknown   D121Y, K122E, D123DE, S162C, D177E, T200E, Q207E, R211K, V245K, A272P, T286A, E291D, V292I, I293V, I309L, Q334L, P345Q, F346H, M357I, A376S, A400I, E404D, V435E, D460N, R461K, S468T, H483C, L491A, K512Q, S519N, Q524E, K530R, A534S, A554S  
2494 2494 Unknown Unknown M41L, M184V, T215Y K103N, Y181C, N348I V35T, T39N, V60I, T69TN, I135V, Q207E, R211K, L228R, V245Q, K249Q, A272P, K277R, E291D, V292I, I293V, G335D, R356K, G359T, T377R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, V467VI, T470N, D471E, H483Y, L491S, S519N, K530R, A534S, V548I, A554S  
2495 2495 Unknown Unknown   V8I, S68G, K122E, I159V, K173R, Q174E, D177E, I178V, Q207A, K238R, V245E, K275R, K277Q, E291D, V292I, I293V, E312T, I326V, G335D, Y342F, M357K, G359S, K366R, A371V, I375V, K390R, K395R, A400I, E432D, D471E, Q480H, H483Q, L491S, K512R, L517I, Q524E, K530R, A534S, A554N  
2643 2643 Unknown Unknown   V35T, E36EA, T39D, S48T, V60I, K122E, S162H, K166R, K173A, D177DE, T200A, Q207E, R211K, V245Q, A272P, K277R, T286TA, E291D, V292I, I293V, P294V, V317AT, Q334N, G335D, P345Q, R356K, G359T, A376S, T377M, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483Y, L484I, Q487QL, L491S, S519N, K530R, A534S, A554S  
2703 2703 Unknown Unknown   E6D, K20R, V35T, T39K, K43E, K49KR, K122KE, I135T, S162C, K173V, Q174K, D177E, V179T, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, E297G, E312T, I329V, G335D, I341L, M357K, G359S, K366R, T369A, A371V, V381I, I382T, K390R, E399D, A400T, T403M, E432D, V435I, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, A554S L26LM 
502 502 Unknown Unknown  E138A V35T, E36A, T39D, S48T, E53D, V60I, K122KE, I135V, S162C, T200A, Q207E, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, V317A, Q334N, G335D, R356K, G359T, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, T470TN, D471E, H483Y, L484I, L491S, S519SN, Q524E, K530R, A534S, A554S  
506 506 Unknown Unknown  E138A V35T, T39D, S48ST, E53D, V60I, I135V, I142V, S162C, T200A, Q207E, R211K, V245Q, A272P, V292I, I293V, V317A, D324E, G335D, G359T, K366R, T377M, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, V466I, D471E, H483Y, L484I, L491S, S519N, K527KQ, K530R, A534S, A554S  
518 518 Unknown Unknown   V35T, E36A, T39D, S48T, E53D, V60I, D121H, K122E, E169D, T200TA, Q207E, R211K, V245KQ, A272P, K277R, T286TA, V292I, I293V, V317A, S322T, D324E, G335D, R356K, G359T, K366R, T377M, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483C, L484I, L491S, S519N, K530R, A534S, V548I, A554S  
523 523 Unknown Unknown  V106I K122E, I135V, S162C, D177N, Q197H, T200A, Q207E, R211RK, V245Q, A272P, K277R, L283I, T286V, E291D, V292I, I293V, Q334Y, G335D, R356K, G359T, E432D, V435E, N447S, D460N, R461K, S468T, L469I, T470A, L491S, K530R, V548I  
568 568 Unknown Unknown  V179E V35T, E36A, T39E, S48T, V60I, K102M, I135V, T165TI, Q207E, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, G335D, R356K, G359T, K366R, T377M, K390R, A400T, E404D, E432D, V435A, L452M, Q464K, V466IT, H483Y, L484I, L491S, E516ED, S519N, K530R, A534S, A554S  
580 580 Unknown Unknown   V35MT, E36A, T39D, S48T, V60I, D121Y, K122E, D177E, V245Q, A272P, K277R, E291D, I293V, I309L, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, D471E, H483C, L491S, S519N, K527R, A534S, A554S  
612 612 Unknown Unknown  V179D E6D, V35T, T39K, K43E, V111I, D123E, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, V292I, I293V, G333E, R356K, G359N, A360T, K366R, T377M, K390R, E432D, L452I, D471E, Q480H, L491S, I506L, K512R, L517V, S519N, Q524E, E529D, A534S, A554S  
614 614 Unknown Unknown   V35T, E36A, T39D, S48T, V60I, I135V, S162C, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, G359T, V381I, T386I, K390R, A400T, E404D, E432D, V435A, L452I, Q464R, V466I, D471E, H483C, L484I, L491S, S519N, K530R, A534S, A554S  
639 639 Unknown Unknown   V35T, E36A, T39D, S48T, E53D, V60I, I135V, S162C, I178IL, Q207E, R211K, V245Q, A272P, K277R, V292I, I293V, D324E, G335D, R356K, G359T, K366R, T377X, V381I, T386I, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, D471E, H483Y, L484I, L491S, S519N, K530R, A534S, A554S  
647 647 Unknown Unknown   V8I, K11S, V35T, T39N, S48T, V60I, K102KQ, D121Y, K122E, K166R, T200I, R211K, V245Q, E248V, A272P, K277R, I293V, P313T, Q334N, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483C, L484I, L491S, S519N, K530R, A534S, A554S  
683 683 Unknown Unknown   E6EK, V35T, E36A, T39D, S48T, E53D, V60I, K122E, I135V, S162C, Q174K, T200A, Q207EK, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, S322A, G335D, E344D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V467I, D471E, H483Y, L484I, L491S, S519N, K527N, K530R, A534S, A554S  
694 694 Unknown Unknown   V35I, S68G, T107S, I135V, I159V, Q174E, D177E, I178MV, E203D, Q207A, K238R, V245E, K277Q, T286A, E291D, V292I, I293V, L310I, E312T, I326V, G335D, Y342F, M357K, G359S, K366R, A371V, K390R, K395R, A400T, E432D, D471E, Q480H, H483Q, L491S, K512R, L517I, Q524E, K530R, A534S, A554N  
712 712 Unknown Unknown   I5V, K11Q, V35T, T39E, S48T, V60I, D121Y, K122E, D177E, Q207D, L210F, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, G335D, R356K, G359T, T377V, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483Y, L484I, Q487R, L491S, K530R, A534S, A554S  
721 721 Unknown Unknown  V179VD K20R, V35T, E36A, T39D, S48T, E53D, V60I, D121Y, K122E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294Q, E297A, V317A, G335D, R356K, G359T, T377M, T386I, K388R, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483C, L491S, S519N, K527R, K530R, A534S, A554S  
728 728 Unknown Unknown   V35T, E36A, T39E, S48T, E53D, V60I, T107S, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, K366R, T377I, T386V, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483Y, L484I, L491S, S519N, Q520S, K527R, K530R, A534S, A554S  
744 744 Unknown Unknown   K32E, V35T, E36A, T39E, S48T, V60I, I135R, R211K, V245Q, S251N, A272P, K277R, T286A, E291D, V292I, I293V, V317T, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452M, Q464K, V466I, D471E, H483Y, L491S, S519N, K530R, A534S, A554T, K558R  
758 758 Unknown Unknown M184V K103N V35T, E36A, T39D, G45R, S48T, V60I, D121H, K122E, I135M, K166R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K275R, K277R, E291D, V292I, I293V, V317A, G335D, P345Q, G359T, T369V, A371V, T377M, K390R, A400T, E404D, E432D, V435A, Q464K, V466I, D471E, H483Y, L484I, L491S, S519N, K530R, A534S, V536A P433S 
778 778 Unknown Unknown   V35T, E36A, T39E, S48T, E53D, V60I, I135V, T139A, S162C, Q207E, R211K, V245Q, V292I, I293V, E312T, I326V, I329V, G335D, M357K, G359S, T369A, A371V, T377M, A400T, T403M, N447S, D471E, Q480H, H483Q, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
792 792 Unknown Unknown A62V, K65R, K70T, V75I, F116Y, Q151M Y181C, G190A E6D, L34I, V35T, T39K, K43E, V60I, S68G, T69I, E79D, K103R, V118I, I135V, T165I, K173I, Q174K, D177E, I178L, V179T, G196E, T200I, E203EK, Q207A, R211S, F214L, D218E, K223KE, V245Q, A272P, V276T, K277R, E291D, V292I, I293V, E312T, V317A, I326V, I329V, G335D, P345T, M357K, G359S, K366R, T369V, A371V, Q373H, I382T, K390R, A400T, E432D, N447S, R461K, D471E, Q480H, H483Y, L491S, K512R, L517I, V518I, S519N, Q524E, A534S, Q547K, A554S  
801 801 Unknown Unknown   I135V, S162C, R211K, V245I, Q278E, L283I, V292I, Q334L, F346Y, M357V, Q373H, E432D, N447S, D471E, Q480H, L491S, K512R, E516K, L517V, S519N, Q524E, A534S, A554S Y532Y_H 
803 803 Unknown Unknown   V35T, E36A, T39N, S48T, V60I, K103R, D121H, K122E, S162C, D177E, T200V, Q207E, R211K, V245R, K277R, Q278E, E312T, D324E, Q334L, F346H, A376S, V435E, N447S, R461K, S468T, L491S, S519N, K530R, A534S, A554S  
813 813 Unknown Unknown   V35T, E36A, T39E, S48T, V60I, D121Y, K122E, K166R, K173A, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, P345Q, R356K, G359T, T377L, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466VI, D471E, H483Y, L484I, L491S, S519N, K530R, A534S  
814 814 Unknown Unknown   V8VI, V35T, T39D, S48T, V60I, D121Y, K122E, K166R, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311Q, Q334K, G335D, R356K, G359T, T377M, S379SC, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483Y, L484I, L491S, S519N, K530R, A534S  
816 816 Unknown Unknown   V35T, E36A, T39D, S48T, V60I, D121Y, K122E, K173AT, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359T, T377L, V381VI, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464K, V466I, D471E, H483Y, L484I, L491S, S519N, K530R, A534S  
818 818 Unknown Unknown   V35T, E36A, T39D, S48T, V60I, D121Y, K122E, I135V, K173A, D177E, V179I, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, H315Q, V317A, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, L452I, D460N, R461K, S468T, L491S, S519N, K530R, A534S, A554S L109P 
822 822 Unknown Unknown   V35T, T39D, S48T, V60I, D121H, K122E, K173T, Q174R, D177E, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483Y, L484I, L491S, S519N, K530R, A534S, A554S  
823 823 Unknown Unknown   V35T, E36A, T39D, S48T, V60I, K103R, D121Y, K122E, K166R, K173A, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335D, K350R, R356K, G359T, T377L, K390R, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483Y, L484I, L491S, S519N, K530R, A534S  

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