Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Sigaloff (2013)
Title Short communication: high rates of thymidine analogue mutations and dual-class resistance among HIV-infected Ugandan children failing first-line antiretroviral therapy.
Citation ARHR
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 44
NumPts 44
Subtype A, D, B, C

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
JCR011_0 JCR011_0 NRTI NNRTI M41L, M184V, L210W, T215Y Y181C, H221Y E6D, V35T, E44D, V60I, V111I, K122E, I135L, K166R, D177E, I178M, V179I, E203K, Q207D, H208Y, R211K, V245Q, D250E, A272P, K277R, L282C, E297A  
JCR017_0 JCR017_0 NRTI NNRTI M184V K103N, P225H, K238T V35T, T39N, K122E, D123S, I135L, K173A, T200A, Q207A, R211K, V245Q, D250E, A272P, K275R, T286A, E291D, V292I, I293V, P294T  
JCR022_0 JCR022_0 NRTI NNRTI M184V G190A V35T, T39L, V60I, D121Y, K122E, I135V, D177E, I178M, V179I, Q197K, T200A, Q207G, R211K, D237E, V245K, D250E, S251N, A272P, I274V, V276T, K277R, L282C, T286A, E297A L283V 
JCR024_0 JCR024_0 NRTI NNRTI M184V A98G, K103N, P225H V35T, E40D, K49R, V60I, D121H, K122E, I135T, S162A, N175H, D177E, I178M, T200M, K201I, Q207E, R211K, F214L, V245T, D250E, A272P, K277R  
JCR046_0 JCR046_0 NRTI NNRTI M41L, M184V, T215Y Y181V V35T, K49R, V60I, D121Y, K122E, I135T, S162SN, T200V, Q207AG, R211K, L228H, V245VI, A272P, K277R, K281R, L282C, R284K, T286A, V292I, E297K  
JCR047_0 JCR047_0 NRTI NNRTI D67G, T69D, K70R, M184V A98G, V108I, Y181C V35T, K43E, K49R, V60I, I94L, K122E, I135M, S163SC, T165L, R172K, D177E, I178M, T200I, E204K, Q207E, R211K, K219H, E224K, V245K, D250E, A272P, Q278H, L282C, L283I, T286A, A288T E203R 
JCR049_0 JCR049_0 NRTI NNRTI K65R, Y115F G190A K11T, K20R, V21I, V35T, T39K, E40D, V60I, K122E, D123N, K173S, Q174K, D177E, V179I, G196A, I202V, Q207A, R211S, V245Q, E248N, A272P, I274V, T286A, E291D, P294T  
JCR061_0 JCR061_0 NRTI NNRTI D67G, K70R, M184V, K219Q A98G, K103N K11T, K20R, V35T, T39A, E40D, K43R, V60I, S68G, K122E, D123N, I135T, K173A, Q174K, D177E, G196E, Q197K, T200A, Q207A, R211S, F214L, D218E, V245E, I293V, P294T P97PS 
JCR066_0 JCR066_0 NRTI NNRTI  E138A V35T, E40ED, V60I, D121H, K122E, D123S, I135T, I142V, S162A, K173S, Q174K, V179I, T200E, I202V, Q207A, R211S, E248D, L283I, T286A, E291D, V292I, I293V, P294T, L295M  
JCR070_0 JCR070_0 NRTI NNRTI M184V, K219Q E138A, G190A E6D, K20R, V35T, E40D, E42K, K43R, K46R, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, E203K, Q207D, R211K, V245Q, E248D, D250E, T286A, E291D, I293V, P294T, E312D  
JCR073_0 JCR073_0 NRTI NNRTI T69D, K70R, M184V Y181C V21I, V35T, T39S, K49R, V60I, D121Y, K122E, I135M, I142V, S162N, K166R, D177E, I178M, T200A, Q207E, R211K, L228R, V245K, D250E, A272P, K277R, L282C, T286A, I293V, E297A  
JCR077_0 JCR077_0 NRTI NNRTI M41L, T69D, K70KR, M184V, L210W, T215F K101E, Y181C, K238T V35T, V60I, V118VI, D121Y, K122E, I135R, D177E, V179I, Q207E, R211K, L228R, V245K, D250E, I257L, A272P, K281R, L282C, T286A, E291A, I293V  
JCR079_0 JCR079_0 NRTI NNRTI V75M, M184V V106A, F227L V35T, T39K, S48T, K122E, I135V, T200A, Q207A, R211K, V245Q, D250E, S251D, A272P, K277R, T286A, E291D, V292I, I293V, P294T R172RS, K173PT 
JCR083_0 JCR083_0 NRTI NNRTI D67N, T69D, K70R, M184V, T215F, K219Q K103N, P225H E6D, K20R, E28A, V35T, V60I, W88C, I94L, K101Q, V118I, K122E, D123S, I135T, E169D, K173A, Q174K, D177E, I178L, E194D, G196E, T200A, Q207E, F214L, V245K, D250E, K277R, E291D, V292I, I293V, P294T  
JCR092_0 JCR092_0 NRTI NNRTI D67N, K70R, M184V, K219Q K101E, E138A, G190A V35T, T39A, E40D, V60I, K122E, D123S, I135T, I202V, Q207A, R211S, F214L, V245M, D250E, A272P, K277R, K281R, L282C, L283I, T286A, I293V  
JCR093_0 JCR093_0 NRTI NNRTI M184V, T215Y K103N V35T, T39K, S48T, K49R, V60I, A98S, D121Y, K122E, I135T, D177E, I178M, T200A, Q207E, R211K, V245K, E248D, A272P, K277R, K281R, L282C, T286A, I293V, I309L  
JCR099_0 JCR099_0 NRTI NNRTI K65R, Y115F Y181C P4T, E28K, V35T, E40ED, V60I, R72K, V118I, I135T, I142V, A158S, K173E, D177E, Q207E, R211K, F214L, V245E, D250E, A272S, K275R, L282C, I293V P243K 
JCR101_0 JCR101_0 NRTI NNRTI M184V V106VI, Y188L V35T, T39M, V60I, I135V, D177E, Q207E, R211K, F214FL, V245K, D250E, A272P, K277R, L282C, V292I, E297A  
JCR104_0 JCR104_0 NRTI NNRTI L74V, Y115F, M184V Y181I E6D, V35T, T39K, V60I, W88C, K122E, D123G, K173S, Q174K, D177E, V179I, T200A, Q207A, F214L, V245E, D250E, I257L, V261I, T286A, E291D, I293V, K311R  
JCR109_0 JCR109_0 NRTI NNRTI D67N, K70R, M184V, T215I, K219E A98G, Y181C E6S, V35T, V60I, D121Y, K122E, I135IT, K173T, Q174K, D177E, V179I, G190X, I202V, Q207A, R211S, F214L, L228H, V245E, E248D, D250E, I293V, P294T  
JCR111_0 JCR111_0 NRTI NNRTI M184V, T215F K101E, G190A E28R, V35T, K49R, V60I, A98S, K122E, I135T, I142V, D177E, V179I, Q207E, R211K, V245Q, D250E, K277R, L282C, E297A  
JCR113_0 JCR113_0 NRTI NNRTI M41L, D67N, M184V, L210W, T215Y A98G, G190A E6N, K11Q, V35T, E44D, K49R, V60I, V75VL, I94L, K101Q, D121Y, K122E, I135M, T165I, D177E, Q207E, R211K, V245Q, L282C, L283I, K287R, I293V V111IM 
JCR116_0 JCR116_0 NRTI NNRTI M184V, T215Y K103N K11KR, K20R, V35T, K49R, V60I, T69S, D121Y, K122E, I135T, A158S, D177E, T200I, Q207E, R211K, D237N, V245N, D250E, A272S, K281R, L282C, L283I, T286A, V292I, I293V  
JCR117_0 JCR117_0 NRTI NNRTI M184V K103N K11T, K20R, K32R, V35T, E40ED, K122E, D123S, S162HN, K173S, Q174K, D177E, V179I, G196K, T200A, I202V, Q207A, R211S, D237E, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E312D  
JCR118_0 JCR118_0 NRTI NNRTI M184V K103N V35T, T39K, K43E, K49R, V60I, S68G, V90I, D121Y, K122E, D123E, S162D, D177E, I178L, T200Q, E204D, Q207G, R211K, P243S, V245K, D250E, A272P, K275R, K277R, L282C, T286A, I293V  
JCR120_0 JCR120_0 NRTI NNRTI M184V, T215F K101E, G190A K20R, V21I, E28K, V35T, T39S, V60I, K122E, D123N, I135T, Q145V, K173A, D177E, V179I, T200A, I202V, Q207AT, R211K, V245Q, E248D, A272P, T286A, E291D, P294T, E297K  
JFP048_0 JFP048_0 NRTI NNRTI M41L, D67N, K70R, M184V, T215F, K219E E138Q, G190A K11T, K20R, V35T, T39N, K43R, E44D, V60I, T69N, K102Q, K122E, D123S, S162A, K173T, D177E, I178F, V179I, G196K, T200K, E203D, Q207A, R211K, L228H, V245Q, E248D, K259KR, K277R, Q278H, E291D, V292I, I293V, E312K  
JFP058_0 JFP058_0 NRTI NNRTI D67N, K70R, M184V, K219Q A98G, K103N, P225H V35T, E40D, V60I, T69S, K122E, D123N, I135L, D177E, T200I, Q207E, R211K, L228H, V245K, D250E, A272S, L282C, L283I, T286A, I293V  
JFP103_0 JFP103_0 NRTI NNRTI M41L, D67N, K70R, L74I, M184V, L210W, T215F, K219Q A98G, K101E, G190A K20R, E28K, K32Q, V35T, T39E, T69N, I94L, K103R, K122E, D123N, S162SN, K173S, Q174K, D177E, T200A, Q207A, R211N, D218E, V245Q, E248D, D250E, S251D, R284K, T286A, E291D, V292I, I293V, P294T, E312N  
MBA005_0 MBA005_0 NRTI NNRTI M41L, D67N, V75M, M184V, T215Y K101E, K103N, G190A K20R, T27S, E28A, V35T, E44ED, V60I, K122E, D123S, I135T, I142Q, K173S, Q174K, D192N, T200A, E203K, Q207D, R211K, V245T, D250E, A272P, T286A, E291D, V292I, I293V  
MBA031_0 MBA031_0 NRTI NNRTI D67N, K70R, M184V, T215F, K219E K101E, G190A V35T, T39L, D121Y, K122E, D177E, I178V, E204Q, Q207E, V245K, D250E, A272P, I274L, K275R, Q278N, T286A  
MBA036_0 MBA036_0 NRTI NNRTI M184V K103N, P225H, K238T V35T, V60I, I142V, S162C, D177E, I178M, Q197E, T200K, Q207K, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, I293V  
MBA041_0 MBA041_0 NRTI NNRTI M41L, M184V, L210W, T215Y Y188L, G190A K11T, V35T, T39K, K43E, K49R, V60I, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, T200A, Q207A, R211N, V245Q, A272P, K275R, E291D, I293V, P294T  
MBA043_0 MBA043_0 NRTI NNRTI D67N, K70R, M184V, T215F, K219E K101E, G190A V35T, T39L, D121Y, K122E, D177E, I178V, E204Q, Q207E, V245K, D250E, A272P, I274L, K275R, Q278N, T286A  
MBA046_0 MBA046_0 NRTI NNRTI M184V A98G, K103N, Y181C E6D, V21I, E28EK, V35T, T39A, E40D, V60I, K122E, D123N, I135T, S162A, K173S, Q174K, D177E, V179I, T200A, I202V, Q207E, R211S, V245E, D250E, S251H, K281R, T286A, E291D, V292I, I293V, P294T, K311R  
MBA047_0 MBA047_0 NRTI NNRTI M184V G190A E6D, K20R, V21I, V35T, T39A, E40D, V60I, K122E, D123N, I135T, S162A, K173S, Q174K, D177E, V179I, V189I, T200A, I202V, Q207E, R211K, V245E, D250E, S251H, A272P, T286A, E291D, V292I, I293V, P294T  
MBA049_0 MBA049_0 NRTI NNRTI D67DN, K70KR, M184V K101E, G190A V35T, T39A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, Q207E, R211K, F214L, V245E, D250E, A272P, K277R, Q278H, L282C, I293V, E297Q  
MBA054_0 MBA054_0 NRTI NNRTI M184V K103N, P225H E6D, V35T, E40D, V60I, V118I, K122E, D123S, I135T, T165L, K173A, Q174N, D177E, T200TA, Q207A, R211S, F214L, V245E, D250E, A272P, K277R, K281R, T286A, E291D, I293V  
MBA059_0 MBA059_0 NRTI NNRTI M184V K103N P4T, V35T, E36A, T39E, S48T, D121Y, K122E, I135T, S162C, D177E, T200A, Q207A, R211K, V245Q, A272P, K281R, T286A, E291D, I293V, P294T  
MBA063_0 MBA063_0 NRTI NNRTI D67N, K70R, M184V, T215F, K219E Y188L K11T, K20R, V21I, V35T, T39R, K43E, T69N, V106L, L109I, K122E, D123N, K173A, Q174K, D177E, V179I, I202V, Q207A, R211S, K238E, V245Q, E248D, K281R, T286A, E291D, V292I, I293V, P294T, E297K  
MBA064_0 MBA064_0 NRTI NNRTI D67N, K70R, M184V, K219Q K103N, V108I, H221Y P4S, E6D, V35T, V60I, K64R, A98S, T107S, V111I, I135M, S162H, K173S, Q174R, D177E, T200A, E203K, Q207D, H208Y, R211S, F214L, V245E, D250E, K277R, T286A, V292I, I293V  
MBA079_0 MBA079_0 NRTI NNRTI M41L, T69D, M184V, T215Y K103N, V108I, M230L V35T, K43E, E44A, V60I, V111I, V118I, K122E, D123S, K173L, Q174K, D177E, V189I, T200A, R206K, Q207A, L210S, R211S, L228R, V245E, A272P, K275Q, K277R, T286A, E291D, I293V, P294T, E297K T216M 
MBA093_0 MBA093_0 NRTI NNRTI M41L, T69D, M184V, L210W, T215Y K101H, Y181C, G190A E28A, V35T, E44D, K49R, V60I, K122E, I135T, T139R, T165I, D177E, T200I, Q207E, R211K, L228R, V245K, D250E, A272P, K275R, L282C, L283I, T286A, V292I, I293V, G316E  
MBA094_0 MBA094_0 NRTI NNRTI D67N, K70R, M184V, L210W, T215Y, K219E K103N V35T, E40D, K49R, V60I, D123E, Q174K, D177E, Q207E, R211K, P243PS, V245K, A272P, K277R, L282C, L283I, T286A, A288T, I293V, E297A  

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