Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Puthanakit (2010)
Title HIV-1 drug resistance mutations in children after failure of first-line nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy.
Citation HIV Med
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 72
NumPts 72
Subtype CRF01_AE, B, A

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
CR1376 CR1376 AZT, 3TC NVP D67N, K70R, M184V, T215F, K219E Y188L, G190A V35T, T39N, K122E, D123S, R172K, K173I, Q174K, D177E, I178L, V179I, Q207A, R211S, K238R, V245E  
CR1509 CR1509 3TC, D4T NVP D67N, M184V, T215F K101E, G190A E28K, V35T, T39K, K43E, V60I, K166R, K173A, Q174R, D177E, V179T, V189I, T200I, Q207A, R211S, V245E  
CR1511 CR1511 3TC, D4T NVP V75M, M184V G190A V35T, T39K, K43E, R72K, K122E, D123S, I135V, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S  
CR1513 CR1513 3TC, D4T NVP M184V Y181C, H221Y V35T, T39Q, E42G, G45R, S68G, K122E, D123S, I135T, A158T, K166R, R172K, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, E203D, Q207A, R211S, K238R, V245E  
CR1514 CR1514 3TC, D4T NVP M184V V108I, Y181C V35T, T39K, K43E, K102R, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E  
CR1515 CR1515 3TC, D4T NVP M184V, T215F K101E, G190S V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, G196R, I202V, Q207A, R211S, V245E  
CR1517 CR1517 3TC, D4T NVP F116Y, Q151M, M184I K103N, Y181C V35T, T39K, K122E, D123S, S162C, T200A, Q207A, R211S, F214L, K238R, V245E  
CR1720 CR1720 3TC, D4T NVP M41L, M184V, T215Y A98G, Y181C, H221Y V35T, T39K, K43E, E44A, S68G, V111I, I135T, S163T, T165I, K173T, Q174K, D177E, I178L, T200A, Q207A, R211S, K238R, V245K  
CR1748 CR1748 3TC, D4T NVP V75I, M184V Y181C I31L, V35T, T39K, K43E, K122E, D123S, I132L, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, V245E  
CR1851 CR1851 3TC, D4T NVP D67N, T69D, M184V, L210W, T215F K101H, Y181C, G190A V35T, T39K, K43E, K122E, D123S, I135T, K173I, Q174K, D177E, T200I, Q207A, R211S, K238R, V245N  
CR1893 CR1893 AZT, 3TC NVP D67N, K70R, M184V, T215F, K219E K103N E28A, V35T, T39Q, M41I, K122E, D123S, I135T, K173T, Q174K, D177E, I178M, T200A, E203Q, Q207D, R211K, K238S, V245Q E44I, G45S, P236R 
CR2283 CR2283 3TC, D4T NVP D67G, K219E G190Q V35T, T39E, K122E, D123S, I135T, S162C, S163C, K173I, Q174K, T200A, Q207A, R211S, K238R, V245E  
CR2525 CR2525 3TC, D4T NVP M184V, T215F K101H, Y181V V35T, T39E, K122E, D123S, I135T, K173I, Q174K, D177E, I180V, T200A, Q207A, R211S, D218E, V245Q  
CR2532 CR2532 3TC, D4T NVP F116Y, Q151M, M184V K103N, Y188L V35T, T39E, S68G, K104R, K122E, D123S, I135T, R172K, K173L, Q174K, D177E, I178L, V179T, T200I, I202V, Q207A, R211S, L228H, V245E, D250E  
CR2534 CR2534 3TC, D4T NVP M184V Y181C V35T, T39K, K43E, K49R, T69N, A98S, K101R, K122E, D123N, I135T, R172K, K173I, Q174K, D177E, I178L, T200A, Q207A, R211K, V245E  
CR2538 CR2538 3TC, D4T NVP D67N K103N, G190A V35T, T39K, K43E, K122E, D123S, S162C, T165I, K173T, Q174K, D177E, I178M, T200A, Q207A, R211K, V245Q  
CR2544 CR2544 3TC, D4T NVP M184V K103N, E138Q V35T, T39K, K43E, T69S, K122E, D123S, S162C, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, V245E  
CR2545 CR2545 3TC, D4T NVP F116Y, Q151M, M184V Y181C V35T, T39K, K43E, S68G, K122E, D123N, I135V, R172K, K173I, Q174K, D177E, I178L, T200I, Q207A, R211S, V245E  
CR3096 CR3096 3TC, D4T NVP K70R, M184V, T215F, K219Q K101E, G190A V35T, T39K, K43E, K122E, D123S, S162C, K173T, Q174K, D177E, T200R, Q207A, R211S, K238R, V245E  
CR3097 CR3097 3TC, D4T NVP A62V, D67E, T69S_TS, M184V, L210W, T215F V106I, Y188L V35T, T39K, K43E, G45R, K64R, L109I, K122E, D123S, I135T, S162Y, K166R, K173I, Q174K, D177E, T200A, I202V, Q207A, R211S, L228H  
CR3131 CR3131 3TC, D4T NVP M41L, D67N, T69D, K70R, M184V, T215F, K219Q Y181V V35T, T39K, K43E, V60I, K122E, D123S, S162D, Q174K, D177E, I178M, V179I, T200A, Q207A, R211S, D218E, L228H, D237E, K238R, V245Q  
CR3194 CR3194 AZT, 3TC NVP M41L, D67N, M184V, L210W, T215Y K101E, V106M, G190A E28K, K32E, V35T, T39K, K43E, E44A, I94L, V111I, K122E, D123S, K173I, Q174K, D177E, V179I, Q207A, R211N, V245E  
CR3197 CR3197 AZT, 3TC NVP D67G, K70R, M184V, T215F, K219E K101E, G190A V35T, T39K, K43E, S68G, K122E, D123S, I135T, K166R, K173I, Q174K, D177E, V179I, T200A, Q207A, R211S, P236L, K238R, V245E  
CR3237 CR3237 AZT, 3TC NVP M184V K103N, P225H I31L, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211K, V245E  
CR3290 CR3290 3TC, D4T NVP M41L, D67N, M184V, L210W, T215Y E138Q, G190A V35T, T39K, K43E, E44D, K101A, K102Q, V118I, D121H, K122E, D123S, S162C, K173I, Q174K, D177E, T200A, Q207A, R211N, K238R, V245E  
CR3300 CR3300 AZT, 3TC NVP D67N, K70R, V75I, M184V, T215I, K219E K101E, V108I, Y181C, H221Y, M230L K20R, V35T, T39K, K43E, K122E, D123S, S162C, K173T, Q174K, D177E, T200A, I202V, Q207A, R211K, V245E  
CR3338 CR3338 3TC, D4T NVP D67N, K70R, M184V, T215F, K219Q K101E, Y181V E28K, V35T, T39K, K43E, T69N, K122E, D123S, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, T240K, V245E  
CR3339 CR3339 AZT, 3TC NVP M41L, D67N, K70R, V75M, M184V, T215F, K219Q K103N, V108I, Y181C, H221Y V35T, T39K, K43E, K49R, V60I, K122E, D123S, T139K, K173I, Q174K, D177E, T200A, Q207A, R211S, K238R, V245E  
CR3405 CR3405 3TC, D4T NVP M41L, M184V, L210W, T215Y V108I, Y181C, H221Y V35T, T39K, K43E, S68G, K122E, D123S, K173T, Q174K, D177E, V179I, Q207A, R211S, K238R, V245E  
CR3406 CR3406 3TC, D4T NVP M41L, M184V, T215Y A98G, Y181C K20R, L34I, V35T, T39R, K43E, K49R, V111I, K122P, D123S, I167V, K173T, Q174K, D177E, G196E, T200A, Q207A, R211S, V245E  
CR3410 CR3410 3TC, D4T NVP M184V K103N, Y181C V35T, T39K, K43E, K49R, V60I, K64R, K122E, D123S, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, V245E  
CR3456 CR3456 AZT, 3TC NVP V75I, M184V, T215Y, K219N Y181C V35T, T39K, K43A, K122E, D123S, I132L, S162C, R172K, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E  
CR3522 CR3522 3TC, D4T NVP K70R, V75I, M184V V108I, Y181C V35T, T39K, K43E, T58S, K101Q, K122E, D123S, A158T, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, F214L, L228H, V245E  
CR3586 CR3586 3TC, D4T NVP M184V, L210W, T215Y Y188L V35T, T39K, K43E, K122E, D123S, K173T, Q174K, N175Y, D177E, G196E, T200A, Q207A, R211S  
CR3665 CR3665 3TC, D4T NVP M184V K101H, Y181C, H221Y K20R, V35T, T39K, K43E, K122E, D123S, S162C, K173R, Q174K, D177E, I178M, Q207A, R211S, V245Q  
CR3767 CR3767 3TC, D4T NVP M41L, V75M, M184V, T215F Y181C K32I, V35T, T39K, K43A, K49R, V60L, V90I, K122E, D123S, I135V, S162D, K166R, K173I, Q174K, D177E, I178M, V179I, Q207A, R211S, F214L, K238R, V245E  
PHPT004 PHPT004 AZT, DDI, 3TC, D4T NVP D67N, T69D, K70R, L74IV, M184MIV, T215F, K219Q K103N, Y181C K43E, V60VI, K122E, D123S, I135T, S162C, K173I, Q174K, D177E, I178M, G196E, T200A, E203D, Q207A, R211S  
PHPT005 PHPT005 3TC, D4T NVP D67N, K70KR, M184I Y181C, H221Y V8I, K20R, V35T, E36D, T39K, K43E, V90VI, K122E, D123S, I135T, T165L, E169EG, K173I, Q174K, T200A, I202V, Q207A, R211S  
PHPT011 PHPT011 3TC, D4T EFV M41L, D67N, M184V, L210W, T215Y K103N, V108I V35T, T39K, K43E, V60I, V75VL, K102Q, V118VI, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, G196E, K201R, Q207A, R211S  
PHPT019 PHPT019 3TC, D4T NVP A62V, D67N, V75VI, F77L, F116Y, Q151M, M184V Y181C, G190A, H221Y V35T, T39K, K43E, K122E, D123S, K166R, K173I, Q174K, D177E, T200I, I202V, Q207D  
PHPT026 PHPT026 3TC, D4T NVP L74V, M184V K101E, Y181C, G190A V35T, T39K, K43E, V111I, K122E, D123S, K173I, Q174K, D177E, V179I, T200A, Q207A, R211S, F214FL, L228LR, K238R  
PHPT027 PHPT027 3TC, D4T EFV A62AV, F116Y, Q151M, M184V K103N, Y188L T39K, K43E, S68G, K101Q, S105ST, K122E, D123N, I135T, T165I, R172K, K173I, Q174K, Q182H, G196E, T200A, Q207A, R211S, F214L, K238R  
PHPT028 PHPT028 3TC, D4T NVP L74V, M184V, T215Y K103N, V108I, Y181C, H221Y K122E, D123E, I135V, Q174R, N175Y, Q197E, T200E, Q207E, R211K  
PHPT029 PHPT029 3TC, D4T NVP A62V, V75I, F116Y, Q151M, M184V A98G, K101E, V106I, G190A V35T, T39K, K43E, T58S, S68G, T69N, K122E, D123S, S162CY, K173I, Q174K, D177E, I178M, G196A, Q207A, R211S, F214X, E224D F77V 
PHPT037 PHPT037 3TC, D4T, AZT NVP, EFV M41L, V75M, F77L, M184V, L210W, T215F, K219N K103N, M230L V35T, T39K, K43E, E44A, K49R, V111I, K122E, D123S, K173T, Q174K, D177E, I178M, V179I, T200A, I202V, Q207A, H208HY, R211N, H221C, L228R, V245E P225R 
PHPT101 PHPT101 AZT, 3TC NVP D67DN, M184V K101E, G190A E6D, K11T, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, K238R Q23QL 
PHPT105 PHPT105 AZT, 3TC NVP M184V, T215F K101E, V106I, G190S E6D, K11T, V35T, T39K, K43E, S68G, K122E, D123S, I135T, K173I, Q174K, Q207A, R211S, E233D, K238R L234F 
PHPT110 PHPT110 3TC, D4T, AZT NVP, EFV M184V A98AG, K103N, V108I V35T, T39K, K43E, V60I, D121H, K122E, I135L, K173T, Q174K, D177E, V189I, Q207A, R211S, T215P  
PHPT111 PHPT111 3TC, D4T NVP M184V Y181C K11T, K32I, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, V179I, Q207A, R211N, K238R  
PHPT113 PHPT113 3TC, D4T NVP M184V, K219N K103N, Y181C V35T, T39E, K122E, D123N, K166R, K173I, Q174K, T200A, Q207A, R211S, L228LR  
PHPT114 PHPT114 3TC, D4T NVP  Y181YC, G190GA T107S, K122E, S162C, T200A, Q207E  
PHPT115 PHPT115 3TC, D4T NVP M184V V108I, Y181C T39K, K43E, K122E, D123S, R172K, K173I, Q174K, D177E, I178M, Q207A, R211S  
PHPT116 PHPT116 3TC, D4T NVP M184V K103T, H221HY, M230L V35T, K122E, D123N, S162C, K173L, Q174K, D177E, I178L, T200A, Q207E, K238R  
PHPT121 PHPT121 3TC, D4T NVP A62AV, M184V K103N, E138EG T39K, K43E, K49KR, K122E, D123S, I135IL, T139A, K173T, Q174K, D177DE, I178M, T200A, Q207A, R211S, K238R  
PHPT122 PHPT122 3TC, D4T NVP M184V K103N V35T, T39K, K43E, K122E, D123S, T165L, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S  
PHPT123 PHPT123 3TC, D4T EFV M184V K103N, V179E V35T, T39K, K43E, K122E, D123S, I135T, K173I, Q174K, D177E, I202V, Q207A, R211S  
PHPT125 PHPT125 3TC, D4T EFV V75VI, T215TN K101E, K103N, Y188L E6D, K32R, V35T, T39E, V60I, S68G, K122E, D123NS, I135R, K166R, K173I, Q174K, D177E, T200A, I202V, Q207A, R211S  
PHPT126 PHPT126 3TC, D4T NVP M184V Y181C K43E, K122E, D123S, K173I, Q174K, D177E, T200E, Q207A, R211S, L228LR  
PHPT127 PHPT127 3TC, D4T NVP V75M, M184V V108I, Y181C, H221HY E6D, V35T, T39K, K43E, K122E, D123S, I142V, K173I, Q174K, D177E, I178M, T200L, Q207A, R211S, L228R, K238R  
PHPT129 PHPT129 3TC, D4T NVP M184V K101E, V106I, G190A V35T, T39K, K43Q, V60I, S68G, V90I, K122E, D123S, I135T, T165I, Q174E, I178M, Q207A, R211S Q23QL 
PHPT130 PHPT130 3TC, D4T NVP D67DN, M184V Y181YC, G190A V35T, T39K, K43E, K49R, K122E, D123S, I135T, K173I, Q174K, D177E, Q207A, R211N, K238R  
PHPT132 PHPT132 3TC, D4T NVP D67N, M184V, T215F Y181C V35T, T39E, K122E, D123S, I135R, K173R, Q174K, D177E, V179I, G196GE, I202V, Q207A, R211S  
PHPT133 PHPT133 3TC, D4T EFV, NVP A62AV, D67DN, V75VA, M184V V179D, Y188L, H221HY V35T, T39E, K103R, V111I, K122E, D123S, I135T, K166R, K173I, Q174K, G196GE, Q207A, R211S, F214C, K238R  
PHPT134 PHPT134 3TC, D4T NVP A62V, M184V K101KE, V108VI, Y181C, H221Y E6D, K11T, K20R, V35T, T39K, K43E, S68G, V75X, K122E, D123S, I135R, S163T, K173L, Q174K, D177E, I178L, V179VI, Q207A, R211S, T215X  
PHPT137 PHPT137 3TC, D4T NVP D67N, K70R, M184MV, T215SY, K219Q K101KE, Y181YC, G190GA K122E, D123N, I135IT, I142IT, K173IT, Q174K, D177E, I178M, Q207A, R211S, F214FL, L228LR  
PHPT138 PHPT138 3TC, D4T NVP K65R, K219R K101E, Y181C, G190A E6D, K11T, K20R, L34I, V35T, T39K, K43E, S68G, V111I, D121H, T139A, K166R, K173I, Q174K, D177E, I202V, Q207A, L210S, R211S, F214L, L228R  
PHPT139 PHPT139 3TC, D4T NVP M184V K103S, G190A T39E, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, K238R  
PHPT142 PHPT142 3TC, D4T NVP M184V K103N T39K, K102KR, K122E, D123S, K173L, Q174K, D177E, I178M, V189VI, T200A, Q207A, R211S  
PHPT143 PHPT143 3TC, D4T EFV M184V, T215Y K103N, V108I, H221HY, M230L, L234LI V35T, T39E, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, V189I, T200K, Q207T, R211S, K238R  
PHPT144 PHPT144 3TC, D4T NVP V75VI, M184V A98AG, Y181C, H221HY E40D, S68SG, K122E, D123S, I132IL, I135IT, K173T, Q174K, D177E, T200A, Q207K, R211S, D218DN, K223KR, K238R G231GE 
PHPT145 PHPT145 3TC, D4T, AZT NVP M184V K103KN, Y181C, H221HY K43E, S68G, T69N, K122E, D123NS, I135V, K173T, Q174K, D177E, I178M, V179I, T200A, Q207A, R211S, K238R  
PHPT146 PHPT146 3TC, D4T NVP M41L, D67DN, L74LI, M184V, L210W, T215Y Y188L V35I, T39K, K43E, K49R, S68SG, T69X, V75X, V118I, K122E, D123S, K173R, Q174K, D177E, I178M, E203K, Q207A, R211S, K223E