Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Li (2013)
Title Relatively high prevalence of drug resistance among antiretroviral-naive patients from Henan, central China.
Citation ARHR
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 98
NumPts 98
Subtype B, C, CRF01_AE, CRF07_BC, CRF08_BC, B + C

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
hnhy37 hnhy37 None None   I135V, S162C, T200A, Q207H, R211K, K277R, Q278E, I293V, Q334L, F346Y, A360T, V417T, V435E, D460N, R461K, S468T, L491V, V548I  
hnhy39 hnhy39 None None D67N, K70R, T215Y Y188L I135V, S162C, T200E, Q278E, L283I, I293V, P294T, I309L, Q334L, F346H, M357T, A371V, V417T, V435E, D460N, R461K, S468T, H483Y, L491V, K527Q, V548I, A554S  
hnhy63 hnhy63 None None   K20R, I135V, S162C, T200A, Q258R, Q278E, Q334P, F346Y, G359S, Q367L, A400T, V417T, V435E, N447S, D460N, R461K, S468T, H483Y, L491V, V548I, A554S  
hnhy64 hnhy64 None None  V106I I135T, S162C, T200A, Q278E, Q334L, P345Q, F346Y, K366R, K390R, V417T, E432D, V435E, G436R, D460N, R461K, S468T, H483L, L491A, A534T, V548I, A554T  
hnhy66 hnhy66 None None   S162C, E169D, Q278E, I293V, K311R, Q334L, P345Q, F346Y, V417T, V435E, A437V, D460N, R461K, S468T, H483Y, L491A, V548I  
hnhy67 hnhy67 None None  V106I I135V, S162C, T200A, K277R, Q278E, Q334L, F346H, G359S, T369S, Q373H, V417T, E432D, V435E, D460N, R461K, V467F, S468T, L491A, V548I  
hnhy72 hnhy72 None None   K122E, I135V, S162C, Q174E, T200A, Q207E, A272T, K277R, Q278E, L283F, Q334L, F346Y, K366R, V417T, V435E, D460N, R461K, S468T, H483Y, L491V, V548I, A554S  
hnhy73 hnhy73 None None   I135V, I142V, S162C, T200A, V276I, K277R, Q278E, Q334L, F346H, T369A, Q373H, V381I, E404N, V417T, V435E, D460N, R461K, S468T, D471N, Q480H, L491V, V548I  
hnhy79 hnhy79 None None   I5V, V35I, K122E, I135L, S162C, N175H, T200A, R211K, K277R, Q278E, I293V, K390R, V417I, V435E, D460N, R461K, S468T, T470N, L491M, V548I  
hnhy80 hnhy80 None None   K102Q, I135V, S162C, T200A, R211K, K277R, Q278E, L283I, I293V, I326V, Q334L, P345Q, F346Y, V417T, V435E, K451R, D460N, R461K, S468T, H483Y, L491V, V548I  
hnhy81 hnhy81 None None   K102R, S162C, K173Q, T200A, Q207E, V245E, K277R, Q278E, I293V, E298A, K311R, Q334L, K366R, K390R, V417T, V435E, D460N, R461K, S468T, L491V, K527Q, V548I, K558R G112GC 
hnhy83 hnhy83 None None   D123E, I135V, S162C, E169D, D177E, V179I, T200A, I202V, R211K, Q278E, L283I, V292I, I293V, Q334L, F346Y, E432D, V435A, R461K, S468T, L491V, S519N I257M, Q258H, K259L 
hnhy85 hnhy85 None None   E6D, S162C, E169D, Q174E, T200A, I202V, Q207K, R211G, V276I, Q278E, V292I, I293V, I309L, Q334L, F346H, K366R, K390R, V417T, V435E, D460S, R461K, V466I, S468T, T470A, L491V, Q524E, V548I, A554S  
hnhy90 hnhy90 None None   V111I, D123E, I135V, S162H, E169D, V179I, T200A, V276I, K277R, Q278E, A288S, P294T, H315Q, V317A, Q334L, F346Y, G359S, V417T, T450S, D460N, R461T, S468T, H483Y, L491A, L533M, Q547K, V548I  
hnhy91 hnhy91 None None   E28K, I135L, S162H, T200A, R211G, A272P, K275R, Q278E, V292I, I293V, K311R, F346Y, T403A, V435E, R461K, S468T, L491V, A554S  
hnkfx67 hnkfx67 None None   V8I, K102R, K122E, I135V, S162C, T200A, V245E, V276T, K277R, Q278E, L283I, A288G, I293V, P345Q, F346Y, E370G, T386I, V417T, V435E, D460N, R461K, S468T, L491V, K512Q, V548I, A554S  
hnkfx84 hnkfx84 None None  V106A, Y188F I135V, S162C, K173E, Q174K, V179I, S251I, K277R, Q278E, L283I, I293V, Q334L, F346H, G359S, T369V, A371T, Q373H, K390R, V417T, V435E, D460N, R461K, S468T, H483N, L491V, K512R, L517I, N545S, E546G  
hnkfx89 hnkfx89 None None   K122E, I135V, S162C, E169D, V179I, I195T, T200A, I202V, R211K, K275R, Q278E, L283I, I293V, P345Q, F346Y, K390R, A400S, V417T, V435E, N447S, D460N, R461K, S468T, L491A, V548I  
hnqx108 hnqx108 None None  V106I V35I, K49R, K102R, K122E, I135V, S162C, E169D, T200A, Q207E, A272S, K277R, Q278E, Q334L, K366R, K390R, V417T, V435E, D460N, R461K, S468T, L491V, I506L  
hnqx110 hnqx110 None None   I135V, S162C, Q174E, I195L, T200A, Q278E, P313T, Q334L, P345Q, F346Y, V435E, D460N, R461K, S468T, H483Y, L491V, A534T, Q547R, V548I  
hnqx69 hnqx69 None None  N348I V35T, E36A, T39E, S48T, E53D, V60I, I135V, S162C, Q207E, R211K, V245Q, D250E, A272P, K281R, T286A, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, K366R, T377M, T386I, K390R, E396Q, A400T, E404D, E432D, A437V, L452I, Q464K, D471E, H483Y, L484I, L491S, S519N, Q524E, K530R, A534S, A554S  
hnqx88 hnqx88 None None   K32R, K102Q, I135V, S162C, T200A, E203D, D237DA, K249KT, Q278E, T286A, Q334L, F346Y, A400T, I411V, V417T, V435E, D460N, R461K, S468T, L491V, V548I, K558R Q145Q*, K238K*, S251S_F 
hnqx89 hnqx89 None None   I135V, P150PS, S162C, T200A, R211K, L246LP, E248EK, V276I, K277R, Q278E, L283LI, I293V, Q334L, F346Y, K366R, T369A, K395KR, E399D, V417T, V435E, E449ED, K451KR, D460N, R461K, S468T, L491V, V548I, A554S Q145Q_XF, Y146F, N147NI 
hnr11 hnr11 None None  V179D K20R, K102Q, I135V, S162C, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, T286V, V292I, I293V, G335D, R356K, G359S, T377M, K390R, A400T, E404D, E432D, V435A, A437V, L452I, Q464S, D471E, H483Y, L484I, L491S, S519N, K527S, K530R, A554S Q242~ 
hnr121 hnr121 None None   K122E, I135V, S162C, I178M, Q197L, T200E, E204D, Q207R, R211A, Q278E, Q334L, F346Y, K390R, E399D, V417I, V435E, D460N, R461K, S468T, L491A  
hnr124 hnr124 None None   V35T, E36A, T39E, S48T, V60I, K101R, T107S, D121Y, K122E, I135T, S162N, K166R, K173A, D177E, T200A, R206Q, Q207G, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, P313T, G335D, R356K, G359T, T377M, K390R, A400T, T403A, E404D, E432D, V435A, A437V, L452R, Q464K, D471E, H483Y, L484I, L491S, S519N, K530R, A534S  
hnr129 hnr129 None None   V35T, E36A, T39D, S48T, V60I, D121H, K122E, S162A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297A, P313S, V317A, E328D, Q334N, G335D, R356K, M357I, G359S, K366R, T377M, K390R, A400I, E404D, E432D, V435A, N447S, Q464K, D471E, H483Y, L484I, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
hnr14 hnr14 None None   I135V, S162C, T200A, A272P, K277R, Q278E, Q334L, F346C, V417T, V435E, D460N, R461K, S468T, L491V, V548I  
hnr141 hnr141 None None   I135V, S162C, F171Y, T200A, K277R, Q278E, L283I, K287R, I293V, P294T, Q334L, F346Y, V417T, V435E, A437T, D460N, R461K, V467I, T477A, L491A, V548I, A554S  
hnr142 hnr142 None None   S68G, D123E, I135R, S162C, I178L, V179I, T200A, K277R, Q278E, L283I, I293V, I329V, Q334L, F346Y, V417T, V435L, R461K, S468T, L491A, K527N, V548I, K558R  
hnr143 hnr143 None None  V179D D86E, D123E, I135L, N147Y, S162C, Q278E, V292I, Q334L, P345Q, F346Y, T386I, K390R, V435E, D460N, R461K, S468T, H483Y, L491V, V548I  
hnr19 hnr19 None None K65R  P1L, E40K, E79K, D121Y, K122E, I135V, S162C, I195V, T200E, R211G, K219*, K249R, Q278E, I293V, E297K, S322A, Q334L, F346Y, E396K, E399D, T409P, E413K, V417I, V423I, E430K, V435G, D443N, E449G, G453E, D460N, R461K, S468T, L491V, K512R L80P, L283P, Y427N, G462K 
hnr25 hnr25 None None   S162C, T200A, Q207E, Q242R, K277R, Q278E, L310P, Q334L, F346Y, A376S, T377M, V417I, V435E, N447S, D460N, R461K, S468T, L491A, V548I  
hnr3 hnr3 None None   I135T, S162C, Q278E, I293V, Q334L, P345Q, F346Y, M357V, F416C, V417T, V435E, D460N, R461K, S468T, L491V, K512Q, V548I  
hnr68 hnr68 None None M184I  I135V, S162C, E169G, T200A, V245M, E248D, K277R, Q278E, I293V, Q334L, F346Y, M357R, R358K, V417T, V435E, D460N, R461K, S468T, T477A, G490E, L491V, P537S, V548I, V559I  
hnsx23 hnsx23 None None  V106I P4S, F87L, I135V, S162C, E169D, T200A, Q207E, K277R, Q278E, I293V, Q334L, P345Q, F346Y, V417T, V435E, D460N, R461K, S468T, L491A, L517V, V548I T128N 
hnsx25 hnsx25 None None   I135V, S162C, T200A, V276I, K277R, Q278E, Q334L, F346H, V365I, A376S, V417T, V435E, A437V, R461K, S468T, L491V, V548I, A554T, I556V, K558R  
hnsx26 hnsx26 None None  K103S I135V, S162C, T200A, E204D, V245E, K275R, K277R, Q278E, E291D, P294T, Q334L, F346Y, K366R, K390R, V417T, V435E, G436E, N447S, D460N, R461K, S468T, L491A, V548I  
hnsx29 hnsx29 None None   I135V, S162C, I195L, T200A, Q278E, P294Q, Q334L, P345Q, F346Y, A360T, V417T, V435E, D460N, R461K, S468T, L491V, V548I  
hnsx30 hnsx30 None None  K103N P14S, K82R, I135L, S162C, T200A, Q207R, R211K, V276T, K277R, Q278E, V314M, Q334L, F346Y, V417T, V435E, D460N, R461K, S468T, L491A, Q509L, Q547H, V548I  
hnsx31 hnsx31 None None   I135V, S162C, K173Q, T200A, V276A, K277R, Q278E, Q334L, F346Y, G359S, V417T, V435E, T450S, D460N, R461K, S468T, L491A, V548I, A554S  
hnsx33 hnsx33 None None   I135V, S162C, T200A, V245M, K277R, Q278E, I293V, K311R, Q334L, F346Y, I375L, A400T, V417T, V435E, D460N, R461K, S468T, L491G, V548I  
hnsx34 hnsx34 None None   K102Q, I135V, S162C, V179I, T200A, K277R, Q278E, Q334L, F346H, K366R, Q373H, K390R, V417T, V435E, D460N, R461K, S468N, L491A, V548I, A554S  
hnsx36 hnsx36 None None   D123E, I135V, S162C, T200V, A272P, Q278E, D324E, Q334L, F346H, M357T, T369V, Q373H, T377I, S379G, V417T, V435E, D460N, R461K, S468T, T470N, L491A, L517I, V548I, A554T, K558R  
hnsx37 hnsx37 None None   S162C, T200A, K277R, Q278E, A288S, Q334L, E344D, P345Q, F346Y, V417T, V435L, N447S, R461K, S468T, L491V, V548I  
hnsx38 hnsx38 None None   I135V, S162C, T200A, D237E, A272S, K277R, Q278E, T286A, I293V, Q334L, F346Y, A360T, K366R, V417T, V435E, D460N, R461K, S468T, H483Y, L491V, A554S  
hnsx41 hnsx41 None None   I135V, S162C, T200A, Q278E, L283I, I293V, Q334L, F346Y, R356K, K366R, T369V, E370G, V417T, V435E, D460N, R461K, S468T, L491V, Q524E, K530R, V548I, A554T  
hnsy16 hnsy16 None None   I135V, S162C, T200E, Q207E, A272P, Q278E, K311R, Q334L, F346Y, M357R, K366R, T369V, I375V, V417T, E432D, V435E, D460N, R461K, S468T, L491A, V548I, A554T, K558R  
hnsy17 hnsy17 None None   V35I, I135L, S162C, T200A, K277R, Q278E, I293V, Q334L, P345Q, F346Y, K390R, V417I, V435E, R461K, S468T, L491V, V548I  
hnsy2 hnsy2 None None   K102R, I135V, S162C, K173E, Q174H, T200A, Q207H, R211K, A272P, Q278E, Q334L, E344D, P345Q, F346Y, K366R, V435E, D460N, R461K, S468T, L491G  
hnsy20 hnsy20 None None   I135V, S162C, T200A, K277R, Q278E, Q334L, E344D, P345Q, F346Y, K366R, V435E, L452S, S468T, L491V, V548I  
hnsy24 hnsy24 None None   I135V, S162C, T200A, R211K, K277R, Q278E, I293V, H315Q, V317A, Q334L, F346Y, K390R, V417T, V435E, R461K, H483Y, L491V, V548I  
hnsy28 hnsy28 None None   R72K, D123E, I135V, S162C, T200A, Q207E, W252*, A272P, K275R, K277R, Q278E, P294S, E312A, Q334L, A360V, T369A, K374R, I375V, V417I, V435E, D460N, R461K, S468T, L491V, Q524E, V548I, A554S L391P 
hnsy48 hnsy48 None None   K64R, D123E, I135V, S162C, K173E, T200A, Q207H, K277R, Q278E, I293V, E312Q, V317A, Q334L, F346Y, K347R, T369A, V417T, V435E, D460N, R461K, S468T, L491V, V548I  
hnsy49 hnsy49 None None   S162C, I178M, T200A, Q207K, R211S, A272P, K277R, Q278E, V317A, Q334L, F346Y, G359S, V417T, V435E, D460N, R461K, S468T, L491A, L517V, V548I  
hnsy5 hnsy5 None None   E79K, I135V, S162C, T200A, R211K, K277R, Q278E, Q334L, F346Y, E396K, E399D, V417T, V435E, D460N, R461K, S468T, H483Y, L491V, L517V, G541E, V548I, A554S  
hnsy50 hnsy50 None None   K122E, S162C, T200A, Q207K, R211A, Q278E, P313S, V317A, Q334L, F346Y, M357T, V435E, D460N, R461K, S468T, L491V, Q509H, K512R, V548I  
hnsy51 hnsy51 None None   I135V, S162C, E194D, T200A, D250E, V276T, K277R, Q278E, Q334L, F346Y, K366R, V417T, V435E, D460N, R461K, S468T, T470A, L491A, Q524E, V548I, A554S  
hnsy54 hnsy54 None None   V35R, T39N, S48T, V60I, D121Y, K122E, I180V, Q207E, V245K, A272P, K277R, K281R, T286A, E291D, V292I, I293V, K311R, G335D, R356K, G359T, K366R, T369A, T377M, A400T, E404D, E432D, V435A, L452I, Q464K, V466I, D471E, H483C, L484I, L491S, S519N, K530R, A534S, A554S  
hnsy57 hnsy57 None None   I142V, S162C, T200A, R211K, Q278E, Q334L, P345Q, A376S, T377Q, K390R, V417T, V435E, D460N, R461K, S468T, L491V, V548I  
hnsy58 hnsy58 None None   I135V, S162C, T200A, V245E, K277R, Q278E, I293V, E297A, I309L, Q334L, P345Q, F346Y, V381I, K390R, E399D, I411V, V417I, V435E, L452T, D460N, R461K, S468T, H483N, L491V, V548I  
hnsy6 hnsy6 None None  V106I I135V, S162C, K173N, T200A, A272P, K277R, Q278E, I293V, E298K, I329V, Q334L, F346Y, R356K, G359S, K366R, T369V, I411IV, V417T, V435E, D460N, R461K, S468T, H483Y, L491V, L533M, V548I, A554S  
hnsy69 hnsy69 None None   I135V, D177DG, T200A, V245K, K277R, Q278E, I293V, Q334L, F346Y, V417T, I434V, V435E, R461K, S468T, H483Y, L491V, V548I  
hnsy8 hnsy8 None None   V35L, I135L, S162C, T200A, R211RK, Q278E, L283I, V292I, I293V, E297K, Q334L, P345Q, F346Y, A371V, I375V, K390R, T403A, V417T, V435E, A437V, D460N, R461K, S468T, L491A, V548I, A554S  
hnsy9 hnsy9 None None   I135V, S162C, T200A, K277R, Q278E, T286A, Q334L, F346Y, V417T, V435E, A437V, E449D, D460S, R461K, S468T, T477A, H483Y, L491V, Q509QH, E516K, V548I  
hntk1 hntk1 None None  V179D E6D, K11T, V35T, T39K, K43E, K122E, D123S, Q174K, P176T, D177E, T200R, I202V, Q207A, R211S, E224D, V245E, V276I, E291D, V292I, I293V, E300Q, E312S, I326V, I329V, M357K, G359S, K366R, T369A, A371V, A400T, T403M, E432D, N447S, D471E, Q480H, H483Q, L491S, K512T, E514D, L517V, S519N, Q524E, A534S, A554S  
hntk12 hntk12 None None K219E  K122E, S162C, T200A, E248V, A272P, Q278E, L283I, I293V, Q334L, F346H, R356K, M357R, K366R, T369V, A376V, S379C, V417T, V435E, K451R, D460N, R461K, S468T, T470N, L491A, K512Q, L517I, S519N, V548I, A554S  
hntk4 hntk4 None None  K103N E6D, S162C, T200A, K277R, Q278E, L283I, Q334L, F346Y, K350R, K366R, K390R, V417T, V435E, N447S, R461K, S468T, L491AV, K527Q, V548I, A554S  
hnwsx34 hnwsx34 None None   D123E, P176S, T200A, K277R, Q278E, I326V, Q334L, F346Y, K366R, K390R, V417T, E432D, D460N, R461K, S468T, L491A, V548I  
hnwsx37 hnwsx37 None None   V35I, T107S, I135V, S162C, T200V, K277R, Q278E, Q334L, P345Q, F346Y, V417T, V435A, R461K, S468T, L491V, S519N, K530R, V548I  
hnwsx38 hnwsx38 None None   I135V, S162C, T200A, K275R, K277R, Q278E, L283I, V317A, Q334L, F346Y, E432D, V435E, D460N, R461K, S468T, L491G, K550R  
hnwsx40 hnwsx40 None None   R83K, I135V, S162C, T200E, R211K, Q278E, E298G, Q334L, F346Y, K366R, T369A, K390R, E399D, V417T, V435E, D460N, R461K, V467I, S468T, L491V, Q509R, V548I, V559I  
hnwsx42 hnwsx42 None None   V35T, S68G, I135V, S162C, T200V, R211K, V245E, Q278E, I326V, Q334L, F346Y, M357R, S379G, V381I, V417T, V435E, A437V, N447S, R461K, S468T, H483Y, L491V, V548I  
hnwsx43 hnwsx43 None None   I135V, S162C, R211K, K275R, Q278E, L283I, I293V, P294T, E312D, Q334L, P345Q, F346Y, M357T, K390R, V417T, E432D, V435E, D460N, R461K, S468T, Q480K, L491A, K530R, V531I, V548I, A554N  
hnwsx44 hnwsx44 None None   K20R, D123E, I135V, R172K, Q197H, T200A, Q207E, R211K, A272P, Q278E, L283I, I293V, D324E, Q334L, F346H, T369A, A371V, I375T, T386I, I411V, V417T, V435E, D460N, R461K, S468T, L491V, S519N, V548I, A554S  
hnwsx46 hnwsx46 None None   K122E, I135V, S162C, T200V, K277R, Q278E, L283I, V292I, I293V, D324E, Q334L, F346Y, K366R, V417T, V435E, N447S, D460N, R461K, S468T, L491A, V548I  
hnwsx51 hnwsx51 None None M41L, D67N, M184I, L210W, T215F K103S, G190A, K238T S162C, T200A, Q207N, R211K, Q278E, I293V, Q334L, P345Q, F346Y, S379C, K388R, A400T, E432D, V435E, N447S, K454R, D460N, R461K, S468T, H483Y, L491V, V548I, K558R  
hnwsx69 hnwsx69 None None   S162C, T200A, A272P, Q278E, I293V, Q334L, F346H, Q367L, T369A, K374R, I411V, V417I, V435E, D460N, R461K, S468T, H483Y, L491V, K512R, V548I, A554S  
hnxx100 hnxx100 None None   K20R, K64R, I135V, S162C, R211G, V245G, Q278E, T286A, Q334L, P345Q, F346Y, V417I, V435E, D460N, R461K, S468T, L491V, E516D, V548I  
hnxx123 hnxx123 None None   D121H, K122E, I135V, S162C, D177E, I195L, T200A, G273R, K277R, Q278E, E297A, Q334L, P345Q, F346Y, V417T, V435E, G436R, D460N, R461K, S468T, T477A, L491A, V548I  
hnxx124 hnxx124 None None   I135V, E169D, Q174E, T200A, I244V, Q278E, L283I, V292I, P313T, Q334L, P345Q, F346Y, K390R, V435E, D460N, R461K, S468T, G490E, L491A, S519N, V548I, A554S  
hnxx188 hnxx188 None None   V90I, I135V, I142V, S162C, I178V, T200A, K277R, Q278E, Q334L, P345Q, F346Y, V417I, V435E, L452S, D460N, R461K, S468T, H483Y, L491V, V548I  
hnxx197 hnxx197 None None   K11R, K32R, D123E, I135V, S162C, D177E, Q207E, V276T, K277R, Q278E, Q334L, F346Y, K366R, V417T, V435A, R461K, S468T, L491A, V548I, A554S  
hnxx198 hnxx198 None None   P4S, D123E, I135V, S162C, T200A, Q278E, L283I, A288G, E312A, I329V, Q334L, F346Y, V372I, V417T, V435E, D460N, R461K, S468T, L491V, V548I, A554S I159T 
hnxx199 hnxx199 None None   K173N, Q174K, T200V, E224G, K277R, Q278E, T286A, Q334L, F346Y, F416C, V417T, V435E, D460N, R461K, S468T, H483Y, L491V, V548I  
hnxx200 hnxx200 None None   E40V, K122E, I135V, S162C, Q174K, D177E, I178M, T200A, Q207E, K277R, Q278E, D324E, Q334L, F346Y, V435E, D460N, R461K, S468T, L491V, V548I  
hnxx254 hnxx254 None None   I135V, S162C, T200A, V276I, K277R, Q278E, L283I, I293V, Q334L, F346H, K366R, V417T, V435E, D460N, R461K, S468T, L491E, V531I, V548I, A554S  
hnxx257 hnxx257 None None   I135V, S162C, T200A, R211K, V276I, K277R, Q278E, K311R, Q334L, F346H, T369V, F416Y, V417T, V435E, N447S, D460N, R461K, S468T, L491E, V548I, A554S  
hnxx3 hnxx3 None None   I135V, S162C, D177E, T200A, Q207E, K249E, Q278E, I293V, V317A, Q334I, P345Q, F346Y, V435E, K454R, D460N, R461K, S468T, L491V, K512R, V531I, V548I  
hnxx45 hnxx45 None None   D123E, I135V, S162C, T200E, I202V, R211Q, K277R, Q278E, I293V, E297A, Q334L, P345Q, F346Y, Q394N, V435E, N447S, D460N, R461K, S468T, T470A, L491A, V548I  
hnxx48 hnxx48 None None  K103N, V106I I135T, S162C, T200A, Q207E, A272T, K277R, Q278E, A288S, V292I, P294T, E297K, E312Q, F346H, K350R, R356K, A376S, T377S, K390R, V417I, E432D, V435E, K454R, D460N, R461K, S468T, L491A, K530R, A534T, Q547H, V548I  
hnxx64 hnxx64 None None   V60I, T107S, S162C, T200A, K277R, Q278E, T286A, I293V, V317A, Q334L, F346Y, K366R, V435E, D460N, R461K, S468T, L491A, L517I  
hnxx65 hnxx65 None None   V35M, T39A, K49R, T107S, K122E, S162C, E169D, T200A, Q207H, R211K, Q278E, I293V, Q334L, P345Q, F346Y, K390R, V435E, N447S, D460N, R461K, V467I, S468T, L491A, Q524E, V548I  
hnxx74 hnxx74 None None   S162C, T200A, Q278E, L283I, I293V, F346Y, V435E, D460N, R461K, S468T, T470N, Q480H, L491A  
hnxx75 hnxx75 None None   V8I, I135V, S162C, T200A, V245E, K277R, Q278E, K311R, I326T, Q334L, F346Y, V417T, V435E, N447S, R461K, S468T, H483N, L491V, L517I, V548I  
hnxx96 hnxx96 None None   T200A, A272P, K275R, Q278E, Q334L, F346Y, I375V, V417T, V435E, D460N, R461K, S468T, L491V, A554T  
hnxy27 hnxy27 None None   I135V, S162C, T200A, V245R, K277R, Q278E, I293V, Q334L, F346Y, A400T, I411V, V417T, V435E, R461K, S468T, L491V, K530R, V548I, A554S  
hnxy44 hnxy44 None None   K102E, K103R, D123E, I135V, S162C, L168*, K173R, Q174K, T200A, Q278E, T286A, D324E, Q334L, F346Y, V417T, E432D, V435E, D460N, R461K, S468T, H483Y, L491A, V531I, V548I, A554S  

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