Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Armenia (2012)
Title Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: A refined analysis by ultra-deep 454 pyrosequencing.
Citation J Infect Dis
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 40
NumPts 22
Subtype B, F


Clinical IN Isolates

PT_12 PT_12_BL None   T97A L101I, S283G  
  PT_12_MO_1 RAL  Y143R T97A L101I, S283G, D286DN  
  PT_12_MO_3 RAL  Y143R T97A L101I, S283G, D286DN  
  PT_12_MO_7 RAL  Y143R T97A L101I, T112TA, S119ST, S283G  
  PT_12_MO_9 RAL  Y143R T97A D3DN, D25DE, L101I, T112TA, S119ST, S283G  
PT_141 PT_141_BL None    D6T, K7E, E11D, K14R, V31I, M50I, I72V, I113V, T125A, V151I, V201I, D256E, V281M  
  PT_141_MO_6 RAL  N155H G163GR D6T, K7E, E11D, K14R, V31I, M50I, I72IV, I113V, S119SR, T125A, V151I, V201I, D256E, V281VM  
PT_145 PT_145_BL None    E10D, L28I, L101I, K136N, K211KT  
  PT_145_MO_10 RAL  N155H T97TA E10D, L28I, K34KR, E92EA, L101I, S119SR, K136N  
PT_15 PT_15_BL None    S17N, T124A, T125A, K156N, F181L, K211R, S230N, D256E, D279G  
PT_151 PT_151_BL None    M22L, A23S, S24G, V37I, A38K, S39C, I72AV, I84IM, T124A, V165I, V201I, D286DN, D288N  
PT_155 PT_155_BL None    E10D, E11D, I60IM, L101I, K111T, I135IV, V201VI, R231K L102LF 
PT_156 PT_156_BL None    I72V, S283G  
PT_16 PT_16_BL None    E11D, S24N, D25E, V31I, L101I, K156N  
PT_162 PT_162_BL None    E11D, S24N, D25E, A49P, I72IV, T112A, S119P, T122IV, T125A, I203M, K215N, D286N  
PT_229 PT_229_BL None    K7R, S17N, L101I, S119P, T122IV, K156N, V165I, V201I, T206S, T218S, K219N, D256E, D278A  
  PT_229_MO_9 RAL  Y143C, N155H S230R K7R, S17N, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, D256E, D278A, V281VM  
  PT_229_MO_11 RAL  Y143C, N155H S230R K7R, S17N, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, N222NK, D256DE, D278A, V281VM E69EQ 
PT_27 PT_27_BL None    E11D, V32I, D41N, I73V, L101I, K111T, N222H  
  PT_27_MO_10 RAL  G140S, Q148H  E11D, V32I, D41N, A91AV, L101I, K111T, N222H  
PT_45 PT_45_BL None    E11D, K14R, A21T, A23V, V31VI, M50I, A91T, T112V, I141IV, K211KR, T218TS, S230G  
PT_49 PT_49_BL None    E11D, S17T, S24SG, L101I, I113L, S119P, T122I, T125A  
PT_5 PT_5_BL None   G163K S17N, R20K, E96D, L101I, S119T, T124A, T125A, K156N, V201I, K211KR, T218I, L234V, D256E  
PT_56 PT_56_BL None    E10D, V88I, T125A, K156N, V201I, K215R, T218S, S230N, R231K, D279G  
PT_57 PT_57_BL None    E11D, L28I, S39C, M50I, F181L, V201I, L234I, D253E  
PT_58 PT_58_BL None    F1I, D25E, L101I, T112V, K159R  
PT_63 PT_63_BL None    S24N, D25DE, L101I, T124Q, T125M, M154I, V165I, D232E, L234V  
PT_69 PT_69_BL None    D25E, L28I, S39C, L101I, V165I, K215N, Q216H  
  PT_69_MO_5 RAL  N155H  D25E, L28I, S39C, E92EA, L101I, V165I, K215N, Q216H A8P 
  PT_69_MO_7 RAL  E138EK, N155H D232DN R20RK, D25E, L28I, E35EK, S39C, G47GE, E92X, L101I, V151VI, V165I, K215KN, Q216H, D286DN  
PT_80 PT_80_BL None    S17N, L101I, T112R, S119T, T124A, T125A, K136Q, K156N, G193E, V201I, A205AS, T206S, T210TI, E212Q, L234V, D256E, D279G  
  PT_80_MO_6 RAL    K14KR, S17N, L101I, T112R, S119T, T124A, T125A, K136Q, K156N, G193E, V201I, A205S, T210I, E212Q, L234V, D256E, D279G, C280X, V281VM, D286DN S283SGR, Q285QH 
PT_81 PT_81_BL None    M22L, L28I, D41DN, T112I, S119P, K156N, V201I, D286DN F26L 
  PT_81_MO_3 RAL  N155H  H16P, L28I, T112I, S119P, K156N, V201I  
PT_84 PT_84_BL None    D6S, K7E, S17N, I72V, V201I, D256E, R269RK, R284I  
  PT_84_MO_2 RAL  Q148QR  D6S, K7E, S17N, I72V, V201I, D256E  
  PT_84_MO_3 RAL  Q148QR  D6DN, K7KE, V31VI, L101I, T124Q, T125M, K156KN, D256DE  
  PT_84_MO_4 RAL  G140S, Q148R  D6S, K7E, S17N, I72V, V201I, D256E  
  PT_84_MO_5 RAL  G140S, Q148QR  D6S, K7E, S17N, I72V, V201I, D256E Q164QR, A276AT 
  PT_84_MO_9s RAL    D6S, K7E, S17N, I72V, V201I, D256E