Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Pariente (2004)
Title Long-term suppression of plasma viremia with highly active antiretroviral therapy despite virus evolution and very limited selection of drug-resistant genotypes.
Citation J Med Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 56
NumPts 56
Subtype B, CRF02_AG


Clinical RT Isolates

SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
pt15 15 None None  E138A T200A, F214L, K277R, P294Q, T369V, I375V, A376T, K390R, A400S, K451R, D460N, H483Y, L517I, S519N  
pt16 16 None None   K22R, K101R, I135L, K166R, A272P, Q336P, P345A, K390R, V435A, D460N, R461K, S468N, L491S, E516G, S519N, A554T  
pt17 17 None None   R83K, K122KE, D123E, S162A, R211K, A272P, K281R, I293V, E297K, A376T, K390R, A400T, V435I, D460DN, R461K, K476Q, Q507H, A554T  
pt18 18 None None   V35I, R83K, I135T, I202V, S251I, V276I, I293V, I326IM, A376V, K395R, D460N, S468F, K530R  
pt19 19 None None   D123E, I135T, D177DE, F214FL, V245E, A272P, V276VI, K277KR, E297EQ, G359S, A376T, A400AT, V435I, R461K, L503LI, S519SR, K558R  
pt20 20 None None   E6D, K20R, K49R, V60I, I135T, R211K, I293V, I329F, G335S, G359S, K390R, V435E, R461K, I506L, A554T  
pt21 21 None None   I2IL, K122E, I135T, I178L, A272P, K277R, A288T, I293V, I329L, Q334QR, G335D, R356K, V435I, L469I, L517I, A554S  
pt22 22 None None   K122E, D123E, I135L, N147H, E169ED, T200A, V245E, E248V, A272P, K277R, R356K, A376T, T386I, K388KN, K390R, K395KN, E396ED, A400PS, V435P, D460S, S519N, A554T Q145R, Y146I, V148D, P150R 
pt23 23 None None   K122E, I135L, N147H, K166R, Q174H, T200TA, R211K, V245M, A272P, K277R, I293V, Q334D, A376T, T386I, A400T, E404D, F440Y, H483Y, K512R, S519N, Q547R Q145R, Y146I 
pt24 24 None None   R211K, V245VE, A272P, K277R, E297K, R356K, A376T, K390R, D460N, L503I, L533M  
pt25 25 None None   V35I, I135T, T200A, I202V, R211K, V245K, E248Q, A272P, K277R, T286TA, A288S, A304E, V317VA, A327V, T386I, K390R, Q394H, A400T, A446S, N447S, K512Q, S519N, A554S F77FC, R78RI, R83IK, Q145R 
pt27 27 None None   R83K, D123E, I135V, R211K, V245EK, K249R, D250DE, A272P, V276I, Q278QH, I329L, K390R, K395R, E449D, D460N, H483Y, E516G, S519N K353KE 
pt28 28 None None   V10I, K166R, Q174H, R211K, A272P, K277R, E297A, Q334D, K366R, I375V, A376T, V381I, T386I, A400T, T403A, H483Y, Q547R, A554S  
pt29 29 None None   V35T, T39K, K43Q, S48T, V60I, D123E, I135V, S162A, K173T, Q174A, D177E, T200A, Q207E, R211K, V245Q, A272P, V276I, T286A, E291D, V292I, P294T, S322T, I326V, G335D, R356K, M357Q, G359S, E370Q, A371V, I375V, K390R, K395R, T403M, E413D, E432D, Q464E, D471E, Q480H, L491LS, A502V, E514D, S519N, Q524E, E529D, A534S, A554S Y427Y* 
pt31 31 None None  E138A R83K, I135V, K166R, T200A, R211K, A272P, K277R, I293V, S322SL, G333E, R356K, A376V, S379C, K390R, L452I, D460N, V467I, E516G, S519N, K527N E438E* 
pt33 33 None None  V108I R83K, D123E, V148X, G152X, S163G, P170X, D177DE, I178V, Q207QE, R211K, K277R, I293V, I329L, G359S, A400T, D460N, R461K, I506L, S519N K154KN 
pt34 34 None None   K49R, K166I, E224ED, K277R, T286TA, I293V, E297K, E308D, E312ED, D324A, I326V, I329V, Q334H, G359S, A371V, A376T, R448K, I506L, K530R  
pt4 None None   S48T, D123E, S162C, R211K, V245VE, K277KR, T286A, I293IV, P294S, I326V, M357T, A400T, T403M, K512R, L517V, A554T, K558R  
pt41 41 None None   K122E, R211K, F214L, I329L, E399G, E404D, V435A, L452S, R461K, T470TA, I506L, A554T  
pt42 42 None None   D123E, I135T, K173N, F214L, A272P, K277R, G333E, Q334H, K366R, T377Q, A400T, T403A, D460N, Q464E, L491S  
pt43 43 None None   V35T, V60I, D123E, K166R, D177E, I178M, A272P, K277R, T286A, M357T, A376T, V381I, K390R, A400T, V435L, L452I, L491P, A502S, A554T  
pt44 44 None None   D177G, Q207E, V245N, K277R, T286A, I293V, E297K, I326V, Q334L, M357T, A376V, T386A, K465R, L491S, S519N, V531I, A554T  
pt45 45 None None   K49R, R83K, K122E, D123N, S162C, A272P, K277R, D324E, Q334M, G335S, K347Q, K366R, A400T, T403A, V435VA, D460N, V467I, Q480E, A554T  
pt46 46 None None   D123E, I135T, I178IL, F214L, K277R, V292I, E297K, I329L, G333E, F346N, A376S, K390R, V435X, D460N, L491S, E492Q, E529D, A534T  
pt47 47 None None K70R V179D T69N, K122N, S162R, S163G, F214L, V245K, T286A, K311R, Q334H, G359S, T369V, A371V, I375V, A376T, A400T, K454R, R461K, H483Y, L491V L168R 
pt48 48 None None   K49R, S68G, I135T, V254G, K277R, G333E, V435VI, S468SP, L491LS V241G 
pt49 49 None None   R83K, V189VI, V245E, I293V, T377M, V381VI, K390R, A400T, L469F, I506L, A554AS D256DG 
pt5 None None   I50IV, K122E, I135T, I178M, T200A, R211K, K277R, E291D, E297K, I326V, M357I, A376S, K390R, E404D, K451KR, D460S, K465KR, A554S  
pt50 50 None None   K49R, A98S, I135T, R211K, E297A, G359S, A376T, G436E, D460N, R461K, H483Y, L491S, I556V V435EK 
pt51 51 None None   E36EK, V60I, K122E, I135T, I142V, K166R, D177E, R211K, F214L, Q278E, I293V, E298A, I329V, R356K, A376T, V381I, K390R, V435I  
pt52 52 None None   V60I, D123E, I135T, Q197QR, F214L, V292I, I293V, E297A, M357V, A376T, K390R, A400T, V435A, D460N, S468T, H483Q, L517I, S519N, K530R, I556V  
pt53 53 None None   K49R, R83K, K249Q, P294Q, P321S, G359S, A371V, A376V, K388KR, V435E, D460N, S519N  
pt54 54 None None   D123E, T139A, D177E, Q197H, R211K, K277R, A288S, E297K, Q334L, R356K, A376T, K390R, T403M, R461K, V466I, V467I, H483Y  
pt55 55 None None T215V  K20R, D123E, S162C, I195T, R211G, A272P, K277R, Q334L, A360T, K374R, I375V, A376S, T377L, A400T, V435A, S468P, K527N  
pt56 56 None None   K49R, V60I, S68SG, I135T, N175NY, G359S, A376T, T386I, A400T, T403M, K454KR, V467I, S468P, S519N, A554H  
pt57 57 None None   D123E, D177E, V179I, Q207E, R211K, V245M, A272P, I329V, A376S, T377A, T386I, T403M, V435L, L452S, S468P, H483Y, L491S, K527N, K530R, A554N  
pt58 58 None None   K20R, K122E, I135T, Q207E, F214L, V245E, T286A, I326V, Q334L, K366R, A376V, I382IM, T386V, K390R, T403M, R461K, S519N, K530R  
pt59 59 None None   I50V, V60I, R83K, S162A, K166R, Q207E, R211K, V245K, K277R, T286A, Q334L, G359S, Q373QH, K390R, A400T, V435E, L452LV, D460N, R461K, I506L R284M 
pt61 61 None None   K49R, I50V, V60I, R83K, I135T, K166R, Q207E, R211K, K277R, T286A, Q334L, K390R, A400T, T403A, D460N, R461KN, S468P, T477A, I506L, A554T  
pt64 64 None None   K122E, S162C, I178IL, G196E, R211K, V292VI, E297R, K311KR, I329L, Q334E, K390R, A400T, L452LV, K454KR, D460N, T470TN, L491S, I506L, S519N, A534T  
pt65 65 None None   K49R, I135T, S163SG, I178L, E204K, R211K, F214L, V245M, K277R, T286A, A288T, E297A, K311R, I326V, A355T, A360T, E370G, K390R, T403M, K451R, L452T, S468P, H483Q, L491S, L517V, I556V D218DH 
pt66 66 None None   K49R, R83K, I135V, S162A, D177E, R211K, V245E, K277R, T286P, I293V, E297K, A376T, E378EG, T386A, I393IL, Q394L, E413D, D460N, S468P, L491S, K550*, I556V, K558R I380IFL, K388K* 
pt67 67 None None  V106I K11R, R211K, R356K, A376T, K390R, A400S, R461K, L469I, T470TI, H483Y, A554S  
pt69 69 None None   V35L, T39A, R83K, A158S, R211K, I375IL, A376T, K395R, A400T, D460N, H483N, S519N, L533M K390GR, D549DY 
pt7 None None   K22R, K101R, I135L, K166R, K173N, A272P, P345S, V435A, D460N, R461K, S468N, L491S, E516G, S519N, A554T  
pt70 70 None None D67N, K219Q  V35I, W88C, Q174H, D177E, G196E, Q207E, R211K, F214L, I293V, E297A, R358K, G359S, A371V, T377Q, R461K, I506L, Q509K, A534T  
pt71 71 None None D67N, T215S, K219E  V35VL, S68N, K104N, K122E, T200V, A272P, E297A, G333E, K366R, A371V, A376T, A400T, D460N, K558R E29E*K 
pt72 72 None None   I135T, D177E, T200V, F214L, V245I, A272G, I293V, E297A, M357T, A360T, A376T, T386I, A400T, V435A, H483Y, L491V, L517I, K527Q  
pt73 73 None None   W24WC, I135V, I142T, T200I, V245VL, D250DA, A272P, K277R, P294Q, Y342F, R356K, K366R, T369V, Q373H, E404EK, V467I, Q509H, A554S K126KN, W252W*, Y405YF 
pt74 74 None None   E6D, V60I, R83K, A98S, D123E, K249Q, S251I, A272P, K281R, T286A, V292I, E297K, M357T, T377S, A400T, V435I, R461K, S519N, A554T  
pt76 76 None None   R83K, V90VI, D123E, G196E, V245E, A272P, K277R, K281R, E297KR, A376V, A400T, V435I, D460N, S468SP, H483L, I495IV, A554T R461IL 
pt77 77 None None   V35I, R83K, K122E, I135T, I178IM, Q197E, Q207X, R211KQ, A272P, T286A, V317A, I329L, G333E, Q334L, M357T, T403I, E404D, V435E, D460N, H483N, K512R, A554S  
pt78 78 None None   R72G, K122E, I135T, I178L, E204N, F214L, A272P, V276I, E297A, D324E, A327V, Q334E, A376T, K390R, A400T, T403S, D460N, H483N, L491K, S519N, K530R, A554T K126KE 
pt81 81 None None   K20R, T200I, R211K, P294Q, K311R, D324E, A327V, R356K, M357T, K366R, A376T, T386I, K390R, A400T, R448K, E449D, D460N, V467I, S468P  
pt86 86 None None   K20R, K32Q, V35I, S68G, D86DN, D123X, I135R, K166Q, I178L, G196E, K281R, T286A, E297K, K311R, I326V, I329V, Q334N, M357T, A360T, A376S, S468P, H483I, K527N, K530R, A554S H96HN 
pt9 None None   D123DE, I135V, T200I, V245L, K277R, E297A, V317VM, I326IT, R356RG, T377TS, I380IL, K388KN, K390KR, S468SP, H483Q, A554T S379SN