Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Riddler (2008)
Title Class-sparing regimens for initial treatment of HIV-1 infection.
Citation N Engl J Med
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 293
NumPts 206
Subtype B, C, CRF01_AE, CRF02_AG, K, CRF45_cpx

 
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Page 1   listing Isolate 1 to Isolate 100 from Total 293 Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
13594 461519Lb TDF, 3TC EFV   E28EK, K32KE, D123E, I135T, S162C, A272P, K281R, E297K, K311R, S322T, M357T, A376T, T377V, K390R, A400T, A437V, D460S, T477A, L491LS, L517I, S519N, A554T  
25553 91271Ca None None   P4S, E6D, D123E, T165I, D177E, T200R, R211K, K277R, Q278H, T286A, M357S, A376T, K390R, A400T, V435VA, D460N, R461K, L491S, K512R, K527N  
  91271Cb 3TC, D4T EFV   P4S, E6D, D123E, T165I, D177E, T200E, R211K, K277R, Q278H, T286A, M357S, A376T, K390R, A400T, V435A, D460N, R461K, L491S, K512R, K527KN  
26597 461525Hb TDF, 3TC EFV   V35M, T39K, K43E, R83K, D177E, A272P, K281R, T286A, E297K, S322T, K366R, T369S, A400T, T409TN, V417I, V435I, L452LI, D460N, S468P, H483Y, S519N, A554S  
  26597w20 TDF, 3TC EFV   V35M, T39K, K43E, R83K, D177E, A272P, K281R, T286A, E297K, S322T, K366R, T369S  
27693 272465Eb AZT, 3TC EFV M184I K103N, Y188H K122E, I142T, G196E, R211K, A272P, T286A, E297K, I309IV, S322A, D324S, G333E, Q334N, G335S, M357V, T369A, K390R, A400T, F440Y, K451R, S468T  
29362 373772Ab TDF, 3TC, D4T EFV  V179D E6D, V35I, I135L, S162A, T200R, A272P, K277R, I293V, E297Q, I326V, V365I, V435VE, L452I, S468P, K558KR, V559VI E28S 
29420 91275Gb 3TC, D4T EFV   E36D, Q174E, F214L, A272P, E297A, V317VA, Q334L, A376T, K390KR, A400T, V435I, E516D, S519N, A554NT, K558KR  
35074 1120020Cb TDF, 3TC EFV  V106M, Y188YH V35T, T39D, S48T, V60I, K122E, D123N, K173A, Q174K, D177E, I178V, T200A, I202V, Q207E, R211K, P243T, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, Q343QH, R356K, G359T, A376S, T377L, K390R, A400I, E404D, V435I, L452M, D471E, H483Q, L491S, S519N, Q520K, K527E, K530R, A534S, A554S  
35577 51320Eb TDF, 3TC, AZT EFV M41ML  K20R, V60I, K102R, K122E, D123A, D177E, I178IM, T200A, R211K, P294Q, I326V, G333E, Q334A, T403M, S468P, K476R, H483Y, L517I, S519N, V531I  
42040 102129Jb AZT, 3TC EFV   K32KR, V35I, D123E, V245M, A272P, K277R, I293V, E297K, S322T, Q334H, R356RK, R358RK, K366R, T369V, A376T, T377L, A400T, K431T, S468SP, K527KQ, A554S  
43021 21512Db TDF, 3TC EFV M184V V106M, V179D I142V, K173Q, Q174K, P243T, V245E, A272P, V292I, M357T, T377L, S379G, K390R, A400S, E404D, V435I, R448K, D460N, R461K, S519N, A554S  
43865 111773Db AZT, 3TC EFV  K103N S68G, K122E, K166R, Q174N, T200I, R211K, E248D, A272AS, K277KR, A288S, Q334D, M357T, A360T, K366R, K385R, K390R, A400T, T450N, K451KR, V467I, L469I, H483Y, L491P, I495V, Q520L, Q524E, E529EK, A554NT T69AV 
46423 258003Jb TDF, 3TC, AZT EFV   I178M, P243S, V245E, K281R, M357T, K390R, K395KR, T397TA, A400AS, V435L, S468P, Q509I, K558R  
50130 151280Lb AZT, 3TC EFV   D123E, K166R, Q174QE, D177E, I180V, R211K, A272P, V276VI, P294A, E297K, S322T, I329L, E344EV, R358K, K385R, A400T, V435M, L452I, D460N, R461K, V467I, L469I, L517I, Q524E, A554T  
RG10540 RG10540w113 None EFV   P4PH, K122KE, D123E, I135V, K173KR, D177Q, I178M, T200A, R211G, A288S, I293V, E300EQ, D324E, I329V, G335D, R356K, M357K, K390R, A400S  
RG10778 RG10778w36 3TC, D4T None   E36D, K122E, D123E, I135T, D177E, T200A, Q207E, V245E, I293V, P294Q, Q334L, M357T, T369A, A376T, T386I N175NS 
RG10828 RG10828w66 TDF, 3TC None V75I  Q197E, R211K, V245M, K281R, I293V, S322T, M357I, A376T  
RG11280 RG11280w87 AZT, 3TC, TDF None   I50IL, K122E, I142IV, K173KN, D177N, I202IV, K219T, H235P, V245M, A272P, R284K, T286A, P294S, E297EA, I329L, M357T, A376T, I393IL, E399D Q23QR, T58TA, I63IM, E79EG, D110DA, T128TA, Q340QL, K353KN, N363T 
RG11340 RG11340w131 AZT, 3TC None M184V  K20R, E36D, V60I, I135T, Q174N, A272P, T286A, V292I, E297K, K311R, R356K, R358K, E370Q, Q373H, K390R  
RG11714 RG11714w33 None EFV  K103N A98S, K122E, D123E, I135T, K173E, Q174K, G196E, A272P, L283I, I293V, E297K, D324E, A376T, K390R  
RG12476 RG12476w44 None EFV  V106I V35I, S48T, K49KR, K122E, S162C, D177E, I178L, I195M, Q197E, T200V, E204K, Q207E, V245T, A272P, I293V, E297Q, L310LV, P313T, I375V, A376AS, T377V, K390R  
RG13005 RG13005w118 AZT, 3TC None A62AV, M184V, T215D E138Q, V179L E6ED, V60I, R83K, N175H, I202V, Q207K, R211K, K275Q, T286A, I293V, T296S, E297K, V317A, I329V, Q334E, A355S, T369A, K385R  
RG13636 RG13636w35 3TC, D4T None  E138A T27S, V35I, V60I, K64R, R83K, K122E, I135T, S162Y, Q207D, R211K, I244V, A272P, K277R, T286A, E297K, Q334E, F346Y, M357V, K366R, K390R  
RG1480 RG1480w23 None EFV  G190A S68G, K101Q, K122E, I135T, K166R, D177E, T200M, R211K, V245E, A272G, T286A, K287R, V292I, I329L, M357T, I380V, V381I, A400S  
RG14944 RG14944w15 AZT, 3TC EFV   K122E, I135T, S162C, I178M, G196E, Q207E, V245EQ, K275S, A288G, I293V, I329IV, F346Y, T377R, V381I, T386I  
RG15374 RG15374w16 3TC, D4T None   K49R, I50V, V60I, A98S, K122Q, E169D, K173R, D177E, R211K, L228LP, W229L, A272P, K277R, L283I, I293V, G335D, R356K, G359S, A376S, T377M, K390R  
  RG15374w24 3TC, D4T None   K49R, I50V, V60I, A98S, K122Q, E169D, K173R, D177E, R211K, A272P, K277R, L283I, I293V, G335D, R356K, G359S, A376S, T377M, K390R  
  RG15374w26 3TC, D4T None   K49R, I50V, V60I, A98S, K122Q, E169D, K173R, D177E, R211K, A272P, K277R, L283I, I293V, G335D, R356K, G359S, A376S, T377M, K390R  
RG16679 RG16679w32 AZT, 3TC None   P4S, R83K, I142T, T165I, V245E, A272S, K277R, T286A, I293V, Q334E, R356K, A376V  
RG17597 RG17597w16 3TC, D4T None   V35I, T200A, Q207A, R211S, P243S, V245E, I293V, R356K, M357T, K390R, A400S  
RG1791 RG1791w74 None EFV  K103N K64R, A98S, Q174A, V245E, V254I, A272S, T286A, I293V, P294A, E297A, E312K, G335D, E344D, R356K, M357V, K390R  
RG17932 RG17932w48 AZT, 3TC None   K20R, K49KR, K103R, D123E, S162C, Q174E, T200A, V245X, A272S, K277R, L283I, A288T, I293V, E297A, E312K, G335D, R356K, G359S, A360T  
RG18536 RG18536w52 None EFV  K103N P1PS, V35T, R72G, D123E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, P243T, V245Q, T286A, E291D, V292I, I293V, P294T, S322A, D324E, G335D, R356K, M357K, G359S, A371V, I375V, S379SG, K388R  
RG18978 RG18978w74 None EFV  L100I, V179D, N348I V35T, D123E, A158S, T200E, Q207E, V245M, E248D, A272P, K277R, T286A, I293V, I326V, M357V, K366R, A376S, K390R, A400S  
RG19024 RG19024w20 3TC, D4T None   V35T, E36A, T39E, S48E, V60I, K122E, D123G, K166R, K173A, Q174R, D177E, I178M, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311R, Q334D, G335D, R356K, M357MR, R358RK, G359T, T377Q, K390R  
RG21379 RG21379w108 None EFV K70KR  I135T, Q174H, Q197E, I202V, R211K, V245M, T286A, A288S, I293V, E297A, I309V, V317A, T338S, M357T, T369S, K390R, A400S  
RG21659 RG21659w27 TDF, 3TC, D4T None M184MIV  R83K, S162C, E169D, Q197E, R211K, K277R, V292I, K390R  
  RG21659w51 TDF, 3TC, D4T EFV M184V K103N, N348NI R83K, S162C, E169D, Q197E, R211K, K277R, V292I, I375IV, K390R  
RG22579 RG22579w24 3TC, D4T None M184MV  V35I, R83K, I135T, R211T, I244V, E248ED, A272P, K277R, E297K, I329L, F346Y, V365I, K390R  
RG23578 RG23578w44 3TC, D4T, TDF None   E6D, V8VI, D121H, K122E, I135T, K166R, T200TI, R211K, A272P, K277R, L283I, R284K, I293V, E297A, P345PQ, I375IV, A376AT, T386I, K390R  
RG23877 RG23877w35 AZT, 3TC EFV M41L, K65R, D67N G190S, K238T, N348I K20R, V60I, T69N, K122E, K173Q, D177E, I178M, R211K, D250N, K259R, A272P, E297R, K390R  
RG24651 RG24651w39 None EFV A62AV K103N K101X, D123E, I135V, Q174QR, D177E, I178M, V179I, E248Q, A272AV, I293IV, G333GE, Q334X, G335GS, M357T  
RG25563 RG25563w11 AZT, 3TC None   E6ED, K11KT, V35I, R83K, Q197P, T200AE, Q207E, R211K, V245E, K277R, I293V, E297R, K311KR, G333E, Q334H, R356RK, K366R, K390R, E399ED, A400AT  
RG25685 RG25685w44 AZT, 3TC EFV  K103N M16L, S68G, T107TP, G196N, T200A, R211K, V245E, E248D, S251I, V276I, I293V, K347R, M357V, E396Q R356T 
RG26742 RG26742w64 AZT, 3TC None   K122P, D123E, I135T, A158S, S162C, N175H, I178IM, V179I, I202V, R211K, A272P, K281R, I293V, E297S, I326V, Q334E, M357A, K390R  
RG27158 RG27158w108 None EFV  K103N K122P, I135T, K173E, I195T, V245M, T286A, A288G, I293V, E297A, E312T, R356K, T369V, Q373H, T397TA  
RG27825 RG27825w95 None EFV  K103N, V106A R83K, K122E, S162C, S163T, Q207E, D237DN, V245EQ, A272P, K277R, T286A, I293IV, E297T, G333E, Q334H, R358RK, A360T, A376T, T386A, K390KR  
RG27982 RG27982w38 None EFV  G190S K103R, I135V, I142T, S162C, V245E, E248T, A272P, K277R, I293V, D324E, Y342F, M357T, I382V, K390R  
RG28049 RG28049w31 None EFV M41L, L210W, T215S K103N E6D, V35T, E40D, V60I, A98S, K102KR, K122E, G196E, I202IV, E248D, Q278H, I293V, I326M, Y342F, T377V, T386I, K390R  
RG28986 RG28986w73 None EFV  K101E, K103N, E138AG D123E, D177E, F214L, V245K, K249Q, D250E, K281R, I326V, Q334Y, T338S, A360T, K366R  
RG29397 RG29397w32 None EFV   R83K, F171FY, I178V, I202IV, R211RK, A272P, I329V, K390R  
  RG29397w44 None EFV   I31IV, V35VI, R83K, T165TI, I202IV, L210LS, R211RK, A272P, I329V, K390R  
RG30110 RG30110w97 AZT, 3TC, TDF, FTC EFV   K49KR, K104R, I135T, E169D, I178MV, G196E, Q197K, T200A, Q207QH, R211A, V245E, A272P, K277R, T286A, V292I, I293V, E297A, I326V, Q334HY, T369A, A376T, T377P  
RG30526 RG30526w18 None EFV  K103N R83K, K122KE, I135IT, S162A, E169D, Q207E, R211K, A272P, K277R, R284K, T286A, I293V, P294S, E297T, D324DE, G359S, A376T, T377L, K390R  
RG31445 RG31445w120 AZT, 3TC EFV   K122E, D123N, I142V, S162C, G196E, T200A, L210F, V245E, K277R, L283I, I293V, K390R  
RG31923 RG31923w67 AZT, 3TC None M184V  K20R, V60I, K64R, Q174N, A272P, K277R, T286V, V292I, E297R, K311R, I326V, G333E, R356K, R358K, Q373H, K390R  
RG32260 RG32260w40 3TC, D4T None   E36D, G196E, T200A, I202V, R211K, V245E, E248D, V292I, I293V, E297Q, S322T, D324E, M357T, S379G, T386I  
RG3239 RG3239w15 AZT, 3TC None M184V  A98S, I142T, L210M, A272P, T286A, E297N, S322T, P345T  
RG32935 RG32935w99 TDF, 3TC None   E6D, V35T, V60I, K64R, D123E, R211K, I293V, M357T, A360T, I375V, S379C, K390R  
RG35343 RG35343w84 TDF, 3TC None   V35T, E40ED, D121N, K122E, D177E, I178L, E248ED, A272P, K277R, V292VI, E312D, Q334E, M357MT, K366KR, A376T, K390R  
RG3536 RG3536w0 None None   V60I, D121Y, K122E, I135T, I142V, S162A, I178M, V245T, K277R, A288S, E297R, I329L, T369S, T386I, K390R  
  RG3536w11 AZT, 3TC None   K11KT, V60I, D121Y, K122E, I135T, I142V, S162A, I178M, I195IV, V245T, K277R, A288S, E297R, I329L, T369S, T386I, K390R  
  RG3536w20 AZT, 3TC None   E53ED, V60I, D121Y, K122E, I135T, I142V, S162A, I178M, V245T, K277R, A288S, E297R, I329L, T369S, T386I, K390R  
RG3642 RG3642w41 AZT, 3TC None   V35T, E36A, T39K, K43E, V60I, K64KR, D121H, K122E, D123S, I142V, S162A, K173A, Q174K, D177E, G196E, T200A, Q207E, V245Q, E248A, T286A, E291D, V292I, I293V, P294T, G335D, R356K, M357R, G359S, A371V, I375V  
RG38236 RG38236w0 None None   K11R, V35T, E36A, T39E, D123S, I135T, K173T, D177E, T200A, Q207E, R211K, V245Q, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, A376AT, T377M, S379C, K390R  
  RG38236w72 None EFV   K11R, V35T, E36A, T39E, D123S, I135T, K173T, Q174QK, D177E, T200A, Q207E, R211K, V245Q, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, K347KR, R356K, G359T, A376AT, T377M, S379C, K390R  
RG38288 RG38288w14 None EFV  K103N K122E, A158S, K173E, V179VI, S251SI, A272S, K277R, T286A, E291D, K311Q, R358K, I375V  
RG41621 RG41621w73 TDF, 3TC EFV  K103KN E36EK, A98S, I135V, D192DN, T200V, R211K, V245M, I293V, I326V, Q334Y, G335D, R356K, M357R  
RG41688 RG41688w0 None None   E6D, K20R, V60I, R83K, D123E, T200I, R211RK, A272P, K281R, T286A, E297K, K311R, D324E, G333E, Q334N, A360V, Q373N, K390R  
  RG41688w13 AZT, 3TC None   E6D, K20R, V60I, R83K, D123E, T200I, R211RK, A272P, K281R, T286A, E297K, K311R, D324E, G333E, Q334N, A360V, Q373N, K390R  
RG41711 RG41711w48 TDF, 3TC None   E28ED, I135T, V245VE, E248Q, A272AS, E291D, E297K, K311R, Q334E, Q367L, S379G, T386V, K390R  
RG41950 RG41950w28 None EFV, NVP  K103N, V106VA R83K, V90I, K102R, K122E, S162A, D177E, G196E, R211K, V245E, Q278H, T286A, V292VI, I293IV, T296S, E297R, V317VA, G359S, T386I, K390R  
RG41981 RG41981w0 None None   D121Y, K122E, V179I, R211K, V245K, S251SI, T286A, P294S, E297EK, K311R, I326IV, I329IL, R356K, A376AV, K390R  
  RG41981w55 None EFV   D121Y, K122E, V179I, R211K, V245K, T286A, P294S, E297K, K311R, I329L, R356K, A376V, K390R  
RG42387 RG42387w5 None EFV  K103N, V179D D121H, K122E, I135T, D177E, I178V, Q207D, R211K, A272T, K277R, I293V, P313Q, I329V, P345Q, F346Y, R358K, K395R  
RG42605 RG42605w0 None None   K11EQ, V35I, K64R, K166KR, I178M, T200TA, R211RK, V245T, K277R, T286A, E297R, R356K, R358K, K366R, A376T, K390R P9R 
  RG42605w20 3TC, D4T None   K11E, V35I, K64R, K166KR, I178M, V245T, K277R, T286A, E297R, R356K, R358K, K366R, A376T, K390R P9R 
RG42767 RG42767w0 None None   P14PL, I142V, T200A, Q207E, R211K, V245K, L283I, I293V, P294T, S322T, R356K, A360T, K390R  
RG42882 RG42882w8 None None   E6D, K104R, K122KE, D123E, G196GE, T200A, R211K, A272P, K277R, P294S, E297EK, A376T, E399D  
RG44036 RG44036w110 TDF, 3TC None   E6K, S48T, V60VI, K122E, D123E, I142IV, G196E, T200I, R211G, V245VE, A272P, T286P, I293V, E297K, V317VA, M357IT, A376T, K390R  
RG44674 RG44674w16 AZT, 3TC None   K20KR, K32KR, K122KE, T200A, R211K, V245M, A272AP, K277R, T286TA, E297EK, D324E, G333GE, P345PQ, R358K, K366KR, A376V  
RG44888 RG44888w43 3TC, D4T None M184V  P4S, V35I, R83K, D123E, D177E, T200A, V245E, A272P, K277R, I293V, E297K, D324E, R358K, A376V  
RG46164 RG46164w0 None None   I135T, D177E, V179I, T200E, Q207E, E248N, T286A, I293V, K311R, Q334L, A376T, T386I D320Y 
  RG46164w125 AZT, 3TC EFV   I135T, D177E, V179I, T200E, Q207E, E248N, T286A, I293V, K311R, Q334L, A376T, T386I  
RG46205 RG46205w36 AZT, 3TC EFV   S162C, R211K, V292I, S322A, I329L  
RG47278 RG47278w59 None EFV   R83K, D123E, V245K, A272P, K277R, E297K, I375V, A376S, T386I, K390R  
RG47535 RG47535w58 None EFV   V35I, K102R, K122E, D123S, R211RK, S251N, K277R, T286A, K366R  
  RG47535w82 None EFV  L100I, K103N V8VI, V35I, K102R, K122E, D123S, S251N, K277R, T286A, K366R  
RG47672 RG47672w8 AZT, 3TC None   D123E, I135T, K173E, Q174R, D177E, I178L, V179I, R211K, V245M, D250E, A272P, K277R, E297K, K385R, K390R  
RG48271 RG48271w0 None None  K103N V35T, T39A, E40D, D123E, S162C, K173R, Q207K, R211K, P243T, V245M, A272P, K277R, T286A, V292I, I293V  
  RG48271w12 None EFV  K103N V35T, T39A, E40D, D123E, S162C, K173R, Q207K, R211K, P243T, V245M, A272P, K277R, T286A, V292I, I293V, V365I, A376S, T377I, V381I, K390R I5IF 
RG48284 RG48284w32 AZT, 3TC EFV  V106M, E138EK V35I, R83K, D123E, I135T, I178L, G196E, R211G, I244V, V245K, A272P, K281R, T286A, E297K, V317A, I329V, G333E, F346Y, M357T, K390R, E399D  
RG49193 RG49193w75 None EFV  K103N V35I, I135L, D177E, R211K, E248D, A272P, K277R, L283I, I293V, Q334C, A376T, K390R, E399D, A400S  
RG49346 RG49346w3 AZT, 3TC None   V35M, D123E, S162A, D177E, T200A, F214L, P243S, R284K, T286A, M357I, R358K, A376S, K390R, E399G  
RG49532 RG49532w9 None EFV  K103N P4S, V35T, T39E, S48T, W88C, K122E, D123N, T165I, K166R, K173A, Q174K, T200A, Q207E, R211K, F214L, A272S, K277R, T286A, E291D, V292I, I293V, R356K, G359T, V365I, T386I, K390R  
RG49708 RG49708w8 None EFV  K103N D123E, A158S, T165I, D177E, G196E, T200A, F214L, T286A, E297K, S322SA, A376T, K390R  
RG50743 RG50743w0 None None   K20R, K122E, D123N, I159V, D177E, I202V, R211RK, F214L, P243T, A272P, P321S, S322T, D324E, M357T, T362TI, V365I, A376S, T386I, K390R  
  RG50743w34 AZT, 3TC None   K20R, K122E, D123N, I159V, D177E, I202V, R211K, F214L, P243T, A272P, P321S, S322T, D324E, M357T, V365I, A376S, T386I, K390R  
RG50847 RG50847w7 TDF, 3TC None D67N, T215I, K219Q Y181C, Y188L V35L, V60I, T69N, K103R, K122E, S163T, G196E, R211KQ, V245T, E248ED, K249KR, K277R, E297K, L301M, G359S, A376S, T377L, S379A, K390R, Q394L  

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