Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Arien (2005)
Title Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time.
Citation AIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 23
NumPts 23
Subtype B, A, G, F, CRF02_AG, CRF01_AE, CRF05_DF


Clinical RT Isolates

SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
VI178 VI178 None None   V35T, E40D, K49R, V60I, S162C, D177E, Q207E, R211K, V245Q, E248N, A272P, K277R  
VI180 VI180 None None   K20R, K122E, I135T, R211T, F214L, V245M  
VI218 VI218 None None   K22R, S48T, I135V, E169D, V245M, A272P, K277R, E297K  
VI2621 VI2621 None None   E6D, K11T, V35T, T39K, K43E, S68G, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, I293V, E312T, V317T  
VI2622 VI2622 None None T215E  V35I, R83K, K103R, D123E, I135L, S162C, R211K, A272P, K277R, T286A  
VI2626 VI2626 None None   D123E, I135T, S162N, Q207K, R211E, T286A, P294T  
VI2627 VI2627 None None   V35T, E40D, K43R, K49R, V60I, S105A, K122E, D123S, K173I, Q174K, D177E, T200A, Q207K, R211S, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A  
VI2641 VI2641 None None   V35T, T39N, K122E, D123S, K173T, Q174R, D177E, I178M, T200A, Q207E, R211K, V245Q, A272S, V276I, K277R, L283I, I293V, E312T  
VI2642 VI2642 None None   V35T, E36D, D123E, I135V, S162A, K173T, Q174E, D177E, T200A, Q207E, R211T, V245Q, Q278N, T286A, E291D, V292I, I293V, P294T, S322T E248G 
VI2673 VI2673 None None   V90I, S162C, I202V, R211K, F214L, I244V, A272P, K277R, L283I, V317A  
VI2676 VI2676 None None   S68G, D123E, R125K, D177E, I178M, R211K, L228S, E248D, I293V, V317A  
VI2678 VI2678 None None   G196E, A272S, K277R, Q278E, I293V, P294T, E297K  
VI2681 VI2681 None None   R83K, K122E, I142M, E169D, R199K, E203K, G262E, A272P, K277R, A288S, E312K  
VI2687 VI2687 None None   E6K, S48T, D121N, K122E, I135T, I180V, T200I, A272P, V276I, K277R, Q278H, I293V, P294T, A304E, P313S  
VI276 VI276 None None   V118I, I135T, I178L, F214L, A272P, V276I, K277R  
VI318 VI318 None None   P55S, I135V, V245K, K277R, E297A E53L, Y56N 
VI321 VI321 None None K70R  S162C, V245R, A272P  
VI334 VI334 None None   K122R, D123E, A158S, K166R, I178M, K277R, I293V, E297A  
VI339 VI339 None None   K122E, I135T, I293V  
VI342 VI342 None None   V35I, R83K, R211K, V245E  
VI48 VI48 None None   V35T, T39N, E40D, V60I, K104R, K122E, D123S, K173T, Q174R, D177E, I178M, Q207E, V245Q, D250E, A272P, E291D, V292I, I293V, E297A, K311R, V317A E6V 
VI64 VI64 None None   V35T, T39A, L100F, D123E, I135V, S162C, K173T, Q174K, Q207N, R211K, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297K  
VI75 VI75 None None   V35T, T39E, K122E, D123N, A158S, K173S, T200A, Q207A, R211S, V245K, K277R, T286A, E291D, V292I, I293V, P294T, E312D