Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Fish (2010)
Title Natural polymorphisms of integrase among HIV type 1-infected south African patients.
Citation ARHR
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 73
NumPts 73
Subtype C, A, G

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
FV09 05ZAFV09 None    K7R, D25E, V31I, L45Q, I84M, L101I, T112A, T124S, T125A, K136Q, R187K, K188R, V201I, T206S, K211Q, T218I, L234I, D278A, R284G, D288N  
FV10 05ZAFV10 None    D25E, V31I, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, K215N, T218I, L234I, A265V, D278A, S283G  
FV11 05ZAFV11 None    D25E, K34R, I72V, I84M, L101I, T112V, T124S, T125P, K136Q, D167E, V201I, L234I, D270E, D278A, S283G  
FV13 05ZAFV13 None    S17N, D25E, V31I, M50I, I72V, F100Y, L101I, K111T, T112V, T124A, T125A, K136Q, D167E, V201I, T218I, L234I, D278A, S283G  
FV14 05ZAFV14 None    D25E, V31I, I72V, L101I, T112V, K136Q, D167E, V201I, T218I, L234I, D279G, S283G  
FV15 05ZAFV15 None    E11D, D25E, V31I, I84M, L101I, T112V, G134D, K136Q, K156R, D167E, V201I, L234I, R269K, D278A, V281M, S283G  
FV2 05ZAFV2 None    D25E, V31I, M50T, I72V, V77I, I84M, P90T, L101I, T112V, T124N, T125A, K136Q, D167E, V201I, L234I, R269K, D278A, S283D  
FV20 05ZAFV20 None    D25E, V31I, M50T, F100Y, L101I, G106A, T112I, T124A, K136Q, G163A, V201I, T218L, L234I, D278A, S283G  
FV22 05ZAFV22 None    K14R, D25E, V31I, L101I, T112V, T124S, K136Q, V201I, N222T, R224Q, L234I, R269K, D270N, D278A, S283G  
FV23 05ZAFV23 None    S24N, D25E, I72T, F100Y, L101I, T112V, T125A, K136Q, V201I, T218I, L234I, D278A  
FV25 05ZAFV25 None   T97A E11D, V31I, M50I, L74I, L101V, T112V, T124A, T125A, V126F, G134D, K136Q, D167E, V201I, L234I, D278A, S283G  
FV26 05ZAFV26 None    K14R, D25E, V31I, I84M, F100Y, L101I, T112V, T124N, T125A, K136Q, G163E, V201I, K215N, L234I, S255G, R269K, D278A, S283G  
FV27 05ZAFV27 None    E10D, V31I, L45I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, S255G, R269K, D278A, S283G  
FV29 05ZAFV29 None    S17N, D25E, V31I, I84M, L101I, T112I, T124A, T125V, K136Q, V165I, V201I, T206S, T218I, L234I, A265V, R269K, D278A, S283G  
FV3 05ZAFV3 None    D25E, L101I, T112V, T124A, T125A, K136Q, Q177L, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
FV30 05ZAFV30 None    D25E, V31I, M50I, F100Y, L101I, T112V, T125A, K136Q, D167E, V201I, I217V, L234I, V260I, D278A, S283G  
FV31 05ZAFV31 None    S17N, S39C, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218L, K219Q, L234I, D278A, S283G  
FV5 05ZAFV5 None    K7R, E11D, D25E, F100Q, L101I, K111T, T112V, T124A, T125A, K136Q, D167E, V201I, K215N, L234I, D278A, R284G, D286N  
FV6 05ZAFV6 None    D25E, V31I, M50T, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, R269K, D278A, S283G, R284G, D286N  
FV7 05ZAFV7 None    D6E, K14R, D25E, V31I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
FV8 05ZAFV8 None    K14R, D25E, V31I, K34R, M50T, F100Y, L101I, T112V, T124N, T125A, K136Q, V201I, K211R, T218I, L234I, A265V, D278A, S283G  
JF04 05ZAJF04 None    S17N, V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283G  
P01 09ZAP01 None    E11D, K14R, D25E, F26Y, V31I, M50I, A91N, L101I, T112V, F121L, K136Q, V201I, L234I, R269K, D278A, S283G  
P02 09ZAP02 None    E11D, K14R, D25E, F26Y, V31I, V37I, M50I, I60V, F100Y, L101I, T112V, T125A, K136Q, V201I, L234I, S283G  
P03 09ZAP03 None    E11D, S24N, D25E, V31I, L101I, T112V, T124N, T125A, I135V, K136H, V165I, V201I, T206S, L234I, A265V, R269K, D278A, S283G  
P04 09ZAP04 None    S17N, R20K, D25E, V31I, I72V, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, N254K, D278A, S283G  
P06 09ZAP06 None    D6E, E11D, D25E, V31I, M50I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218L, L234I, R269K, D278A, S283G  
P07 09ZAP07 None    E11D, S24N, D25E, V31I, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, T218I, L234I, R269K, D278A, S283G  
P09 09ZAP09 None    D25E, V31I, F100Y, L101I, T112V, T124A, T125A, K136H, F181L, K188R, V201I, T206S, T218L, I220V, L234I, I268L, D278A, S283G  
P10 09ZAP10 None    E11D, K14R, S17T, V37I, M50I, I84M, Q95A, E96D, L101I, T112V, T125A, I135V, K136Q, V201I, L234I, S255G, D278A, R284G  
P12 09ZAP12 None    R20K, V31I, L45Q, M50I, I60V, F100Y, L101I, T112V, T124A, T125V, D167E, H171Q, K188R, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
P13 09ZAP13 None    E11D, K14R, D25E, V31I, L63I, L74I, E96D, L101I, G106A, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, R269K, D278A, S283G  
P14 09ZAP14 None    S17N, D25E, V31I, M50I, I72V, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283G  
P15 09ZAP15 None    E11D, S24G, D25E, V31I, L101I, K111R, T112V, T124Q, I135V, K136Q, K188R, V201I, L234I, A265V, D278A, S283G  
P16 09ZAP16 None    S17N, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
P18 09ZAP18 None    E11D, A21T, S24N, D25E, M50I, I84M, L101I, G106A, T112M, K136N, V201I, T218I, L234I, A265V, D278A, S283G  
P19 09ZAP19 None    D25E, I72V, Y99F, F100Y, L101I, T112V, T124A, T125A, K136T, V201I, T218L, I220V, L234I, S283G  
P21 09ZAP21 None    D6E, E10D, D25E, V31I, M50T, I72V, A91G, F100Y, L101I, G106A, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283G  
P22 09ZAP22 None    V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, K215N, L234I, A265V, D278A, S283G  
P23 09ZAP23 None    E11D, S24N, D25E, V31I, Q95N, L101I, T112V, T124N, K136Q, V201I, L234I, R269K, D278A, S283G  
P25 09ZAP25 None    E11D, S24N, D25E, V31I, I84M, F100Y, L101I, T112V, T124A, T125P, K136Q, V201I, K215N, L234I, R269K, D278A, S283G  
P26 09ZAP26 None    D6E, S17N, D25E, V31I, L45Q, F100Y, L101I, T112V, T124N, T125A, K136Q, V201I, K215N, T218I, L234V, D278A, S283G  
P27 09ZAP27 None    S17T, N18T, D25E, V31I, I84M, L101I, T112I, T124A, T125A, K136Q, V201I, T218I, L234I, R269K, D278A, S283G  
P29 09ZAP29 None    E11D, S24N, D25E, V31I, M50I, I60V, L101I, T112V, V201I, T218I, L234I, A265V, R269K, S283G, D286N  
P30 09ZAP30 None    S17N, V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, L234I, A265V, R269K, D278A, S283G  
P31 09ZAP31 None    K7R, E11D, S24N, D25E, V31I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, L234I, A265V, D278A, S283D  
P32 09ZAP32 None    K14R, D25E, K34R, L101I, T112V, T124A, T125A, K136Q, G163Q, D167E, V201I, L234I, D278A, S283G  
P33 09ZAP33 None    V31I, M50I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T206S, K215N, Q216K, T218I, K219Q, L234I, R269K, D278A, S283G, R284G, D288N  
P34 09ZAP34 None   E157Q K14R, D25E, V31I, L101I, T112V, T124N, T125S, K156N, G193D, S195C, V201I, L234I, A265V, R269K, D278A, S283G  
P35 09ZAP35 None    K14R, S24N, S39C, I60M, I72V, T112V, I113V, T124A, T125A, K136Q, V201I, T206S, T218I, Q221R, L234I, S283G  
P36 09ZAP36 None    K14R, D25E, V31I, M50I, L101I, T112V, T124A, T125A, K136Q, D167E, K188R, V201I, K211R, T218I, L234I, A265V, D278A, S283G  
P37 09ZAP37 None    S17N, D25E, V31I, I72V, I84M, L101I, T112V, T124A, T125A, K136Q, Q177L, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
P38 09ZAP38 None    D6E, K14R, S24N, D25E, L45Q, V54I, I72V, I84M, T112V, T124A, T125A, K136Q, V150A, V201I, L234I, D278A, S283G  
P39 09ZAP39 None    D25E, I72V, L101I, T112V, T124A, K136Q, V201I, T218I, L234I, D278A, S283G  
P40 09ZAP40 None    K14R, V31I, M50T, E96D, F100Y, L101I, G106A, T112V, T124N, T125A, K136Q, Y194C, V201I, T206S, K211N, L234I, A265V, D278A, S283G  
P41 09ZAP41 None    R20K, D25E, V31I, M50I, Q95P, F100Y, L101I, T112V, T124N, T125A, K136Q, V201I, T218L, L234I, A265V, R269K, D278A, S283G  
P43 09ZAP43 None    K14R, D25E, V31I, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, L234I, D278A, S283G  
P45 09ZAP45 None    D25E, V31I, L101I, T112V, T124A, T125A, K136Q, K156R, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
P46 09ZAP46 None    S17N, V31I, M50I, L74I, L101I, K111R, T112V, T125A, K136Q, V201I, K219N, N222K, L234I, S283G  
P49 09ZAP49 None    D25E, V31I, I72V, I84M, E96D, L101I, G106A, T112V, T125V, K136Q, V201I, K215Q, L234I, D278A, S283G  
P50 09ZAP50 None    D3E, E11D, S17N, D25E, M50T, H51Q, I72T, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, L234I, D278A, S283G  
P51 09ZAP51 None   E157Q E11D, D25E, V31I, V37I, M50I, I72V, A91G, L101I, T124A, T125A, K136Q, K160Q, D167E, V201I, K211T, L234I, A265V, R269K, D278A, R284G, D286N  
P52 09ZAP52 None   E157Q S17N, K34R, L101I, T112V, T124A, T125A, G134D, K136T, K160Q, D167E, V201I, T206S, L234I, D270E, S283G  
P53 09ZAP53 None    S17N, S24D, D25E, P30S, S39C, M50I, T112V, T124N, K136Q, V201I, T206S, L234I, D278A, S283G  
P54 09ZAP54 None    D25E, V31I, M50T, I84M, L101I, K111R, T112V, T124N, T125A, V165I, V201I, T206S, L234I, R269K, D278A, S283G  
P55 09ZAP55 None    E10D, E11D, S24N, D25E, V31I, L101I, T112M, T125A, K136Q, V201I, L234I, R269K, D278A, S283G  
P56 09ZAP56 None    K14R, D25E, V31I, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, I257L, R269K, D278A, S283G Q252P 
P57 09ZAP57 None    S17N, K34R, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K211R, T218I, K219Q, L234I, Q274K  
P58 09ZAP58 None    K14R, D25E, L28I, P30A, F100Y, L101I, T112V, T124A, T125A, K136N, G193D, V201I, T206S, L234I, K273Q, D278A, S283G  
P59 09ZAP59 None    K14R, D25E, V31I, I72V, L101I, T112V, S119P, T124A, T125A, K136Q, V201I, T206S, D207E, Q216R, T218I, K219Q, L234I, R269K, D278A, S283G  
P60 09ZAP60 None    S17N, V31I, M50T, F100Y, L101I, T112V, T124G, T125P, K136Q, V201I, T218L, K219Q, L234I, D278A, S283G  
P61 09ZAP61 None    D25E, V31I, K34R, F100Y, L101I, T112V, T124N, T125A, K136Q, D167E, V201I, L234I, D278A, S283G  
P62 09ZAP62 None    D25E, V31I, M50T, I72V, I84M, A91G, L101I, T112V, T124G, T125A, K127Q, K136Q, A169G, V201I, L234I, I257L, R269K, D278A, S283G, Q285P R231I 

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