Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Winters (1998)
Title Human immunodeficiency virus type 1 protease genotypes and in vitro protease inhibitor susceptibilities of isolates from individuals who were switched to other protease inhibitors after long-term saquinavir treatment.
Citation J Virol
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 17
NumPts 10
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
CA1149 CA10385 SQV 74   T4TN  
CA1313 CA10393 SQV 30   L10I, L63P, A71T, I72E, V77I, I93L  
  CA10395 SQV, NFV 55 L90M  L10I, K20KM, L63P, A71T, I72E, V77I, I93L  
CA4089 CA10383 SQV, NFV 112 L90M G73GS I13V, K20IM, L63P, A71T  
CA642 CA10388 SQV 48 L90M G73S N37D, K55KR, L63P, A71V, I93L  
  CA10391 SQV, NFV 70 L90M G73S N37D, R57RK, D60DE, L63P, A71V, I93L  
  CA24542 SQV, NFV, IDV, RTV, Unknown 202 M46I, I84V, L90M G73S L10LI, N37D, K55R, R57K, D60E, L63P, A71V, V77VI, I93L  
CA793 CA10399 SQV, NFV 107 D30N Q58QE I13V, I15V, E35D, M36I, N37S, R41K, I62X, L63P  
CA795 CA4233 SQV 40 G48V, I54V  L10I, I15V, M36I, I62V  
  CA10419 SQV, NFV 60 G48V, I54V, V82A  L10I, I15V, M36I, I62V  
CA796 CA4231 SQV 39 L90M F53L, G73S L10I, K14R, I15V, N37D, A71V, V77I  
  CA10425 SQV, NFV 56 M46I, L90M F53L, G73S L10I, K14KR, N37D, A71V, V77I  
JL-Pt11 JL-11-pre SQV 35 I84V, L90M  L10I, E35D, N37S, R41K, I62V, L63P, A71V, I93L  
  JL-11-post SQV, NFV 52 I84V, L90M G73S L10I, I13IM, E35D, M36I, N37S, R41K, I62V, L63P, A71V, I93L  
JL-Pt4 JL-4-pre SQV 51   T12S, K14KR, R41K, L63P, I72IV, V77I, I93L  
  JL-4-post SQV, NFV 68 L90M  T12S, R41K, L63P, I72V, V77I, I93L  
JL-Pt6 JL-6-pre SQV 35 L90M G73S L10LV, I62V, A71V