Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Knops (2010)
Title The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V.
Citation AIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 26
NumPts 15
Subtype B, CRF02_AG, C, CRF45_cpx

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
ID0237 ID0237-GT1 Unknown Unknown M41L, D67N, T69E_KREKNSE, L74LI, M184I, L210W, T215Y K103N, V108I, M230L T39A, K43E, E44A, V118I, S162C, I178M, Q207E, R211K, V245E, A272P L149LV, Q258H 
  ID0237-GT2 Unknown, ABC, DDI Unknown M41L, D67N, T69E_KREKTSE, V75VIL, L210W, T215Y  K20KR, V35L, T39A, K43E, E44A, V118I, K122E, S162C, I178M, Q207E, R211K, V245E, A272P  
ID0460 ID0460 Unknown Unknown M184V K103N, Y318F V35T, E36D, T39A, S162A, K173A, Q174K, I178M, T200A, Q207E, R211K, F214L, V245Q, E248N, A272P, T286A, I293V, P294T, S322A  
ID0462 ID0462-GT1 RTI RTI   V35T, E36D, K43KQ, K46KQ, K49R, K122E, D123S, S162A, K166KR, K173I, Q174K, D177E, V179I, T200A, Q207E, V245Q, V261VL, K277R, T286A, E291D, V292I, I293V, S322A  
  ID0462-GT2 RTI, ABC, 3TC RTI M184V  V35T, E36D, E40EK, K43E, K49R, K122E, D123S, S162A, K166R, K173I, Q174K, D177E, V179I, T200A, Q207E, V245Q, K277R, T286A, E291D, V292I, I293V, S322A, I326V  
ID1046 ID1046-GT1 RTI RTI M41L, A62V, D67N, V75I, F116Y, Q151M, M184V, L210W, T215Y K103KN, G190AE E6K, K122E, D123E, S162Y, D177E, V179G, E203K, H208Y, R211D, K223E, E224ED, L228H, V245T, A272PS, K277R, T286A, A288AT  
  ID1046-GT2 RTI, 3TC, D4T RTI M41L, A62V, D67N, V75I, F116Y, Q151M, M184V, L210W, T215Y V106VI, G190A K122E, D123E, S162Y, D177E, E203K, H208Y, R211D, K223E, E224ED, L228LH, V245T, A272S, K277R, T286A, A288T  
ID1083 ID1083-GT1 RTI RTI M41L, D67N, L74IV, M184V, L210W, T215Y, K219N A98G, K103N, V108I, F227L V35I, K43Q, E53D, K102KQ, V118I, K122E, I135V, S162C, E203K, H208Y, R211K, K223E, A272P, K277R  
  ID1083-GT2 RTI, ABC, D4T, DDI RTI M41L, D67N, L74V, L210W, T215Y, K219N A98EG V35I, K43Q, K102R, V118I, K122E, S162C, E203K, H208Y, R211K, K223E, A272P, K277R, D324E  
ID1318 ID1318-GT1 RTI RTI F116Y, Q151M, M184V L100LI, V179D S68G, T69TN, K103R, D123E, I135T, T200A, Q207H, R211K, A272P, T286A, E312AT, S322SL  
  ID1318-GT2 RTI, 3TC RTI F77L, Y115F, F116Y, Q151M, M184V, K219E V179D S68G, K103R, D123E, I135T, S163A, T200A, Q207H, R211K, A272P, T286A, E312A  
ID1348 ID1348-GT1 RTI RTI D67N, K70R, M184V, K219Q K101P, K103N T69N, K122E, D123N, I142V, F214L, L228H, V245T, K277R, T286A, E297K  
  ID1348-GT2 RTI, ABC, TDF RTI D67N, K70R, M184MV, T215FI, K219Q K101PS, K103NS K11T, V60VI, T69N, K122KE, D123N, I142V, R211RS, F214L, L228H, V245T, K277R, T286A, I293IV, E297KR, Q334L  
ID1561 ID1561-GT1 RTI RTI M41L, T69A_VG, V75M, L210W, T215CY V106VIM, Y181C, G190A S68G, K101Q, K103KR, K122E, I135T, I142V, L228K, K277R, Q278E, E297K  
  ID1561-GT2 RTI, DDI RTI, NVP M41L, T69A_XG, V75M, L210W, T215Y V106VI, Y181C, G190A S68G, K101Q, K122E, I135T, I142V, L228K, K277R, E297K  
ID1585 ID1585-GT1 RTI RTI M41L, D67N, T69D, K70R, L74LV, M184V, L210W, T215F, K219Q A98G, K103KN, Y181YC V35T, T39E, K122E, D123DN, K173T, Q174K, G196E, I202V, E203K, Q207E, R211RK, L228H, V245Q, E248D, D250E, T286A, E291D, V292I, I293V, E297A  
  ID1585-GT2 RTI, D4T, DDI RTI M41L, D67N, T69D, K70R, L74V, L210W, T215F, K219Q A98G, K103N, Y181C S3C, E6K, K20R, V35T, T39E, K122E, M164I, K173T, Q174K, G196E, I202V, E203K, Q207E, R211K, K223Q, L228H, Q242H, V245Q, E248D, D250E, T286A, E291D, V292I, I293V, E297A, A327P  
ID1713 ID1713 Unknown Unknown M41L, T215F K103N, V108I T39A, K102Q, D123E, I142V, S162Y, R211K, A272P, K277R, T286A, E297K  
ID2117 ID2117-GT1 RTI RTI  V179D V60I, V118I, K122Q, D123N, I135IT, V189VA, F214L, A272P, K277R, T286A, I293V, I329L  
  ID2117-GT2 RTI RTI  V179D V60I, V118I, K122Q, D123N, I135IT, I142IT, Q174QK, Q207QE, F214L, A272P, K277R, T286A, I293V, E297EK, E302A  
ID2137 ID2137-GT1 RTI RTI D67N, K70R, T215Y, K219E Y181C I2V, K32E, V35T, E36A, T39E, V90I, K122P, I135M, T139K, I142V, S162N, K173A, Q174K, V179I, I195L, G196E, Q197H, T200A, I202V, E203K, Q207E, L228H, V245K, A272P, L283I, T286V, E291D, V292I, I293V, D324E K20T, E28T 
  ID2137-GT2 RTI, DDI RTI D67N, K70R, T215Y, K219E Y181C E28K, K32E, V35T, E36A, T39E, K46R, V90I, K122P, I135M, T139R, I142V, S162N, K166R, K173A, Q174K, V179I, G196E, Q197QH, T200A, Q207A, R211K, V245K, A272P, L283I, T286V, E291D, V292I, I293V, D324E  
ID2159 ID2159-GT1 RTI RTI M41L, D67N, K70R, T215Y, K219E K103KN, V108VI K20R, K32KT, V35VI, T39K, V60VI, S68SG, K122KE, D177E, T200TA, D218E, L228R, V245T, V317A, I329L  
  ID2159-GT2 RTI, TDF, AZT, FTC RTI M41L, D67N, K70R, M184V, L210W, T215Y, K219E  K20R, V21I, K32T, T39K, V60I, K122E, D177E, V179VI, T200A, D218E, L228H, V245T, V317A, I329L  
ID2429 ID2429 Unknown Unknown A62AV, M184V, T215Y K103N, V108VI, H221Y E6K, K64KR, K122KE, I178IM, T200Q, Q207E, R211K, V245T, A272P, I293V L187LM 
ID3139 ID3139 Unknown Unknown M41L, T69DN, M184V, L210W, T215Y  E44D, A98S, V118I, I142V, Q207E, R211K, A272P, K277R, K281R, L283I, I293V, E297K  

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