Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Delelis (2009)
Title Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo.
Citation AAC
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 8
NumPts 4
Subtype B

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
Pt1 Pt1 None    V32I, S39C, K111R, T124N, T125A, G193E, N254K  
   RAL 48 Y143R  V32I, S39C, K111R, T124N, T125A, G193E, N254K  
Pt2 Pt2 None    A205S, I208L, K211Q, E212A  
   RAL 42 Y143R  A205S, I208L, K211Q, E212A  
Pt3 Pt3 None    I113V, T124NS, T125A, T206S, I220L, Y227F  
   RAL 16 Y143R  I113V, T124NS, T125A, T206S, I220L, Y227F  
Pt4 Pt4 None    H51D, K111T, S119T  
   RAL 40 Y143YC, N155NH  H51D, K111T, S119T  

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