Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Burda (2010)
Title HIV-1 reverse transcriptase drug-resistance mutations in chronically infected individuals receiving or naive to HAART in Cameroon.
Citation J Med Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 49
NumPts 49
Subtype CRF02_AG, A, D, F, G, J, G + J, CRF09_cpx

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
06ARC001 06ARC001 3TC, D4T NVP M184V K103N V35K, E36D, K122E, D123S, I135M, S162A, K173T, Q174N, D177E, T200A, Q207E, V245Q, E291D, V292I, I293V, S322T, G335D, R356K, M357K, G359S, K366R, T369A, A376V, I380V, T386A, K390R, K395R, A400T, W410C  
06ARC003 06ARC003 3TC, D4T NVP   K20R, V35T, T39A, E40D, K122P, I135V, I142T, S162A, K173A, Q174K, T200E, E203Q, Q207E, F214L, V245K, A272P, V276I, L283I, T286A, I293V, P294A, S322A, I326V, G335D, R356K, M357R, G359S, A371V, I375V, A376T, T377V, K390R, T403M, E404D, E432D, V435I  
06ARC004 06ARC004 None None   V35T, E40D, K122E, I135V, S162A, K173T, Q174K, D177E, T200A, L205LF, Q207E, V245Q, T286A, I293V, P294A, R307RS, S322A, I326V, G335D, R356K, M357K, G359S, K366R, A371V, I375V, T377L, T386X, K390R, T403M, W426X  
06ARC007 06ARC007 3TC, D4T, AZT NVP, EFV A62V, K65R, V75I, F116Y, Q151M, M184I V108I, Y181C I31L, V35I, S68G, T69I, V90I, K104R, K122E, S162A, K173T, Q174K, D177E, I178M  
06ARC009 06ARC009 3TC, D4T None  V179E V35T, E36D, T39A, D123E, I135V, A158P, S162A, E169Q, K173T, Q174E, D177E  
06ARC010 06ARC010 None None   V35T, E36D, T39X, D123E, I135V, S162A, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, R358G, G359S, A371V, I375V, T377R, K390R, T403M  
06ARC011 06ARC011 3TC, D4T NVP   V35T, D121H, K122E, I135V, S162A, K173T, Q174K, D177E  
06ARC013 06ARC013 None None  V179E V21I, V35T, T39E, V60I, K122E, D123N, I135K, S162C, K173R, Q174K, D177E  
06ARC036 06ARC036 3TC, D4T, AZT NVP, EFV M184V K103N, V179E, Y181C, G190A V35T, K43N, K49R, I135V, S162D, E169A, K173A, Q174K, D177E, I178M  
06ARC053 06ARC053 3TC NVP   V35T, E36D, T39K, K43E, K49R, K104R, I135V, S162A, E169A, K173A, Q174K, D177E, V179I  
06ARC055 06ARC055 3TC, D4T NVP   V35T, K49R, V60I, K122E, S162C, R172K, D177E, I178L, G196E  
06ARC058 06ARC058 3TC NVP   V35T, T39L, D121Y, K122E, I135V, S162A, K173T, Q174K, D177E  
06ARC071 06ARC071 3TC, D4T NVP M184V K103N P4T, E6D, V35T, E40D, K49R, K122E, D123G, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, S322A, I326V, G335D, R356K, M357K, G359S, K366R, T369V, A371V, I375V, T377I, K390R, A400T, T403M, E432D, V435M  
06ARC075 06ARC075 3TC, D4T NVP   V35T, E36D, T39S, I135V, S162A, K173T, Q174A, D177E, T200E, Q207E, R211K, P243T, V245Q, E248D, A272P, E291D, V292I, I293V, T296X, S322T, I326V, I329V, G335D, R356K, M357K, G359S, K366R, A371V, V381I, K390R, T403M, E432D  
06ARC076 06ARC076 None None K65R, T69~, K219R K101E I31L, V35T, E44D, I63L, S68G, D123E, P157A, S162C, K173A, Q174K, D177E, T200K, Q207E, R211K, P243A, V245Q, E248D, D250S, A272P, K275R, Q278H, E291D, I293V, E297A, D324E, G335D, F346H, R356K, M357R, R358K, G359S, T386I, K388R, K390R, A400I, E404D, K431T, V435L Y181L 
06BDHS004 06BDHS004 3TC, D4T NVP   V35T, E36D, T39K, V60I, K122P, D123E, I135L, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q, E248N, K275Q, T286A, E291D, V292I, I293V, P294T, D320E, S322T, D324E, I326V, G335D, R356K, M357R, G359S, A371V, I375V, T377V, T403M, E432D, V435L E79Q 
06BDHS005 06BDHS005 3TC, D4T NVP A62V, V75I, F77L, F116Y, Q151M, M184V Y188L I5V, E6D, V35T, T39A, E40D, S68G, D123S, G141R, K173T, D177E, Q197K  
06BDHS006 06BDHS006 3TC, D4T NVP   V35T, E36D, T39L, L100LF, S162A, Q174T, D177E, T200A, Q207E, R211K, V245E, T286A, E291D, V292I, I293V, S322T, I326V, G335D, R356K, M357R, G359S, A360T, T369A, A371V, I375V, A376T, K390R, A400T, T403M, E413D, E432D, V435A  
06BDHS007 06BDHS007 3TC, D4T NVP   V35T, T39L, S162A, K173T, Q174K, D177E, I195L  
06BDHS019 06BDHS019 None None   V35T, T39M, S48T, K49R, V60I, K102Q, D121Y, K122E, K166R, E169Q, K173N, Q174K, D177E, I178M, G196E, T200A, Q207N, R211K, V245Q, E248N, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297A, K311R, D324E, L325I, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, A376S, T386I, Q394R, E399D, A400V, E404D, E413D, K431T, V435P, F440Y  
06BDHS020 06BDHS020 None None   V35T, E36D, T39A, E40D, I135V, S162A, F171Y, K173T, Q174K, D177E, T200A, Q207E, V245Q, K281R, T286A, A288K, E291D, V292I, I293V, P294T, V317A, D320E, S322T, D324E, I326V, G335D, R356K, M357K, G359S, V365I, A371V, I375V, T377L, K390R, T403M, E432D, V435IM  
06BDHS023 06BDHS023 None None   V35T, E40D, K49R, T69S, K122E, I135T, A158S, K173T, D177E, T200K, I202V, Q207E, V245E, E248D, W252Y, K281R, T286A, E291D, I293V, E297A, P313S, V317S, S322E, E328D, G335E, F346G, R356K, M357R, R358G, G359A, I375V, T377V, T386I, K390R, Q394R, A400V, Q428R, K431T, V435P  
06BDHS024 06BDHS024 None None M184V V108I, Y181C K20R, V35T, T39A, D123E, A158T, F171Y, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, P243A, V245Q, E248D, D250S, A272P, K275R, Q278H, K281R, L283I, T286A, E291D, I293V, E297A, I329V, Q334H, G335D, F346H, R356K, M357R, R358K, G359S, A371V, K385R, T386V, K390R, A400T, K431T, V435X  
06BDHS028 06BDHS028 None None M184V K103N K11T, V35T, T39K, K43S, V60I, K64R, D121Y, K122E, I135V, S162A, F171Y, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245Q, A272P, K275Q, K277R, L283I, E291D, I293V, E312N, G335D, M357K, R358K, G359S, K366R, A371V, I375V, A400T, P420S, E432D, V435L H208P 
06BDHS035 06BDHS035 None None   P4S, V35T, E36D, T39I, D123E, I135V, S162A, K173T, Q174K, D177E, T200A, I202V, F214L, V245Q, K277R, L283I, T286A, V292I, I293V, P294T, L295M, E297K, S322A, I326V, G335D, R356K, M357R, G359S, A371V, I375V, A376S, K390R, T403M  
06LPH01OJ 06LPH01OJ None None   V21I, V35T, T39A, D121Y, K122E, K173R, Q174K, D177E  
06LPH02MG 06LPH02MG None None   V35T, V60I, K122E, D123N, I135V, S162A, K173T, Q174R, D177E, I178M  
06LPH03VJ 06LPH03VJ None None   V35T, E36D, T39A, E40D, S162A, K173T, Q174K, D177E, V179I, G196E  
06LPH05DE 06LPH05DE None None   K20R, V35T, V60I, I135V, S162A, K173A, Q174K, D177E  
06LPH11TT 06LPH11TT None None   K11T, V35T, K122E, D123N, K173S, V179I  
06LPH16SL 06LPH16SL 3TC, D4T NVP   V35T, E36D, E40ED, K122E, D123S, I135V, S162A, K173A, D177E, T200A, Q207E, R211K, V245Q, K281R, T286A, E291D, V292I, I293V, S322A, I326V, G335D, R356K, M357K, G359S, A371V, I375V, T377L, T403M  
06LPH17HT 06LPH17HT 3TC, D4T NVP  G190A E6K, V35T, E36D, T39A, K104R, K122E, I135V, I142V, S162A, T165I, K173T, Q174K, D177E, I178M  
06LPH19CM 06LPH19CM None None   E6K, V35T, E40D, K102Q, V118I, K122E, D123N, I135T, T139L, S162A, K173S, V179I K11V, L12S 
06LPH20SC 06LPH20SC 3TC, D4T NVP F116Y, Q151M, M184V V108I, Y181C, H221Y, F227L K20R, V35T, E36D, T39L, K49R, S68G, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, E224D, P243H, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, D320DE, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403M  
06LPH21ZC 06LPH21ZC None None   T27S, V35T, T39A, E40D, D86E, D121Y, K122E, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q, T286A, V292I, I293V, S322A, G335D, R356K, M357K, R358K, G359S, I375V, K390R, K395R, T403A, E432D, V435I, A437V  
06LPH22NH 06LPH22NH None None   V35T, E36D, T39L, V60I, D123E, I135V, S162A, F171Y, K173T, Q174K, D177E, T200A, Q207E, V245Q, K281R, T286A, A288T, E291D, I293V, P294T, S322T, G335D, R356K, M357R, R358K, G359S, A371V, I375V, T377V, K390R, T403M, E432D, V435A, A437V Q407QH 
07BDHS053 07BDHS053 None None   K11T, V35T, T39K, D121Y, K122E, D123G, I135T, T165I, F171Y, K173A, Q174K, D177E, G196E, Q207A, R211S, F214L, E233K, V245Q, E248Q, G262E, T286A, E291D, I293V, E308K, E312D, G335D, M357K, R358T, G359S, E370Q, A371V, I375V, T377Q, S379G, K390R, T403M, E432N  
07BDHS054 07BDHS054 None None  G190A V35T, E36D, K122E, I135V, S162A, K173I, Q174K, D177E  
07BDHS055 07BDHS055 None None   V35T, K43Q, I135V, S162A, K173T, D177E, T200E, E203Q, Q207E, F214L, Q222X, I244K, V245K, L246I, T286A, V292I, I293V, P294T, S322A, I326V, G335D, R356K, M357R, R358K, G359S, T369A, A371V, I375V, A376T, K390R, T403Q, E432D, V435I  
07BDHS077 07BDHS077 3TC, D4T NVP D67N, K70R, L74I, M184V, T215Y, K219E V106A, P225H, F227L V35T, L109I, K122E, I135V, S162A, K173I, Q174K, D177E, T200A, I202V, R211K, A272P, K275R, K277R, T286A, I293V, P294T, S322V, G335D, M357K, G359S, A371V, I375V, I382L, K390R, A400T, T403Q, E432D, V435E, A437V R78P 
07BDHS40 07BDHS40 3TC, D4T NVP M184V V106I, Y181C, H221Y, N348I V35T, T39A, E40D, K49R, V60I, I135T, S162C, R172K, N175H, D177E, I178L, Q197R, T200E, K201I, E204K, Q207E, F214L, V245K, A272P, T286A, I293V, E297K, Q334E, G335S, T338S, Y339W, R356K, K374Q, T377R, K390R, A400T, T403M, V435I  
07LPH01SG 07LPH01SG None EFV   V35T, F77S, K122A, S162A, K173T, Q174K, D177E, I178V, V179I, T200A, Q207E, V245Q, A272X, T286A, E291D, V292I, I293V, S322A, R356K, M357K, G359S, A371V, I375V, A376S, K390R, T403M, E432D, V435A  
07LPH110 07LPH110 3TC, D4T NVP   V35T, K122E, D123S, S162A, K166R, K173T, Q174K, D177E, I178M, Q197P, T200A, Q207E, V245K, N265K, A272P, K277R, T286A, E291D, I293V, P294T, S322A, I326V, G335D, Y342F, R356K, M357K, G359S, K366R, A371V, I375V, K390R, T403M  
07LPH112 07LPH112 3TC, D4T NVP   V35T, T39N, T69S, I135M, S162A, K173A, Q174E, D177E, T200A, Q207E, V245K, E248K, L260I, L264X, K277R, L283F, T286A, E291D, V292I, I293V, P294T, S322A, G335D, R356K, M357R, G359S, K366R, A371T, I375V, T386I, K390R, T403L, V435A E79P 
07LPH128 07LPH128 3TC, D4T NVP   K20R, V35T, E36D, T39L, I135R, S162A, K173T, Q174K, D177E, I178M  
07LPH142 07LPH142 3TC, D4T NVP M184V, T215Y Y181C V35P, E36D, T39L, K49R, S68G, A98S, I135V, S162T, F171Y, K173T, Q174R, D177E, I178M, T200A, Q207E, R211K, H221X, P243H, V245Q, T286A, E291D, V292I, I293V, P294T, S322A, I326V, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403M, E413D, E432D, V435I  
07LPH149 07LPH149 3TC, D4T NVP M184V V106A, F227L P14X, V35T, E36D, E40Q, K43E, K49R, V60I, D123E, S162C, D177E, I178L, T200A, Q207E, F214L, V245T, A272P, T286A, I293V, K311R, Y339W, R356K, A376S, K390R, T403M, E432D, V466I, S468P, L469F, H483N, L491P, S519T  
07LPH162 07LPH162 3TC, D4T NVP   V35T, E36D, T39V, D123E, I135V, S162A, K173T, Q174K, D177E, T200A, Q207S, R211K, F214L, P243Q, V245Q, K277R, Q278H, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357R, G359S, A371V, T377I, K390R, T403M, E413D, E432D, R461K, V466I, T470N, D471E, Q480H, H483Y, L491S, K512R, S519N  
LPH02NJM LPH02NJM 3TC, D4T NVP M184V K103S, G190A V35T, S48E, V60I, I135V, S162A, K173I, Q174K, D177E, I178M, T200A, Q207E, V245T, W252G, A272P, V276I, L282X, L283X, T286A, V292I, I293V, G335S, Y339W, R356K, K390R, T403M, V435A  

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