Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Shafer (1998)
Title Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients.
Citation Ann Intern Med
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 14
NumPts 4
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
HMDR-1 1-90 AZT, DDI None M41L, L210W, T215Y  I135T, G196E  
  1-896-6B AZT, DDI, DDC, 3TC, D4T None M41L, D67N, M184V, L210W, T215Y  K20R, V21I, V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D, A272P, I293V  
  1-896P AZT, DDI, DDC, 3TC, D4T None M41L, D67N, M184V, L210W, T215Y  V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D  
  1-1096 AZT, DDI, DDC, 3TC, D4T None M41L, D67N, L210W, T215Y  V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D  
  1-197 AZT, DDI, DDC, 3TC, D4T None M41L, D67N, L210W, T215Y  K20R, V21I, V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D, A272P  
HMDR-2 2-896 AZT, DDI, DDC, 3TC, D4T None M41L, D67N, T69D, M184V, L210W, T215Y  K43E, E44A, V60I, K102Q, V118I, K122E, Q207E, R211K  
  2-1196-6D AZT, DDI, DDC, 3TC, D4T None M41L, D67N, T69D, M184V, L210W, T215Y  K20R, T39K, K43E, E44D, V60I, K102Q, V118I, K122E, Q207E, R211K, V245E, A272P, K277R, I293V, E297K  
  2-1196P AZT, DDI, DDC, 3TC, D4T None M41L, D67N, T69D, M184V, L210W, T215Y  K20R, T39K, K43E, E44D, V60I, K102Q, V118I, K122E, Q207E, R211K, V245E  
  2-197 AZT, DDI, DDC, 3TC, D4T None M41L, D67N, T69D, M184V, L210W, T215Y  T39K, K43E, E44D, V60I, K102Q, V118I, K122E, Q207E, R211K, V245E  
HMDR-3 3-896 AZT, DDI, 3TC, D4T None M41L, D67DN, L210W, T215Y  V35I, K43N, V60I, A98S, V118I, K122KE, I135V, G196GE, Q207E, R211K, V245L  
  3-1196 AZT, DDI, 3TC, D4T None M41L, L210W, T215Y  V35I, K43N, V60I, A98S, V118I, K122KE, I135V, G196E, Q207E, R211K, V245M K154KT 
  3-197P AZT, DDI, 3TC, D4T None M41L, D67DN, M184V, L210W, T215Y, K219N  K43N, V60I, A98S, V118I, K122KE, I135V, G196GE, Q207E, R211K  
  3-197C AZT, DDI, 3TC, D4T None M41L, D67N, M184V, L210W, T215Y, K219N  V35I, E40X, K43N, V60I, A98S, V118I, K122E, I135V, G196GE, Q207E, R211K  
HMDR-4 AZT, DDC, DDI, D4T, 3TC None M41L, D67N, L74I, M184V, L210W, T215Y, K219N A98G K43E, E44A, K64R, R83K, V118I, S163C, G196E, H208Y, R211K, D218E Q161P