Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Shafer (1998)
Title Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients.
Citation Ann Intern Med
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 16
NumPts 4
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
HMDR-1 1-90 None    L63H, V77I  
  1-896-6B SQV, IDV 60 G48V, I54T, V82A  L10I, L63H, A71V, V77I  
  1-896P SQV, IDV 60 G48V, I54T, V82A  L10I, L63H, A71V, V77I  
  1-1096 SQV, IDV, RTV 68 G48V, I54T, V82A  L10I, L63H, A71V, V77I  
  1-197 SQV, IDV, RTV 86 G48V, I54T, V82A  L10I, L63H, A71V, V77I  
HMDR-2 2-896 SQV, RTV, IDV 132 G48V, I54V, V82A  L10I, N37T, R41K, I62V, L63P, T74S, V77I  
  2-1196-6D SQV, RTV, IDV 145 G48V, I54T, V82A  L10I, N37T, R41K, I62V, L63P, H69Y, A71AV, T74TS, V77I  
  2-1196P SQV, RTV, IDV 145 G48V, I54T, V82A  L10I, N37T, R41K, I62V, L63P, H69Y, A71V, T74S, V77I  
  2-197 SQV, RTV, IDV 154 G48V, I54T, V82A  L10I, N37T, R41K, I62V, L63P, H69Y, A71V, T74S, V77I  
HMDR-3 HMDR3-994 None    R41K, V77I, I93L  
  HMDR3-395 SQV 25 G48V  R41K, Q61H, I62V, L63H, A71V, T74A, V77I, I93L  
  3-896 SQV, IDV, RTV 54 G48V, I54IT, V82A  L10I, R41K, Q61H, I62V, L63Q, A71V, T74A, V77I, I93L  
  3-1196 SQV, IDV, RTV 67 G48V, I54T, V82A  L10I, R41K, Q61H, L63Q, A71V, T74A, V77I, I93L  
  3-197P SQV, IDV, RTV 76 G48V, I54T, V82A  L10I, R41K, Q61N, I62V, L63Q, A71V, T74A, V77I, I93L  
  3-197C SQV, IDV, RTV 76 G48V, I54T, V82A  L10I, G16A, R41K, Q61H, I62V, L63Q, A71V, T74A, V77I, I93L  
HMDR-4 SQV, RTV 69 M46I, G48V, I54T, V82A, L90M  L10LI, N37D, L63P, A71L, V77I, I93L I84IM