Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Poveda (2008)
Title Phenotypic impact of resistance mutations on etravirine susceptibility in HIV patients with prior failure to nonnucleoside analogues.
Citation AIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 39
NumPts 39
Subtype B, G

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
Pt01 Pt01 NRTI NNRTI A62V, V75I, F77L, Y115F, F116Y, Q151M, M184I K101E, V108I, Y181C, G190A V35I, I50V, S68G, D123E, D177E, T200A, R211K, F214L, L228H, V245E, E248D, D250E, K277R, T286A, I293V, E297A, G359S, A371V, I375V, T386TI, K390R L92LM 
Pt02 Pt02 NRTI NNRTI L74V, M184V K101E, Y181C, G190A E28K, K49R, I50V, K122E, I135T, S162C, R211K, I293V, E297K, M357V, T369A  
Pt03 Pt03 NRTI NNRTI M41ML, A62AV, L74V, M184V, T215Y K101E, Y181C, G190S V35M, K49R, R83K, D177E, I202V, R211K, A272P, K277R, I293V, P294Q, K311R, D324E, I326IV, Q334L, G359S, V365I, A376T, S379C, V381I, T386A  
Pt04 Pt04 NRTI NNRTI D67N, K70R, M184V, T215Y, K219E K101E, Y181C, G190A E6EK, T39TI, K103R, V118I, K122E, I135T, K166R, T200A, F214L, D218E, A272P, E297A, K311R, R356RK, E370D, K390R  
Pt05 Pt05 NRTI NNRTI M41L, A62V, T69T_CT, L74V, M184MV, L210W, T215Y A98G, K101E, Y181C, G190A T39TA, V118I, K122KE, I135M, I142IV, V189VI, R211RK, L228R, T286A, I293IV, L325I, I329V, A371V  
Pt06 Pt06 NRTI NNRTI M41L, L74V, L210W, T215Y Y181C, G190S T39K, K43E, E44D, K101Q, K102R, V118I, K122E, I142V, G196E, T200V, E203K, Q207E, H208Y, R211K, K223E, L228R, R284K, T286A, P294T, E297R, S322T, I329V, Q334E, M357T  
Pt07 Pt07 NRTI NNRTI A62V, T69T_TT, L74V, M184V, T215F A98G, V108VI, V179E, Y181C, G190A T7A, K64R, S68T, R83K, K103R, D121Y, K122E, Q174R, I178L, V189I, H208Y, R211K, L228H, K249Q, A272P, T286A, V292VI, E297R, K311KR, I329V, G333D, K366R, T369A, A371V, T377M, I382T, K390R, E399D  
Pt08 Pt08 NRTI NNRTI M41L, M184V, L210W, T215Y A98G, K101E, G190A V35T, K43Q, V60VI, K122E, I135L, S162C, G196E, Q207N, I293V, E297Q, M357T, K390R  
Pt09 Pt09 NRTI NNRTI M41L, V75M, L210W, T215Y K103N, Y181YC, G190GA, H221HY, N348I V35I, K43E, E44D, K73M, R83K, V90I, V118I, K122E, S162N, I178M, G196E, R211K, L228R, V245M, A272P, L283I, I293V, P294T, A355G, R356K, K366R, A371V, A376T, K385R, K390R E29EQ 
Pt10 Pt10 NRTI NNRTI M41L, A62V, T69T_CX, L74V, M184V, L210W, T215Y A98G, K101E, Y181C, G190A K20KR, T39TA, V118I, K122KE, I135M, I142IV, R211RK, L228R, T286A, I293IV, L325I, I329V, A371V  
Pt11 Pt11 NRTI NNRTI  Y181YC K20KR, K122KE, I135T, K166KR, I178IV, V179I, I195IL, T200A, V245I, E248D, A272AP, V276T, K277R, Q278H, I293V, P294ST, E297A, Q334LP, M357MT, G359S, A376V, E396D  
Pt12 Pt12 NRTI NNRTI D67N, K70R, T215FY, K219E Y181C V35IM, T39TA, K122E, I135T, I167IV, G196E, T200A, E203K, E204D, R211S, K223E, L228R, I293IV, V317A, D324E, I329L, Q334N, G335GD, M357T, A376AT, E399D  
Pt13 Pt13 NRTI NNRTI  K103KN, Y181YC, H221HY T39TA, I135IT, S162A, G196E, T200TA, E204Q, Q207E, F214L, K277KR, R284K, T286TA, A288S, V292VI, I293V, E297R, R307RK, K311R, D324E, I329L, M357T  
Pt14 Pt14 NRTI NNRTI A62V, D67N, T69D, V75I, F77L, Y115F, F116Y, Q151M, K219E K101H, Y181C, G190A P4S, T7P, P9T, E40K, K46Q, I63V, V118I, I135T, N137S, S162Y, Q174K, T200A, R211I, F214L, V245E, T296S, E297R, L301I, E312Q, D324E, M357T, V365I, K390R, E399G S156A 
Pt15 Pt15 NRTI NNRTI A62V, D67N, T69D, V75I, F77L, Y115F, F116Y, Q151M, M184V K101H, Y181C, G190A P4S, T7P, P9T, K46Q, V118I, N137S, S162Y, Q174K, T200A, R211X, F214L, V245E, T296S, E297R, L301I, E312Q, D324E, M357T, V365I, K390R, E399G  
Pt16 Pt16 NRTI NNRTI M41ML, D67DG, K70KR, M184MV, T215Y, K219KE K103KN, G190GA P4PS, S68SG, R83RK, T200TI, V245E, I293IV, M357T, I375V, V381VI, K390R  
Pt17 Pt17 NRTI NNRTI M41L, L74LV, M184V, L210W, T215Y L100I, K103N, G190GA, K238RT M16MV, K43N, R83K, K122P, D177E, V189VI, I195L, G196E, T200A, A272P, K277R, A288AG, I293V, E297EA, E312Q, Q334E, M357T, T369V, A376T, T386TA  
Pt18 Pt18 NRTI NNRTI M41L, D67H, M184V, T215Y K101E, G190A W88C, A98S, D121H, K122E, G196E, R211A, V245E, A272S, E297K, P313T, I329L, R358K, V365I, K366R, A376S, T386I  
Pt19 Pt19 NRTI NNRTI D67N, K70R, M184MIV, T215Y, K219E G190A, N348I K11R, V35I, R83K, G196A, T200I, R211K, I293V, E297A, I326V, G333E, V365I, K390R, E399G  
Pt20 Pt20 NRTI NNRTI  G190A R83K, K166R, V179VI, R211T, F214FL, K277R, T286A, E297EK, T369TA, V381VI  
Pt21 Pt21 NRTI NNRTI M41L, D67N, L74V, L210W, T215Y Y181C, G190S P4S, K20R, K43Q, E44D, K101Q, V118I, D121H, K122E, Q174QR, D177E, T200A, E203A, Q207E, R211K, K223Q, T286A, A288G, E297K, I326V, Q334E, A376S, K390R, K395R, E399D  
Pt22 Pt22 NRTI NNRTI T215Y G190S V35M, K49R, R83K, I135IT, D177E, I202V, R211K, A272P, K277KR, I293V, P294Q, K311R, D324E, I326V, Q334L, G359S, A360AV, V365VI, A376T, S379C, V381I, T386A  
Pt23 Pt23 NRTI NNRTI M41L, L74V, M184V, T215S G190S K20R, V60I, D123E, I135M, I178IM, T200A, R211K, A272P, L283LI, T286P, P294T, M357T, A376V, V381I, K390R Q197DE 
Pt24 Pt24 NRTI NNRTI M41ML, A62V, T69T_SA, L74V, L210W, T215Y K101EQ, Y181C, G190S V118I, I135M, V189VI, R211K, L228R, T286TA, I293IV, L325I, I329V, A371V, V381I  
Pt25 Pt25 NRTI NNRTI M41L, D67N, L210W, T215Y K101E, G190S V35I, E40F, K43E, V60I, K122E, D123N, I178M, A272P, K277R, A371V  
Pt26 Pt26 NRTI NNRTI K65R V106I, Y188L, H221Y V35T, S68G, K122E, I135T, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, V245Q, E248D, D250E, T286TA, E291D, V292I, I293V, E297EK, D324E, I329V, Q334H, G335D, F346Y, R356K, M357R, R358G, G359S, T386V, Q394R, E399D  
Pt27 Pt27 NRTI NNRTI M41L, D67N, T69D, L74I, M184V, L210W, T215Y A98G, V106I, V179E, Y188L T39A, E44D, V118I, K122E, I142V, E169D, T200A, E203X, Q207E, H208Y, R211K, E224D, V245R, K277R, T286A, E297R, E312AT, D324DE, I329L, G333E, Q334P, F346Y, K350R, G359S, T386I, Q394H  
Pt28 Pt28 NRTI NNRTI  V106I, Y181C, H221Y R83K, K166R, G196V, A272P, V276I, E344D, P345Q, F346Y, A376T, T386I  
Pt29 Pt29 NRTI NNRTI M41L, D67N, T69D, M184I, L210W, T215Y, K219R V106I, V179E, Y188L, H221Y T39TA, K43KE, E44EAD, V118I, K122E, I135IV, E203ED, H208Y, R211K, D237E, V245K, E248D, D250E, T286A, G333E, Q334H, G335C, R356RK, E370D, T377M, S379SC, T386I, K390R  
Pt30 Pt30 NRTI NNRTI D67N, K70R, T215Y, K219E K101KE, V108VI, G190AS K20R, E28EG, K103X, K104R, D123E, I135T, T165I, R211K, F214L, V245VM, A272P, Q278H, T286A, E291D, E297R, L301IM, F346Y, R356RK, A376T, T386TA, K390R  
Pt31 Pt31 NRTI NNRTI M41L, L210W, T215Y K101KEQ, K103KN, Y181C, G190A, K238KT, N348I V35VI, K43KQ, E44ED, V118I, I135T, P176PS, R211K, L228R, K277R, T286A, G359S, V365I, A376T, T386TA, I393V  
Pt32 Pt32 NRTI NNRTI  V106VIM, V179D, G190GA S48ST, K103KR, K122KE, K166R, R211K, V245K, A272P, K277R, I293V, G333E, M357MI, T377L, S379G, K390R  
Pt33 Pt33 NRTI NNRTI L74V, M184V V179D, G190A V35R, S68N, R83K, K103R, D123E, L283LI, T286A, A288S, E297K, K311R, D324E, I329L, Q334E, T377LS H208HLQ 
Pt34 Pt34 NRTI NNRTI M41L, L74I, V75T, Y115F, M184V, T215Y V179D K20R, R83K, K103R, D123E, K173E, T200A, Q207K, R211A, F214L, A272P, Q278E, E298G, L310I, E312K, S322T, I329L, Q334D, G335N, M357Q, K366R, A376T, T386I K395Q 
Pt35 Pt35 NRTI NNRTI  V179D V118I, I135T, R211T, F214L, T286A, K311R, I326V, Q334H, A360T, V365I  
Pt36 Pt36 NRTI NNRTI  V179D V118I, I135T, R211T, F214L, T286A, K311R, I326V, Q334H, A360T, V365VI  
Pt37 Pt37 NRTI NNRTI D67N, K70R, V75A V108I, Y181C, N348I K20R, T39TK, K43E, V60I, K64Y, S68T, V90I, V118I, K122E, D123DN, S162Y, R172K, I178L, V179VI, T200R, E203V, Q207R, R211RK, K219H, A272P, K277KR, T286A, I293IV, E297K, P313T, M357V, R358K, A360T, K385R  
Pt38 Pt38 NRTI NNRTI M41L, D67N, L74V, M184V, L210W, T215Y G190E P4T, K20R, K43Q, D123E, I135T, D177E, Q207E, R211K, V276I, Q278H, T286A, I293V, E297K, I329IV, R358K, G359S, A371V, K390R, E399D  
Pt39 Pt39 NRTI NNRTI   K11KR, A98S, K104R, K122E, I178M, E204Q, R211K, A272P, T286A, E328D, M357T, A376AT, T377TI, K390R  

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