Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Pillay (2008)
Title HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy.
Citation ARHR
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 68
NumPts 68
Subtype C, B, A

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
DR10 DR10 AZT, DDI, 3TC, D4T EFV M41L, D67N, T69D, M184I, L210W, T215Y A98G, Y188L, G190A K20R, V35T, T39E, E44D, S48T, V60I, V118I, K122E, D123G, K166R, K173A, D177E, T200A, Q207E, H208HY, R211K, V245Q, A272P, K277R, L279M, T286A, E291D, V292I, I293V  
DR100 03ZA.DR100 3TC, D4T None M184V  E6A, M16L, V35T, T39E, S48T, K122E, K173A, Q174R, D177E, T200E, I202V, Q207A, R211K, P243T, V245Q, A272P, L279T, T286A, E291D, V292I, I293V, E297K, G333E, Q334H K30M 
DR102 03ZA.DR102 D4T, DDI None A62AV, V75I, F77FL, F116Y, Q151M  A33AV, V35T, T39E, S68SG, T69S, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, V245Q, S251N, A272P, K275Q, K277R, T286A, E291D, V292I, I293V  
DR11 02ZA.DR11 Unknown Unknown K65KR  V35T, E36A, T39E, S48T, E53D, S68SG, V75X, K122E, D123S, K173A, Q174K, D177E, G196M, T200A, I202V, Q207G, R211K, F214L, V245Q, E248D, A272P, K275Q, Q278N, E291D, I293V T296TM 
DR13 02ZA.DR13 None None   S3SI, I5IM, T7TI, P9PQ, V10VL, K11KQ, D17X, P19PQ, V21VF, K22KN, W24WC, T27TP, V35T, E36A, T39E, E44ED, S48AT, K49KQ, N57NK, V60VL, K122E, F124FL, K173A, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324E K13KM, G15G*, P25PS, K30KN, K32K*, K46K*Q, F61FI, K64KE, D123RST, K126N 
DR14 02ZA.DR14 AZT, 3TC None  E138EA L26LF, V35K, E36EA, T39E, E40ED, S48T, V60I, R72RG, E89EK, Q91QH, K122E, D123G, K173T, T200A, Q207DE, R211RK, V245Q, A272P, T286A, E291D, I293V, I309F W71W*, V90VG, H96HP, D110DY, V292IK, T296TI 
DR15 DR15 AZT, DDI None D67N, K70R, K219E  K20R, V35T, T39K, S48T, V60I, V118I, K122E, D123N, A158S, S162G, K173T, Q174A, T200A, E203EK, Q207E, R211K, F214L, V245Q, D250E, S251D, A272P, K277R, Q278E, E291D, V292I, I293V, E297K  
DR16 02ZA.DR16 ABC, AZT, 3TC None M41L, D67N, T69D, M184V, L210W, T215F A98G, E138EA V35T, T39E, E44D, S48T, E53D, V111I, V118VI, K122E, D123S, K173A, Q174K, D177E, G196E, T200A, E203V, Q207E, H208Y, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V D121DG 
DR17 02ZA.DR17 Unknown Unknown M41L, D67N, T69D, K70R, V75M, L210W, T215F, K219Q  K11T, K20R, V21I, V35T, T39KR, K43E, V60I, L109I, K122E, D123N, I135V, S162A, K173S, Q174K, D177E, V179I, I202V, Q207A, R211N, D218E, L228H, V245Q, E248D, A272P, K281KR, T286A, E291D, V292I, I293V, P294AT, E312N, A327V  
DR18 02ZA.DR18 D4T, DDI EFV D67DN, K70KR L100LV, V106M, V179D E6EK, K20KR, V35T, T39E, G51GW, K66E, K102Q, K103R, K122E, I135IM, I142IV, K173T, T200A, E204Q, Q207E, F214L, V245Q, A272P, T286V, V292I, I293V, G333E, Q334H S48IT 
DR19 02ZA.DR19 AZT, DDI EFV M41L, D67E, T69S_SS, L210W, T215Y K101E, V106M, G190A, F227FL V8VA, V35I, T39E, E53D, K122E, D123S, S162C, E169A, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250DE, A272P, K277KR, E291D, V292VI  
DR20 02ZA.DR20 3TC, D4T None M184V E138A P4H, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135IV, K173A, D177G, R199RT, T200A, Q207A, P243T, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, K311E, V317A  
DR23 02ZA.DR23 D4T, DDI, ABC, AZT, 3TC MKC442 D67N, K70R, M184V, T215TI, K219Q K103S, E138KQ K20KR, V35T, E36A, T39E, V60VI, K102R, K122E, D123G, I142K, S162A, K173T, Q174K, D177E, I178M, V179VI, T200A, Q207D, R211K, F214L, V245Q, A272P, K277KR, E291D, V292I, I293V, K311R, D324E  
DR26 02ZA.DR26 D4T, DDI None A62V, K65R, V75T E138A I2V, V35T, T39E, S48T, E53D, S68G, V118I, K122E, D123S, I135T, E169ED, K173AT, Q174K, I178M, T200A, Q207E, R211RK, F214L, K219G, V245VE, D250E, K263KN, A272P, K277R, L283I, T286A, E291D, V292I, I293V, V317A  
DR27 02ZA.DR27 AZT, 3TC None M41*LQ, M184V, T215Y A98G V35T, E36A, T39K, K43E, K122E, D123G, I135L, K173A, Q174K, D177E, T200A, Q207D, R211K, P236L, V245Q, E248D, A272P, K277R, K281R, T286A, E291D, V292I  
DR28 02ZA.DR28 D4T, DDI, AZT, 3TC EFV M184V, T215Y A98G, K103N, M230L V35T, T39E, S48T, K122E, I159V, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, I293V, P294Q  
DR29 02ZA.DR29 D4T, DDI, AZT, 3TC NVP D67N, K70R, K219Q K103N, G190A, H221Y V35T, E36A, T39E, S48T, V60I, K122E, D123G, V148VG, K173A, D177E, T200A, E203Q, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A  
DR30 02ZA.DR30 D4T, DDI None T215Y  V35T, T39E, S48T, D121DE, K122E, D123S, A158S, S162N, E169A, K173E, I178IM, T200A, Q207E, V245Q, A272P, Q278N, T286A, E291D, V292I, I293V, D324E  
DR31 02ZA.DR31 3TC, D4T NVP M184V K101KE, G190A V35T, E36A, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, I178M, T200A, Q207E, R211Q, V245Q, A272P, K277R, E291D, V292I, I293V, E297EA  
DR32 DR32 AZT, DDI, 3TC, D4T EFV D67N, K70KR, T215Y, K219EQ K103N, G190A V35T, E36A, T39E, K122E, D123G, K166R, K173A, D177E, T200A, Q207E, R211K, D237N, V245Q, A272P, K277R, L283I, V292I, I293V  
DR33 DR33 D4T, DDI None L74V  V35T, T39E, S48T, V60I, K122E, K173A, Q174K, D177E, I178L, T200A, K201KR, I202V, Q207E, R211K, V241I, V245Q, A272S, E291D, V292I, I293V  
DR34 DR34 AZT, 3TC NVP D67N, K70R, M184V, T215TI, K219KEQ K103N, Y318YF V35T, T39K, K46KQ, S48T, V60I, T69TN, K122E, D123G, I135X, K173A, D177EK, I178M, T200A, I202IV, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, V317VA  
DR35 DR35 AZT, DDI None M41L, T215Y  V35T, E36EA, T39E, S48T, V90I, K122E, D123S, S162C, K173A, Q174K, D177E, T200A, Q207E, L228LR, Q242P, V245Q, K277R, T286A, E291D, V292I, I293V  
DR36 DR36 D4T, DDI, AZT, 3TC MKC442, NVP D67N, K70R, M184V, K219EQ K101KE, G190A V35T, T39E, S48T, K122E, D123N, I135T, K173T, D177E, T200A, E203K, Q207E, D250DE, A272P, K277R, V292*, I293L, L325I  
DR37 DR37 AZT, 3TC, D4T, DDI, ABC None D67N, K70R, L74IV, M184V, K219KE  V35M, T39D, S48T, V60VI, D123DN, K173A, Q174K, T200A, E203K, Q207E, R211K, V245Q, K249KQ, D250E, A272P, K277R, E291D, V292I, I293V  
DR39 DR39 D4T, DDI EFV D67DG V106M, Y188C V35T, T39K, S48T, V60I, K122E, D123G, K173I, Q174E, D177E, I178L, T200A, E204K, Q207E, V245Q, A272P, K277R, Q278N, T286TA, E291D, V292I, I293V, S322E, D324DE, G333E  
DR41 DR41 D4T, DDI, AZT, 3TC NVP M41L, L74V, M184V, L210W, T215Y, K219KN A98G, Y181C, M230L T39D, E44D, S48T, K122E, D123S, S162C, I167V, K173A, D177DE, T200A, Q207E, L228H, Q242H, V245Q, P247A, K249Q, A272P, K275Q, Q278H, T286A, E291D, V292I, I293V, Q334X  
DR42 02ZA.DR42 AZT, 3TC None M184MV, T215TA  K32KR, V35T, E36EA, T39E, V60VI, D121Y, K122E, I135IL, K173KR, Q174K, P176T, D177G, T200A, I202IV, R211K, D250E, A272P, K277R, T286A, V292*, I293V, S322AE Y115YN 
DR43 DR43 AZT, 3TC, D4T, DDI None F116Y, Q151M  K32E, V35T, E36A, T39AE, S48T, K122E, D123G, I135K, I142IV, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, F214FL, V245Q, A272P, I274V, K275Q, K277R, T286A, E291D, V292I, I293V  
DR44 DR44 D4T, DDI None K65KR, L74LV  K11H, V35T, T39N, S48T, V60I, D121Y, K122E, S162C, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, K277R, T286TA, E291D, V292I, I293V  
DR46 DR46 D4T, DDI EFV K65R, D67DN, K219KR V106M, G190A, F227FL V35T, T39E, S48T, S68SG, K101X, K122E, S162C, K173A, D177E, T200A, Q207E, V245E, E248N, A272P, E291D, I293V, L310Q  
DR47 DR47 D4T, DDI EFV K65KR, D67DN, F116FY, Q151M K103N, V106M V35T, E36EA, T39DE, E53D, K122E, D123G, K173T, D177E, T200A, Q207A, R211K, V245Q, E248D, A272P, K277R, T286A, E291D, V292I  
DR49 DR49 AZT, 3TC NVP M184V V108I, Y181C, H221HY V35T, E36A, T39E, E40D, S48T, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, V241VL, V245Q, A272P, K277R, E291D, V292I, K311R, D324E  
DR5 DR5 AZT EFV D67N, K70R L100I, K103N K20R, V35T, E36A, T39D, V60I, K122E, D123S, K173A, D177E, I178L, T200A, E203K, Q207E, R211Q, V245Q, E248N, D250E, A272P, T286A, E291D, V292I, I293V  
DR50 DR50 D4T, DDI, AZT, 3TC EFV M184V K103N, V106M, E138A P4S, E6K, V35T, E36A, T39E, S48T, V90VI, V118I, K122E, I135IL, T165I, K173I, Q174K, D177DE, T200A, Q207E, R211K, F214L, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293V  
DR51 DR51 AZT, 3TC None M41ML, M184V K103KN, P225PH V35T, T39E, S48T, V60I, D121HY, K122E, I135IL, K173A, D177K, E194ED, T200A, R211K, V241I, V245Q, A272P, K275R, E291D, V292I, I293V  
DR52 DR52 3TC, D4T EFV M184V V106M, F227FL, M230L E6K, K32KR, V35T, T39R, S48T, K122E, K173A, D177G, T200A, Q207E, R211K, P225S, V245Q, E248D, D250E, S251N, A272P, E291ED, V292I, I293V, S322A  
DR53 DR53 3TC, D4T None   V35T, E36A, T39E, S48T, K122E, D123G, P140T, K173T, D177G, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, I293V N136S 
DR54 DR54 AZT, 3TC None M184V  S3SC, V35T, E36A, T39E, S48T, E53D, K122E, D123G, I135IT, S162SC, K173A, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, S322A, D324E P1PA 
DR55 DR55 3TC, D4T None M184V  V35T, T39K, S48T, D86N, K122E, D123S, I142IT, K173T, Q207A, V245C, A272P, T286A, E291D, V292I, I293V  
DR56 DR56 AZT, 3TC, D4T, DDI EFV L74LV L100LI, K103N S3I, E28K, K32E, V35T, E36A, T39E, S48T, T69TN, K101X, K122E, D123N, I135L, K173A, Q174K, D177E, T200A, Q207E, R211RK, V245Q, E248DN, S251C, A272P, K277R, T286A, E291D, V292I, Q334D  
DR58 DR58 AZT, 3TC None M184V V108I, E138K V35M, E36EA, T39E, S48T, D123E, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, V317A, S322SA  
DR59 DR59 D4T, DDI None A62V, K65R, V75I, F77L, F116Y, Q151M  T39E, S68G, A98S, K122A, S162X, S163ST, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, V245Q, A272P, Q278H, I293V, S322A, Q334X  
DR6 00ZA.DR6 Unknown Unknown  K103KN, V179E, Y181C, H221HY V35T, T39A, S48T, V60I, S68G, T69N, K122E, D123N, I135R, K173A, Q174R, P176Q, D177E, Q197QK, T200A, Q207E, R211RK, D250E, S251E, A272S, E291D, V292I, I293V  
DR60 DR60 AZT, D4T, DDI None M41L, D67N, L210W, T215Y E138A P4T, K20R, T27S, V35T, T39E, S48T, V60I, V118I, K122E, D123S, K173T, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294PQ  
DR61 DR61 AZT, 3TC, D4T, DDI None M41ML  V35T, E36A, T39E, S48T, W88WC, K122E, D123DG, I135IV, K166R, K173A, Q174K, D177E, G196R, T200V, Q207D, T215X, V245Q, D250N, A272P, K277R, T286A, E291D, V292I  
DR64 DR64 AZT, 3TC NVP M184V Y181YC, G190GA E6K, V35T, E36A, T39E, K122E, T139TR, K173T, D177E, I178M, T200A, Q207E, R211RK, V245Q, A272P, K277R, E291D, V292I, I293V  
DR66 DR66 AZT, 3TC, D4T, DDI EFV M184V, T215Y K103N V35T, T39E, S48T, K102Q, K122E, D123S, A158S, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V  
DR67 DR67 AZT, 3TC NVP  E138A T27TS, V35T, T39E, S48T, K122E, D123N, T165I, F171Y, K173T, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248D, D250DE, A272P, K277KR, Q278H, T286A, E291D, V292I, I293V, I329V  
DR68 DR68 AZT, 3TC None A62V, K65KR, V75I, F77L, F116Y, Q151M, M184V  V35T, T39EK, E40EK, S48T, S68G, T69TI, K122E, D123S, S162C, K166KR, K173T, Q174K, I178IL, E194AT, G196E, T200A, I202IV, Q207E, F214L, V245Q, E248D, A272P, E291D, V292VI, I293V, E297K  
DR69 DR69 D4T, DDI EFV K65R, D67N V106M, V179D, Y188C V35T, T39D, S48T, K122E, D123S, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, I293V, H315HQ  
DR70 DR70 AZT, 3TC None   T39G, S48T, R83RK, K122E, D123N, K173A, D177E, T200AG, Q207D, R211K, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293V, Q334X  
DR71 DR71 D4T, DDI None T69D  V35T, E36A, T39E, S48T, K122E, D123G, K173T, Q174K, T200A, Q207E, V245Q, A272P, K275R, Q278H, T286TA, E291D, V292I, I293V, D324E  
DR74 03ZA.DR74 DDI None   V35T, E36A, T39D, E40D, S48T, D121H, K122E, I135T, K173A, D177E, Q197QK, T200A, Q207E, V245Q, T286A, E291D, V292I, I293V, P313T, V314I, V317A  
DR76 03ZA.DR76 D4T, DDI None D67N, K70R, K219Q  V35T, E36A, T39E, K64KN, K122E, D123DG, K173A, Q174K, D177E, I178L, T200A, Q207KN, L210LF, R211KM, V245Q, A272P, K277R, Q278H, T286A, I293V  
DR79 03ZA.DR79 D4T, DDI EFV K65KR, K70KR, V75VA, Q151LM K103N, V106M S3SR, T7X, T27S, V35T, T39E, S48T, V60I, S68G, K73KM, K122E, D123N, I159V, D177E, I178L, T200A, E203EK, Q207D, R211K, V245Q, A272P, T286V, V292I, I293V, S322T, D324E I5IS 
DR80 03ZA.DR80 AZT, 3TC, D4T, DDI EFV, NVP  K103N, P225H V35T, T39E, S48T, K122E, D123G, K173A, Q174R, D177E, T200A, Q207A, L210F, R211K, V245Q, A272P, K277R, E291D, V292I, I293V  
DR81 03ZA.DR81 D4T, DDI None M41L, D67N, T215Y  K11Q, V35T, T39E, S48T, V60I, K101Q, V118I, D121Y, K122E, D123G, I142V, S162C, K166R, K173A, D177E, T200A, Q207E, R211K  
DR82 03ZA.DR82 D4T, DDI None   K11Q, V35T, T39DE, D121Y, K122E, D123GS, I135R, S162C, K173A, Q174K, D177E, T200A, Q207E, T215X, V245Q, A272P, K277R, T286A, E291D, V292I, I293V  
DR84 03ZA.DR84 D4T, DDI EFV  V179D, Y188L, G190A V8I, V35K, T39E, S48E, V60I, K103R, I159V, K173T, Q174K, T200A, Q207E, R211K, V245Q, D250E, A272P, K277T, K281KR, T286A, V292I, I293V, E297K, L301F  
DR88 03ZA.DR88 D4T, DDI None M41L, D67N, L210W, T215Y  V35T, T39E, S48T, V60I, F77FS, G93GR, K101T, V118I, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A F116FL, S134I 
DR90 03ZA.DR90 Unknown Unknown M41ML, V75I, F77L, F116Y, Q151M  S68SG, A98S, D177N, T200TA, Q207E, R211K, F214FL, T286A, E297A, I326V C280C* 
DR91 03ZA.DR91 Unknown Unknown D67N, K70R, M184V, K219Q  V118I, K122E, I135T, K173N, Q174K, Q207E, R211RK, F214L, L228H, R284K, A288S, I293V, V317A, Q334L  
DR92 03ZA.DR92 AZT, 3TC, D4T EFV M41L, D67N, T69D, K70R, T215C, K219Q V106M, Y188YC, G190GA P4S, V35T, T39E, V60I, K122E, I135V, S163C, K166R, K173V, D177E, T200A, I202V, Q207E, R211K, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, K311KR, V317A Q197I, I244IR, I274IS 
DR93 03ZA.DR93 3TC, D4T EFV D67N, T69D, K70R, K219Q V106M, V179VD, G190GA, F227FL A33G, V35T, E36A, T39E, K101Q, K122E, D123N, K173A, D177E, Q197L, T200A, Q207E, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, V317A  
DR94 03ZA.DR94 AZT, 3TC EFV M184V K103N, P225H I31L, V35T, E36A, T39D, S48T, K122E, I135L, E138D, I142V, K173T, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K275Q, K277R, Q278N, T286A, E291D, V292I, I293V, E297A  
DR95 03ZA.DR95 AZT, 3TC EFV M41L, L74V, T215Y K103N, V106M V35T, E36A, T39E, S48T, K122E, D123G, I142V, T165L, K173T, Q174K, D177E, T200A, Q207E, V245Q, A272P, Q278H, K281R, E291D, V292I, I293V  
DR98 03ZA.DR98 D4T, DDI EFV D67N, K70KR K103N, V106M V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, K173T, D177E, I178M, T200A, E203K, Q207E, V245K, A272P, T286A, E291D, V292I, I293V  

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