Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Bradshaw (2007)
Title Characterization of a novel drug-resistance pattern associated with the mutations K70G and M184V in HIV-1 reverse transcriptase.
Citation AAC
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 5
NumPts 1
Subtype G

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
pt01 Pop03-2005 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70E, M184V  V35T, V60I, K122E, I135V, I142IV, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, D250E, S251N, A272P, T286A, E291D, V292I, I293V, E297A, S322A, D324E, I329IV, Q334L, G335D  
  Ph_03-2005 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70E, M184V  V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, D250E, S251N, A272P, T286A, E291D, V292I, I293V, E297A, S322A, D324E, I329IV, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, I375V, A376AS, T377L, Q394KR, E399ED  
  Pop11-2005 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, D250E, S251N, A272P, T286A, E291D, V292I, I293V, E297A, S322A, D324E, I329IV  
  Ph_11-2005 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, D250E, S251N, A272P, T286A, E291D, V292I, I293V, E297A, S322A, D324E, I329IV, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, I375V, A376S, T377L, Q394KR, E399D, A400T  
  Clone
Consensus 		AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V Y188YC K20KR, E29EG, V35T, V60I, K122E, D123DH, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, V179VG, T200A, Q207E, R211RK A114AV, L168LS 
  clone: 1 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  V35T, V60I, K122E, D123H, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, V179G, T200A, Q207E, R211K A114V 
  clone: 10 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K  
  clone: 2 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  E29G, V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K  
  clone: 3 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E  
  clone: 4 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V Y188C V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K  
  clone: 6 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K  
  clone: 7 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K  
  clone: 8 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K L168S 
  clone: 9 AZT, 3TC, D4T, DDI, TDF, FTC NVP K70G, M184V  K20R, V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K  

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