Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author King (2006)
Title Phenotypic susceptibility to TMC-114 and tipranavir before and after lopinavir/ritonavir-based treatment in subjects demonstrating evolution of lopinavir resistance.
Citation IHDRW 2006
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 18
NumPts 9
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
9113 9113_d1 PI  M46L, I54V, V82A L24I L10LI, R41K, I62V, L63P, A71V, T74A, V77I, I93L  
  9113_d339 PI, LPV  M46L, I54V, V82A L10FVI, L24I R41K, I62V, L63P, A71V, T74A, V77VI, I93L  
9124 9124_d1 PI  G48V, I54S, V82A  L10I, E34Q, I62V, L63P, A71V, T74S, V77I, I93L  
  9124_d339 PI, LPV  M46MIV, G48V, I50V, I54S, V82A L33LF L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93L  
9163 9163_d1 PI  V32I, I47V, V82A  Q61E, L63P, I93L  
  9163_d358 PI, LPV  V32I, M46I, I47V, V82A L10F, L33F Q61E, L63P, I93L  
9182 9182_d1 PI  M46I, I54V, V82A, L90M G73GC L10I, T12TK, E35D, M36MI, I62V, L63P, I64IV, T74S, I93L, C95F  
  9182_d359 PI, LPV  M46I, I54V, V82A, L90M L33F, K43T, G73GC L10I, T12K, I13V, K20KR, E35D, M36I, I62V, L63P, I66IV, T74S  
DK-2314 DK-2314 NFV 133 M46I, N88S, L90M  L10IM, I13V, Q18H, N37D, K55KR, Q61QH, L63P, A71T, I72T, V77I, I93L  
  8362_d501 NFV, LPV 204 M46I, I54V, L76V, V82VA, N88G, L90M L33F L10I, I13V, G16A, Q18H, N37D, Q61H, I62IV, L63P, A71L, I72T, V77I, I93L  
DK-5204 DK-5204 SQV 57 I84V, L90M L10F, T74P E35D, L63P, A71V, I93L  
  8347_d1170 SQV, LPV 224 M46I, I54V, I84V, L90M L33F, T74P L10I, L63P, A71V, I93L  
DK-9014 DK-9014 IDV 147 V32VI, M46I, I47V  L10IV, L63P, V77I, Q92QKR, I93L, C95F  
  8359_d1091 IDV, LPV 302 V32I, M46I, I47A  L10I, I62V, L63P, V77I, V82I, Q92K, I93L, C95F  
DK-9415 DK-9415 SQV, RTV, IDV 133 I54IV, L90LM  L10LI, I15V, G16GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63LH, I64IM, K70KR, L89M  
  6367_d427 SQV, RTV, IDV, LPV 194 M46I, I50V, I54V, V82A, L90M  L10V, I15V, G16E, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64IL, A71V, I72R, L89I, Q92K  
PtC PtC_base Unknown  I84IV, L90M  L10LI, I15IV, G17DE, K20IMR, R41RK, I62IV, L63P, A71V, G73X, V77VI, I85IV, I93L  
  PtC_56wk Unknown, LPV 56 M46I, I47V, I54V, I84V, L90M G73T L10I, I15V, G17D, K20I, M36I, I62V, L63P, A71V, I85V, I93L L19W, I72N