Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Seyler (2007)
Title Impact of genotypic drug resistance mutations on clinical and immunological outcomes in HIV-infected adults on HAART in West Africa.
Citation AIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 43
NumPts 43
Subtype CRF02_AG, A, CRF09_cpx, CRF06_cpx

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
003 CS_003 AZT, 3TC None   V21I, V35T, E36D, V60I, K102E, D123E, I135V, S162A, Q174E, D177E, I178V, T200A, E204K, Q207E, V245Q, T286TA, E291D, V292I, I293V, P294T, S322AT, I326V T84TP 
004 CS_004 AZT, 3TC None M184V  V35T, T39KN, E40D, I135V, S162A, K173T, Q174E, D177E, T200A, Q207E, V245Q  
006 CS_006 DDC, AZT, 3TC, D4T, DDI None M41ML, D67DN, M184V, L210LW, T215S, K219N  K22R, V35T, T39TA, W88C, K122E, D123N, I135L, R143RK, S162A, T165TI, E169Q, K173T, Q174K, D177E, I178M, E194ED, G196E, Q197QP, T200A, E203D, R211K, F214FC, K238KE N137NK, G152GE, H235HL 
027 CS_027 AZT, 3TC None M41ML, M184V, T215SY  V21VI, V35T, E36D, T39A, E79EK, W88C, V118I, K122E, I135R, S162A, K173T, Q174K, D177E, T200A, E203K, Q207E, R211K, F214L, V245Q, Y271F, T286A, E291D, I293V, S322T, I326V  
034 CS_034 3TC, D4T EFV   V35T, V60I, K102E, I135V, S162A, K173IM, Q174K, D177E, I178M, T200A, Q207E, V245Q, E248D, T286A, E291D, I293V, P294T, S322T  
065 CS_065 AZT, 3TC, D4T, DDI EFV M184MV  V35T, E36D, D121H, K122E, I135V, S162A, K173A, Q174K, D177E, I178M, T200A, Q207E, V245Q  
067 CS_067 AZT, 3TC, D4T EFV   V35T, K49KR, D123E, I135T, K173T, Q174K, D177E, E194D, T200A, Q207E, R211K, F214L, V245Q, E248D, D250E  
070 CS_070 AZT, 3TC, D4T, DDI None M184MV  S3SI, A33AG, V35T, E36ED, T39TK, K49KR, V60VI, E79EK, K122E, D123X, I135V, Q145C, S162A, K173T, Q174KR, D177E, I178M, T200A, Q207E, R211K, D237E, V245E K32K*, I37IN 
126 CS_126 AZT, 3TC, D4T, DDI EFV  K103N V35T, T39M, V60I, K102E, Y127F, I135V, S162Y, K173T, Q174K, D177DE, T200A, E204Q, Q207E  
138 CS_138 D4T, DDI EFV M41L K103N I31L, V35T, E36D, T39TA, V60VI, K122E, D123N, I135V, S162A, K166R, K173T, Q174N, D177E, I195R, Q197E, H198P, T200A, Q207K, R211G, T215P, T216P, Q222P, W229G, L234LP, Q242H, V245Q, E248K K13T, G196W, L209F, H221P, Y232N, L246F 
145 CS_145 D4T, DDI None   V35T, D121DH, K122E, I135V, A158AS, S162A, T165TI, E169K, K173T, Q174N, D177E, I178M, E194K, T200A, E203EG, R206K, Q207E, R211N, W212G, F214I, T216TP, D218N, Q222P, L234LP, W239G, Q242H, I244K, V245Q, E248K, D250N  
164 CS_164 AZT, 3TC, D4T EFV   L34F, V35T, E36D, T39L, K43KE, D86E, D123E, K154E, S162A, K173T, Q174K, D177E, L187F, D192E, H198P, R199K, T200A, I202V, R206K, Q207K, R211E, T216P, H221L, Q222P, H235P, W239G, V245R, E248K T240R 
179 CS_179 AZT, 3TC, D4T EFV  Y188F E6D, V35T, V60I, K102MR, I135V, S162A, K173T, Q174K, D177E, I178M, H198P, T200A, E203G, Q207G, R211K, T216P, H221L, Q222P, W239G, Q242P, V245K, E248K H208P, Y232N 
195 CS_195 AZT, 3TC, D4T, DDI EFV  K103KN V35T, E36D, T39M, K122X, D123DE, S162A, K173T, Q174K, D177E, V179VIM, T200A, I202V, Q207E, V245Q  
197 CS_197 AZT, 3TC None   V35T, K102Q, I135IV, T139TA, S162A, K173T, Q174K, D177E, I178IM, V179VM, T200A, Q207E, V245Q  
205 CS_205 AZT, 3TC EFV K70R, M184V, K219Q K103N, P225H, M230L V35T, E36A, T39K, K43E, K64KR, T69TAS, D123E, S162A, K173A, Q174K, D177E, T200TA, Q207A, R211K, T215X, L228R, P243H, V245Q  
239 CS_239 3TC, D4T EFV   V35T, E36D, I135V, S162A, K173AT, Q174K, D177E, I178IM, T200A, Q207E, V245E  
252 CS_252 AZT, 3TC None   V35T, E36D, G51GR, G112GE, K122P, D123DE, I135V, G141GR, S156X, S162X, S163X, M164X, T165TP, I167X, E169EG, R172RG, Q174K, D177E, I178IV, E194EG, I195IL, G196GDE, Q197QHR, T200AE, I202IL, E204EK, Q207D, R211X, W212X, F214FIL, T215TP, K223R, F227FS W88W*, G155GDE, P157PQ, A158AE, I159IFL, L168L*, K173PT, H198HL, R199RG, L205L*W, L210L*, G213GDE, Q222QK 
265 CS_265 3TC, D4T EFV   V35T, E36A, T39K, K43E, K104KN, K122E, D123N, I135T, I142V, S162H, K173S, D177E, T200TA, Q207A, V245Q  
282 CS_282 AZT, 3TC, D4T, DDI None M41L, D67N, T69D, M184V, T215Y  V35T, E36ED, T39TK, K43KE, V60I, I135L, S162A, K173I, Q174K, I178L, G196E, T200A, Q207E, V245Q V8VM 
292 CS_292 AZT, 3TC, D4T, DDI EFV M184MV K103KN V35I, D121Y, K122E, I135L, I159IV, S162A, K173T, Q174K, T200A, Q207E, R211K, V245Q  
293 CS_293 AZT, 3TC None K65KN, K70KQ, M184MV  E6D, K11KT, V35T, E36A, T39K, K43E, I47IL, V60I, K122E, D123S, I135AT, I142V, S162SY, K173S, D177E, V179I, T200A, Q207A, E224D, V245Q  
405 CS_405 AZT, 3TC, D4T, DDI EFV   K11KQ, V35KT, K64R, D121H, K122E, I135T, A158S, S162A, T165I, K173T, Q174K, D177E, G196E, T200A, Q207E, R211K, V245Q, A272P, K275R T39*E 
422 CS_422 AZT, DDI None M184V, T215Y K103N, V106I, Y188F, M230L V35T, E36ED, T39A, K102R, D121H, K122E, D123DG, I135V, S162A, K173T, Q174K, D177E, G196E, T200A, Q207E, R211K, V245Q  
440 CS_440 3TC, D4T None  V106I E28G, V35T, T39K, K122KE, I142V, K173S, Q174K, T200A, Q207A, R211K, F214L, V245E  
443 CS_443 AZT, 3TC EFV   M16T, K20R, K22E, V35T, E36D, K122E, D123DN, I135V, S162A, T165I, K173T, Q174K, D177E, T200A, I202V, Q207D, V245Q, E248D, K281R, L283I  
472 CS_472 AZT, 3TC, D4T None M41ML, D67N, K70R, M184V, K219Q  K20R, V21VI, V35T, T39TA, V60I, D123E, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, H208HY, R211K, V245Q, E248D, D250E  
474 CS_474 AZT, 3TC, D4T, DDI EFV   I5V, E6X, V35T, E36D, V60VI, K122E, D123S, I135V, A158AS, S162A, K173S, Q174K, V179I, G196GE, T200A, I202V, Q207A, R211RS, V245Q  
483 CS_483 3TC, D4T EFV   K11T, V35T, E36A, T39K, K43E, D121H, K122E, D123S, I135IT, I142V, S162AD, K173S, Q174K, D177E, V179I, T200A, Q207AD, V245Q  
501 CS_501 AZT, 3TC, D4T EFV   V35T, E36D, V60I, S68SG, V90I, I135V, S162A, K173T, Q174KR, D177E, I178M, T200A, Q207E, R211K, V245Q  
518 CS_518 D4T, DDI None   V35T, E36D, K49R, E53D, V60VI, I135V, S162A, K173A, Q174K, D177E, I178M, T200A, Q207E, V245Q  
522 CS_522 AZT, 3TC, D4T, DDI EFV   V35T, T39L, V60I, D121Y, K122E, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q  
527 CS_527 AZT, 3TC, D4T, DDI None D67DN, T215TI  M16V, E29G, L34F, V35T, E36D, V60I, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211RK, V245K  
535 CS_535 AZT, 3TC, DDI EFV M41L, D67N, L210W, T215C K101P, K103N, E138Q V35T, C38CS, K43N, V60I, D123N, S162A, Q174E, D177E, T200A, Q207E, R211K, V245E Y232M, E233N, L234S 
536 CS_536 AZT, 3TC None M184MV  V35T, E36D, T39M, V60VI, I135V, S162A, K173T, Q174K, D177E, T200A, Q207N, R211K, W212WG, V245Q, A272P, K281R, T286A, E291D, V292I, I293V, S322T, I326V  
545 CS_545 AZT, 3TC, D4T, DDI None D67DN, K70KR, M184V  V35T, E36D, K122E, S134SR, I135V, V148VG, S162A, K173T, Q174K, D177E, I178M, L193F, T200A, Q207E, R211K, V245Q  
547 CS_547 AZT, 3TC, D4T, DDI EFV  K103KN, K238T K11T, V35T, T39K, K43E, K102KE, K122E, D123ST, I142V, S162H, K173T, Q174K, D177E, I178L, V179VI, I195L, T200A, Q207A, R211K, V245Q, E248D  
567 CS_567 3TC, D4T EFV   K20R, V35T, T39E, K49KR, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, P243S, V245Q  
580 CS_580 D4T, DDI None   V35T, E36D, D123E, I135V, S162A, K173T, Q174KN, D177E, I178L, T200A, Q207E, R211K, P243T, I244IV, V245Q, E248D  
593 CS_593 AZT, 3TC, DDI EFV   V35T, E36D, V60I, K122E, I135L, S162A, K173T, Q174K, D177E, V189VI, T200A, Q207E, R211K, V245E, D250E, S251N  
599 CS_599 D4T, DDI EFV  L100I, K103N E28EK, V35T, E36D, V60I, K101KQ, K122E, I135V, S162A, K173T, Q174K, D177E, Q207E, R211K, L228R, V245Q, E248N, S251V  
619 CS_619 AZT, 3TC, D4T EFV M184MV  V35T, T39TA, E40D, I135V, S162A, K173T, Q174K, D177E, T200A, K201KR, Q207E, V245Q, E248D  
643 CS_643 3TC, D4T EFV M184MV K103N, P225PH I31IL, V35T, E36D, V60VI, D123E, I135V, S162A, K173T, Q174K, D177E, I178L, G196E, T200A, Q207E, R211K, V245E, A272P