Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Doualla-Bell (2006)
Title High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens.
Citation AAC
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 23
NumPts 23
Subtype C

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
Pt1 FDB_Pt1 AZT, 3TC, D4T, DDI NVP  Y188L, H221Y V35T, T39E, S48T, V60I, K122E, D123N, I135L, K173A, D177E, I178M, E194G, T200A, Q207D, R211K, L228R, P243T, V245Q, E248T, A272P, E291D, V292I, I293V  
Pt10 FDB_Pt10 D4T, DDI NVP K65R, D67DG Y181C, H221Y T39E, E40K, E79ED, K102KQ, K122E, K173A, T200A, Q207E, R211K, L228LR, V245E, D250E, A272P, K277R, E291D, V292I, I293V D86DG, T139TP, D177GR 
Pt11 FDB_Pt11 AZT, 3TC, D4T, DDI NVP D67N, K70R, V75T, K219E G190A K20R, V35T, E36A, T39E, E40D, K43R, K122E, D123E, I142V, K173T, Q174K, D177E, I178F, T200A, E203K, Q207E, R211K, K223Q, V245Q, A272P, K277R, E291D, V292I, I293V  
Pt12 FDB_Pt12 D4T, DDI, AZT, 3TC EFV M41L, D67N, M184V, L210W, T215Y Y188L, K238KT V35T, E36A, T39D, S48T, V60I, V118I, K122E, D123S, K173A, D177E, I178V, T200A, Q207E, R211K, V245Q, A272P, E291D, V292I, I293V, E297K  
Pt13 FDB_Pt13 D4T, DDI, AZT, 3TC EFV K65R, K70R, V75A, F77L, Y115F, F116Y, Q151M, K219E K103N, V106M, P225H V35T, E36A, T39E, T58N, S68G, K122E, D123S, R172K, K173T, D177E, I178M, T200A, Q207K, R211K, V245Q, E248D, A272P, K277R, E291D, V292I  
Pt14 FDB_Pt14 AZT, 3TC, D4T, DDI NVP M184V A98G, K103N Q23QP, V35T, E36A, T39E, S48T, T69TA, K122E, K173T, D177E, T200A, Q207E, T286A, E291D, V292I, I293V  
Pt15 FDB_Pt15 D4T, DDI NVP K65R K103KN, V106VM, Y181C V35T, T39E, S48T, K122E, K173A, D177G, T200A, Q207E, R211K, V245Q, E248D, A272S, T286A, E291D, V292I A114AS, N136NST 
Pt16 FDB_Pt16 AZT, DDI, 3TC NVP K65R, M184V K101E, Y181C, G190A T27S, V35T, T39E, S48T, K122E, D123G, T139TK, S162C, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, L228R, V245Q, A272S, K277R, E291D, V292I, I293V  
Pt17 FDB_Pt17 AZT, 3TC, D4T, DDI EFV M41L, L74LV, V75M, M184MV, T215Y K101H, K103N, G190A P4S, V35T, E36A, T39E, S48T, V60VI, V90I, K122E, I135V, S162A, K173A, D177E, Q197K, Q207E, R211K, V245Q, A272P, T286A, E291D, I293V, E297D  
Pt18 FDB_Pt18 D4T, DDI, AZT, 3TC EFV   V35T, E36A, T39E, K122E, D123N, S162C, K166R, K173T, D177E, T200A, Q207N, R211K, V245Q, A272P, K277R, E291D, V292I, I293V  
Pt19 FDB_Pt19 D4T, DDI, AZT, 3TC NVP   V35T, E36A, T39E, E40D, S48T, E53D, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245E, D250E, K281R, T286A, E291D, V292I, I293V, V317A I94T, A267AP 
Pt2 FDB_Pt2 AZT, 3TC, D4T, DDI NVP  K103N V35T, T39E, S48T, K122E, D123S, K173A, D177E, I178L, T200A, E204K, Q207D, R211K, V245Q, K249Q, A272P, K281R, T286A, E291D, V292I, I293V, K311R  
Pt20 FDB_Pt20 AZT, 3TC, D4T, DDI, ABC NVP  K103N, E138A V35T, T39E, K122E, D123S, T139A, K173T, Q174K, T200E, Q207E, R211K, F214L, D250E, S251D, A272P, Q278H, T286A, A288T, V292I, I293V  
Pt21 FDB_Pt21 AZT, 3TC, D4T, DDI NVP D67N, K70R, M184V, K219Q A98G, Y181C, H221Y V35T, T39AE, S48E, D123E, I135T, K173A, D177E, I178L, T200A, E203EK, Q207E, F214FL, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, N306ND  
Pt22 FDB_Pt22 AZT, 3TC, D4T, DDI NVP K70R, T215F, K219E A98G, V108I, Y181C V35T, T39E, L109I, K122E, D123S, K173A, D177E, Q197K, T200A, I202V, R211K, D218E, V245Q, A272P, K277R, A288T, E291D, V292I, I293V  
Pt23 FDB_Pt23 AZT, 3TC, D4T, DDI NVP M41L, D67N, T69D, V75T, T215Y V108I, E138A, V179D, Y181C, H221Y K20R, V35T, T39D, E44D, D121C, K122E, I135T, K173T, D177E, I178L, V189I, T200A, E203D, E204K, Q207D, R211K, P243S, V245Q, A272P, E291D, V292I, I293V  
Pt3 FDB_Pt3 D4T, DDI, AZT, 3TC, ABC EFV K65R, F116Y, Q151M, M184V K103N, V106M V8I, V35T, E36A, T39E, S48T, S68G, T69I, K122E, D123S, S163C, K166Q, K173T, Q174R, T200A, I202V, E203K, Q207A, H208Y, R211E, V245M, D250E, A272P, E291D, V292I, I293V  
Pt4 FDB_Pt4 AZT, 3TC, D4T, DDI, ABC NVP M41L, D67N, L74V, L210W, T215Y A98G, Y181YC, G190A V35T, T39E, E44ED, S48T, K122E, D123S, K173A, D177E, T200A, E203EK, Q207E, R211K, V245Q, D250E, K277R, T286A, E291D, V292I, I293V  
Pt5 FDB_Pt5 AZT, 3TC, D4T, DDI NVP M41L, T215Y K103KN, Y188L V35T, E36A, T39D, S48T, V60I, V118VI, K122E, D123N, I135RT, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, A272P, K277R, T286A, E291D  
Pt6 FDB_Pt6 AZT, 3TC, D4T, DDI EFV K65R, K70R, V75I, F116Y, Q151LM K103N, V106VA, E138A V35Q, T39D, S48T, V60I, S68SG, T69TI, K122E, I135T, I142T, K173A, Q174K, D177E, I178LV, G196E, T200A, Q207E, R211K, F214L, V245K, D250E, A272P, E291D, V292I, I293V, V317A P1PA, L26LS 
Pt7 FDB_Pt7 D4T, DDI NVP K65R K103KN, Y181C, G190GA, Y318F K22KN, V35T, T39K, S48E, T69N, D123DE, I135IM, K173IT, T200A, Q207E, R211K, V245Q, K277KR, K281KR, T286A, E291D, V292I, I293V E312F, V314P, Y319C 
Pt8 FDB_Pt8 D4T, DDI, AZT, 3TC NVP, EFV   I5IM, V35T, E36A, T39E, S48E, D123DE, S162AG, K173A, D177E, T200A, Q207E, V245Q, D250DE, A272P, K275R, Q278N, T286A, E291D, V292I, I293V  
Pt9 FDB_Pt9 AZT, 3TC, D4T, DDI EFV   P4S, V35K, T39E, S48T, V60I, K64R, K122E, D123S, S162C, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V