Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Baxter (2006)
Title Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir.
Citation J Virol
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 3372
NumPts 3223
Subtype B, CRF12_BF, F, D, B + F, C, A, G, CRF02_AG, CRF45_cpx, CRF05_DF, J, CRF01_AE, CRF09_cpx, CRF04_cpx, CRF18_cpx, CRF44_BF, H

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 3372 Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
12-1001 1001-30227 PI  I54T, V82A L33F L10I, V11L, G16A, L19V, K20R, E34Q, E35D, M36I, N37E, G48X, D60E, L63P, I64IL, A71V, V77I, L89I, I93L  
12-1004 1004-30304 PI  M46I, I54L, I84V, L90M L10F, L33F, G73T I13V, L19I, E34Q, K55R, I62V, L63P, I66F, H69Q, V77VI  
12-1006 1006-30310 PI  V32VI, I47IV, I54LV, V82A, I84V, L90M L33F, Q58E, L89LV L10I, I15V, L19LI, K20R, E35D, M36L, N37D, R57K, I62V, L63P, A71V, I72IL, I85V, Q92K  
12-1007 1007-30519 PI  M46L, I54IV, V82A, L90M L33F, K43KT L10I, I15V, L19T, K20R, E35D, M36I, R41K, Q61E, I62IV, L63P, H69K, T74S, L89M, I93L  
12-1009 1009-30522 PI  M46I, I54M, L76V, I84V, L90M L10F I15V, K20I, E34K, E35D, M36I, R57K, Q61H, L63P, A71V, I72L, I85V  
12-1024 1024-30319 PI    E35D, N37D, K43R, L63P, I64V  
  1024-30513 PI, RTV, TPV M46I, L76LV, V82F, L90LM L33F, Q58E L10V, I13V, E35D, M36I, R57K, I62V, L63S, L89M  
12-1027 1027-30324 PI    I15V, M36I, L63X  
12-1044 1044-30603 PI    L10I, K14KR, R41K, Q61H, I93L  
12-1093 1093-30224 PI  G48V, I50V, I54V, V82S L89V L10I, V11L, K14R, I15V, K20I, M36I, R41K, I62V, L63P, A71V, T74S, I85V, T91TS  
12-1099 1099-30303 PI  M46MI, N88NS L24LI L10LI, T12KR, I15IV, L19IV, N37CST, P39PQ, L63P, K70R, A71AT, V77I  
12-1103 1103-30610 PI  M46I, I54V, I84V, L90M L10FI, G73C I15IV, K20I, M36I, N37D, Q61QH, I62V, L63P, A71AV, I72V, I93L  
12-1111 1111-30410 PI  M46L, G48V, I54LV, V82A, I84V, L90M  L10I, I15V, E35D, N37D, D60DE, L63P, A71V, I93L  
12-1119 1119-30318 PI  V82A L10F, L24I, F53FL E35D, M36I, R57K, I62V, L63P, A71V, T74S  
12-1120 1120-30319 PI  M46I, L90M L24F, G73C L10I, K14KR, K20I, I62V, L63P, A71V, I72V, T74S, V77I, I93L  
12-1127 1127-30310 PI  L90M Q58E L10I, P39T, L63P, V77I, I93L  
12-1129 1129-30311 PI  M46L, I54V, V82A, I84V L10F, L24I, Q58E I15V, K20M, E35D, M36MIV, R57K, I62V, L63P, I64V, A71AV, T74K, T91TA  
12-1132 1132-30320 PI  V32I, M46I, I47V, I54M, I84V L10FI, L33F G16E, E35D, M36I, P39S, I62V, L63P, I66IF, A71V, V77VI, Q92QK  
12-1134 1134-30326 PI  V32I, M46I, I47V, I54M, I84V, L90M L10F, K20T, L33F, G73D, L89V I13V, I15V, M36I, N37S, R41K, L63P, A71V, I93L  
12-1143 1143-30403 PI    L10LI, G16GE, K20KR, E35D, L63C, I64V  
12-1145 1145-30318 PI  M46L, I54L, V82A, I84V L24I, L33F, K43T, L89V L10I, I13V, K20R, E35D, M36I, N37E, L63P, A71V, P79PS, T91S, I93L  
  1145-30401 PI, RTV, TPV M46L, I54L, V82A, I84V L24I, L33F, K43T, L89V L10I, I13V, K20R, E35D, M36I, N37E, L63P, A71V, P79S, T91S, I93L  
12-1150 1150-30408 PI  I54L, V82A, I84V, L90M L33F, K43T, T74P L10I, I13V, E35D, M36IL, N37ND, I62V, L63P, A71V, I72V, I93L  
12-1278 1278-30417 PI  L90M G73GS N37D, D60E, L63P, A71AV, V77I, I85IV, I93L  
12-1281 1281-30424 PI  M46I, L90M L24LM, G73S L10I, K20V, D25N, D60E, Q61E, I62IV, L63P, H69Q, A71V, I72R, V77IM  
12-1283 1283-30220 PI  M46L, I54M, V82A, L90M L10F, K20KT, L33F, K43KT T12P, I13V, K14R, N37D, R57K, I62V, L63P, A71V, I93L, C95F  
12-1313 1313-30513 PI  V32I, M46L, I54L, I84V, L90M L33F, K43T L10V, I13V, E21EQ, E34K, D60E, L63PS, H69HY, T74TA, V77VI, L89F  
12-1321 1321-30402 PI  I54M, I84V, L90M L10F, Q58E, G73S, L89V V11L, T12S, I13V, K14R, I15V, Q18H, L19Q, K20I, E34Q, M36MI, N37S, G51A, D60E, L63P, A71V, P79Q  
12-1326 1326-30701 PI  M46L, I54V, V82A, I84V L24I, L33F, F53L L10IV, N37D, K55R, L63P, I64V, A71V, T74S, V77I, I93L  
12-1337 1337-30414 PI  V32I, I47A, L90M L10F, F53L K20R, E35D, M36I, R41K, K45KR, I62V, L63P, H69Y, A71V, V77I  
12-1345 1345-30501 PI  M46MI, I54V, V82AT, L90M  K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63P, A71V, I85V  
12-1350 1350-30624 PI  I54V, V82A  L10I, I15V, L63P, T74S  
12-1359 1359-30729 PI  M46MI, I84IV, L90LM  L10LI, T12TA, I13IV, K14KR, K20KI, E35D, M36MI, L63LP, I64V, A71AV, I72IV, P79PH, I93IL  
12-1365 1365-30728 PI  V32I, M46I, I54V, V82A, L90M F53FL W6L, L10I, I13IV, G16A, L19I, M36I, L63P, A71V  
12-1366 1366-30821 PI  M46IL, I54V, V82S L24I, K43T, F53FL L10IV, L19I, K20R, E35D, M36I, N37NS, R41K, K55KR, D60E, L63P, I64IMV, A71V, V77I, I93L  
12-1380 1380-30422 PI  M46I, I54V, V82A, I84V L24I L10I, E35D, N37D, L63P, A71V, I93L  
12-1417 1417-30729 PI  M46I, I54V, V82F, L90M Q58E L10I, R57K, L63P, I64V, V77I, I93L  
12-1421 1421-30331 PI  D30N, M46L, I54L, L90M K20T, N88D L10R, I15V, L19Q, R41K, K55KR, L63P, K70R, A71V, V77I V32V_W 
12-1424 1424-30401 PI  V32I, M46I, I47V, I54LV, V82A, L90M L10F, F53L, Q58E I15V, D60E, L63P, A71V  
12-1428 1428-30313 PI  M46I, I84V, L90M  L10I, I13V, K20I, M36I, Q61N, L63A, I64L, I93L  
12-1437 1437-30731 PI  M46I, I54V, V82A, L90M Q58QE, G73C L10I, I15V, K20R, M36I, R41K, D60E, I62V, L63P, H69HR, I72L  
12-1623 1623-30320 PI  I54A, V82A, L90M G73S, L89V L10I, T12K, I13V, G16E, L19I, K20I, M36I, L38F, I62V, L63H, A71V, T74S, I93L E34E_KQY*K 
12-1626 1626-30328 PI  M46L, I54V, V82A, L90M L23I L10I, T12TS, K20R, M36MI, N37D, I62V, L63P, A71V, Q92R, I93L  
12-1645 1645-30313 PI  M46L, I54L, V82A, I84V, L90M L33F, K43T, T74P L10V, V11VL, I13V, K20R, E35D, M36I, N37D, R41RK, K55R, R57K, I62V, L63P, A71V, I93L E34DY 
12-1669 1669-30319 PI  M46I, I47V, I54V, V82A, L90M L33F, F53L, Q58E L10I, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I93L  
12-1670 1670-30319 PI  M46I, I54IMV, V82A, I84IV, L90M F53FL L10I, N37D, R41K, I62IV, L63AP, I64IM, A71LV, I72V, T74S, I93L  
12-1676 1676-30331 PI  I54LV, I84V, L90M L33F, Q58E, G73S L10I, I13V, Q18E, K20R, E35D, M36I, K55KR, L63P, I66IL, A71V, I93L  
12-1696 1696-30429 PI  M46I, I54V, V82A, L90M L24F, L33F, F53L L10I, E35ED, N37E, I62V, L63P, A71I, I93L  
12-1712 1712-30410 PI  L90M  L10V, I15V, E35D, N37T, L63P  
12-1731 1731-30501 PI    E35D, L63P, I72IM, V77VI, I93IL  
12-1741 1741-30515 PI  M46I, I47V, I54V, I84V, L90M L10F, K20T, G73NS, L89V I13V, I15V, R57K, I62V, L63P, A71V, I72IM, P79A L33L_V 
12-1757 1757-30604 PI  M46L, G48V, I54V, V82A L24I, F53L L10I, N37D, K55R, L63E, I64V, E65D, T74S, V77I  
12-1803 1803-30515 PI  M46MI, I54V, V82S L24I, Q58E L10I, K20R, E35D, M36I, N37D, R57K, L63P, I64V, A71X, I93L  
12-1809 1809-30429 PI  M46I, I54V, V82A, I84IV L10F, L24I, L33LF, K43T M36MI, N37S, R41K, K55R, I62IV, L63P, I64V, A71AT, T91S  
12-1841 1841-30728 PI    L10LV, E35D, M36I, N37E, R41K, I62IV, L63P, K70R, V77I  
12-1870 1870-30811 PI  L90LM  L63T, I64IV, H69Y, I72T, V77I R8A 
12-1877 1877-30602 PI  V32I, M46I, I47V, I54IM, V82VA, L90M L33F, F53FL, G73S L10I, V11VI, I13V, I15IV, E34EQ, N37C, R41K, I62IV, L63P, A71AV, V77I, I93L, C95CF  
12-1888 1888-30625 PI  M46I, I54IV, I84V, L90M L10F, G73T I15V, K20L, M36I, I62V, I64V, I85V, I93L  
12-1900 1900-30527 PI  I54V, V82A, L90M G73S L10I, I15V, K20R, E35D, M36I, R57K, D60E, I62V, L63P, A71V, I72IL  
12-1915 1915-30714 PI  M46I, I54V, L90M L10F, L23I, L33F, F53L, G73S T12E, R41K, Q61R, I62V, L63P, C67Y, A71V, I72L, V77VI, I93L  
12-1926 1926-30519 PI  M46I, I84V, L90M G73C L10IV, K20I, I62IV, L63P, I64V, I72IT, I93L  
12-1927 1927-30527 PI  M46I, I47V, I54M, I84V, L90M G73C L10I, I15V, L19V, K20R, M36I, L63P, I64V, I66V, I85IV  
12-1928 1928-30818 PI  M46I, I54L, I84V, L90M L33LF L10I, N37NS, R41K, F53Y, I62V, L63P, I64V, H69Q, V77I, Q92R, I93M, C95F  
12-1964 1964-30527 PI  M46I, I84V, L90M L10F T12TA, K20I, R41K, L63P, A71V, V77I, I85V, Q92K, I93L  
12-1970 1970-30604 PI  M46I, I47V, I54M, I84V, L90M L10F, G73A I15V, L19V, K20I, E34Q, E35D, M36I, N37S, R57K, Q61H, L63P, I64V, I85IV, Q92K  
12-1976 1976-30604 PI  M46I, I47V, I54M, I84V, L90M G73T L10I, K20R, E35D, M36I, N37E, R57K, I62IV, L63P, C67F, H69R, A71V, P79AS, I85V, I93L, C95V  
12-1979 1979-30514 PI  M46MI, I54A, V82A, L90LM L10FV, K20T, K43T I13V, I15V, E35D, M36I, R41K, I62V, L63P, I64V, A71V, T74S, V77I, I93L  
12-2002 2002-30610 PI  V32I, M46I, I47V, I54M, V82A L10F, L33F, K43T K20R, E35D, M36L, L63P, A71V  
12-2005 2005-30630 PI  M46I, I54V, I84V, L90M L10F, L24M, G73T V11I, K14R, I15V, K20I, E35N, M36I, R41K, I62V, L63P, A71V, I85V, I93L  
12-2029 2029-30724 PI  M46I, I54IL, I84V, L90M G73T L10I, I15V, K20I, E35D, L63P, A71V, I85V, I93L  
12-2031 2031-30728 PI  D30N, M46I, I54V, L90M N88D I13V, E35D, M36I, N37E, I62V, L63P, A71T  
12-2038 2038-30709 PI  M46MI, I50V, I54V, V82A, L90M L10FV, K43T, G73S, L89V V11VI, K14R, I15V, G16A, K20I, M36I, Q61QH, I62IV, L63P, A71V, I72IM, I85V L19LHQ 
12-2050 2050-30625 PI  V32I, M46I, I47V, L90M N88D L10I, I15V, L19V, E35D, M36I, N37S, L63P, I85V, Q92K  
12-2077 2077-30609 PI  V32I, M46I, I47V, I54M, V82T, L90M  L10R, V11I, I13V, K20I, L33V, K55R, I62V, L63P, A71L, I72L, Q92R  
12-2098 2098-30613 PI    E35D, N37S, R41K, I62V, L63P, K70E, A71T, V77I, I93L  
12-2100 2100-30613 PI  V32VI, M46I, I54L, I84V Q58E L10I, T12K, I15V, G16A, L19I, K20R, M36I, N37A, G51A, L63C, I66F, A71V, V82X, T91S  
12-2127 2127-30729 PI  V32I, M46I, I47V, L90M G73A, L89V I13V, N37T, K43R, R57K, L63P, I64V  
12-2137 2137-30723 PI  V32I, M46I, I47V, I54M, L90M L33F, G73A L10I, I13V, N37NS, I62V, L63P, I66F, V77I  
  2137-31022 PI, RTV, TPV 13 V32I, M46I, I47V, I54M, L90M L33F, G73A L10I, I13V, I62V, L63P, I66F, I72IT, V77I  
  2137-40728 PI, RTV, TPV 53 V32IL, M46I, I47V, I54M, V82L, L90M L33F, G73A L10I, I13V, K55KR, I62IV, L63P, I66F, V77I, I85L  
12-2160 2160-30702 PI  I54V, I84V, L90M L10F, K20T, G73S V11I, I15V, E34T, E35D, N37T, I62V, L63P, A71V, I85V  
12-2168 2168-30804 PI  D30N, L90LM N88D R41K, K45R, L63P, V77VI, I93L  
12-2177 2177-30627 PI  M46I, I84V, L90M L10FI, G73C I15IV, R41K, I62IV, L63P, I72K  
12-2183 2183-30701 PI  M46I, I54M, I84V, L90M L10F, L24LM, L33F, G73T I13V, L19I, L63P, A71AV  
12-2184 2184-30807 PI  D30N, M46I  T12N, L63P, V77I, Q92E, I93L  
12-2195 2195-30630 PI  M46I, I47V, I54M, L90M G73S, L89V L10I, R57K, L63P, A71V, V75I, V77I, I85V, I93L V32I_P 
12-2231 2231-30715 PI  M46I, I54M, V82A, L90M L10FI T12TP, I13V, Q18H, K20I, R41K, K55R, D60E, L63P, A71I, I93L, C95F  
12-2251 2251-30730 PI   L10LF I13V, I15V, R57K, L63P, I64V  
12-2254 2254-30710 PI  V32I, M46I, I47V, I54L, L90M L10F, G73T K20I, M36V, I62V, L63P, I66L, A71V, I72T  
12-2275 2275-30725 PI  M46I, I84V, N88S L10F, K20T, L33F I13V, L19V, R57K, L63P, A71T, V77I  
12-2395 2395-30728 PI  M46I, I54M, L76V, I84V, L90M L10F I15V, Q18QL, K20I, E34K, E35D, M36I, R57K, Q61H, L63P, A71V, I72L, I85V  
  2395-30807 PI, RTV, TPV M46I, I54M, L76V, I84V, L90M L10F I15V, K20I, E34K, E35D, M36I, R57K, Q61H, L63P, A71V, I72L, I85V  
12-2412 2412-30812 PI  V32I, M46I, I47V, I54V, V82A, L90M K43T, F53L, G73GS L10I, I15V, K20R, E35D, M36I, R41K, L63P, A71V, I72V  
  2412-31119 PI, RTV, TPV 14 V32I, M46I, I47V, I54V, V82AT, L90M K43T, F53L, G73S L10I, I15V, K20R, E35D, M36I, R41K, L63P, A71V, I72V  
12-2415 2415-30821 PI  M46MI, I54V, V82VF, L90M F53L, G73T L10I, L19I, K43R, I62V, L63P, I66IL, A71AV, V77I, I93L  
12-4009 4009-30129 PI  M46L, I54V, V82A L24I, Q58E L10I, I15V, G16E, L19P, K20I, E35D, M36I, K55R, I62V, L63H, A71T, Q92K  
12-4023 4023-30529 PI  I54V, V82A, I84V L89V L10I, V11VL, I13V, K20IM, M36I, R41RK, K43KR, D60E, I62V, L63P, A71V, Q92K L33L_L 
12-4070 4070-30226 PI  M46I, I54ILM, L76V, I84V L10FI, K20T, L24LI, L89LV I13V, E34K, M36MI, L63P, A71V, I72L, V77I  
12-4077 4077-30318 PI  G48V, L90M M46V L10V, K14R, R41K, D60E, L63P  
12-4083 4083-30311 PI    N37ND, L63P