Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Skinner (1998)
Title Analysis of a large collection of natural HIV-1 integrase sequences, including those from long-term nonprogressors.
Citation JAIDS
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 16
NumPts 16
Subtype B

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
103 ED103
Consensus 
None    M22MR, E35EK, C40CR, D41DN, G47GR, E48EK, G52GR, G70GR, I72V, G82GR, I84IM, E92EK, T124TA, G134GE, E152EK, E157EK, R166RG, H171HR, R187RG, T218TA, R224RQ, A265V, R269RK, G272GR W19W*, A76AT, W131W*, W132W*, G149GE, R228RK, W235W* 
  clone: 1 None    D41N, E48K, I72V, A265V  
  clone: 12 None    C40R, I72V, A265V  
  clone: 15 None    I72V, R224Q, A265V  
  clone: 16 None    I72V, R166G, H171R, A265V G149E 
  clone: 17 None    G47R, G52R, I72V, G82R, T124A, W131*, W132*, W235*, A265V, R269K, G272R G149E, R228K 
  clone: 18 None    W19*, E35K, G47R, G52R, G70R, I72V, G82R, I84M, E92K, W132*, G134E, R224Q, W235*, A265V, R269K, G272R R228K 
  clone: 19 None    W19*, E35K, G47R, G52R, G70R, I72V, G82R, I84M, E92K, W132*, G134E, R224Q, A265V  
  clone: 2 None    I72V, T218A, A265V  
  clone: 3 None    M22R, D41N, E48K, I72V, E152K, R187G, A265V  
  clone: 4 None    I72V, T124A, A265V A76T 
  clone: 5 None    I72V, A265V  
  clone: 6 None    D41N, E48K, I72V, E152K, E157K, A265V  
127 ED127
Consensus 
None   H51HY D3DN, S17SN, M50MI, I72IV, G82X, L101LI, I113IV, T122TI, T124GN, I203IM, K258KE, A265V Y83YN, T93TI, T112TPA, N144ND, I257IM 
  clone: 1 None    M50I, I72V, T124G, A265V  
  clone: 2 None    I72V, T124G, A265V T112P, I257M 
  clone: 3 None    S17N, I72V, G82X, Y83X, I113V, T124G, A265V T93I 
  clone: 4 None    D3N, I72V, T124G, A265V N144D 
  clone: 5 None   H51Y I72V, G82X, Y83X, L101I, T112A, T122I, T124N, K258E, A265V  
  clone: 6 None    G82X, Y83X, L101I, T124G, I203M, A265V  
143 ED143
Consensus 
None  N155NS  I72V, G94GR, L101LI, K111KT, S119SG, T122I, T124TA, T125TA, R187RG, G193E, R224RQ, G247GR, A265V, D286N W132W*, A179AT, G192GE 
  clone: 1 None    I72V, S119G, T122I, T125A, G193E, A265V, D286N  
  clone: 2 None    I72V, L101I, T122I, T124A, G193E, A265V, D286N  
  clone: 3 None  N155S  I72V, G94R, L101I, K111T, T122I, W132*, G193E, R224Q, G247R, A265V, D286N A179T, G192E 
  clone: 4 None    I72V, L101I, T122I, T124A, G193E, R224Q, G247R, A265V, D286N  
  clone: 5 None    I72V, L101I, T122I, T124A, G193E, A265V, D286N  
  clone: 6 None    I72V, S119G, T122I, T125A, R187G, G193E, A265V, D286N  
157 ED157
Consensus 
None   A128T E10A, S17SN, D55DG, I72V, S119G, T125TA, K188KR, T210TA, K211KR, A265V, R284G A86AT, H183HY, G192GW, Q209QR, L234LP, W235WR 
  ER157
Consensus 
None   A128T E10A, S17SN, I72V, S119G, T125A, V126VA, K215KR, A265V, K273KN, R284G  
  ED157
clone: 1 
None   A128T E10A, I72V, S119G, A265V, R284G  
  ER157
clone: 1  
None   A128T E10A, S17N, I72V, S119G, T125A, K215R, A265V, R284G  
  clone: 2 None   A128T E10A, I72V, S119G, T125A, A265V, R284G  
  ED157
clone: 3 
None   A128T E10A, D55G, I72V, S119G, T125A, K188R, T210A, K211R, A265V, R284G G192GRW 
  clone: 4 None   A128T E10A, I72V, S119G, A265V, R284G H183Y 
  ER157
clone: 4  
None   A128T E10A, I72V, S119G, T125A, V126A, A265V, R284G  
  clone: 5 None   A128T E10A, I72V, S119G, T125A, A265V, R284G  
  ED157
clone: 6 
None   A128T E10A, I72V, S119G, A265V, R284G A86T 
  ER157
clone: 6  
None   A128T E10A, S17N, I72V, S119G, T125A, A265V, K273N, R284G  
  clone: 7 None   A128T E10A, I72V, S119G, T125A, A265V, R284G  
  ED157
clone: 8 
None   A128T E10A, I72V, S119G, A265V, R284G L234P 
  clone: 9 None   A128T E10A, S17N, I72V, S119G, T125A, A265V, R284G Q209R, W235R 
  LD157
Consensus 
None   A128AT E10D, I72V, K111KR, S119SG, T122I, T125A, G190GR, I200IV, T206TA, S230SG, R284RG, E287EG G189GE, K240KE, K273KI 
  LR157
Consensus 
None  S147SG A128AT E10D, K14KR, M22MI, I36IV, I72V, S81SR, S119SG, T122I, T125A, D167DG K240KE 
  clone: 1 None   A128T E10D, M22I, I72V, S81R, T122I, T125A  
  LD157
clone: 2 
None    E10D, I72V, S119G, T122I, T125A, G190R, E287G G189E 
  clone: 3 None    E10D, I72V, S119G, T122I, T125A K240E 
  LR157
clone: 3  
None  S147G  E10D, I72V, S119G, T122I, T125A  
  LD157
clone: 4 
None    E10D, I72V, K111R, S119G, T122I, T125A, R284G  
  LR157
clone: 4  
None    E10D, K14R, I36V, I72V, S119G, T122I, T125A, D167G  
  LD157
clone: 5 
None   A128T E10D, I72V, T122I, T125A, R284G  
  LR157
clone: 5  
None   A128T E10D, I72V, S119G, T122I, T125A  
  LD157
clone: 6 
None   A128T E10D, I72V, S119G, T122I, T125A, I200V, S230G K273I 
  clone: 7 None    E10D, I72V, S119G, T122I, T125A, T206A, R284G  
  LR157
clone: 8 
None    E10D, I72V, S119G, T122I, T125A K240E 
  clone: 9 None   A128T E10D, I72V, T122I, T125A K240E 
171 ED171
Consensus 
None   G163GR E11D, E13EK, S17SR, K46KR, G59GE, I72V, G82GR, S119G, T122I, G134GK, I135IV, I200IV, K236KR, A265V, R269RK W19W*, E96EK, G106GE, R107RK, W108W*, W131W*, W132W*, G149GR, S153SP 
  clone: 1 None    E11D, I72V, S119G, T122I, A265V  
  clone: 2 None    E11D, I72V, S119G, T122I, I135V, I200V, A265V S153P 
  clone: 3 None    E11D, I72V, S119G, T122I, A265V  
  clone: 4 None   G163R E11D, E13K, S17R, W19*, G59E, I72V, G82R, W108*, S119G, T122I, W131*, W132*, G134K, A265V, R269K E96K, R107K, G149R 
  clone: 5 None    E11D, K46R, I72V, S119G, T122I, K236R, A265V  
  clone: 6 None    E11D, I72V, S119G, T122I, A265V G106E 
ED002
Consensus 
None    D41N, G59GR, I72V, V110VI, S119SG, E152EK, M154I, E157EK, K159KR, V201VL, K211R, L234LI Q137Q*, I204IM, D256DG, K273KE 
  clone: 1 None    D41N, I72V, M154I, K211R K273E 
  clone: 2 None    D41N, I72V, M154I, K211R  
  clone: 4 None    D41N, I72V, V110I, M154I, K159R, V201L, K211R  
  clone: 5 None    D41N, I72V, Q137*, E152K, M154I, E157K, K211R I204M, D256G 
  clone: 6 None    D41N, G59R, I72V, M154I, K211R, L234I  
  clone: 7 None    D41N, I72V, S119G, M154I, K211R  
28 ED028
Consensus 
None    V32VI, E35EQ, I72V, T124A, V201VI, I217IV, D256E, K264KE, A265V V176VA 
  clone: 1 None    E35X, I72V, T124A, D256E, A265V  
  clone: 2 None    I72V, T124A, D256E, A265V  
  clone: 3 None    I72V, T124A, V201I, I217V, D256E, A265V V176A 
  clone: 4 None    I72V, T124A, D256E, A265V  
  clone: 5 None    I72V, T124A, D256E, A265V  
  clone: 7 None    V32I, I72V, T124A, V201I, D256E, K264E, A265V  
48 ED048
Consensus 
None    I72V, T124G, A265AV C65CG, L74LP, A133AS, K266KQ 
  clone: 1 None    I72V, T124G A133S 
  clone: 2 None    I72V, T124G, A265V L74P, K266Q 
  clone: 3 None    I72V, T124G, A265V  
  clone: 4 None    I72V, T124G, A265V C65G, A133S 
  clone: 5 None    I72V, T124G, A265V  
  clone: 6 None    I72V, T124G, A265V  
61 ED061
Consensus 
None    E11D, E13EG, E48Q, M50I, Q62QR, G106A, S119TP, N144NS, I161IV, V201I, I203M, Q252QR, D256E, A265V P145PL, R166RS 
  ER061
Consensus 
None    E11D, E48Q, M50I, G106A, S119T, G192X, V201I, I203M, D256E, A265V, I268IV I162IT 
  ED061
clone: 1 
None    E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V  
  ER061
clone: 1  
None    E11D, E48Q, M50I, G106A, S119T, G192X, V201I, I203M, D256E, A265V  
  clone: 2 None    E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V, I268V  
  clone: 3 None    E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V  
  ED061
clone: 4 
None    E11D, E13G, E48Q, M50I, G106A, S119T, N144S, V201I, I203M, D256E, A265V  
  ER061
clone: 4  
None    E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V I162T 
  ED061
clone: 5 
None    E11D, E48Q, M50I, G106A, S119T, I161V, V201I, I203M, D256E, A265V  
  ER061
clone: 5  
None    E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V  
  clone: 6 None    E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V  
  ED061
clone: 7 
None    E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V  
  clone: 8 None    E11D, E48Q, M50I, G106A, S119T, V201I, I203M, Q252R, D256E, A265V R166S 
  clone: 9 None    E11D, E48Q, M50I, Q62R, G106A, S119P, V201I, I203M, D256E, A265V P145L 
  LD061
Consensus 
None    E11D, E48Q, M50I, G106A, S119T, T124N, A129AS, K160KR, L172LF, V201I, I203M, T210TI, Q221X, Y227X, D256E, K264KE, A265V N222N~-, F223F~-, R224R~-, V225V~-, Y226Y~- 
  LR061
Consensus 
None    K7X, E11D, E48Q, M50I, V79VA, G106A, S119T, T124N, E157EK, V201I, I203M, D256E, A265V L28LP, K186K*, K188KE 
  LD061
clone: 1 
None    E11D, E48Q, M50I, G106A, S119T, T124N, K160R, V201I, I203M, T210I, D256E, A265V  
  LR061
clone: 1  
None    E11D, E48Q, M50I, G106A, S119T, T124N, E157K, V201I, I203M, D256E, A265V  
  LD061
clone: 2 
None    E11D, E48Q, M50I, G106A, S119T, T124N, K160R, L172F, V201I, I203M, D256E, A265V  
  LR061
clone: 2  
None    E11D, E48Q, M50I, V79A, G106A, S119T, T124N, V201I, I203M, D256E, A265V  
  LD061
clone: 3 
None    E11D, E48Q, M50I, G106A, S119T, T124N, A129S, K160R, V201I, I203M, D256E, A265V  
  LR061
clone: 3  
None    K7X, E11D, E48Q, M50I, G106A, S119T, T124N, E157K, V201I, I203M, D256E, A265V  
  LD061
clone: 4 
None    E11D, E48Q, M50I, G106A, S119T, T124N, V201I, I203M, Q221X, Y227X, D256E, A265V N222~, F223~, R224~, V225~, Y226~ 
  clone: 5 None    E11D, E48Q, M50I, G106A, S119T, T124N, V201I, I203M, Q221X, Y227X, D256E, A265V N222~, F223~, R224~, V225~, Y226~ 
  clone: 6 None    E11D, E48Q, M50I, G106A, S119T, T124N, K160R, V201I, I203M, D256E, K264E, A265V  
  LR061
clone: 7 
None    E11D, E48Q, M50I, G106A, S119T, T124N, E157K, K186*, V201I, I203M, D256E, A265V K188E 
  clone: 8 None    E11D, E48Q, M50I, G106A, S119T, T124N, E157K, V201I, I203M, D256E, A265V L28P 
  clone: 9 None    E11D, E48Q, M50I, G106A, S119T, T124N, E157K, V201I, I203M, D256E, A265V  
62 ED062
Consensus 
None    R20K, I72IV, E87EK, L101I, T112X, T124A, I135IV, I141IT, A169AT, G193E, I220L, Q221QRH, N222NT, Y227YF, S230SN, D286DN H114HR, W131WG 
  clone: 1 None    R20K, I72V, L101I, T112A, T124A, I141T, G193E, I220L, Q221R, Y227F, D286N  
  clone: 2 None    R20K, L101I, T112V, T124A, G193E, I220L, Q221H, N222T  
  clone: 3 None    R20K, I72V, L101I, T112V, T124A, G193E, I220L, Y227F, S230N  
  clone: 4 None    R20K, I72V, L101I, T112A, T124A, A169T, G193E, I220L, Y227F W131G 
  clone: 5 None    R20K, E87K, L101I, T112A, T124A, G193E, I220L, Y227F H114R 
  clone: 6 None    R20K, L101I, T112V, T124A, I135V, G193E, I220L, Y227F, D286N