Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Parkin (2006)
Title The K101P and K103R/V179D mutations in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nonnucleoside reverse transcriptase inhibitors.
Citation AAC
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 76
NumPts 76
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
P_1 K101P_1 Unknown Unknown M41L, D67S, T69T_CT, L74V, L210W, T215Y K101P K20R, K43E, E44A, R83K, A98S, V118I, K122E, D123E, I135T, S162DG, K166R, D177DN, I178M, V179VI, G196E, T200A, R211K, V245E, A272P, K281KR, E297K  
P_10 K101P_10 Unknown Unknown M41L, D67N, L74I, M184V, T215Y, K219Q K101P K20R, K43E, E44D, A98S, V118I, D123E, D177E, I178IL, G196GE, E203EK, Q207E, H208Y, R211K, D218E, L228H, V245E, T286A, I293V, E297K  
P_11 K101P_11 Unknown Unknown A62AV, M184V K101P, H221HY D123E, I135T, T139V, I178M, G196E, R211G, F214L, L228LR, A272P, K281R, T286P, I293V, E297K  
P_12 K101P_12 Unknown Unknown M41L, L74LV, M184V, L210W, T215Y K101P, V108I, V179L K43KN, V75VL, V118VI, I135T, R211K, L228R, V245E, T286TA, I293V, E297R, L301I  
P_13 K101P_13 Unknown Unknown M41L, M184V, L210LW, T215Y K101P, H221CY K30KR, V245T, K277R, E297K  
P_14 K101P_14 Unknown Unknown M41L, M184V, T215Y K101P V35E, T39A, K43KN, E44ED, V90VI, V118I, D123E, T139K, I142V, S162D, K166KR, D177E, V179I, T200A, Q207E, R211K, L228H, K238KR, Q242QH, V245VM, E248Q, D250DE, A272P, A288AS  
P_15 K101P_15 Unknown Unknown D67N, M184V, T215Y, K219E K101P K11KT, K122KE, I135T, V179VI, Q207N, R211K, D218E, E224EA, V245IM, I274IV, K277R, I293V, P294S, E297R  
P_16 K101P_16 Unknown Unknown M41L, D67N, L210W, T215Y, K219N K101P, V106I V35I, T39A, K43X, E44D, V118I, D121DH, K122KE, D123DE, K166R, V179I, G196E, T200A, E203D, H208F, R211K, D218E, D250E, A272P, K277KR, A288S, I293V, E297K  
P_17 K101P_17 Unknown Unknown D67N, K70G, T215F, K219E K101P, V179D K20R, S68N, I178M, R211K, V245E, E248D, A272P, R284K, E291D  
P_18 K101P_18 Unknown Unknown D67N, K70KR, M184V, T215Y, K219E K101P K11KR, E53EG, K122KE, I135T, V179VI, Q207N, R211K, D218E, V245M, K277R, T286TA, I293V, P294S, E297R  
P_19 K101P_19 Unknown Unknown M41ML, A62V, V75I, M184V, T215Y K101P I31L, K49KR, D123E, I135IT, D177E, T200A, R211T, Q242QR, V245E, I293V, E297K  
P_2 K101P_2 Unknown Unknown A62V, D67G, T69G, K70KR, V75I, F77L, F116Y, Q151M, M184V, K219E K101P V35I, R83K, K104KR, K122E, D123N, S162C, I202V, Q207N, A272P, T286A, E297A  
P_20 K101P_20 Unknown Unknown M184V K101P V60I, R83K, K122P, I142V, I178L, T200A, R211K, V245I, A272P, L283I  
P_21 K101P_21 Unknown Unknown M41L, D67N, L74I, M184MV, T215Y, K219Q K101P K20R, V35IL, T39TA, K43E, E44D, A98S, V118VI, D123E, D177E, G196E, E203K, Q207E, H208Y, R211K, D218E, L228H, V245E, T286A, I293V, E297K  
P_22 K101P_22 Unknown Unknown M41L, D67N, L74I, M184V, L210W, T215Y, K219N K101P E6K, K20R, V35I, K43E, E44AD, V118I, K122E, R211Q, D218E, A272P, I293IV, E297EK  
P_23 K101P_23 Unknown Unknown M41L, D67N, L210W, T215Y, K219N K101P, V106I V35I, T39A, K43X, E44D, V118I, D121H, K122E, K166KR, V179I, G196E, T200A, E203D, H208F, R211K, D218E, D250E, A272P, K277KR, A288S, I293V, E297K  
P_24 K101P_24 Unknown Unknown D67N, K70R, K219KE K101P T39TI, R83K, E203K, Q207H, R211K, V292I  
P_25 K101P_25 Unknown Unknown M41L, D67N, T69D, M184V, L210W, T215Y K101P V35L, T39A, K43S, E44D, V118VI, K122E, D123E, I135T, I178L, V179I, I202IV, R211K, A272P, I293IV, T296TS, E297A  
P_26 K101P_26 Unknown Unknown T215Y K101P, E138EG, V179L K49R, R83K, I135T, I178IM, A272P, I293V, P294A  
P_27 K101P_27 Unknown Unknown D67G, T69D, K70R, T215Y, K219KE K101P K20R, V35T, K49KR, V60I, R83K, K122KE, S162SN, D177E, V179VI, I202IV, A272P  
P_28 K101P_28 Unknown Unknown M41L, D67N, L210W, T215Y K101P, V179L V21VI, K43E, E44A, T69E, V118I, K122E, D123DN, I178L, G196E, Q207E, R211K, T286TA, I293V, E297Q  
P_29 K101P_29 Unknown Unknown M184V K101P K104KR, K122P, I142V, S163SN, T286A, E297K  
P_3 K101P_3 Unknown Unknown D67N, K70R, K219Q K101P, H221Y, K238T K64KN, T69TN, K102Q, I178M, R211K, V245E, I293V  
P_30 K101P_30 Unknown Unknown  K101P T69N, K122E, Q174N, R211K, V245M, A272P, T286A, E297K, L301I  
P_31 K101P_31 Unknown Unknown M41L, L74I, M184V, L210W, T215Y K101P V35M, K43Q, V118I, K122E, D123DN, V179VI, T200A, E203D, Q207E, R211K, L228H, I293IV  
P_32 K101P_32 Unknown Unknown M41L, A62V, T69D, V75T, L210W, T215Y, K219R K101P V35VI, K43N, E44D, V118I, K122E, I135T, T139M, S162HN, H208Y, R211K, K223E, E224EK, L228R, D250E, A272P, K281KR, T286P, E291D  
P_33 K101P_33 Unknown Unknown M184V K101P, H221Y V90VI, D123E, S162SN, Q174H, I178L, V179I, E194ED, G196E, I202V, A272P, K277R, I293V, E297V  
P_34 K101P_34 Unknown Unknown M41L, D67N, V75VA, L210W, T215Y, K219N K101P, V106I V35I, T39A, K43E, E44D, V118I, D121H, K122E, K166R, D177DE, V179I, G196E, T200A, E203D, H208F, R211K, D218E, D250E, A272P, K277KR, A288S, I293V, E297K  
P_35 K101P_35 Unknown Unknown M41L, A62AV, T69D, L210W, T215Y, K219R K101P V35VI, K43N, E44ED, V75X, V118VI, K122E, D123DE, I135T, T139TM, S162X, H208HY, R211K, K223KE, E224EK, L228LHR, D250E, A272P, K281KR, T286TP, E291D  
P_4 K101P_4 Unknown Unknown A62V, D67G, T69G, K70KR, V75I, F77L, Y115YF, F116Y, Q151M, M184V, K219KE K101P V35IT, R83K, K104KR, K122E, D123N, S162C, V179VI, I202V, Q207N, A272P, R284RK, T286A, E297A  
P_5 K101P_5 Unknown Unknown M41L, M184V, T215Y K101P, H221Y V245T, K277R, E297K  
P_6 K101P_6 Unknown Unknown M41L, D67N, L74V, M184V, L210W, T215Y, K219N K101P K13KN, K43Q, E44D, I94L, V118I, K122E, D123E, I135T, N137NS, T200A, E203K, Q207E, D218E, K223Q, L228H, Q242H, T286TA, I293V  
P_7 K101P_7 Unknown Unknown T69D, Q151M, T215Y K101P V35R, T39A, K82R, R83K, K122E, I135T, I142IT, S162Y, K173E, V179VI, I244IV, A272P, I293V, E297K  
P_8 K101P_8 Unknown Unknown M41L, D67N, L210W, T215Y, K219N K101P, V106I V35VI, T39A, K43KN, E44D, V60VI, V118VI, K122KE, D123X, K166KR, V179VI, G196E, T200A, E203ED, H208X, R211K, D218DE, D250DE, A272P, I274IV, K277KR, A288AS, I293V, E297K  
P_9 K101P_9 Unknown Unknown M41L, D67N, L210W, T215Y, K219N K101P, V106I V35VI, T39A, K43X, E44D, V60VI, V118I, D121DH, K122KE, D123X, K166KR, V179I, G196E, T200A, E203D, H208F, R211K, D218E, D250E, A272P, I274IV, K277KR, A288S, I293V, E297K  
V179D_1 K103R_V179D_1 Unknown Unknown M41L, D67DG, L74I, V75VA, M184V, L210W, T215Y V179D K20R, K32KR, K43KE, S68SG, K103R, V118VI, I135M, K166KT, I178IM, V189I, T200A, H208HY, R211K, R284K, T286A  
V179D_10 K103R_V179D_10 Unknown Unknown K70R V179D V35T, K66R, K102Q, K103R, G196E, F214L, V245M, E248N, D250E, A272P, T286A  
V179D_11 K103R_V179D_11 Unknown Unknown M184V V179D E6K, K103R, V118I, K122AE, I135IT, D177DE, I202V, R211E, F214FL, A272P, I293V  
V179D_12 K103R_V179D_12 Unknown Unknown M184V V108I, V179D K20R, V35A, K103R, R211RK, A288AG, I293V  
V179D_13 K103R_V179D_13 Unknown Unknown A62V, Y115F, M184V, T215Y E138A, V179D V35I, K49E, I50IT, K102KR, K103R, V118I, I135IT, I142R, I178L, F214L, D218DE, H221X, A272P, V276I, L283I, I293IV  
V179D_14 K103R_V179D_14 Unknown Unknown M41L, L74LV, T215Y V179D E6K, V35VI, T39A, K43KQ, E44ED, K103R, K122E, I142V, I178M, E203D, Q207R, H208Y, R211E, V245L, A272P, L283I, A288T, I293V, T296S  
V179D_15 K103R_V179D_15 Unknown Unknown M184V V179D E6D, K102Q, K103R, D121Y, K122E, I135M, A158S, S162Y, T200A, R211K, E248D, A272P, L283I, A288S  
V179D_16 K103R_V179D_16 Unknown Unknown M41L, L210LW, T215Y V179D L34I, K103R, D121Y, K122E, D123E, S162C, I178M, G196E, T200I, R211G, D218DE, V245M, A272P, P294PQ  
V179D_17 K103R_V179D_17 Unknown Unknown M184V V179D E6D, S68G, V90I, K103R, K122E, K126KR, I135T, T200K, E203D, Q207D, R211K, A288S, E297A  
V179D_18 K103R_V179D_18 Unknown Unknown M41L, D67DN, L210W, T215Y V179D E6D, V35T, T39A, R83K, K103R, D123E, I142IV, I178M, G196GD, H208Y, R211K, V245EK, A272P, K277R, K281KR, T286PS, I293V, E297KR  
V179D_19 K103R_V179D_19 Unknown Unknown M184V V179D P9S, I31L, K103R, K122E, T200A, R211K, K238R  
V179D_2 K103R_V179D_2 Unknown Unknown A62AV, K70R, M184V V179D E6EK, K64R, K103R, K122E, I178M, T215X, S251SI, K277R, T286TA, I293V  
V179D_20 K103R_V179D_20 Unknown Unknown  V179D V21I, V60I, K103R, V118I, K122E, A158S, F214L, I244V, A272P, I293V  
V179D_21 K103R_V179D_21 Unknown Unknown M41L, D67N, K70R, M184V, T215F, K219Q E138A, V179D E6D, V35T, T39AS, D86E, W88S, K103R, V118I, K122E, D123E, I202V, Q207E, F214L, E248D, A272P, K277R, I293V, E297Q  
V179D_22 K103R_V179D_22 Unknown Unknown  V179D, K238T K102Q, K103R, K122E, D123DN, I178L, F214L, A272P, V276I, L283I, I293V  
V179D_23 K103R_V179D_23 Unknown Unknown M41L, L74I, M184V, T215Y V179D S3C, E6K, T39A, E44D, K103R, K122E, I142V, I178M, E203D, Q207K, H208Y, R211E, V245L, A272P, L283I, A288T, I293V, T296S  
V179D_24 K103R_V179D_24 Unknown Unknown M41L, L74LI, T215Y V179D E6D, V35T, T39A, R83K, K103R, D123E, I142IV, I178IM, G196GS, H208Y, R211K, V245E, A272P, K277R, K281KR, T286P, I293V, E297K  
V179D_25 K103R_V179D_25 Unknown Unknown M41L, L74LI, M184V, L210W, T215Y V179D E6D, V35T, T39A, R83K, K103R, V118I, D123E, I142V, I178IM, G196D, H208Y, R211K, V245E, A272P, K277R, K281KR, T286P, I293V, E297KR  
V179D_26 K103R_V179D_26 Unknown Unknown M184V V179D E6D, S48E, K103R, K122P, I135V, F214L, V245T, K277R, T286A, I293V, E297A T27TK 
V179D_27 K103R_V179D_27 Unknown Unknown  V179D R83K, K103R, D123E, Q174E, Q207R, F214L, L228LR, V245Q, E248Q, A272P, T286A, E297A I293IT 
V179D_28 K103R_V179D_28 Unknown Unknown M184V V179D V60I, K103R, D121Y, K122E, D123DE, I135T, I180IV, G196E, T200I, E203D, R211RS, F214L, V245M, Q278E, T286P, I293V, E297K  
V179D_29 K103R_V179D_29 Unknown Unknown  V179D E6D, A98S, K101Q, K103R, V118VI, D121H, K122E, I135KR, S162A, K173N, Q174K, D177E, R211K, F214L, A272P, A288AT, I293V  
V179D_3 K103R_V179D_3 Unknown Unknown A62AV, M184V V179D V35M, D86E, K103R, D123E, D177K, I202V, Q207A, R211K, V241I, A288G, I293V  
V179D_30 K103R_V179D_30 Unknown Unknown M184V V179D V60I, K103R, D121Y, K122E, D123DE, I135T, I180IV, G196E, T200I, E203D, R211RS, F214L, V245M, Q278E, T286P, I293V, E297K  
V179D_31 K103R_V179D_31 Unknown Unknown M41L, D67N, M184MV, L210W, T215Y, K219E V179D V35VI, E44D, K103R, K122E, D123X, I178M, T200A, H208Y, R211K, V245M, A272P, K277R, I293V  
V179D_32 K103R_V179D_32 Unknown Unknown K70N, L74I, Y115F, M184V V179D T39N, K103R, K122P, D123E, Q145QH, D177E, R211RK, V245M, I293V  
V179D_33 K103R_V179D_33 Unknown Unknown M184MV V179D, K238T E6EK, V35T, T39A, V60I, K103R, T107S, K122KE, I142V, D177E, Q197QR, T200A, Q207E, F214FL, T286A, I293V  
V179D_34 K103R_V179D_34 Unknown Unknown D67N, T69D, K70R, M184V, K219KQ V179D P14PL, A33AV, V35M, T39TI, V60I, K103R, V118VI, I135T, D177DE, G196E, F214L, V245EKQ, K277R, Q278E, L283I, A288T, I293V, E297K P19PL, P25PL 
V179D_35 K103R_V179D_35 Unknown Unknown M41L, D67N, K70R, V75VI, T215F, K219Q V108I, V179D E6K, V35R, K49R, K82R, K102E, K103R, K122E, I135L, A158S, S162C, K173KT, R211K, D218E, A272P, T286A, E291D, E297A  
V179D_36 K103R_V179D_36 Unknown Unknown  V179D K20R, K49R, K103R, D121Y, K122E, I135T, S162C, T200E, R211K, F214L, D250E, S251I, K277R, T286A, I293V  
V179D_37 K103R_V179D_37 Unknown Unknown M41L, L210LW, T215Y V179D E6D, V35T, T39A, R83K, K103R, D123E, I142IV, I178M, H208Y, R211K, V245EK, S251SI, A272P, K277R, K281KR, T286PS, I293V, E297KR  
V179D_38 K103R_V179D_38 Unknown Unknown  V179D V8VI, V35T, V60VI, K103R, D121Y, K122E, D123E, A158S, S162SC, E169ED, I180IV, T200TA, R211RK, F214L, P243PS, E248X, A272P, K277R, T286A  
V179D_39 K103R_V179D_39 Unknown Unknown A62V, K65R, M184V V179D S68T, K103R, I135M, T200TA, R211RK, V245K, A272P, V276VI, K277R, A288S, I293V, E297V  
V179D_4 K103R_V179D_4 Unknown Unknown M184V V179D K20R, V35VI, K103R, K122E, I135V, E169D, Q174K, G196E, T200A, F214L, V245E, T286A, A288S, I293V  
V179D_40 K103R_V179D_40 Unknown Unknown  V179D K20R, K102R, K103R, K104R, S105SA, K122E, A158S, K173R, R211S, F214L, A272P, I293V, E297PT  
V179D_41 K103R_V179D_41 Unknown Unknown M184V V108I, V179D, L234LI K103R, K173T, V189I, V245M, A272P, I293V  
V179D_5 K103R_V179D_5 Unknown Unknown M184MV V179D V35IL, W88C, K103R, V118I, K122E, D123E, K173E, F214L, A272P, K277R, Q278H, K281R, I293V, E297T  
V179D_6 K103R_V179D_6 Unknown Unknown D67N, M184V, T215F, K219Q V179D V35VE, K64H, K103R, V118I, I135T, T139R, T165L, F214L, V245M, A288S, I293V  
V179D_7 K103R_V179D_7 Unknown Unknown M41L, L74I, M184V, T215Y V179D E6D, V35T, T39A, R83K, K103R, D123E, I142IV, I178IM, G196GD, T200TI, H208Y, R211K, V245E, A272P, K277R, K281KR, T286P, I293V, E297K  
V179D_8 K103R_V179D_8 Unknown Unknown M41L, M184V, T215Y V179D L34I, K64KR, K103R, D121Y, K122E, D123E, S162C, I178M, G196E, T200I, R211G, V245M, A272P, P294Q  
V179D_9 K103R_V179D_9 Unknown Unknown A62V, Y115F, M184V, T215Y E138A, V179D, H221HY V35I, E44ED, K49E, I50IT, K102KR, K103R, V118I, I135IT, I142R, I178L, F214L, D218DE, A272P, V276I, L283I, I293V  

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