Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Murphy (1999)
Title Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team.
Citation J Infect Dis
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 46
NumPts 25
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
ACTG347_0008 008_PR_w0 None    E35D, M36I, N37D, L63P  
  008_PR_w12 APV 12  K20KT I13IL, T31S, E35D, M36I, N37D, L63P V75A 
ACTG347_0009 009_PR_w0 None   N83NDH V11VA, I15M, K20KR, E21ED, N37S, L63Q, N98NK L33L*, V82VG, L89LP 
  009_PR_w14 APV 13   L63Q  
ACTG347_0034 034_PR_w0 None    L63P  
  034_PR_w16 APV 14 M46MI, I50V  L63P  
ACTG347_0035 035_PR_w0 None    N37S, R41K, I62V, I64V, I72M V11VG 
  035_PR_w17 APV 17 I84V L10FI I13IV, N37S, R41K, I62V, I64IV, I72M  
ACTG347_0039 039_PR_w0 None    T12P, L19I, L33I, N37S, L63P, I64IL, H69N, A71V, P79S, I93L R87RS 
  039_PR_w13 APV, IDV 13   L10LI, T12S, R41K, I64V, V77I  
ACTG347_0040 040_PR_w11 APV 11   N37S, L63T, H69Y, K70KE, N98D  
ACTG347_0043 043_PR_w20 APV 20 I54IL  L10I, L63T, I93IL  
ACTG347_0044 044_PR_w0 None    T12S, R41K, I64V, V77I  
ACTG347_0068 068_PR_w21 APV 21   L10I, Q18QR, N37S, L63S, V77I, I93L  
ACTG347_0070 070_PR_w0 None    E35D, R57K, L63P  
  070_PR_w16 APV 16   E35D, R57K, L63P  
ACTG347_0073 073_PR_w0 None    L63P, H69Q  
  073_PR_w22 APV 22 I54IT  L63P, H69Q G49GR 
ACTG347_0129 129_PR_w0 None    K14R, R41K, D60E, I62V, L63C  
  129_PR_w12 APV 12   L10LV, K14R, R41K, D60E, I62V, L63C  
ACTG347_0131 131_PR_w0 None    E35D, N37DE, L63S, I64V, E65D  
  131_PR_w12 APV 11   E35D, N37E, L63S, I64V, E65D  
ACTG347_0132 132_PR_w0 None    N37NS, I62V, L63P, H69Q  
  132_PR_w8 APV I50V K43T N37K, L63P, H69Q  
  132_PR_w12 APV 11 I50V  N37S, L63P, H69Q  
ACTG347_0134 134_PR_w0 None    E35D, M36I, R57K  
  134_PR_w12 APV 12   K20R, E35D, M36I, R41K, R57K, R87X, N88X, N98I  
ACTG347_0140 140_PR_w0 None    I13V, K20R, M36I, R41K, I64V  
  140_PR_w8 APV I54IL F53FL I13V, K20R, M36I, R41K, I64V, I66X, C67CG  
ACTG347_0193 193_PR_w0 None   L33LF L10I, I13IV, E34EG, L63S, I64M, I72V  
  193_PR_w12 APV 12 I84IV  L10I, I13V, L63S, I64M, I72V  
ACTG347_0194 194_PR_w0 None    T31TP, R41K, I62IV, L63A  
  194_PR_w13 APV 12   K14R, R41K, L63A  
ACTG347_0195 195_PR_w0 None    E35D, M36I, N37D, L63P  
  195_PR_w9 APV, NFV   E35D, M36I, N37D, L63P  
ACTG347_0291 291_PR_w0 None    L19LI, R57RG, I62IV, L63LP, I64IV, C67CY  
  291_PR_w8 APV   I15V, L19I, E34V, I62V, L63P, I64V, C67Y  
ACTG347_0293 293_PR_w0 None    L63Q  
  293_PR_w22 APV 21 I54IM  Q7QR, K14KR, E21EG, L63Q, I72IV  
ACTG347_0321 321_PR_w0 Unknown    T12TA, M36MI, N37D, R57RK, D60E, L63A, V77I  
ACTG347_0323 323_PR_w0 None    I15IV, E35D, L63P, I72V V11G, D29E 
  323_PR_w12 APV   E35D, F53X, I54X, K55X, V56X, R57X, Q58X, L63P, I72V  
ACTG347_0386 386_PR_w0 None    K14R, I15V, E35D, N37E  
  386_PR_w25 APV 15   K14R, I15V, E35D, N37E  
ACTG347_0391 391_PR_w0 None   L23LI I13V, L63P, E65D Q58QR 
  391_PR_w16 APV 16   I13V, L63P, E65D