Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Rodes (2005)
Title Treatment response and drug resistance in patients infected with HIV type 1 group O viruses.
Citation ARHR
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup O
SelectedType Clinical
NumIsolates 10
NumPts 6
Host Human

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
RD_ESP1 ESP1_T0 None None  A98G, V179E, Y181C T27S, E28K, K32E, V35T, E36A, T39Q, K43Q, K49R, V60I, K102Q, K104Q, V118C, K122P, I135V, I142V, E169D, Q174D, D177E, I178L, E194P, I195LR, G196T, Q197E, T200K, K201R, I202V, Q207E, L210Y, R211Q, D237DN, K238E, V245K, E248N, S251V, N255D, I257IV, K259KE, V261I, A272Q, K275R, K277R, Q278E, L283I, A288S, I293V, T296S, E297K, L301M, A304E, A327V, Q334E, E344D, P345E, F346H, A355T, M357Q, G359A, A360S, V365I, K366R, T369A, A371V, V372L, I375V, A376S, T377Q, V381I, T386L, I393V, Q394T, K395R, A400T, T403A, E404D, F416Y, N418S, V423I, Q428R, K431S, V435M, F440Y, E449D, D460E, R461Q, R463K, V466I, V467I, S468K, T470D, D471E, T477A, I482V, H483L, G490K, L491E, E492K, A502V, A508S, K512Q, L517I, S519Q, Q524E, K530Q E204*W, M230D, K249KI, L264F, S268SI, K281KN, I309K, D320Q, S322D, I326W, E328N, Q480M, Q507S, D511T, E516P, I526T 
RD_ESP2 ESP2_T64 AZT, DDI, 3TC, D4T None M41L, D67DN, M184MV, T215Y A98G, V179E, Y181YC, G190A T27S, E28K, K32E, V35T, T39Q, K43Q, E44ED, V60I, K102Q, K103R, K104QR, V111VI, V118C, K122P, I135V, I142V, E169D, Q174D, D177E, I178L, E194P, I195L, G196A, Q197E, T200K, K201R, I202V, E203EK, Q207E, H208HY, L210Y, R211Q, K223KQ, L228M, V245T, E248N, S251V, V261I, A272Q, K275R, K277KR, Q278E, L283I, A288S, I293V, T296S, E297K, L301M, A304E, A327V, Q334E, E344D, P345E, F346H, A355AT, M357Q, R358RK, G359A, A360S, V365I, K366R, T369A, A371V, V372I, I375V, A376S, T377Q, T386L, I393V, Q394T, K395R, A400T, T403A, E404D, F416Y, N418S, V423I, K431S, V435R, F440Y, E449DG, D460E, R461Q, R463K, V466I, V467I, S468K, T470D, D471E, T477A, I482V, H483L, G490K, L491E, E492K, A502V, I506IT, A508S, K512Q, L517I, S519Q E204L, D320Q, S322D, I326W, E328N, R356RW, Q480M, Q507S, D511T, E516PR 
  ESP2_T75 AZT, DDI, 3TC, D4T None M41L, D67N, V75M, M184V, T215Y A98G, V179E, G190A T39Q, K43Q, E44D, V60I, K102Q, K103R, K104Q, D113DN, V118C, K122P, I135V, I142V, F160X, I167V, Q174D, D177E, I178L, E194P, I195L, G196A, Q197E, T200X, K201R, I202V, E203K, Q207E, H208F, L210Y, R211Q, K223Q, L228M, K238X, V245T, E248N, V261I, Y271YF, A272Q, K275KR, K277R, Q278E, L283I, A288S, E291EK, I293V, T296S, E297K, L301M, A304E, I309L, A327V, Q334E, E344D, P345E, F346H, Y354YF, M357Q, R358K, G359A, V365I, K366R, T369A, A371V, V372I, I375V, A376S, T377Q, S379A, T386L, I393V, Q394T, K395R, A400T, T403A, E404D, F416Y, N418S, V423I, K431S, V435R, F440Y, E449D, D460E, R461Q, R463K, V466I, V467I, S468K, T470D, D471E, T477A, I482V, H483L, G490K, L491E, E492K, A502V, A508S, D511X, L517I, S519Q, Q524E S191SP, E204L, S251LV, L264LF, D320Q, S322D, I326W, E328N, Q480M, Q507S, E514Q, E516P, I526T 
  ESP2_T95 AZT, DDI, 3TC, D4T, TDF None M41L, D67N, V75M, M184V, T215Y A98G, V179E, G190A E36K, T39Q, K43Q, E44D, V60I, K102Q, K103R, K104Q, V111I, V118C, K122P, I135V, I142V, I167V, Q174D, D177E, I178L, E194P, I195L, G196A, Q197E, T200K, K201R, I202V, E203K, Q207E, H208F, L210Y, R211Q, K223Q, L228M, V245T, E248N, S251V, V261I, A272Q, K275R, K277R, Q278X, M357Q, R358K, G359A, V365I, K366R, T369A, A371V, V372I, I375V, A376S, T377Q, S379A, T386L, I393V, Q394T, K395R, A400T, T403A, E404D, F416Y, N418S, V423I, K431S, V435R, F440Y, E449D, D460E, R461Q, R463K, V466I, V467I, S468K, T470D, D471E, T477A, I482V, H483L, G490K, L491E, E492K, A502V, A508S, K512Q, E514D, L517I, S519Q, Q524E E204L, L279~, C280~, K281~, L282~, L283~, R284~, G285~, T286~, K287~, A288~, L289~, T290~, E291~, V292~, I293~, P294~, L295~, T296~, E297~, E298~, A299~, E300~, L301~, E302~, L303~, A304~, E305~, N306~, R307~, E308~, I309~, L310~, K311~, E312~, P313~, V314~, H315~, G316~, V317~, Y318~, Y319~, D320~, P321~, S322~, K323~, D324~, L325~, I326~, A327~, E328~, I329~, Q330~, K331~, Q332~, G333~, Q334~, G335~, Q336~, W337~, T338~, Y339~, Q340~, I341~, Y342~, Q343~, E344~, P345~, F346~, Q480M, Q507S, D511T, E516P, I526T 
RD_ESP3 ESP3_T0 None None  A98G, V179E, Y181C I31L, K32E, V35T, E36A, T39Q, K43Q, V60I, K102Q, K104QR, V118C, K122P, I135V, I142V, E169D, Q174D, D177E, I178L, E194P, I195L, G196T, Q197E, T200K, K201R, I202V, Q207E, L210Y, K220KR, K223R, E224N, L228Q, V245PQ, E248N, V261I, A272Q, K275R, K277R, Q278EK, L283F, A288S, I293V, P294T, T296S, E297K, L301M, A304E, E312EG, A327V, Q334E, E344G, P345E, F346H, A355T, M357Q, R358K, G359A, A360S, V365I, K366R, T369A, A371V, V372L, I375V, A376S, T377Q, V381I, T386L, I393V, Q394T, K395R, A400AT, T403A, E404D, N418S, V423I, Q428R, K431S, V435M, F440Y, E449ED, D460E, R461Q, V466I, V467I, S468K, T470D, D471E, T477A, I482V, H483L, G490K, L491E, E492K, A502V, A508S, Q509L, K512Q, L517I, S519Q, Q524E, K530Q D186NY, E204L, R211*K, D218DH, K238K*, S251LV, L264F, I309K, D320Q, S322D, I326W, E328N, Y354C, K374K*, S379SY, R463EK, Q480M, Q507S, D511T, E516P, I526T 
  ESP3_T21 3TC, D4T None K70N, V75A, M184V A98G, V179E E28K, I31L, K32E, V35T, E36A, T39Q, K43Q, V60I, K73M, K102Q, V118C, K122P, I135V, I142V, E169D, Q174D, D177E, I178L, E194P, I195L, G196A, Q197E, T200K, K201R, I202V, Q207E, L210Y, L228Q, V245Q, E248N, S251I, V261I, A272Q, K275R, K277R, Q278E, L283I, A288S, I293V, P294T, T296S, E297T, L301M, A304E, A327V, Q334E, E344D, P345E, F346H, Y354YF, A355T, M357Q, R358K, G359A, A360S, V365I, K366R, T369A, A371V, V372L, I375V, A376S, T377Q, V381I, T386L, I393V, Q394T, K395R, T403A, E404D, N418S, V423I, Q428R, K431S, V435M, F440Y, D460E, R461Q, R463K, V466I, V467I, S468K, T470D, D471E, T477A, I482V, H483L, G490K, L491E, E492K, A502V, A508S, K512Q, L517I, S519Q, Q524E, K530Q T27FS, E204L, R211*K, K238K*, D250~, I309R, D320Q, S322D, I326W, E328N, Q480M, Q507S, D511T, E516P, I526T 
RD_ESP4 ESP4_T0 None None  A98G, V179E, Y181C K32E, V35T, E36A, T39Q, K43Q, K49R, V60I, D86E, K102Q, V118C, K122P, I135V, I142V, E169D, Q174D, D177E, I178L, E194P, I195L, G196T, Q197E, T200K, K201R, I202V, Q207E, L210Y, R211Q, V245Q, E248N, S251V, V261I, A272Q, K275R, K277R, L279LM, L283I, A288S, I293V, T296S, E297K, E302D E204L, Q278~ 
  ESP4_T47 3TC, D4T None  A98G, V179E, Y181C K32E, V35T, E36A, T39Q, K43Q, K49R, V60I, D86E, K102Q, V118C, K122P, I135V, I142V, E169D, Q174D, D177E, I178L, E194P, I195L, G196T, Q197E, T200K, K201R, I202V, Q207E, L210Y, R211Q, V245Q, E248N, S251V, V261I, A272Q, K275R, K277R, L279M, L283I, A288S, I293V, T296S, E297X, A304E, A327V, Q334E, E344D, P345E, F346H, Y354YF, M357Q, R358K, G359A, A360S, V365I, K366R, T369A, A371V, V372L, I375V, A376S, T377Q, S379A, T386L, K390R, I393V, Q394T, K395R, T403A, E404D, N418S, V423I, Q428R, K431S, V435M, F440Y, E449N, D460E, R461Q, R463K, V466I, V467I, S468K, T470D, D471E, T477A, I482V, H483L, G490K, L491E, E492K, A508S, K512Q, L517I, S519Q, Q524E, K530Q E204L, K238K*, Q278~, I309K, D320Q, S322D, I326W, E328N, Q480M, Q507S, D511T, E516P, I526T 
RD_GB1 GB1_T0 None None  A98G, V179E, Y181C K32E, V35T, E36A, T39Q, K43Q, K49R, V60I, K102Q, K104Q, V118C, K122P, I135V, E169D, Q174D, D177E, I178L, E194P, I195L, G196T, T200K, K201R, I202V, E204A, Q207E, L210Y, R211Q, V245Q, E248N, S251V, A272Q, K275R, Q278E, L283I Q197GV 
RD_GB2 GB2_T0 None None  A98G, V179E, Y181C K32E, V35ST, E36A, T39Q, K43Q, K49R, V60I, T69X, F87FL, K102Q, V118C, K122P, I135V, E169D, Q174D, D177E, I178L, E194P, I195L, G196T, Q197E, T200K, K201R, I202V, E204A, Q207E, L210Y, R211Q  

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