Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Mo (2005)
Title Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: mutation patterns and baseline correlates.
Citation J Virol
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 87
NumPts 54
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
8256 8256_d1 PI    I13IV, R41RK  
  8256_d1v PI    I13IV  
  8256_d510 PI, LPV    R41RK  
  8256_d678 PI, LPV    R41RK  
  8256_d841 PI, LPV    R41RK  
  8256_d1097 PI, LPV    R41RK, L63LP  
8265 8265_d1 PI  V82VA  I15V, E35D, N37E, L63P, E65ED, K70R  
  8265_d776 PI, LPV    I15V, K20KR, E35D, N37E, L63LP, K70R  
  8265_d1104 PI, LPV    I15V, K20KR, E35D, N37E, L63LP, K70R  
8985 8985_d1 PI  M46I, I84V, L90M  L10IV, E35D, M36I, I62V, L63P, A71V, I93L  
  8985_d330 PI, LPV  M46I, I54V, I84V, L90M G73S L10I, K20KR, E35D, M36I, I62V, L63P, A71V, I93L  
9004 9004_d1 PI    T12TA, L63A  
  9004_d337 PI, LPV    L63A  
9014 9014_d1 PI  M46L, I54V, V82AT  L10I, I13V, L19MT, K20R, M36MI, R41K, I62V, L63P, I64V, I66F  
  9014_d315 PI, LPV  M46L, I54V, V82AT L23LI L10I, I13V, L19MT, K20R, M36MI, R41K, I62V, L63P, I64V, I66F  
9019 9019_d1 PI    I15IV, M36I, L63T, I64IV, E65ED, I72IT  
  9019_d349 PI, LPV    L10LI, M36MI, L63T, E65ED, I72IT  
9035 9035_d334 PI, LPV  M46L, I54V, L76V, V82A L33F, K43T T12I, I13V, K20KR, E35D, M36I, R57RK, Q61E, I62V, L63P, I64V, A71V, I93L  
9049 9049_d221 PI, LPV    L38V, R57K, D60E, Q61E, L63P, A71V, I72V, V77I, I93L  
9053 9053_d1 PI  M46L, I54V, V82A  I62V, I64V  
  9053_d233 PI, LPV  M46L, I54V, V82A  L19LF, I62V, I64V  
9079 9079_d1 PI    T12S, L63P, H69Q  
  9079_d344 PI, LPV    T12S, L63P, H69Q  
9085 9085_d1 PI  M46MI, I54IV, V82T, I84IV, L90LM  N37S, Q61E, L63P, A71V, I85IV, I93IL  
  9085_d316 PI, LPV  M46I, L76LV, V82T, I84V  L10LI, N37S, Q61E, L63P, A71V, I93L  
9086 9086_d356 PI, LPV    E35D, N37E, L63P, V77VI, I93L  
9095 9095_d1 PI  M46MI, I54V, V82A K20KT, L24LI L10I, T12P, K14R, G16E, M36MI, P39S, K55KR, I62V, L63T, I64IL, G68D, A71V, I93L  
  9095_d337 PI, LPV  I54V, V82A K20T L10I, T12P, K14R, G16E, M36I, P39S, I62V, L63T, G68D, A71V, I93L  
9113 9113_d1 PI  M46L, I54V, V82A L24I L10LI, R41K, I62V, L63P, A71V, T74A, V77I, I93L  
  9113_d339 PI, LPV  M46L, I54V, V82A L10FVI, L24I R41K, I62V, L63P, A71V, T74A, V77VI, I93L  
9124 9124_d1 PI  G48V, I54S, V82A  L10I, E34Q, I62V, L63P, A71V, T74S, V77I, I93L  
  9124_d59 PI, LPV  G48V, I54S, V82A  L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93L  
  9124_d164 PI, LPV  G48V, I54S, V82A  L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93L  
  9124_d339 PI, LPV  M46MIV, G48V, I50V, I54S, V82A L33LF L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93L  
9126 9126_d299 PI, LPV    L63LP, I93IL  
9154 9154_d1 PI  V32VI, L76LV, V82VA  I15V, R41K, L63P, I93L  
  9154_d168 PI, LPV  M46ML, I47IV, I54IV, L76LV, V82VA  I15V, R41K, L63P, I93L  
9163 9163_d1 PI  V32I, I47V, V82A  Q61E, L63P, I93L  
  9163_d358 PI, LPV  V32I, M46I, I47V, V82A L10F, L33F Q61E, L63P, I93L  
9172 9172_d1 PI  M46L, L90M K20T L10V, I13V, I15V, G16A, K55R, I62V, L63P, I66F, A71T, I72LM, V77I  
  9172_d330 PI, LPV  M46L, L90M K20T L10LV, I13V, I15V, G16A, K55R, I62V, L63P, I66F, A71T, I72LM, V77I  
9182 9182_d1 PI  M46I, I54V, V82A, L90M G73GC L10I, T12TK, E35D, M36MI, I62V, L63P, I64IV, T74S, I93L, C95F  
  9182_d359 PI, LPV  M46I, I54V, V82A, L90M L33F, K43T, G73GC L10I, T12K, I13V, K20KR, E35D, M36I, I62V, L63P, I66IV, T74S  
9189 9189_d1 PI  I54V, V82A, L90M L10F, K43KT K20KR, E35D, M36I, N37DE, R57K, I62V, L63P, A71V, I93L, C95CF  
  9189_d175 PI, LPV  I54V, V82A, L90M L10F, K43KT K20R, E35D, M36I, N37D, R57K, I62V, L63P, A71V, I93L, C95CF  
9200 9200_d340 PI, LPV    R41K  
9208 9208_d362 PI, LPV    E35D, N37D, L63S, V82I  
9226 9226_d1 PI    T12TA, I13V, N37T, L63SA, I64V, V77I  
  9226_d167 PI, LPV    L10I, I13V, N37T, L63S, I64V, V77VI  
9231 9231_d1 PI  I54IV, V82A Q58QE L10LI, L19I, K20R, M36I, R41K, Q61X, L63P, H69K, T74S, L89M, I93L  
  9231_d268 PI, LPV  M46I, I54V, L76LV, V82A Q58QE L10I, L19I, K20R, M36I, R41RK, Q61X, L63P, H69K, T74S, L89M, I93L  
9246 9246_d1 PI    I13V, K14R, L19LI, R41K, I64V, H69HY, I72IV  
  9246_d344 PI, LPV    I13V, K14R, R41K, I64V, I72IV  
9255 9255_d1 PI    T12N, L19LI, N37S, L63LP, I64IV, V77VI  
  9255_d279 PI, LPV    T12N, N37S  
9287 9287_d1 PI  I54V, V82A  L10I, I15V, M36MI, R41K, D60E, I62IV, L63P, A71AT  
  9287_d337 PI, LPV  I54V, V82A  L10I, I15V, M36I, R41K, D60E, I62IV, L63P, A71T  
DK-125 DK-125 IDV, NFV 172 M46I, I54V, V82F, L90M Q58E L10I, D60DE, I62IV, L63LP, I64V, I72IM, V77I, I93L  
  6376_d427 IDV, NFV, LPV 233 M46I, I54V, V82F, L90M Q58E, G73C L10I, D60DE, L63P, I64IV, V77I, I93L G52GS 
  6376_d508 IDV, NFV, LPV 244 M46I, I54V, V82F, L90M Q58E, G73C L10I, D60DE, L63P, I64IV, H69HR, V77I, I93L  
DK-1584 DK-1584 RTV, NFV, IDV 76 D30N, M46MI  R41K, I62V, L63P, V75VI, V77I, I93L  
  6325_d342 RTV, NFV, IDV, LPV 124   R41K, I62V, L63P, V77VI, I93L  
  6325_d430 RTV, NFV, IDV, LPV 137   R41K, I62V, L63P, V77VI, I93L  
DK-2314 DK-2314 NFV 133 M46I, N88S, L90M  L10IM, I13V, Q18H, N37D, K55KR, Q61QH, L63P, A71T, I72T, V77I, I93L  
DK-294 DK-294 SQV, IDV, RTV 181   I15V, M36I, R41K, L63P, E65D, K70R  
DK-3443 DK-3443 NFV 57  N88ND P39PT, R57K, L63P  
DK-3494 DK-3494 SQV, RTV 165 G48V, I54V, V82A, L90M  L10I, L63P, A71V, I72M, V77I, I93L  
DK-354 DK-354 IDV 58   I13V, R57K, L63P  
DK-3705 DK-3705 SQV, RTV, IDV, NFV 139 I54V, V82T, L90M  L10I, L19R, N37NY, R41K, D60E, L63P, A71V, V77I, I93L  
DK-3914 DK-3914 NFV 19   I13V, I15V, E35D, R41K, I62V, L63P, A71T  
DK-4094 DK-4094 IDV, SQV, RTV, NFV 151 M46I, I54V, V82A, L90M L10VF L63P, H69K, A71V, I93L  
DK-4214 DK-4214 RTV 80 M46L, V82L Q58E L63LP  
DK-4305 DK-4305 IDV, NFV, RTV 161 M46I, I54V, V82A L24I L10I, K14R, L63P, H69Q, A71V, V77I, I93M  
DK-4784 DK-4784 IDV, SQV, RTV 193 M46L, G48S, I54V, V82A L10IF, L24I, F53L K20R, L33I, E35D, M36I, N37D, R41K, K55R, R57K, L63P, I64V  
DK-5204 DK-5204 SQV 57 I84V, L90M L10F, T74P E35D, L63P, A71V, I93L  
DK-5973 DK-5973 IDV 83 I54V, V82A L10F E35D, M36V, R41K, D60E, Q61E, I62V, L63P, I64V  
DK-6333 DK-6333 IDV 97 V32I, M46L, V82A L10F E35D, M36I, K43KE, I64V, A71V  
DK-6804 DK-6804 NFV 49 L90M  L10I, I13IV, E35D, M36I, R57RK, Q61QE, I62V, L63PA, C67DY, A71V, I93L  
DK-6905 DK-6905 SQV, IDV, RTV, NFV 150 M46VL, I54V, V82A, N88NS L24I, F53FL L10I, T12D, K14R, I15V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, A71V  
DK-7623 DK-7623 IDV 111 I54V, V82A  L10I, E35D, L63A, A71V, I85V, I93L  
DK-7815 DK-7815 IDV, RTV, SQV, NFV 165 I54V, V82VA, I84IV, L90M L33F, F53L, G73GS L10VI, I13V, K14KR, K20KR, E35D, M36I, R41K, D60E, Q61G, I62V, L63P, A71V  
DK-815 DK-815 RTV, IDV 72 I54V, V82A, L90M K43T, F53L L10I, K20R, E35D, M36I, R41RK, I62V, L63P, A71V  
DK-873 DK-873 NFV 37 D30N  E35D, M36MI, K45KR, L63P, I64L  
DK-8805 DK-8805 IDV, SQV, RTV 169 M46L, G48V, I54T, V82A  L10I, R41K, L63P, A71L, I72IT, V77I, I93L  
DK-8873 DK-8873 NFV 76 D30N N88D L10I, L63T, I64V, E65D, A71V, V77VI  
DK-9014 DK-9014 IDV 147 V32VI, M46I, I47V  L10IV, L63P, V77I, Q92QKR, I93L, C95F  
DK-9415 DK-9415 SQV, RTV, IDV 133 I54IV, L90LM  L10LI, I15V, G16GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63LH, I64IM, K70KR, L89M