Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Weber (2005)
Title Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation.
Citation J Clin Microbiol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 10
NumPts 4
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
WJ_pat7101 7101_W0 None None  V106I, V179D E6D, V21VD, D123E, I178L, G196E, T200I, F214L, V245T, K249Q, K275R, V276I, I293V, P294Q  
  7101_W12 TDF, 3TC EFV D67N, M184V V106M, V179D E6D, D123E, I178L, G196E, T200I, F214L, V245T, K249Q, K275R, V276I, I293V, P294Q  
  7101_W24 TDF, 3TC EFV A62AV, K65KR, M184V V106M, V179D E6D, V21VD, S68SN, D123E, I178L, E194EK, G196E, T200I, R211RK, F214L, V245T, K249Q, K275R, V276I, I293V, P294Q  
WJ_pat7152 7152_W0 None None  V179D V35L, K43S, I50V, R83K, D121C, K122E, E169D, D177E, F214L, E248D, A272P, K277R, R284K, T286A, I293V  
  7152_W36 3TC, D4T EFV K65R, T69~, K70R V106M, V179D K20R, V35L, K43S, I50V, R83K, D121H, K122E, E169D, D177E, F214L, E248D, A272P, K277R, T286A  
WJ_pat7225 7225_W0 None None   D123E, K173E, D177E, I178M, T200A, E204K, Q207A, R211K, P243T, A272P V21VDE 
  7225_W36 3TC, D4T EFV K65R L100I, K103N D123E, K173E, D177E, I178M, T200A, E204K, Q207A, R211K, P243T, A272P  
  7225_W56 3TC, D4T EFV K65R L100I, K103N V21VD, D123E, D177E, I178M, T200A, E204K, Q207A, R211K, P243T, A272P  
WJ_pat7728 7728_W0 None None   V21VD, K64R, D123E, I135T, S162C, T200A, V245M, T286A, T296S, E297K  
  7728_W32 TDF, 3TC EFV A62V, K65R, M184V Y188L K102Q, D123E, I135T, S162C, V179I, I195T, T200A, V245M, T286A, P294A, T296S, E297K